Involvement of the secosteroid vitamin D in autoimmune rheumatic diseases and COVID-19
Nature Reviews Rheumatology, Published online: 28 March 2023; doi:10.1038/s41584-023-00944-2In this Review, Cutolo et al. provide an overview of the vitamin D endocrine system and explore the biological and clinical effects of vitamin D3 on innate and adaptive immunity in the context of autoimmune rheumatic diseases and COVID-19. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - March 28, 2023 Category: Rheumatology Authors: Maurizio Cutolo Vanessa Smith Sabrina Paolino Emanuele Gotelli Source Type: research
The 2022 ACR vaccination guideline: a call-to-action
Nature Reviews Rheumatology, Published online: 27 March 2023; doi:10.1038/s41584-023-00954-0Among the limited quality and quantity of evidence on vaccination use in individuals with rheumatic and musculoskeletal diseases, a new guideline, developed with a rigorous methodology, provides useful support to clinicians and patients in making health-related decisions. Most recommendations are conditional, serving as a call to action for further research. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - March 27, 2023 Category: Rheumatology Authors: In és Colmegna Michael Libman Source Type: research
Reply to: Hypothetical model ignores many important pathophysiologic mechanisms in fibromyalgia
Nature Reviews Rheumatology, Published online: 24 March 2023; doi:10.1038/s41584-023-00952-2Reply to: Hypothetical model ignores many important pathophysiologic mechanisms in fibromyalgia (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - March 24, 2023 Category: Rheumatology Authors: Ana Margarida Pinto Rinie Geenen Tor D. Wager Winfried H äuser Eva Kosek Jacob N. Ablin Kirstine Amris Jaime Branco Dan Buskila Jo ão Castelhano Miguel Castelo-Branco Leslie J. Crofford Mary-Ann Fitzcharles Marina L ópez-Solà Mariana Lu ís Tiago Reis Source Type: research
Hypothetical model ignores many important pathophysiologic mechanisms in fibromyalgia
Nature Reviews Rheumatology, Published online: 24 March 2023; doi:10.1038/s41584-023-00951-3Hypothetical model ignores many important pathophysiologic mechanisms in fibromyalgia (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - March 24, 2023 Category: Rheumatology Authors: Daniel J. Clauw Ernest H. S. Choy Vitaly Napadow Anushka Soni Kevin F. Boehnke Bruce Naliboff Afton L. Hassett Anne Arewasikporn Andrew Schrepf Chelsea M. Kaplan David Williams Neil Basu Rachel S. Bergmans Richard E. Harris Steven E. Harte Andrea Chadwick Source Type: research
Biologic choice matters in PsA prevention
Nature Reviews Rheumatology, Published online: 24 March 2023; doi:10.1038/s41584-023-00955-zIn a large cohort of patients with psoriasis, treatment with biologic DMARDs targeting the IL-23 pathway was associated with a reduced risk of developing inflammatory arthritis as compared with anti-TNF treatment. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - March 24, 2023 Category: Rheumatology Authors: Sarah Onuora Source Type: research
Reply to ‘Imbalance of threat and soothing systems in fibromyalgia: rephrasing an established mechanistic model?’
Nature Reviews Rheumatology, Published online: 23 March 2023; doi:10.1038/s41584-023-00950-4Reply to ‘Imbalance of threat and soothing systems in fibromyalgia: rephrasing an established mechanistic model?’ (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - March 23, 2023 Category: Rheumatology Authors: Ana Margarida Pinto Rinie Geenen Tor D. Wager Mark A. Lumley Winfried H äuser Eva Kosek Jacob N. Ablin Kirstine Amris Jaime Branco Dan Buskila Jo ão Castelhano Miguel Castelo-Branco Leslie J. Crofford Mary-Ann Fitzcharles Marina L ópez-Solà Mariana Lu Source Type: research
Imbalance of threat and soothing systems in fibromyalgia: rephrasing an established mechanistic model?
