Mouse models for human hyperuricaemia: a critical review
Nature Reviews Rheumatology, Published online: 22 May 2019; doi:10.1038/s41584-019-0222-xHyperuricaemia is a risk factor for gout, and mouse models of this condition can help dissect the underlying regulatory mechanisms. However, these models come with both advantages and disadvantages, and interpreting and comparing data from these models can be challenging. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 22, 2019 Category: Rheumatology Authors: Jie Lu Nicola Dalbeth Huiyong Yin Changgui Li Tony R. Merriman Wen-Hua Wei Source Type: research

Patrolling monocytes promote kidney disease
Nature Reviews Rheumatology, Published online: 20 May 2019; doi:10.1038/s41584-019-0239-1Patrolling monocytes promote kidney disease (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 20, 2019 Category: Rheumatology Authors: Joanna Collison Source Type: research

HLA associations in inflammatory arthritis: emerging mechanisms and clinical implications
Nature Reviews Rheumatology, Published online: 15 May 2019; doi:10.1038/s41584-019-0219-5The HLA region is strongly associated with many rheumatic diseases, including inflammatory arthritis. In this Review, potential mechanisms underpinning these associations are discussed, as are the clinical implications of HLA associations for the diagnosis and treatment of these diseases. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 15, 2019 Category: Rheumatology Authors: Robert Busch Simon Kollnberger Elizabeth D. Mellins Source Type: research

Should 18F-FDG-PET imaging be used in the diagnosis of GCA?
Should 18F-FDG-PET imaging be used in the diagnosis of GCA?Should 18F-FDG-PET imaging be used in the diagnosis of GCA?, Published online: 09 May 2019; doi:10.1038/s41584-019-0236-418F-FDG-PET is not currently recommended for use in the diagnosis of cranial giant cell arteritis (GCA). A new study has compared 18F-FDG-PET with temporal artery biopsy and clinical diagnosis as gold standards, but is 18F-FDG-PET accurate enough to be used on temporal arteries? (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 9, 2019 Category: Rheumatology Authors: Dario Camellino Christian Dejaco Source Type: research

Therapeutic options for targeting inflammatory osteoarthritis pain
Therapeutic options for targeting inflammatory osteoarthritis pain, Published online: 08 May 2019; doi:10.1038/s41584-019-0221-yPain management is presently the focus of osteoarthritis (OA) therapy, but traditional pain-relieving drugs such as NSAIDs and glucocorticoids have limited utility. In this Review, the next generation of OA analgesics and their potential mechanisms of action are discussed. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 8, 2019 Category: Rheumatology Authors: Philip G. Conaghan Andrew D. Cook John A. Hamilton Paul P. Tak Source Type: research

Single-cell technologies — studying rheumatic diseases one cell at a time
Single-cell technologies — studying rheumatic diseases one cell at a timeSingle-cell technologies — studying rheumatic diseases one cell at a time, Published online: 07 May 2019; doi:10.1038/s41584-019-0220-zSingle-cell sequencing technologies enable transcriptomic, epigenomic and proteomic analysis of rare or heterogeneous populations of cells. In this Review, Kuo and colleagues discuss current and future uses of single-cell sequencing technologies for rheumatology research. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 7, 2019 Category: Rheumatology Authors: Peggie Cheung Purvesh Khatri Paul J. Utz Alex J. Kuo Source Type: research

FRA1 in macrophages promotes arthritis
FRA1 in macrophages promotes arthritis, Published online: 03 May 2019; doi:10.1038/s41584-019-0233-7FRA1 in macrophages promotes arthritis (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 3, 2019 Category: Rheumatology Authors: Jessica McHugh Source Type: research

Preventing NETosis to reduce thrombosis
Preventing NETosis to reduce thrombosis, Published online: 03 May 2019; doi:10.1038/s41584-019-0234-6Preventing NETosis to reduce thrombosis (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 3, 2019 Category: Rheumatology Authors: Joanna Collison Source Type: research

TIGIT-Ig shows therapeutic potential in SLE
TIGIT-Ig shows therapeutic potential in SLE, Published online: 02 May 2019; doi:10.1038/s41584-019-0230-xTIGIT-Ig shows therapeutic potential in SLE (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 2, 2019 Category: Rheumatology Authors: Sarah Onuora Source Type: research

