Which DMARD for ICI-associated arthritis?
Nature Reviews Rheumatology, Published online: 22 May 2023; doi:10.1038/s41584-023-00983-9In a retrospective study, biologic DMARD therapy was associated with faster control of immune checkpoint inhibitor-associated arthritis but also with a shorter time to cancer progression, compared with methotrexate therapy. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 22, 2023 Category: Rheumatology Authors: Sarah Onuora Source Type: research
PJP prophylaxis with rituximab
Nature Reviews Rheumatology, Published online: 22 May 2023; doi:10.1038/s41584-023-00982-wIn a retrospective study, risk–benefit analyses suggest that primary prophylaxis against Pneumocystis jirovecii pneumonia is beneficial in patients receiving rituximab and high-dose glucocorticoids. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 22, 2023 Category: Rheumatology Authors: Sarah Onuora Source Type: research
Juvenile idiopathic inflammatory myositis: an update on pathophysiology and clinical care
Nature Reviews Rheumatology, Published online: 15 May 2023; doi:10.1038/s41584-023-00967-9This Review provides an overview of the clinical features and subtypes, pathophysiology and management of juvenile idiopathic inflammatory myopathies, including updates to our understanding of this heterogenous group of diseases that might change clinical practice in the near future. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 15, 2023 Category: Rheumatology Authors: Charalampia Papadopoulou Christine Chew Meredyth G. Ll. Wilkinson Liza McCann Lucy R. Wedderburn Source Type: research
Antibodies cross-reactive with DNase1L3 and dsDNA discovered
Nature Reviews Rheumatology, Published online: 10 May 2023; doi:10.1038/s41584-023-00977-7Clinical and molecular analysis of autoantibodies against the endonuclease DNase1L3 in patients with systemic lupus erythematosus led to the identification of a subset of pathogenetic antibodies that are cross-reactive with double-stranded DNA. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 10, 2023 Category: Rheumatology Authors: Sarah Onuora Source Type: research
Targeting KDM2/7 histone demethylases could protect against OA
Nature Reviews Rheumatology, Published online: 10 May 2023; doi:10.1038/s41584-023-00978-6New research suggests that pharmacological restoration of H3K79 methylation could offer a way to prevent osteoarthritis onset and progression. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 10, 2023 Category: Rheumatology Authors: Sarah Onuora Source Type: research
Evidence-Based Guideline for the diagnosis and management of eosinophilic granulomatosis with polyangiitis
This article presents the first Evidence-Based Guideline dedicated specifically to the diagnosis and management of eosinophilic granulomatosis with polyangiitis. The 16 statements and five overarching principles cover the diagnosis and staging, treatment, outcome and follow-up of eosinophilic granulomatosis with polyangiitis. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 9, 2023 Category: Rheumatology Authors: Giacomo Emmi Alessandra Bettiol Elena Gelain Ingeborg M. Bajema Alvise Berti Stella Burns Maria C. Cid Jan W. Cohen Tervaert Vincent Cottin Eugenia Durante Julia U. Holle Alfred D. Mahr Marcos Martinez Del Pero Chiara Marvisi John Mills Sergey Moiseev Fra Source Type: research
Matrix metalloproteinases in arthritis: towards precision medicine
This article reviews several aspects of matrix metalloproteinase biology related to arthritis and discusses how they relate to opportunities for precision medicine and diagnosis. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 9, 2023 Category: Rheumatology Authors: Bernard Grillet Rafaela Vaz Sousa Pereira Jo Van Damme Ahmed Abu El-Asrar Paul Proost Ghislain Opdenakker Source Type: research
G-CSF implicated as therapeutic target in APLAID
Nature Reviews Rheumatology, Published online: 09 May 2023; doi:10.1038/s41584-023-00973-xCharacterization of a new mouse model highlights allogeneic bone marrow transplantation and granulocyte colony-stimulating factor neutralization as potential avenues for the treatment of APLAID. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 9, 2023 Category: Rheumatology Authors: Jessica McHugh Source Type: research
Gut metabolite mediates neoantigen generation in AS
Nature Reviews Rheumatology, Published online: 09 May 2023; doi:10.1038/s41584-023-00975-9In screening for post-translational modifications associated with ankylosing spondylitis, researchers have identified a microbiome-metabolite-mediated modification that can lead to neoantigen generation and subsequent autoimmunity. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 9, 2023 Category: Rheumatology Authors: Jessica McHugh Source Type: research
Down syndrome: insights into autoimmune mechanisms
Nature Reviews Rheumatology, Published online: 05 May 2023; doi:10.1038/s41584-023-00970-0Understanding why individuals with Down syndrome are highly predisposed to autoimmunity has broad mechanistic and therapeutic implications. New work identifies novel potential mechanistic pathways driving increased autoimmunity-relevant CD11c+ B cells and provides the broadest view to date of the repertoire of autoantibodies generated in individuals with Down syndrome. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 5, 2023 Category: Rheumatology Authors: Bernard Khor Jane H. Buckner Source Type: research
A safe and effective treatment for MAS
Nature Reviews Rheumatology, Published online: 05 May 2023; doi:10.1038/s41584-023-00974-wPhase II trial results demonstrate rapid remission of macrophage activation syndrome in patients treated with the anti-IFNγ antibody emapalumab. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 5, 2023 Category: Rheumatology Authors: Robert Phillips Source Type: research
Osteoarthritis research is failing to reach consumers
Nature Reviews Rheumatology, Published online: 04 May 2023; doi:10.1038/s41584-023-00972-yGiven that intra-articular injections for the knee of treatments such as hyaluronic acid, stem cells and platelet-rich plasma are advised against or only weakly recommended by current clinical-practice guidelines, why do people continue to seek information about these treatments? (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 4, 2023 Category: Rheumatology Authors: Vicky Duong David J. Hunter Source Type: research
Chimeric receptors broaden the therapeutic landscape for autoimmune disease
Nature Reviews Rheumatology, Published online: 28 April 2023; doi:10.1038/s41584-023-00968-8Emerging research suggests that chimeric antigen receptor T cell therapy could be an effective treatment for a range of difficult-to-treat autoimmune diseases, and sophisticated approaches are in tests, yet initial reports also highlight several questions that remain to be answered. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 28, 2023 Category: Rheumatology Authors: Terri H. Finkel Marko Radic Source Type: research
Real-world data provide insights into PsA treatment patterns
Nature Reviews Rheumatology, Published online: 14 April 2023; doi:10.1038/s41584-023-00965-xAmong the wide range of drugs now available for the treatment of psoriatic arthritis, the best option for an individual patient remains unclear. Emerging real-world evidence from several Nordic registries suggests that differences exist in the response rates to different classes of biologic and targeted synthetic DMARDs in psoriatic arthritis. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 14, 2023 Category: Rheumatology Authors: Helena Marzo-Ortega Stephanie R. Harrison Source Type: research
High risk of autoimmune diseases after COVID-19
Nature Reviews Rheumatology, Published online: 12 April 2023; doi:10.1038/s41584-023-00964-yThe full picture of post-COVID-19 autoimmune diseases and their prevalence is lacking despite numerous case reports and small series. Two studies that use large cohorts now highlight that SARS-CoV-2 infection is linked to a substantially increased risk of developing a diverse spectrum of new-onset autoimmune diseases. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 12, 2023 Category: Rheumatology Authors: Chetan Sharma Jagadeesh Bayry Source Type: research
