Using social media to promote medication adherence
Using social media to promote medication adherence, Published online: 18 June 2018; doi:10.1038/s41584-018-0037-1Poor medication adherence and depression interfere with the management of patients with systemic lupus erythematosus, especially adolescent and young adult patients. For patients for whom clinic visits and education programs fail to improve adherence, novel social media-based interventions are demonstrating the ability to increase patient agency, self-efficacy, and adherence. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - June 18, 2018 Category: Rheumatology Authors: Rebecca E. Sadun Laura E. Schanberg Source Type: research

Redefining systemic lupus erythematosus — SMAARTT proteomics
Redefining systemic lupus erythematosus — SMAARTT proteomicsRedefining systemic lupus erythematosus — SMAARTT proteomics, Published online: 15 June 2018; doi:10.1038/s41584-018-0035-3As the diagnosis and management of systemic lupus erythematosus (SLE) can be challenging, reclassification of SLE on the basis of biomarker data provides novel insights. Definitions of antinuclear antibodies and attention to SMAARTT criteria (specificity – sensitivity, measurable, actionable, added value, realistic, titres, timely) are needed to translate these new analytical frameworks into real-time clinical use. (Source: N...
Source: Nature Reviews Rheumatology - June 15, 2018 Category: Rheumatology Authors: Marvin J. Fritzler Michael Mahler Source Type: research

Molecular transport in articular cartilage — what have we learned from the past 50 years?
Molecular transport in articular cartilage — what have we learned from the past 50 years?Molecular transport in articular cartilage — what have we learned from the past 50 years?, Published online: 13 June 2018; doi:10.1038/s41584-018-0033-5The development of cartilage-penetrating therapies relies on an in-depth understanding of the biophysical properties of this complex tissue. In this Review, knowledge accumulated over 50 years is synthesized to reveal the key principles of solute transport in cartilage. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - June 13, 2018 Category: Rheumatology Authors: Chris D. DiDomenico Marianne Lintz Lawrence J. Bonassar Source Type: research

Big data boost for osteoarthritis genetics
Big data boost for osteoarthritis genetics, Published online: 13 June 2018; doi:10.1038/s41584-018-0023-7The largest study to date on the genetics of hip and knee osteoarthritis (OA) has yielded new associations with genes encoding a cytokine, a kinase and a transcriptional repressor, as well as genetic correlations with other diseases. Can these clues help to unravel details of the pathogenesis of OA? (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - June 13, 2018 Category: Rheumatology Authors: Antonio Gonzalez Ana M. Valdes Source Type: research

Hormone status regulates autoantibody pathogenicity
Hormone status regulates autoantibody pathogenicity, Published online: 11 June 2018; doi:10.1038/s41584-018-0036-2Hormone status regulates autoantibody pathogenicity (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - June 11, 2018 Category: Rheumatology Authors: Jessica McHugh Source Type: research

A cellular cascade of GM-CSF production
A cellular cascade of GM-CSF production, Published online: 11 June 2018; doi:10.1038/s41584-018-0038-0A cellular cascade of GM-CSF production (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - June 11, 2018 Category: Rheumatology Authors: Jessica McHugh Source Type: research

Obstetric and vascular antiphospholipid syndrome: same antibodies but different diseases?
Obstetric and vascular antiphospholipid syndrome: same antibodies but different diseases?, Published online: 11 June 2018; doi:10.1038/s41584-018-0032-6Vascular and obstetric antiphospholipid syndrome are associated with the same pathogenic antiphospholipid antibodies but differ with respect to their associated clinical manifestations. The expression and distribution of β2 glycoprotein I, the main target of antiphospholipid antibodies, might explain these differences. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - June 11, 2018 Category: Rheumatology Authors: Pier Luigi Meroni Maria Orietta Borghi Claudia Grossi Cecilia Beatrice Chighizola Paolo Durigutto Francesco Tedesco Source Type: research