Namilumab improves RA symptoms
Namilumab improves RA symptoms, Published online: 02 May 2019; doi:10.1038/s41584-019-0231-9Namilumab improves RA symptoms (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 2, 2019 Category: Rheumatology Authors: Sarah Onuora Source Type: research

Daily atorvastatin safe for patients with RA
Daily atorvastatin safe for patients with RA, Published online: 02 May 2019; doi:10.1038/s41584-019-0229-3Daily atorvastatin safe for patients with RA (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 2, 2019 Category: Rheumatology Authors: Sarah Onuora Source Type: research

Amyloid-PET: a new tool for diagnosing IBM?
Amyloid-PET: a new tool for diagnosing IBM?, Published online: 02 May 2019; doi:10.1038/s41584-019-0223-9Inclusion body myositis (IBM) and polymyositis can normally be distinguished on the basis of clinical features. However, patients with an atypical disease presentation, particularly those with early-stage disease, can be challenging to diagnose. Can imaging with amyloid-PET help distinguish these two diseases? (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 2, 2019 Category: Rheumatology Authors: Iago Pinal-Fernandez Andrew L. Mammen Source Type: research

Choline uptake is vital for IL-1β-driven inflammation
Choline uptake is vital for IL-1β-driven inflammationCholine uptake is vital for IL-1β-driven inflammation, Published online: 02 May 2019; doi:10.1038/s41584-019-0228-4Choline uptake is vital for IL-1β-driven inflammation (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 2, 2019 Category: Rheumatology Authors: Isobel Leake Source Type: research

Burden of musculoskeletal diseases increasing
Burden of musculoskeletal diseases increasing, Published online: 02 May 2019; doi:10.1038/s41584-019-0232-8Burden of musculoskeletal diseases increasing (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 2, 2019 Category: Rheumatology Authors: Sarah Onuora Source Type: research

Controlling chondrocyte senescence
Controlling chondrocyte senescence, Published online: 01 May 2019; doi:10.1038/s41584-019-0227-5Controlling chondrocyte senescence (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 1, 2019 Category: Rheumatology Authors: Nicholas J. Bernard Source Type: research

X-chromosome inactivation altered in SLE
X-chromosome inactivation altered in SLE, Published online: 30 April 2019; doi:10.1038/s41584-019-0226-6X-chromosome inactivation altered in SLE (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 30, 2019 Category: Rheumatology Authors: Joanna Collison Source Type: research

Can personalized use of NSAIDs be a reality in the clinic?
Can personalized use of NSAIDs be a reality in the clinic?, Published online: 30 April 2019; doi:10.1038/s41584-019-0225-7The use of NSAIDs in rheumatology could be improved by an appropriate risk scoring system that accounts for adverse events such as bleeding and thrombosis. Such a risk score has now been developed using data from the PRECISION trial, but is this score ready to be applied in clinical practice? (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 30, 2019 Category: Rheumatology Authors: Michael T. Nurmohamed Source Type: research

Soluble CD83: a proresolving mediator in inflammatory arthritis?
Soluble CD83: a proresolving mediator in inflammatory arthritis?, Published online: 26 April 2019; doi:10.1038/s41584-019-0224-8Soluble CD83: a proresolving mediator in inflammatory arthritis? (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 26, 2019 Category: Rheumatology Authors: Jessica McHugh Source Type: research

Insights into rheumatic diseases from next-generation sequencing
Insights into rheumatic diseases from next-generation sequencing, Published online: 18 April 2019; doi:10.1038/s41584-019-0217-7Next-generation sequencing (NGS) technologies are being developed at a rapid pace. This Review highlights advances in our understanding of rheumatic diseases that have been gained from NGS and offers guidance to rheumatology researchers using these technologies. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 18, 2019 Category: Rheumatology Authors: Laura T. Donlin Sung-Ho Park Eugenia Giannopoulou Aleksandra Ivovic Kyung-Hyun Park-Min Richard M. Siegel Lionel B. Ivashkiv Source Type: research

