Coronary sodium [ < sup > 18 < /sup > F]fluoride activity predicts outcomes post-CABG: a comparative evaluation with conventional metrics
CONCLUSION: Quantification of coronary microcalcification activity via [18F]NaF PET displayed a strong ability to predict early and long-term post-CABG cardiovascular outcomes, thereby outperforming conventional metrics of coronary macrocalcification burden and stenosis severity.TRIAL REGISTRATION: The trial was registered with the Chinese Clinical Trial Committee (number: ChiCTR1900022527; URL: www.chictr.org.cn/showproj.html?proj=37933 ).PMID:38730084 | DOI:10.1007/s00259-024-06736-4 (Source: Molecular Medicine)
Source: Molecular Medicine - May 10, 2024 Category: Molecular Biology Authors: Mingxin Gao Wanwan Wen Haiyang Li Yaqi Zheng Mingkai Yun Jingjing Meng Shipan Wang Bolin Wang Biao Hu Tiantian Mou Yang Yu Xiaoli Zhang Xiang Li Source Type: research
Biological characterization of renal masses using immuno-PET
Eur J Nucl Med Mol Imaging. 2024 May 11. doi: 10.1007/s00259-024-06757-z. Online ahead of print.NO ABSTRACTPMID:38730085 | DOI:10.1007/s00259-024-06757-z (Source: Molecular Medicine)
Source: Molecular Medicine - May 10, 2024 Category: Molecular Biology Authors: Fabrizia Gelardi Alessandro Larcher Lidija Antunovic Umberto Capitanio Andrea Salonia Arturo Chiti Source Type: research
CYP3A4 inhibitors may influence the quantification of [ < sup > 123 < /sup > I]I-FP-CIT SPECT scans
CONCLUSION: Our preliminary data suggest that the use of CYP3A4 inhibitors may influence striatal [123I]I-FP-CIT binding ratios. This information, when reproduced in larger studies, may be relevant for studies in which quantification of [123I]I-FP-CIT SPECT imaging is used for diagnostic or research purposes.PMID:38730086 | DOI:10.1007/s00259-024-06748-0 (Source: Molecular Medicine)
Source: Molecular Medicine - May 10, 2024 Category: Molecular Biology Authors: Jan Booij Eda Ya ğci Zulfiqar H Sheikh Youssef Chahid Source Type: research
Radiolabelling and preclinical characterisation of [ < sup > 89 < /sup > Zr]Zr-Df-ATG-101 bispecific to PD-L1/4-1BB
CONCLUSION: [89Zr]Zr-Df-ATG-101 in vivo distribution is dependent on PD-L1 expression in the MDA-MB-231 xenograft model. Immuno-PET with [89Zr]Zr-Df-ATG-101 provides real-time information about ATG-101 distribution and tumour uptake in vivo. Our data support the use of [89Zr]Zr-Df-ATG-101 to assess tumour and tissue uptake of ATG-101.PMID:38730087 | DOI:10.1007/s00259-024-06742-6 (Source: Molecular Medicine)
Source: Molecular Medicine - May 10, 2024 Category: Molecular Biology Authors: Zhipeng Cao Christian Werner Wichmann Ingrid Julienne Georgette Burvenich Laura Danielle Osellame Nancy Guo Angela Rigopoulos Graeme Joseph O'Keefe Fiona Elizabeth Scott Nirmal Lorensuhewa Kevin Patrick Lynch Andrew Mark Scott Source Type: research
Polyphyllin I Mitigated IL-1 β-Induced Chondrocytes Damage through Downregulating TWIST1 Expression
Conclusion: PPI suppressed apoptosis, senescence, inflammation, and ECM degradation of OA chondrocytes by downregulating the expression of TWIST1.PMID:38726777 | DOI:10.2174/0115665240258324231009115920 (Source: Molecular Medicine)
Source: Molecular Medicine - May 10, 2024 Category: Molecular Biology Authors: Feng Liu Bowen Han Deshun Yang Xiaopeng Ji Liangliang Yan Chaoyong Han Source Type: research
Establishment and Validation of Lactate Metabolism-Related Genes as a Prognostic Model for Gastric Cancer
Conclusion: Eight lactate metabolism-related genes were constructed into a new predictive signal that better predicted the overall survival of gastric cancer patients and can guide clinical decisions for more precise and personalized treatment.PMID:38726778 | DOI:10.2174/0115665240290237240424054233 (Source: Molecular Medicine)
Source: Molecular Medicine - May 10, 2024 Category: Molecular Biology Authors: Jinyu Hu Qinxuan Xu Yuchang Fei Zhengwei Tan Lei Pan Source Type: research
Mechanism of efferocytosis in atherosclerosis
J Mol Med (Berl). 2024 May 10. doi: 10.1007/s00109-024-02439-3. Online ahead of print.ABSTRACTAtherosclerosis (AS) is a chronic inflammatory vascular disease that occurs in the intima of large and medium-sized arteries with the immune system's involvement. It is a common pathological basis for high morbidity and mortality of cardiovascular diseases. Abnormal proliferation of apoptotic cells and necrotic cells leads to AS plaque expansion, necrotic core formation, and rupture. In the early stage of AS, macrophages exert an efferocytosis effect to engulf and degrade apoptotic, dead, damaged, or senescent cells by efferocytos...
