Utility of human epidermal growth factor 2 heterogeneity as a prognostic factor in triple-negative breast cancer
Med Mol Morphol. 2024 Apr 15. doi: 10.1007/s00795-024-00386-z. Online ahead of print.ABSTRACTIn some cases of human epidermal growth factor 2 (HER2)-negative breast cancer, including triple-negative breast cancer, HER2 expression is sporadically and strongly upregulated, a condition known as HER2 heterogeneity. We investigated the clinicopathological features of patients with HER2 heterogeneity in triple-negative breast cancers treated with neoadjuvant chemotherapy. Thirty-nine patients with triple-negative breast cancer who had undergone preoperative chemotherapy participated in this study. To assess for HER2 heterogeneit...
Source: Molecular Medicine - April 15, 2024 Category: Molecular Biology Authors: Eriko Narusawa Sasagu Kurozumi Ayaka Katayama Yukio Koibuchi Akira Ogawa Daisuke Takata Shoko Tokuda Sayaka Obayashi Tetsunari Oyama Jun Horiguchi Ken Shirabe Takaaki Fujii Source Type: research
Loss of SREBP-1c ameliorates iron-induced liver fibrosis by decreasing lipocalin-2
In this study, we examined the role of SREBP-1c in NASH and the regulation of LCN2 gene expression. Wild-type and SREBP-1c knockout (1cKO) mice were fed a high-fat/high-sucrose diet, treated with carbon tetrachloride (CCl4), and subjected to lipocalin-2 (LCN2) overexpression. The role of LCN2 in NASH progression was assessed using mouse primary hepatocytes, Kupffer cells, and HSCs. LCN2 expression was examined in samples from normal patients and those with NASH. LCN2 gene expression and secretion increased in CCl4-induced liver fibrosis mice model, and SREBP-1c regulated LCN2 gene transcription. Moreover, treatment with ho...
Source: Molecular Medicine - April 15, 2024 Category: Molecular Biology Authors: Eun-Ho Lee Jae-Ho Lee Do-Young Kim Young-Seung Lee Yunju Jo Tam Dao Kyung Eun Kim Dae-Kyu Song Ji Hae Seo Young-Kyo Seo Je Kyung Seong Changjong Moon Eugene Han Mi Kyung Kim Seungwan Ryu Minsang Shin Gu Seob Roh Hye Ra Jung Timothy F Osborne Dongryeol Ryu Source Type: research
STK16 promoted colorectal cancer progress in a c-MYC signaling-dependent manner
CONCLUSION: We discovered that STK16 phosphorylates c-MYC at serine 452, hindering its degradation via the ubiquitin-proteasome pathway. STK16 inhibition, either genetically or pharmacologically, effectively curtails cancer growth and c-MYC expression in vivo. These findings highlight STK16 as a potential therapeutic target for colorectal cancer.PMID:38622518 | DOI:10.1186/s10020-024-00816-9 (Source: Molecular Medicine)
Source: Molecular Medicine - April 15, 2024 Category: Molecular Biology Authors: Li Peng Liu Guangshi Lai Bijiang Wusman Li Tao Source Type: research
The added value of [ < sup > 18 < /sup > F]Fluorocholine PET/TC in the assessment of secondary or tertiary hyperparathyroidism
Rev Esp Med Nucl Imagen Mol (Engl Ed). 2024 Apr 13:500005. doi: 10.1016/j.remnie.2024.500005. Online ahead of print.NO ABSTRACTPMID:38621476 | DOI:10.1016/j.remnie.2024.500005 (Source: Molecular Medicine)
Source: Molecular Medicine - April 15, 2024 Category: Molecular Biology Authors: S Abouzian D A L ópez-Mora A Fern ández-León C Facundo P Stefaneli A Flotats Source Type: research
Ossification of the falx cerebri in a patient with metastatic breast cancer
Rev Esp Med Nucl Imagen Mol (Engl Ed). 2024 Apr 13:500001. doi: 10.1016/j.remnie.2024.500001. Online ahead of print.NO ABSTRACTPMID:38621477 | DOI:10.1016/j.remnie.2024.500001 (Source: Molecular Medicine)