Has lupus anticoagulant testing had its day?
Has lupus anticoagulant testing had its day?, Published online: 18 April 2019; doi:10.1038/s41584-019-0218-6Antibodies against phosphatidylserine–prothrombin complexes (PS–PT) are one type of antiphospholipid antibody that is responsible for lupus anticoagulant activity. Anti-PS–PT antibodies are not currently included in the classification criteria for antiphospholipid syndrome (APS), but should they replace lupus anticoagulant testing to improve the diagnosis of APS? (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 18, 2019 Category: Rheumatology Authors: Yuichiro Fujieda Tatsuya Atsumi Source Type: research

B cell checkpoints in autoimmune rheumatic diseases
B cell checkpoints in autoimmune rheumatic diseases, Published online: 09 April 2019; doi:10.1038/s41584-019-0211-0B cells contribute to the pathogenesis of many rheumatic diseases. Targeting immune checkpoints that control the activation and effector function of B cells represents a promising therapeutic avenue. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 9, 2019 Category: Rheumatology Authors: Samuel J. S. Rubin Michelle S. Bloom William H. Robinson Source Type: research

Spontaneous dog osteoarthritis — a One Medicine vision
Spontaneous dog osteoarthritis — a One Medicine visionSpontaneous dog osteoarthritis — a One Medicine vision, Published online: 05 April 2019; doi:10.1038/s41584-019-0202-1Osteoarthritis occurs spontaneously in pet dogs, which often share environmental and lifestyle risk-factors with their owners. This Review aims to stimulate cooperation between medical and veterinary research under the One Medicine initiative to improve the welfare of dogs and humans. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 5, 2019 Category: Rheumatology Authors: Richard L. Meeson Rory J. Todhunter Gordon Blunn George Nuki Andrew A. Pitsillides Source Type: research

Involvement of the myeloid cell compartment in fibrogenesis and systemic sclerosis
Involvement of the myeloid cell compartment in fibrogenesis and systemic sclerosis, Published online: 05 April 2019; doi:10.1038/s41584-019-0212-zMyeloid cells come in many shapes and sizes and are central to inflammatory processes. This Review puts myeloid cells and their inflammatory functions into the context of fibrosis and their contribution to pathology in systemic sclerosis. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 5, 2019 Category: Rheumatology Authors: Gabriela Kania Michal Rudnik Oliver Distler Source Type: research

Bone inflamm-ageing
Bone inflamm-ageing, Published online: 04 April 2019; doi:10.1038/s41584-019-0216-8Bone inflamm-ageing (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 4, 2019 Category: Rheumatology Authors: Nicholas J. Bernard Source Type: research

CAR T cells drive out B cells in SLE
CAR T cells drive out B cells in SLE, Published online: 04 April 2019; doi:10.1038/s41584-019-0214-xCAR T cells drive out B cells in SLE (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 4, 2019 Category: Rheumatology Authors: Jessica McHugh Source Type: research

Blocking CD40–CD40L interactions in Sjögren syndrome
Blocking CD40–CD40L interactions in Sjögren syndromeBlocking CD40–CD40L interactions in Sjögren syndrome, Published online: 03 April 2019; doi:10.1038/s41584-019-0215-9Blocking CD40–CD40L interactions in Sjögren syndrome (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 3, 2019 Category: Rheumatology Authors: Jessica McHugh Source Type: research

NGF vaccine reduces pain
NGF vaccine reduces pain, Published online: 28 March 2019; doi:10.1038/s41584-019-0213-yNGF vaccine reduces pain (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - March 28, 2019 Category: Rheumatology Authors: Nicholas J. Bernard Source Type: research

Recombinant IL-1Ra as first-line therapy in sJIA
Recombinant IL-1Ra as first-line therapy in sJIA, Published online: 27 March 2019; doi:10.1038/s41584-019-0208-8Recombinant IL-1Ra as first-line therapy in sJIA (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - March 27, 2019 Category: Rheumatology Authors: Joanna Collison Source Type: research

New species of gut bacteria associated with AS
New species of gut bacteria associated with AS, Published online: 27 March 2019; doi:10.1038/s41584-019-0209-7New species of gut bacteria associated with AS (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - March 27, 2019 Category: Rheumatology Authors: Joanna Collison Source Type: research

