Exploiting pancreatic cancer metabolism: challenges and opportunities
Trends Mol Med. 2024 Apr 10:S1471-4914(24)00063-7. doi: 10.1016/j.molmed.2024.03.008. Online ahead of print.ABSTRACTPancreatic ductal adenocarcinoma (PDAC) is a highly aggressive form of pancreatic cancer, known for its challenging diagnosis and limited treatment options. The focus on metabolic reprogramming as a key factor in tumor initiation, progression, and therapy resistance has gained prominence. In this review we focus on the impact of metabolic changes on the interplay among stromal, immune, and tumor cells, as glutamine and branched-chain amino acids (BCAAs) emerge as pivotal players in modulating immune cell func...
Source: Molecular Medicine - April 11, 2024 Category: Molecular Biology Authors: Maria Chiara De Santis B Bockorny E Hirsch P Cappello M Martini Source Type: research
Trauma diagnostic-related target proteins and their detection techniques
Expert Rev Mol Med. 2024 Apr 11;26:e7. doi: 10.1017/erm.2024.3.ABSTRACTTrauma is a significant health issue that not only leads to immediate death in many cases but also causes severe complications, such as sepsis, thrombosis, haemorrhage, acute respiratory distress syndrome and traumatic brain injury, among trauma patients. Target protein identification technology is a vital technique in the field of biomedical research, enabling the study of biomolecular interactions, drug discovery and disease treatment. It plays a crucial role in identifying key protein targets associated with specific diseases or biological processes,...
Source: Molecular Medicine - April 11, 2024 Category: Molecular Biology Authors: YiLiu Wei Xiaohan Ren Zhitao Yuan Jie Hong Tao Wang Weizhi Chen Yuqing Xu Jinwang Ding Jun Lin Wenqian Jiang Peng Zhang Qiaoyi Wu Source Type: research
Intensive management from diagnosis improves HbA1c at 12 months post-diagnosis: results from a prospective cohort study in children with newly diagnosed type 1 diabetes
CONCLUSION: Intensive management when implemented with consistent messaging from the multi-disciplinary team resulted in clinic-wide improvements in HbA1c and the proportion meeting HbA1c targets.PMID:38603784 | DOI:10.26635/6965.6424 (Source: Molecular Medicine)
Source: Molecular Medicine - April 11, 2024 Category: Molecular Biology Authors: Caroline Griffin Erin Roxburgh Neil Owens Olivia Sanders Sharon Walsh Chloe Hudson Janet Ferguson Karen MacKenzie Martin de Bock Source Type: research
Engeletin alleviates depressive-like behaviours by modulating microglial polarization via the LCN2/CXCL10 signalling pathway
In conclusion, engeletin can alleviate CSDS-induced depressive-like behaviours by regulating the LCN2/CXCL10 pathway and thereby altering the polarization of microglia. These data suggest that the antidepressant effects of engeletin are correlated with the polarization of microglia, highlighting a potential avenue for future design of antidepressant strategies that specifically target the microglia.PMID:38597406 | PMC:PMC11005460 | DOI:10.1111/jcmm.18285 (Source: Molecular Medicine)
Source: Molecular Medicine - April 10, 2024 Category: Molecular Biology Authors: Jie Zhang Zheng Song Yanchao Huo Guangqiang Li Liming Lu Chuanmei Wei Shuping Zhang Xinfu Gao Xingyue Jiang Yangyang Xu Source Type: research
A single-chain antibody construct with specificity of a natural IgM antibody reduces hepatic ischemia reperfusion injury in mice
J Cell Mol Med. 2024 Apr;28(8):e18291. doi: 10.1111/jcmm.18291.ABSTRACTNatural immunoglobulin M (IgM) antibodies have been shown to recognize post-ischemic neoepitopes following reperfusion of tissues and to activate complement. Specifically, IgM antibodies and complement have been shown to drive hepatic ischemia reperfusion injury (IRI). Herein, we investigate the therapeutic effect of C2 scFv (single-chain antibody construct with specificity of a natural IgM antibody) on hepatic IRI in C57BL/6 mice. Compared with PBS-treated mice, C2 scFv-treated mice displayed almost no necrotic areas, significant reduction in serum ALT...