Cannabinoids for the treatment of rheumatic diseases — where do we stand?
Cannabinoids for the treatment of rheumatic diseases — where do we stand?Cannabinoids for the treatment of rheumatic diseases — where do we stand?, Published online: 08 June 2018; doi:10.1038/s41584-018-0025-5Therapeutic application of cannabis remains controversial despite evidence of pain-relieving functions, particularly for rheumatic diseases. However, whether cannabis can also be used as an immunomodulatory therapeutic agent needs to be counterbalanced by risk assessment for adverse effects. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - June 8, 2018 Category: Rheumatology Authors: Daphna Katz-Talmor Itay Katz Bat-Sheva Porat-Katz Yehuda Shoenfeld Source Type: research

Endothelium–osteoblast crosstalk
Endothelium–osteoblast crosstalkEndothelium–osteoblast crosstalk, Published online: 06 June 2018; doi:10.1038/s41584-018-0034-4Endothelium–osteoblast crosstalk (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - June 6, 2018 Category: Rheumatology Authors: Nicholas J. Bernard Source Type: research

Microvascular endothelial dysfunction in rheumatoid arthritis
Microvascular endothelial dysfunction in rheumatoid arthritis, Published online: 31 May 2018; doi:10.1038/s41584-018-0022-8Endothelial dysfunction is thought to be an important contributor to the increased risk of cardiovascular diseases seen in patients with rheumatoid arthritis. Microvascular endothelial dysfunction could be a useful predictive marker of cardiovascular events in early rheumatoid arthritis. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 31, 2018 Category: Rheumatology Authors: Romain Bordy Perle Totoson Cl ément Prati Christine Marie Daniel Wendling C éline Demougeot Source Type: research

T cell metabolism connects complement and autoimmune regulation
T cell metabolism connects complement and autoimmune regulation, Published online: 30 May 2018; doi:10.1038/s41584-018-0027-3T cell metabolism connects complement and autoimmune regulation (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 30, 2018 Category: Rheumatology Authors: Jessica McHugh Source Type: research

Tocilizumab or TNF inhibitors in RA?
Tocilizumab or TNF inhibitors in RA?, Published online: 29 May 2018; doi:10.1038/s41584-018-0031-7Tocilizumab or TNF inhibitors in RA? (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 29, 2018 Category: Rheumatology Authors: Isobel Leake Source Type: research

Changing patterns of lupus nephritis over five decades
Changing patterns of lupus nephritis over five decades, Published online: 29 May 2018; doi:10.1038/s41584-018-0029-1Changing patterns of lupus nephritis over five decades (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 29, 2018 Category: Rheumatology Authors: Isobel Leake Source Type: research

Validating canakinumab therapy for autoinflammation
Validating canakinumab therapy for autoinflammation, Published online: 29 May 2018; doi:10.1038/s41584-018-0030-8Validating canakinumab therapy for autoinflammation (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 29, 2018 Category: Rheumatology Authors: Isobel Leake Source Type: research

Novel autoantibody in Sjögren syndrome
Novel autoantibody in Sjögren syndromeNovel autoantibody in Sjögren syndrome, Published online: 29 May 2018; doi:10.1038/s41584-018-0028-2Novel autoantibody in Sjögren syndrome (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 29, 2018 Category: Rheumatology Authors: Isobel Leake Source Type: research

IL-27 links lipids to autoimmunity
IL-27 links lipids to autoimmunity, Published online: 25 May 2018; doi:10.1038/s41584-018-0026-4IL-27 links lipids to autoimmunity (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 25, 2018 Category: Rheumatology Authors: Nicholas J. Bernard Source Type: research

AhR controls tolerance to cell debris
AhR controls tolerance to cell debris, Published online: 23 May 2018; doi:10.1038/s41584-018-0024-6AhR controls tolerance to cell debris (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 23, 2018 Category: Rheumatology Authors: Joanna Collison Source Type: research