Cholesterol and cartilage do not mix well
Cholesterol and cartilage do not mix well, Published online: 26 March 2019; doi:10.1038/s41584-019-0204-zThe molecular mechanisms responsible for initiation and progression of osteoarthritis (OA) are incompletely understood. New data implicate cholesterol, its metabolites and the receptor RORα as catabolic drivers of OA-like disease in mice, but do these data identify new targets for treating patients with OA? (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - March 26, 2019 Category: Rheumatology Authors: Frank Beier Source Type: research

Targeting NF-κB in tendinopathy
Targeting NF-κB in tendinopathyTargeting NF-κB in tendinopathy, Published online: 26 March 2019; doi:10.1038/s41584-019-0206-xTargeting NF-κB in tendinopathy (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - March 26, 2019 Category: Rheumatology Authors: Jessica McHugh Source Type: research

IVIG and ciclosporin for Kawasaki disease
IVIG and ciclosporin for Kawasaki disease, Published online: 26 March 2019; doi:10.1038/s41584-019-0207-9IVIG and ciclosporin for Kawasaki disease (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - March 26, 2019 Category: Rheumatology Authors: Joanna Collison Source Type: research

Serum biomarkers of disease activity in JDM
Serum biomarkers of disease activity in JDM, Published online: 26 March 2019; doi:10.1038/s41584-019-0210-1Serum biomarkers of disease activity in JDM (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - March 26, 2019 Category: Rheumatology Authors: Joanna Collison Source Type: research

Aspirin meets cGAS
Aspirin meets cGAS, Published online: 26 March 2019; doi:10.1038/s41584-019-0205-ySensing of cytosolic DNA by cyclic GMP–AMP synthase (cGAS) is central to the pathogenesis of a number of autoinflammatory syndromes and possibly some autoimmune diseases, such as systemic lupus erythematosus (SLE). Activation of cGAS signalling requires its deacetylation, so might aspirin have therapeutic potential to treat SLE by acetylating cGAS? (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - March 26, 2019 Category: Rheumatology Authors: Keith B. Elkon Source Type: research

Tapering bDMARDs in axial SpA — what is the current evidence?
Tapering bDMARDs in axial SpA — what is the current evidence?Tapering bDMARDs in axial SpA — what is the current evidence?, Published online: 22 March 2019; doi:10.1038/s41584-019-0201-2Biologic DMARDs are a cornerstone treatment for severe axial spondyloarthritis. Although indications for treatment initiation are well codified, the timing and modalities for tapering remain unclear, despite medical and economic concerns. Encouraging data about treatment tapering are emerging that might guide future management strategies. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - March 22, 2019 Category: Rheumatology Authors: Nelly R. Ziade Xenofon Baraliakos Source Type: research

Bacterial cell wall offcasts linked to autoimmune disease
Bacterial cell wall offcasts linked to autoimmune disease, Published online: 20 March 2019; doi:10.1038/s41584-019-0203-0Bacterial cell wall offcasts linked to autoimmune disease (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - March 20, 2019 Category: Rheumatology Authors: Joanna Collison Source Type: research

mTORC1 promotes pathological bone–cartilage interplay
mTORC1 promotes pathological bone–cartilage interplaymTORC1 promotes pathological bone–cartilage interplay, Published online: 06 March 2019; doi:10.1038/s41584-019-0200-3mTORC1 promotes pathological bone–cartilage interplay (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - March 6, 2019 Category: Rheumatology Authors: Jessica McHugh Source Type: research

Oncogenes and inflammasomes in lupus nephritis
Oncogenes and inflammasomes in lupus nephritis, Published online: 05 March 2019; doi:10.1038/s41584-019-0194-xOncogenes and inflammasomes in lupus nephritis (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - March 5, 2019 Category: Rheumatology Authors: Joanna Collison Source Type: research

Cholesterol test for T cells
Cholesterol test for T cells, Published online: 05 March 2019; doi:10.1038/s41584-019-0195-9Cholesterol test for T cells (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - March 5, 2019 Category: Rheumatology Authors: Nicholas J. Bernard Source Type: research

