Rheumatoid arthritis prevention in arthralgia: fantasy or reality?
Nature Reviews Rheumatology, Published online: 09 October 2023; doi:10.1038/s41584-023-01035-yTreatment of patients with arthralgia during the ‘window of opportunity’ could prevent disease development or a severe disease course. This Review summarizes available information on the completed and ongoing prevention trials in rheumatoid arthritis, including patient preferences and future considerations. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - October 9, 2023 Category: Rheumatology Authors: Hanna W. van Steenbergen Andrew P. Cope Annette H. M. van der Helm-van Mil Source Type: research
Pan American League of Associations for Rheumatology recommendations for the management of axial spondyloarthritis
Nature Reviews Rheumatology, Published online: 06 October 2023; doi:10.1038/s41584-023-01034-zThis Evidence-Based Guideline presents the first Pan American League of Associations for Rheumatology recommendations for the management of axial spondyloarthritis, addressing therapeutic targets, the use of pharmacological and non-pharmacological interventions and monitoring of patients. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - October 6, 2023 Category: Rheumatology Authors: Wilson Bautista-Molano Daniel G. Fern ández-Ávila Mar ía Lorena Brance Mar ía Gabriela Ávila Pedretti Ruben Burgos-Vargas In és Corbacho Vanesa Laura Cosentino Jos é Francisco Díaz Coto Enrique Giraldo Ho Gustavo Gomes Resende Luis Arturo Guti ér Source Type: research
Epidemiology of the idiopathic inflammatory myopathies
Nature Reviews Rheumatology, Published online: 06 October 2023; doi:10.1038/s41584-023-01033-0In this Review, the authors present epidemiological data relating to the idiopathic inflammatory myopathies and summarize the current understanding of the risk factors associated with these conditions, as well as highlighting areas that require further research. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - October 6, 2023 Category: Rheumatology Authors: Thomas Khoo James B. Lilleker Bernard Yu-Hor Thong Val érie Leclair Janine A. Lamb Hector Chinoy Source Type: research
A roadmap for delivering a human musculoskeletal cell atlas
Nature Reviews Rheumatology, Published online: 05 October 2023; doi:10.1038/s41584-023-01031-2A single-cell atlas of the human musculoskeletal system could help to improve the understanding of musculoskeletal function in growth, homeostasis, ageing and disease. This Roadmap delineates the steps required and challenges involved in creating such an atlas. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - October 5, 2023 Category: Rheumatology Authors: Mathew Baldwin Christopher D. Buckley Farshid Guilak Philippa Hulley Adam P. Cribbs Sarah Snelling Source Type: research
Back to the future: targeting the extracellular matrix to treat systemic sclerosis
Nature Reviews Rheumatology, Published online: 03 October 2023; doi:10.1038/s41584-023-01032-1The autoimmune disease systemic sclerosis is characterized by fibrosis, which is poorly targeted by the use of anti-inflammatory and immunosuppressive drugs. In this Review, the authors describe the fibrotic mechanisms underlying SSc and attempts to develop drugs to specifically target the fibrotic extracellular matrix. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - October 3, 2023 Category: Rheumatology Authors: Andrew Leask Angha Naik Richard J. Stratton Source Type: research
SLC26A2 deficiency, matrix stiffness and mechanotransduction linked in osteoporosis
Nature Reviews Rheumatology, Published online: 03 October 2023; doi:10.1038/s41584-023-01041-0New research shows that deficiency of the sulfation-related SLC26A2 affects osteocyte formation, and that targeting downstream mediators can ameliorate SLC26A2-deficient osteoporosis. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - October 3, 2023 Category: Rheumatology Authors: Sarah Onuora Source Type: research
FGF signalling implicated in relapsing RA
Nature Reviews Rheumatology, Published online: 03 October 2023; doi:10.1038/s41584-023-01040-1New research shows that the FGF10–FGFR1 axis is highly activated in lining fibroblast-like synoviocytes during relapsing rheumatoid arthritis and is a potential therapeutic target. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - October 3, 2023 Category: Rheumatology Authors: Jessica McHugh Source Type: research
Pre-exposure prophylaxis reduces risk of COVID-19
