Systemic sclerosis gastrointestinal dysmotility: risk factors, pathophysiology, diagnosis and management
Nature Reviews Rheumatology, Published online: 06 February 2023; doi:10.1038/s41584-022-00900-6Gastrointestinal dysmotility is a major complication of systemic sclerosis but remains poorly understood. In this Review, the authors discuss the current understanding of systemic sclerosis gastrointestinal disease, existing and emerging therapies, and promising directions for future research (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - February 6, 2023 Category: Rheumatology Authors: Zsuzsanna H. McMahan Subhash K. Kulkarni Joan Chen Jiande Z. Chen Ramnik J. Xavier P. Jay Pasricha Dinesh Khanna Source Type: research
IL-37 has a protective role in IVD degeneration
Nature Reviews Rheumatology, Published online: 03 February 2023; doi:10.1038/s41584-023-00923-7IL-37 can delay intervertebral disc degeneration in rats by regulating the NF-κB pathway and ameliorating the senescence phenotype of nucleus pulposus cells. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - February 3, 2023 Category: Rheumatology Authors: Jessica McHugh Source Type: research
IKKε promotes catabolic responses in OA
Nature Reviews Rheumatology, Published online: 02 February 2023; doi:10.1038/s41584-023-00920-wIKKε, an upstream regulator of the NF-κB signalling pathway, mediates cartilage degradation in a mouse model of osteoarthritis and is a potential therapeutic target. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - February 2, 2023 Category: Rheumatology Authors: Jessica McHugh Source Type: research
ERAP1 and the return of the UPR in ankylosing spondylitis
Nature Reviews Rheumatology, Published online: 01 February 2023; doi:10.1038/s41584-023-00910-yThe mechanisms underlying the genetic association between HLA-B27 and ankylosing spondylitis, including the contribution of endoplasmic reticulum aminopeptidase 1 (ERAP1), continue to elude the field. New findings support the involvement of the unfolded protein response and highlight the therapeutic potential and limitations of targeting ERAP1 in this disease. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - February 1, 2023 Category: Rheumatology Authors: Nigil Haroon Robert D. Inman Source Type: research
Are the origins of adult arthritis seeded during embryonic development?
Nature Reviews Rheumatology, Published online: 31 January 2023; doi:10.1038/s41584-023-00911-xThe phenotypic and functional heterogeneity of synovial tissue fibroblasts are well described, whereas the cellular and molecular mechanisms that establish this diverse fibroblast repertoire in the adult joint have remained unclear. When is the fate of synovial fibroblast repertoire determined, and what are the consequences for arthritis development as adults? (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - January 31, 2023 Category: Rheumatology Authors: Annie Hackland Adam P. Croft Source Type: research
Benefits of sirtuin-6 in OA
Nature Reviews Rheumatology, Published online: 31 January 2023; doi:10.1038/s41584-023-00918-4Benefits of sirtuin-6 in OA (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - January 31, 2023 Category: Rheumatology Authors: Robert Phillips Source Type: research
New drug formulation reduces bone loss
Nature Reviews Rheumatology, Published online: 31 January 2023; doi:10.1038/s41584-023-00917-5New drug formulation reduces bone loss (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - January 31, 2023 Category: Rheumatology Authors: Robert Phillips Source Type: research
Draining OA from the synovium
Nature Reviews Rheumatology, Published online: 31 January 2023; doi:10.1038/s41584-023-00919-3New research suggests that impaired synovial lymphatic function contributes to the pathogenesis of age-related osteoarthritis and could represent a new therapeutic target. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - January 31, 2023 Category: Rheumatology Authors: Sarah Onuora Source Type: research
Arthritogenic peptide motif identified
Nature Reviews Rheumatology, Published online: 31 January 2023; doi:10.1038/s41584-023-00915-7Arthritogenic peptide motif identified (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - January 31, 2023 Category: Rheumatology Authors: Robert Phillips Source Type: research
RA risk from occupational inhalation
Nature Reviews Rheumatology, Published online: 31 January 2023; doi:10.1038/s41584-023-00916-6RA risk from occupational inhalation (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - January 31, 2023 Category: Rheumatology Authors: Robert Phillips Source Type: research
Proteins profile pre-symptomatic AAV
Nature Reviews Rheumatology, Published online: 30 January 2023; doi:10.1038/s41584-023-00913-9Proteins profile pre-symptomatic AAV (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - January 30, 2023 Category: Rheumatology Authors: Sarah Onuora Source Type: research
No benefit from adding MTX to ustekinumab
Nature Reviews Rheumatology, Published online: 30 January 2023; doi:10.1038/s41584-023-00912-wNo benefit from adding MTX to ustekinumab (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - January 30, 2023 Category: Rheumatology Authors: Sarah Onuora Source Type: research
TNF inhibitors linked to septic arthritis
Nature Reviews Rheumatology, Published online: 30 January 2023; doi:10.1038/s41584-023-00914-8TNF inhibitors linked to septic arthritis (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - January 30, 2023 Category: Rheumatology Authors: Sarah Onuora Source Type: research
Intervertebral disc degeneration and osteoarthritis: a common molecular disease spectrum
Nature Reviews Rheumatology, Published online: 26 January 2023; doi:10.1038/s41584-022-00888-zIn this Review, the authors discuss the similarities and differences between intervertebral disc degeneration and osteoarthritis of the facet joint and argue that both diseases should be viewed as being part of the same molecular disease spectrum. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - January 26, 2023 Category: Rheumatology Authors: Noah Fine Starlee Lively Cheryle Ann S éguin Anthony V. Perruccio Mohit Kapoor Raja Rampersaud Source Type: research
Fetuin-A peptide inhibits cartilage calcification
Nature Reviews Rheumatology, Published online: 10 January 2023; doi:10.1038/s41584-023-00907-7A calcium-binding peptide derived from fetuin-A inhibited pathological cartilage calcification in an experimental model of osteoarthritis, suggesting therapeutic potential. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - January 10, 2023 Category: Rheumatology Authors: Sarah Onuora Source Type: research