Existing and novel biomarkers for precision medicine in systemic sclerosis
Existing and novel biomarkers for precision medicine in systemic sclerosis, Published online: 22 May 2018; doi:10.1038/s41584-018-0021-9Biomarkers are urgently needed to improve diagnosis and patient care in systemic sclerosis (SSc). Jimenez and colleagues discuss the current state of biomarkers for SSc and provide an update on how new biomarkers could make personalized medicine a reality. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 22, 2018 Category: Rheumatology Authors: Peter J. Wermuth Sonsoles Piera-Velazquez Joel Rosenbloom Sergio A. Jimenez Source Type: research

Neurobiological similarities between RA and fibromyalgia
Neurobiological similarities between RA and fibromyalgia, Published online: 15 May 2018; doi:10.1038/s41584-018-0011-yPain management can be a difficult problem for patients with rheumatoid arthritis (RA), some of whom can experience pain similar to that reported by patients with fibromyalgia. Now, advanced imaging techniques are revealing neurobiological alterations in patients with RA that mirror those seen in fibromyalgia, hinting at new treatment possibilities. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 15, 2018 Category: Rheumatology Authors: Fabiola Atzeni Piercarlo Sarzi-Puttini Source Type: research

Fyn-ding a target for OA therapy
Fyn-ding a target for OA therapy, Published online: 14 May 2018; doi:10.1038/s41584-018-0020-xFyn-ding a target for OA therapy (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 14, 2018 Category: Rheumatology Authors: Nicholas J. Bernard Source Type: research

Biomarkers as drug development tools: discovery, validation, qualification and use
Biomarkers as drug development tools: discovery, validation, qualification and use, Published online: 14 May 2018; doi:10.1038/s41584-018-0005-9The use of biomarkers for drug development, clinical investigation and management is fundamental to the success of molecular medicine. This Review discusses the framework for the development of biomarkers as drug development tools, including discovery, analytical validation, clinical qualification and utilization. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 14, 2018 Category: Rheumatology Authors: Virginia B. Kraus Source Type: research

Multimerized IgG1 Fc molecule as an anti-inflammatory agent
Multimerized IgG1 Fc molecule as an anti-inflammatory agent, Published online: 14 May 2018; doi:10.1038/s41584-018-0013-9The success of intravenous immunoglobulin immunotherapy in autoimmune diseases has inspired the development of novel Fc-based therapeutics, in particular, multimerized polyvalent Fc molecules. A new study reports that a recombinant IgG1 Fc hexamer alleviates acute and chronic autoimmune diseases in mice. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 14, 2018 Category: Rheumatology Authors: Emmanuel Stephen-Victor Jagadeesh Bayry Source Type: research

Axial disease in psoriatic arthritis and ankylosing spondylitis: a critical comparison
Axial disease in psoriatic arthritis and ankylosing spondylitis: a critical comparison, Published online: 11 May 2018; doi:10.1038/s41584-018-0006-8Axial disease occurs in psoriatic arthritis (PsA) and ankylosing spondylitis, but questions remain over whether axial PsA is a distinct disease. In this Review, the authors address the current state of knowledge concerning axial PsA and propose a research agenda. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 11, 2018 Category: Rheumatology Authors: Joy Feld Vinod Chandran Nigil Haroon Robert Inman Dafna Gladman Source Type: research

Synergy of environmental and genetic risk in RA
Synergy of environmental and genetic risk in RA, Published online: 11 May 2018; doi:10.1038/s41584-018-0015-7Synergy of environmental and genetic risk in RA (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 11, 2018 Category: Rheumatology Authors: Nicholas J. Bernard Source Type: research