Source: Molecular Medicine - April 15, 2024 Category: Molecular Biology Authors: S de la Torre Fern ández M J Tello Gal án B Aradas Cabado A E Seva Delgado C M Hern ández Heredia A J Fern ández Sánchez Source Type: research
The Role of the Cytochrome P450 Superfamily in the Skin
Expert Rev Mol Med. 2024 Apr 15:1-16. doi: 10.1017/erm.2024.5. Online ahead of print.NO ABSTRACTPMID:38621674 | DOI:10.1017/erm.2024.5 (Source: Molecular Medicine)
Source: Molecular Medicine - April 15, 2024 Category: Molecular Biology Authors: Qianqian Chen Tuan Wang Hong Pan Xia Wu Huipu Yuan Jianling Mo Yuan Wei Ying Xiao Source Type: research
Overcoming BRAF and CDK4/6 inhibitor resistance by inhibiting MAP3K3-dependent protection against YAP lysosomal degradation
In conclusion, our study reveals a previously unrecognized mechanism for the regulation of YAP stability, suggesting MAP3K3 inhibition as a promising strategy for overcoming resistance to CDK4/6 and BRAF inhibitors in cancer treatment.PMID:38622197 | DOI:10.1038/s12276-024-01210-5 (Source: Molecular Medicine)
Source: Molecular Medicine - April 15, 2024 Category: Molecular Biology Authors: Sanghyun Park Won-Ji Ryu Tae Yeong Kim Yumi Hwang Hyun Ju Han Jeong Dong Lee Gun Min Kim Joohyuk Sohn Sang Kyum Kim Min Hwan Kim Joon Kim Source Type: research
Neuroplastin splice variants Np55 and Np65: Who is doing the job in macrophages?
Mol Immunol. 2024 Apr 13;170:57-59. doi: 10.1016/j.molimm.2024.03.008. Online ahead of print.ABSTRACTNeuroplastin, a paralog of CD147/Basigin, is known as a neuronal cell adhesion molecule and as an auxiliary subunit of plasma membrane calcium ATPases in both neurons and adaptive immune cells. Recently, an interesting study by Ren et al. (2022) provided evidence for an important role of neuroplastin in macrophages during bacterial infection. Here, we critically discuss one aspect of this study, the assignment of this role to Np65 as one of two prominent splice variants of neuroplastin.PMID:38615628 | DOI:10.1016/j.molimm.2...
Source: Molecular Medicine - April 14, 2024 Category: Molecular Biology Authors: Kristina Langnaese Nikhil Tiwari Klaus-Dieter Fischer Ulrich Thomas Mark Korthals Source Type: research
Stool Glycoproteomics Signatures of Pre-Cancerous Lesions and Colorectal Cancer
This study offers a thorough analysis of the stool glycoproteome, laying the groundwork for harnessing glycosylation alterations to improve non-invasive cancer detection.PMID:38612533 | PMC:PMC11012158 | DOI:10.3390/ijms25073722 (Source: Molecular Medicine)
Source: Molecular Medicine - April 13, 2024 Category: Molecular Biology Authors: Janine Soares Mariana Eiras Dylan Ferreira Daniela A R Santos Marta Relvas-Santos Beatriz Santos Martina Gon çalves Eduardo Ferreira Renata Vieira Lu ís Pedro Afonso L úcio Lara Santos M ário Dinis-Ribeiro Lu ís Lima Jos é Alexandre Ferreira Source Type: research
Mobocertinib in Patients with EGFR Exon 20 Insertion-Positive Non-Small Cell Lung Cancer (MOON): An International Real-World Safety and Efficacy Analysis
Int J Mol Sci. 2024 Apr 3;25(7):3992. doi: 10.3390/ijms25073992.ABSTRACTEGFR exon 20 (EGFR Ex20) insertion mutations in non-small cell lung cancer (NSCLC) are insensitive to traditional EGFR tyrosine kinase inhibitors (TKIs). Mobocertinib is the only approved TKI specifically designed to target EGFR Ex20. We performed an international, real-world safety and efficacy analysis on patients with EGFR Ex20-positive NSCLC enrolled in a mobocertinib early access program. We explored the mechanisms of resistance by analyzing postprogression biopsies, as well as cross-resistance to amivantamab. Data from 86 patients with a median a...
