Are the origins of adult arthritis seeded during embryonic development?

Nature Reviews Rheumatology, Published online: 31 January 2023; doi:10.1038/s41584-023-00911-xThe phenotypic and functional heterogeneity of synovial tissue fibroblasts are well described, whereas the cellular and molecular mechanisms that establish this diverse fibroblast repertoire in the adult joint have remained unclear. When is the fate of synovial fibroblast repertoire determined, and what are the consequences for arthritis development as adults?

Source: Nature Reviews Rheumatology - January 31, 2023 Category: Rheumatology Authors: Annie Hackland Adam P. Croft Source Type: research