The role of radiography and MRI for eligibility assessment in DMOAD trials of knee OA
The role of radiography and MRI for eligibility assessment in DMOAD trials of knee OA, Published online: 11 May 2018; doi:10.1038/s41584-018-0010-zIn this Perspectives article, Roemer et al. argue that the time has come to use MRI, rather than radiography, as the primary imaging modality for defining eligibility criteria for clinical trials of potential disease-modifying osteoarthritis drugs (DMOADs). (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 11, 2018 Category: Rheumatology Authors: Frank W. Roemer C. Kent Kwoh Daichi Hayashi David T. Felson Ali Guermazi Source Type: research

Denosumab shows promise for GIOP
Denosumab shows promise for GIOP, Published online: 11 May 2018; doi:10.1038/s41584-018-0016-6Denosumab shows promise for GIOP (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 11, 2018 Category: Rheumatology Authors: Sarah Onuora Source Type: research

RNA sequencing and machine learning as molecular scalpels
RNA sequencing and machine learning as molecular scalpels, Published online: 11 May 2018; doi:10.1038/s41584-018-0012-xThe application of new technologies including RNA sequencing and machine learning to the analysis of synovial tissue is yielding new insights into the pathology of rheumatoid arthritis, with potential implications for the clinical management of the disease. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 11, 2018 Category: Rheumatology Authors: Myles J. Lewis Michael R. Barnes Source Type: research

Obesity hampers effects of anti-TNF agents
Obesity hampers effects of anti-TNF agents, Published online: 10 May 2018; doi:10.1038/s41584-018-0018-4Obesity hampers effects of anti-TNF agents (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 10, 2018 Category: Rheumatology Authors: Sarah Onuora Source Type: research

Triple therapy boosts survival in catastrophic APS
Triple therapy boosts survival in catastrophic APS, Published online: 10 May 2018; doi:10.1038/s41584-018-0017-5Triple therapy boosts survival in catastrophic APS (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 10, 2018 Category: Rheumatology Authors: Sarah Onuora Source Type: research

Flares not linked to ultrasound findings in JIA
Flares not linked to ultrasound findings in JIA, Published online: 10 May 2018; doi:10.1038/s41584-018-0019-3Flares not linked to ultrasound findings in JIA (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 10, 2018 Category: Rheumatology Authors: Sarah Onuora Source Type: research

Drugs deliver themselves during flares
Drugs deliver themselves during flares, Published online: 09 May 2018; doi:10.1038/s41584-018-0014-8Drugs deliver themselves during flares (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 9, 2018 Category: Rheumatology Authors: Joanna Collison Source Type: research

Arthritis gene therapy is becoming a reality
Arthritis gene therapy is becoming a reality, Published online: 09 May 2018; doi:10.1038/s41584-018-0009-5After more than 25 years of development, arthritis gene therapy is finally entering clinical practice. In South Korea, a gene therapeutic has been approved for the treatment of osteoarthritis, and other gene therapeutics are in the pipeline elsewhere. Genetic medicines for arthritis should enter the rheumatological armamentarium in the foreseeable future. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 9, 2018 Category: Rheumatology Authors: Christopher H. Evans Steven C. Ghivizzani Paul D. Robbins Source Type: research

An update on the genetics of hyperuricaemia and gout
An update on the genetics of hyperuricaemia and gout, Published online: 08 May 2018; doi:10.1038/s41584-018-0004-xIn this Review, the authors summarize the results of genetics studies that confirm the importance of modulating urate levels in gout pathophysiology, and discuss how these discoveries could be applied to the treatment of hyperuricaemia and gout. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 8, 2018 Category: Rheumatology Authors: Tanya J. Major Nicola Dalbeth Eli A. Stahl Tony R. Merriman Source Type: research

Surprising safety outcomes of urate-lowering therapy
Surprising safety outcomes of urate-lowering therapy, Published online: 01 May 2018; doi:10.1038/s41584-018-0007-7Surprising safety outcomes of urate-lowering therapy (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - May 1, 2018 Category: Rheumatology Authors: Jessica McHugh Source Type: research