Source: Molecular Medicine - April 13, 2024 Category: Molecular Biology Authors: Oliver Illini Felix Carl Saalfeld Petros Christopoulos Micha ël Duruisseaux Anders Vikstr öm Nir Peled Ingel Demedts Elizabeth Dudnik Anna Eisert Sayed M S Hashemi Urska Janzic Waleed Kian Katja Mohorcic Saara Mohammed Maria Silvoniemi Sacha I Rothschil Source Type: research
Genotype and phenotype in patients with ACAN gene variants: Three cases and literature review
CONCLUSION: Our study achieves a new understanding of the phenotypic spectrum, diagnosis, and management of individuals with ACAN variants. No clear genotype-phenotype relationship of patients with ACAN variants was found. Gene sequencing is necessary to diagnose ACAN variants that cause short stature. In general, appropriate rhGH and/or GnRHa therapy can improve the adult height of affected pediatric patients caused by ACAN variants.PMID:38613222 | PMC:PMC11015147 | DOI:10.1002/mgg3.2439 (Source: Molecular Medicine)
Source: Molecular Medicine - April 13, 2024 Category: Molecular Biology Authors: Wei Tang Ke-Mi Wu Qiong Zhou Yan-Fei Tang Jun-Fen Fu Guan-Ping Dong Chao-Chun Zou Source Type: research
Identification and characterization of novel genetic variants in the first Chinese family of mucopolysaccharidosis IIIC (Sanfilippo C syndrome)
In this study, we utilized whole-exome sequencing (WES) to identify novel compound heterozygous variants in the HGSNAT gene from a Chinese patient with typical MPS IIIC symptoms: c.743G>A; p.Gly248Glu and c.1030C>T; p.Arg344Cys. We performed in silico analysis and experimental validation, which confirmed the deleterious pathogenic nature of both variants, as evidenced by the loss of HGSNAT activity and failure of lysosomal localization. To the best of our knowledge, the MPS IIIC is first confirmed by clinical, biochemical and molecular genetic findings in China. Our study thus expands the spectrum of MPS IIIC pathoge...
Source: Molecular Medicine - April 13, 2024 Category: Molecular Biology Authors: Hongjun Zhao Lijing Wang Mengfei Zhang Huakun Wang Sizhe Zhang Junjiao Wu Yu Tang Source Type: research
Comprehensive analysis of the interaction of antigen presentation during anti-tumour immunity and establishment of AIDPS systems in ovarian cancer
J Cell Mol Med. 2024 Apr;28(8):e18309. doi: 10.1111/jcmm.18309.ABSTRACTThere are hundreds of prognostic models for ovarian cancer. These genes are based on different gene classes, and there are many ways to construct the models. Therefore, this paper aims to build the most stable prognostic evaluation system known to date through 101 machine learning strategies. We combined 101 algorithm combinations with 10 machine learning algorithms to create antigen presentation-associated genetic markers (AIDPS) with outstanding precision and steady performance. The inclusive set of algorithms comprises the elastic network (Enet), Rid...
Source: Molecular Medicine - April 13, 2024 Category: Molecular Biology Authors: Wenhuizi Sun Ping Xu Kefei Gao Wenqin Lian Xiang Sun Source Type: research
Integrated analysis highlights the significance role of ITGAL in lung adenocarcinoma
In this study, we utilized the TCGA dataset to analyse ITGAL mRNA expression in LUAD and examined its correlation with clinical prognosis. Three-dimensional (3D) Matrigel culture, 5-bromodeoxyuridine (BrdU) ELISA, wound-healing migration and cell adherence assays were used to demonstrate the potential role of ITGAL in LUAD progression. Additionally, we analysed single-cell sequencing data of LUAD to determine the expression and biological function of ITGAL. Our research revealed that the expression of ITGAL in LUAD samples is an independent predictor of prognosis. Patients with high expression of ITGAL had significantly be...
Source: Molecular Medicine - April 13, 2024 Category: Molecular Biology Authors: Zengtuan Xiao Zhe Nian Mengzhe Zhang Zuo Liu Zhe Liu Zhenfa Zhang Source Type: research
Pathway-based stratification of gliomas uncovers four subtypes with different TME characteristics and prognosis
This study aimed to develop a reliable molecular stratification based on these key components of TME. The TCGA data set (training cohort) and two independent cohorts from CGGA database (validation cohort) were enrolled in this study. First, the enrichment score of 277 TME-related signalling pathways was calculated by gene set variation analysis (GSVA). Then, consensus clustering identified four stable and reproducible subtypes (AFM, CSS, HIS and GLU) based on TME-related signalling pathways, which were characterized by differences in hypoxia and immune responses, metabolism status, somatic alterations and clinical outcomes...
Source: Molecular Medicine - April 13, 2024 Category: Molecular Biology Authors: Ruoyu Huang Bo Han Ying Zhang Jingchen Yang Kuanyu Wang Xing Liu Zhiliang Wang Source Type: research