Nature Reviews Rheumatology, Published online: 03 October 2023; doi:10.1038/s41584-023-01039-8In an observational study, SARS-CoV-2 antibody therapy used as pre-exposure prophylaxis reduced the incidence of COVID-19 in individuals with rheumatic diseases. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - October 3, 2023 Category: Rheumatology Authors: Sarah Onuora Source Type: research
Re-thinking the perception of long-term opioid use in RMDs
Nature Reviews Rheumatology, Published online: 18 September 2023; doi:10.1038/s41584-023-01022-3Emerging data suggest that the frequency of long-term opioid use is high among individuals with rheumatic and musculoskeletal diseases, which is of concern given the risks of opioid misuse. But is long-term opioid use really that high or is the situation more complicated? (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - September 18, 2023 Category: Rheumatology Authors: Serge Perrot Anne-Priscille Trouvin Source Type: research
Placebo effects in osteoarthritis: implications for treatment and drug development
Nature Reviews Rheumatology, Published online: 11 September 2023; doi:10.1038/s41584-023-01021-4Placebo responses are prevalent in clinical trials for osteoarthritis, and they hinder the identification of effective new treatments. In this Review, Colloca and Neogi describe various aspects of the placebo phenomenon, and demonstrate how this knowledge can help to improve the design of clinical trials. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - September 11, 2023 Category: Rheumatology Authors: Tuhina Neogi Luana Colloca Source Type: research
Imaging in inflammatory arthritis: progress towards precision medicine
Nature Reviews Rheumatology, Published online: 08 September 2023; doi:10.1038/s41584-023-01016-1In this Perspective, the authors discuss select examples of advancements in high-resolution imaging, functional molecular imaging and artificial intelligence-based analysis that hold promise for addressing current imaging limitations, enabling earlier diagnosis, improved monitoring and ultimately, personalized patient management. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - September 8, 2023 Category: Rheumatology Authors: Ioanna Minopoulou Arnd Kleyer Melek Yalcin-Mutlu Filippo Fagni Stefan Kemenes Christian Schmidkonz Armin Atzinger Milena Pachowsky Klaus Engel Lukas Folle Frank Roemer Maximilian Waldner Maria-Antonietta D ’Agostino Georg Schett David Simon Source Type: research
Mechanisms and rationale for uricase use in patients with gout
Nature Reviews Rheumatology, Published online: 08 September 2023; doi:10.1038/s41584-023-01006-3In this Review, the authors provide an overview of the therapeutic effects of uricases, outcomes related to gout and its comorbidities in clinical trials and challenges surrounding the use of uricases as potent urate-lowering therapy for the treatment of gout. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - September 8, 2023 Category: Rheumatology Authors: Naomi Schlesinger Fernando P érez-Ruiz Fr édéric Lioté Source Type: research
HIF-1 inhibition mitigates skin damage in CLE
Nature Reviews Rheumatology, Published online: 07 September 2023; doi:10.1038/s41584-023-01029-wHIF-1 can regulate the cytotoxic activity of skin-infiltrating T cells in cutaneous lupus erythematosus and is a potential therapeutic target. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - September 7, 2023 Category: Rheumatology Authors: Jessica McHugh Source Type: research
Repolarizing macrophages using antagomirs
Nature Reviews Rheumatology, Published online: 07 September 2023; doi:10.1038/s41584-023-01030-3New findings suggest that liposome-mediated delivery of a specific microRNA inhibitor can restore anti-inflammatory macrophage polarization and reduce joint inflammation in mice. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - September 7, 2023 Category: Rheumatology Authors: Jessica McHugh Source Type: research
Properties of a new anti-IL-17 antibody
Nature Reviews Rheumatology, Published online: 07 September 2023; doi:10.1038/s41584-023-01028-xA monoclonal antibody targeting a peptide that replicates the proinflammatory properties of IL-17 has shown potent activity and an acceptable profile of adverse effects in pre-clinical studies. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - September 7, 2023 Category: Rheumatology Authors: Robert Phillips Source Type: research