Bacterial orthologues of Ro60 trigger disease
Bacterial orthologues of Ro60 trigger disease, Published online: 24 April 2018; doi:10.1038/s41584-018-0008-6Bacterial orthologues of Ro60 trigger disease (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 24, 2018 Category: Rheumatology Authors: Joanna Collison Source Type: research

Optimization of CVD prevention in psoriatic arthritis
Optimization of CVD prevention in psoriatic arthritis, Published online: 23 April 2018; doi:10.1038/s41584-018-0002-zPatients with psoriatic arthritis and other inflammatory joint diseases have a high risk of cardiovascular disease (CVD), but use relatively little preventive medication such as antihypertensive and lipid lowering agents. An unmet need exists for the optimization of CVD prevention in this high-risk patient population. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 23, 2018 Category: Rheumatology Authors: Anne Grete Semb Silvia Rollefstad Source Type: research

Selective p38α MAPK inhibitor shows promise
Selective p38α MAPK inhibitor shows promiseSelective p38α MAPK inhibitor shows promise, Published online: 23 April 2018; doi:10.1038/s41584-018-0003-ySelective p38α MAPK inhibitor shows promise (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 23, 2018 Category: Rheumatology Authors: Jessica McHugh Source Type: research

Autoantibodies in myositis
Autoantibodies in myositis, Published online: 20 April 2018; doi:10.1038/nrrheum.2018.56Myositis-specific or myositis-associated antibodies can be found in most patients with myositis and are associated with distinct disease phenotypes. These antibodies also provide valuable insights into the pathogenesis of myositis and can help guide treatment. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 20, 2018 Category: Rheumatology Authors: Neil J. McHugh Sarah L. Tansley Source Type: research

Risk factors and disease mechanisms in myositis
Risk factors and disease mechanisms in myositis, Published online: 20 April 2018; doi:10.1038/nrrheum.2018.48Multiple genetic and environmental factors contribute to the risk of developing idiopathic inflammatory myopathies; both immune and non-immune related mechanisms are involved in the pathogenesis of these disorders, the understanding of which might lead to novel treatment approaches. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 20, 2018 Category: Rheumatology Authors: Frederick W. Miller Janine A. Lamb Jens Schmidt Kanneboyina Nagaraju Source Type: research

Rheumatoid arthritis: RA synovium harbours distinct fibroblast subsets
Rheumatoid arthritis: RA synovium harbours distinct fibroblast subsets, Published online: 20 April 2018; doi:10.1038/nrrheum.2018.47Rheumatoid arthritis: RA synovium harbours distinct fibroblast subsets (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 20, 2018 Category: Rheumatology Authors: Sarah Onuora Source Type: research

Mitochondrial DNA variation and the pathogenesis of osteoarthritis phenotypes
Mitochondrial DNA variation and the pathogenesis of osteoarthritis phenotypes, Published online: 18 April 2018; doi:10.1038/s41584-018-0001-0Mitochondrial dysfunction and mitochondrial DNA (mtDNA) influence several molecular processes underlying the pathogenesis of osteoarthritis (OA), and mtDNA variants are associated with the development and progression of knee OA, pointing to a role for mtDNA variation in OA pathogenesis and its phenotypic presentation. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 18, 2018 Category: Rheumatology Authors: Francisco J. Blanco Ana M. Valdes Ignacio Rego-P érez Source Type: research

Myositis: Prognostic factors in 'pneumo-myositis'
Myositis: Prognostic factors in 'pneumo-myositis', Published online: 12 April 2018; doi:10.1038/nrrheum.2018.55Interstitial lung disease (ILD) is a major cause of death and disability in patients with polymyositis or dermatomyositis. To begin to improve patient outcomes, the clinical, demographic and therapeutic factors associated with poor prognosis for patients with ILD associated with polymyositis or dermatomyositis need to be identified. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 12, 2018 Category: Rheumatology Authors: Sonye K. Danoff Source Type: research