Source: Molecular Medicine - May 10, 2024 Category: Molecular Biology Authors: Li-Xia Shu Liu-Li Cao Xin Guo Zong-Bao Wang Shu-Zhi Wang Source Type: research
Diagnostic efficacy of [ < sup > 68 < /sup > Ga]Ga-DOTA-GPFAPI-04 in patients with solid tumors in a head-to-head comparison with [ < sup > 18 < /sup > F]F-FDG: results from a prospective clinical study
CONCLUSION: Despite prominent glandular uptake, [68Ga]Ga-DOTA-GPFAPI-04 demonstrates favorable diagnostic performance. It is a promising probe scaffold for further development of FAP-targeted tumor theranostic agents.PMID:38727829 | DOI:10.1007/s00259-024-06756-0 (Source: Molecular Medicine)
Source: Molecular Medicine - May 10, 2024 Category: Molecular Biology Authors: Hui Yuan Entao Liu Guojin Zhang Chaoquan Lai Qing Zhang Yuxiang Shang Zhen Cheng Lei Jiang Source Type: research
Glucagon-like peptide-1 receptor agonist exendin 4 ameliorates diabetes-associated vascular calcification by regulating mitophagy through the AMPK signaling pathway
CONCLUSION: EX4 could promote mitophagy by activating the AMPK signaling pathway, attenuate insufficient mitophagy, and thus inhibit the osteogenic phenotype switching of VSMCs.PMID:38720283 | PMC:PMC11080124 | DOI:10.1186/s10020-024-00817-8 (Source: Molecular Medicine)
Source: Molecular Medicine - May 9, 2024 Category: Molecular Biology Authors: Kui Chen Hao-Jie Jin Zi-Heng Wu Bao-Fu Zhang Jun Wu Zi-Yi Huang Ying-Peng Huang Xin-Wu Lu Xiang-Tao Zheng Source Type: research
A novel technique of percutaneous transhepatic treatment of biliary-enteric anastomotic occlusive strictures with compliant balloon-occluded distal cholangiography and large-bore catheter: a retrospective case series
CONCLUSIONS: Percutaneous transhepatic compliant balloon-occluded distal cholangiography and the maintenance of a large-bore catheter probably provide an effective and safe alternative method for resolving BEAOS and/or coexisting stones.PMID:38720868 | PMC:PMC11074752 | DOI:10.21037/qims-23-1693 (Source: Molecular Medicine)
Source: Molecular Medicine - May 9, 2024 Category: Molecular Biology Authors: Chaojie Li Ju Gong Wei Huang Qungang Shan Ziyin Wang Zhongmin Wang Source Type: research
Novel insight into FCSK-congenital disorder of glycosylation through a CRISPR-generated cell model
CONCLUSION: This study expands insight into the FCSK-CDG molecular mechanism; to the best of our knowledge, it is the first research conducted to reveal a gene whose expression level alters due to this disease.PMID:38722107 | PMC:PMC11080630 | DOI:10.1002/mgg3.2445 (Source: Molecular Medicine)
Source: Molecular Medicine - May 9, 2024 Category: Molecular Biology Authors: Maryam Fazelzadeh Haghighi Hossein Jafari Khamirani Jafar Fallahi Ali Arabi Monfared Korosh Ashrafi Dehkordi Seyed Mohammad Bagher Tabei Source Type: research
EPAS1, a hypoxia- and ferroptosis-related gene, promotes malignant behaviour of cervical cancer by ceRNA and super-enhancer
J Cell Mol Med. 2024 May;28(9):e18361. doi: 10.1111/jcmm.18361.ABSTRACTHypoxia and Ferroptosis are associated with the malignant behaviour of cervical cancer. Endothelial PAS domain-containing protein 1 (EPAS1) contributes to the progression of cervical cancer. EPAS1 plays important roles in hypoxia and ferroptosis. Using the GEO dataset, machine-learning algorithms were used to screen for hypoxia- and ferroptosis-related genes (HFRGs) in cervical cancer. EPAS1 was identified as the hub gene. qPCR and WB were used to investigate the expression of EPAS1 in normal and cervical cancer tissues. The proliferation, invasion and ...