Tocilizumab improves quality of life in GCA
Tocilizumab improves quality of life in GCA, Published online: 05 March 2019; doi:10.1038/s41584-019-0197-7Tocilizumab improves quality of life in GCA (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - March 5, 2019 Category: Rheumatology Authors: Joanna Collison Source Type: research

Inclusion body myositis: clinical features and pathogenesis
Inclusion body myositis: clinical features and pathogenesis, Published online: 05 March 2019; doi:10.1038/s41584-019-0186-xInclusion body myositis (IBM) is a slowly progressive disease characterized by unique clinical and pathological features. This Review discusses the historical and clinical aspects of IBM and the mounting evidence arguing for the important pathogenic function of the immune system. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - March 5, 2019 Category: Rheumatology Authors: Steven A. Greenberg Source Type: research

No need for DMARD holiday before arthroplasty
No need for DMARD holiday before arthroplasty, Published online: 05 March 2019; doi:10.1038/s41584-019-0199-5No need for DMARD holiday before arthroplasty (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - March 5, 2019 Category: Rheumatology Authors: Joanna Collison Source Type: research

Gut microbiota linked to kidney disease in SLE
Gut microbiota linked to kidney disease in SLE, Published online: 05 March 2019; doi:10.1038/s41584-019-0196-8Gut microbiota linked to kidney disease in SLE (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - March 5, 2019 Category: Rheumatology Authors: Joanna Collison Source Type: research

Gut microbiota changes pre-date onset of RA
Gut microbiota changes pre-date onset of RA, Published online: 05 March 2019; doi:10.1038/s41584-019-0198-6Gut microbiota changes pre-date onset of RA (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - March 5, 2019 Category: Rheumatology Authors: Joanna Collison Source Type: research

AMPK: a therapeutic target in RA?
AMPK: a therapeutic target in RA?, Published online: 04 March 2019; doi:10.1038/s41584-019-0192-zAMPK: a therapeutic target in RA? (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - March 4, 2019 Category: Rheumatology Authors: Jessica McHugh Source Type: research

Glucocorticoid response mapped
Glucocorticoid response mapped, Published online: 01 March 2019; doi:10.1038/s41584-019-0191-0Glucocorticoid response mapped (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - March 1, 2019 Category: Rheumatology Authors: Jessica McHugh Source Type: research

Platelets: emerging facilitators of cellular crosstalk in rheumatoid arthritis
Platelets: emerging facilitators of cellular crosstalk in rheumatoid arthritis, Published online: 01 March 2019; doi:10.1038/s41584-019-0187-9Platelets mediate inflammatory responses by facilitating immune cell crosstalk and participating in inflammatory signalling cascades. In this Review, the authors discuss the emerging role of platelet signalling pathways in the pathogenesis of rheumatoid arthritis. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - March 1, 2019 Category: Rheumatology Authors: Oore-ofe Olumuyiwa-Akeredolu Martin J. Page Prashilla Soma Etheresia Pretorius Source Type: research

Advances in antibody engineering for rheumatic diseases
Advances in antibody engineering for rheumatic diseases, Published online: 27 February 2019; doi:10.1038/s41584-019-0188-8Antibody therapeutics are a mainstay of treating patients with rheumatic diseases but are mostly basic monoclonal structures. What can the history of and modern developments in antibody technology tell us about the next generation of antibody-based therapeutics? (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - February 27, 2019 Category: Rheumatology Authors: Anja S. Schmid Dario Neri Source Type: research

PU.1 pulls the strings in fibrotic disease
PU.1 pulls the strings in fibrotic disease, Published online: 27 February 2019; doi:10.1038/s41584-019-0193-yPU.1 pulls the strings in fibrotic disease (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - February 27, 2019 Category: Rheumatology Authors: Nicholas J. Bernard Source Type: research

Measuring disease activity in SLE is an ongoing struggle
Measuring disease activity in SLE is an ongoing struggle, Published online: 25 February 2019; doi:10.1038/s41584-019-0190-1New disease activity measures are needed for systemic lupus erythematosus (SLE). Is the new SLE-DAS better than existing measures or are other instruments, or combined scoring methods, required to manage the spectrum of SLE? (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - February 25, 2019 Category: Rheumatology Authors: Anca D. Askanase Joan T. Merrill Source Type: research