Classification of myositis
Classification of myositis, Published online: 12 April 2018; doi:10.1038/nrrheum.2018.41The idiopathic inflammatory myopathies are a group of disorders that involve inflammation of skeletal muscles and extramuscular manifestations. New classification criteria capture a broad range of these disorders but should be further defined in the future to incorporate new data. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 12, 2018 Category: Rheumatology Authors: Ingrid E. Lundberg Marianne de Visser Victoria P. Werth Source Type: research

Update on outcome assessment in myositis
Update on outcome assessment in myositis, Published online: 12 April 2018; doi:10.1038/nrrheum.2018.33The idiopathic inflammatory myopathies are characterized by muscle weakness and inflammation. A range of tools are available to evaluate outcomes in the treatment of myositis, including, among others, core set measures that were developed by international networks of myositis researchers. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 12, 2018 Category: Rheumatology Authors: Lisa G. Rider Rohit Aggarwal Pedro M. Machado Jean-Yves Hogrel Ann M. Reed Lisa Christopher-Stine Nicolino Ruperto Source Type: research

Myositis: Are autoantibodies pathogenic in necrotizing myopathy?
Myositis: Are autoantibodies pathogenic in necrotizing myopathy?, Published online: 12 April 2018; doi:10.1038/nrrheum.2018.54What causes muscle fibre necrosis in necrotizing myopathy? The authors of a new study propose that specific autoantibodies contribute to disease via immune-mediated processes; but given that these processes also occur in muscular dystrophies, how likely is that these antibodies trigger muscle fibre necrosis? (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 12, 2018 Category: Rheumatology Authors: Marinos C. Dalakas Source Type: research

Systemic lupus erythematosus: Escape of gut microbe to the liver drives autoimmunity
Systemic lupus erythematosus: Escape of gut microbe to the liver drives autoimmunity, Published online: 05 April 2018; doi:10.1038/nrrheum.2018.53Systemic lupus erythematosus: Escape of gut microbe to the liver drives autoimmunity (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 5, 2018 Category: Rheumatology Authors: Jessica McHugh Source Type: research

Treatment in myositis
Treatment in myositis, Published online: 29 March 2018; doi:10.1038/nrrheum.2018.42Many immunosuppressive and immunomodulatory therapies are available to clinicians for managing myositis, and numerous biologic and small-molecule therapies are emerging that target implicated pathogenic targets. However, care must be taken when considering the numerous extramuscular complications of this disease. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - March 29, 2018 Category: Rheumatology Authors: Chester V. Oddis Rohit Aggarwal Source Type: research

Spondyloarthritis: Low-level inflammation promotes bone growth
Spondyloarthritis: Low-level inflammation promotes bone growth, Published online: 22 March 2018; doi:10.1038/nrrheum.2018.52Spondyloarthritis: Low-level inflammation promotes bone growth (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - March 22, 2018 Category: Rheumatology Authors: Joanna Collison Source Type: research

Skeletal changes during and after spaceflight
Skeletal changes during and after spaceflight, Published online: 21 March 2018; doi:10.1038/nrrheum.2018.37Space travel induces bone loss in crewmembers, who often develop signs of accelerated bone ageing. Here, Vico and Hargens describe the effects of space travel on the skeleton and explain how these findings can inform research into ageing and immobility. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - March 21, 2018 Category: Rheumatology Authors: Laurence Vico Alan Hargens Source Type: research

The controversy of using PGA to define remission in RA
The controversy of using PGA to define remission in RA, Published online: 21 March 2018; doi:10.1038/nrrheum.2018.35The controversy of using PGA to define remission in RA (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - March 21, 2018 Category: Rheumatology Authors: Ricardo J. O. Ferreira C átia Duarte Mwidimi Ndosi Maarten de Wit Laure Gossec J. A. P. da Silva Source Type: research