Nature Reviews Rheumatology, Published online: 23 March 2023; doi:10.1038/s41584-023-00949-xImbalance of threat and soothing systems in fibromyalgia: rephrasing an established mechanistic model? (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - March 23, 2023 Category: Rheumatology Authors: Manuel Mart ínez-Lavín Source Type: research
The potential contribution of in silico studies to improved treatment of osteoarthritis
Nature Reviews Rheumatology, Published online: 22 March 2023; doi:10.1038/s41584-023-00953-1Osteoarthritis has many appearances and can stabilize or progress aggressively. However, there is not yet an aetiological classification of osteoarthritis subtypes. Can in silico approaches, despite difficulties in validation, help with the identification of experimentally challenging subtypes? And if they can, will these approaches translate to clinical benefits? (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - March 22, 2023 Category: Rheumatology Authors: Corrinus C. van Donkelaar Source Type: research
Genetics and epigenetics of primary Sjögren syndrome: implications for future therapies
Nature Reviews Rheumatology, Published online: 13 March 2023; doi:10.1038/s41584-023-00932-6This Review summarizes the genetic and epigenetic basis of primary Sjögren syndrome, including genetic interactions with factors such as sex and environment. Understanding these processes provides insight into the molecular basis of this disease and might reveal new treatment targets. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - March 13, 2023 Category: Rheumatology Authors: Gudny Ella Thorlacius Albin Bj örk Marie Wahren-Herlenius Source Type: research
Citrulline immunity in RA: CD8+ T cells enter the scene
Nature Reviews Rheumatology, Published online: 13 March 2023; doi:10.1038/s41584-023-00945-1The involvement of citrulline-specific CD4+ T cells in anti-citrulline protein antibody-positive rheumatoid arthritis (RA) is well described, whereas less attention has been given to CD8+ T cells. New data suggest that CD8+ T cells also contribute to citrulline-specific immune responses in RA. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - March 13, 2023 Category: Rheumatology Authors: Karine Chemin Vivianne Malmstr öm Source Type: research
Mechanism of B cell survival in lupus nephritis
Nature Reviews Rheumatology, Published online: 10 March 2023; doi:10.1038/s41584-023-00941-5Expression of the Na+-K+-ATPase transmembrane ion transporter is upregulated in kidney-infiltrating B cells in lupus-prone mice and is a potential target for reducing renal B cell survival in patients with lupus nephritis. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - March 10, 2023 Category: Rheumatology Authors: Susan J. Allison Source Type: research
Co-trimoxazole reduces mortality in anti-MDA5-DM
Nature Reviews Rheumatology, Published online: 10 March 2023; doi:10.1038/s41584-023-00939-zResults indicate that prophylactic use of co-trimoxazole can reduce infection-related mortality in patients with new-onset anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - March 10, 2023 Category: Rheumatology Authors: Robert Phillips Source Type: research
PPM1A: TGFβ regulator and therapeutic target in OA
Nature Reviews Rheumatology, Published online: 10 March 2023; doi:10.1038/s41584-023-00940-6Protein phosphatase magnesium-dependent 1A is a negative modulator of transforming growth factor β signalling and a potential new therapeutic target in osteoarthritis. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - March 10, 2023 Category: Rheumatology Authors: Jessica McHugh Source Type: research
Allogeneic iPSC-derived organoids repair articular cartilage
Nature Reviews Rheumatology, Published online: 09 March 2023; doi:10.1038/s41584-023-00937-1Allogeneic transplantation of cartilage organoids derived from induced pluripotent stem cells promoted cartilage repair in a primate model without eliciting immune reactions. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - March 9, 2023 Category: Rheumatology Authors: Robert Phillips Source Type: research
New biomarker panel best yet for prediction of OA progression
Nature Reviews Rheumatology, Published online: 09 March 2023; doi:10.1038/s41584-023-00936-2A panel of serum biomarkers identified by proteomic analysis outperforms the best current alternatives for prediction of the progression of osteoarthritis. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - March 9, 2023 Category: Rheumatology Authors: Robert Phillips Source Type: research
