ERAP1 and the return of the UPR in ankylosing spondylitis

Nature Reviews Rheumatology, Published online: 01 February 2023; doi:10.1038/s41584-023-00910-yThe mechanisms underlying the genetic association between HLA-B27 and ankylosing spondylitis, including the contribution of endoplasmic reticulum aminopeptidase 1 (ERAP1), continue to elude the field. New findings support the involvement of the unfolded protein response and highlight the therapeutic potential and limitations of targeting ERAP1 in this disease.
Source: Nature Reviews Rheumatology - Category: Rheumatology Authors: Source Type: research