Source: Molecular Medicine - May 9, 2024 Category: Molecular Biology Authors: Xiaoqin Lu Wenyi Zhang Jingyan Zhang Dan Ren Panpan Zhao Yanqi Ying Source Type: research
Clinical significance of PNO1 as a novel biomarker and therapeutic target of hepatocellular carcinoma
J Cell Mol Med. 2024 May;28(9):e18295. doi: 10.1111/jcmm.18295.ABSTRACTThe RNA-binding protein PNO1 plays an essential role in ribosome biogenesis. Recent studies have shown that it is involved in tumorigenesis; however, its role in hepatocellular carcinoma (HCC) is not well understood. The purpose of this study was to examine whether PNO1 can be used as a biomarker of HCC and also examine the therapeutic potential of PNO1 knockout for the treatment of HCC. PNO1 expression was upregulated in HCC and associated with poor prognosis. PNO1 expression was positively associated with tumour stage, lymph node metastasis and poor s...
Source: Molecular Medicine - May 9, 2024 Category: Molecular Biology Authors: Sanjit K Roy Shivam Srivastava Caroline McCance Anju Shrivastava Jason Morvant Sharmila Shankar Rakesh K Srivastava Source Type: research
The combination of breast cancer PDO and mini-PDX platform for drug screening and individualized treatment
J Cell Mol Med. 2024 May;28(9):e18374. doi: 10.1111/jcmm.18374.ABSTRACTThe majority of advanced breast cancers exhibit strong aggressiveness, heterogeneity, and drug resistance, and currently, the lack of effective treatment strategies is one of the main challenges that cancer research must face. Therefore, developing a feasible preclinical model to explore tailored treatments for refractory breast cancer is urgently needed. We established organoid biobanks from 17 patients with breast cancer and characterized them by immunohistochemistry (IHC) and next generation sequencing (NGS). In addition, we in the first combination ...
Source: Molecular Medicine - May 9, 2024 Category: Molecular Biology Authors: Yuxin Cui Ran Ran Yanyan Da Huiwen Zhang Meng Jiang Xin Qi Wei Zhang Ligang Niu Yuhui Zhou Can Zhou Xiaojiang Tang Ke Wang Yu Yan Yu Ren Danfeng Dong Yan Zhou Hui Wang Jin Gong Fang Hu Shidi Zhao Huimin Zhang Chengsheng Zhang Jin Yang Source Type: research
3D printed kombucha biomaterial as a tissue scaffold and L929 cell cytotoxicity assay
In this study, it was aimed to investigate the usage of SCOBY, which produces bacterial cellulose, as a biomaterial and 3D scaffold material. 3D printable biomaterial was obtained by partial hydrolysis of oolong tea and black tea kombucha biofilms. In order to investigate the usage of 3D kombucha biomaterial as a tissue scaffold, "L929 cell line 3D cell culture" was created and cell viability was tested in the biomaterial. At the end of the 21st day, black tea showed 51% and oolong tea 73% viability. The cytotoxicity of the materials prepared by lyophilizing oolong and black tea kombucha beverages in fibroblast cell cultur...
Source: Molecular Medicine - May 9, 2024 Category: Molecular Biology Authors: İlkyaz Bağlan Edag ül Yanbakan Tu ğba Tuncel Ay şe Koçak Sezgin Emirhan Bozo ğlan Derya Berikten Fatih Kar Source Type: research
