TNF and TNF receptors as therapeutic targets for rheumatic diseases and beyond

Nature Reviews Rheumatology, Published online: 04 August 2023; doi:10.1038/s41584-023-01002-7The TNF–TNF receptor signalling network has pleiotropic effects that can both promote and protect against immune-mediated diseases. Modulation of this network through the use of TNF receptor-targeting biologic drugs holds promise for treating various diseases, including TNF inhibitor-refractory diseases.

Source: Nature Reviews Rheumatology - August 4, 2023 Category: Rheumatology Authors: Daniela Siegmund Harald Wajant Source Type: research