Source: Molecular Medicine - April 10, 2024 Category: Molecular Biology Authors: Zhi Yang Chunmei Li Yongqin Wang Wei Dong Moujie Yang Junfei Jin Source Type: research
Purine metabolism in lung adenocarcinoma: A single-cell analysis revealing prognostic and immunotherapeutic insights
J Cell Mol Med. 2024 Apr;28(8):e18284. doi: 10.1111/jcmm.18284.ABSTRACTLung adenocarcinoma (LUAD) is a prevalent subtype of lung cancer, yet the contribution of purine metabolism (PM) to its pathogenesis remains poorly elucidated. PM, a critical component of intracellular nucleotide synthesis and energy metabolism, is hypothesized to exert a significant influence on LUAD development. Herein, we employed single-cell analysis to investigate the role of PM within the tumour microenvironment (TME) of LUAD. PM scoring (PMS) across distinct cell types was determined using AUCell, UCell, singscore and AddModuleScore algorithms. S...
Source: Molecular Medicine - April 10, 2024 Category: Molecular Biology Authors: Pengpeng Zhang Shengbin Pei Guangyao Zhou Mengzhe Zhang Lianmin Zhang Zhenfa Zhang Source Type: research
Irradiated riboflavin over nonradiated one: Potent antimigratory, antiproliferative and cytotoxic effects on glioblastoma cells
In conclusion, radiated riboflavin clearly demonstrates superior antiproliferative and apoptotic effects on C6 cells at lower doses compared to nonradiated riboflavin.PMID:38597418 | PMC:PMC11005454 | DOI:10.1111/jcmm.18288 (Source: Molecular Medicine)
Source: Molecular Medicine - April 10, 2024 Category: Molecular Biology Authors: Sedat Kacar Ceyhan Hacioglu Fatih Kar Source Type: research
The transcription factor bmi1 increases hypoxic signaling in oral cavity epithelia
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 8:167161. doi: 10.1016/j.bbadis.2024.167161. Online ahead of print.ABSTRACTThe tongue epithelium is maintained by a proliferative basal layer. This layer contains long-lived stem cells (SCs), which produce progeny cells that move up to the surface as they differentiate. B-lymphoma Mo-MLV insertion region 1 (Bmi1), a protein in mammalian Polycomb Repressive Complex 1 (PRC1) and a biomarker of oral squamous cell carcinoma, is expressed in almost all basal epithelial SCs of the tongue, and single, Bmi1-labelled SCs give rise to cells in all epithelial layers. We previously develope...
Source: Molecular Medicine - April 10, 2024 Category: Molecular Biology Authors: Jorge Baquero Xiao-Han Tang Annalisa Ferrotta Tuo Zhang Krysta M DiKun Lorraine J Gudas Source Type: research
The role of the immunosuppressive PD-1/PD-L1 checkpoint pathway in the aging process and age-related diseases
J Mol Med (Berl). 2024 Apr 11. doi: 10.1007/s00109-024-02444-6. Online ahead of print.ABSTRACTThe accumulation of senescent cells within tissues is a hallmark of the aging process. Senescent cells are also commonly present in many age-related diseases and in the cancer microenvironment. The escape of abnormal cells from immune surveillance indicates that there is some defect in the function of cytotoxic immune cells, e.g., CD8+ T cells and natural killer (NK) cells. Recent studies have revealed that the expression of programmed death-ligand 1 (PD-L1) protein is abundantly increased in senescent cells. An increase in the am...
Source: Molecular Medicine - April 10, 2024 Category: Molecular Biology Authors: Antero Salminen Source Type: research
Correction: Huntingtin HTT1a is generated in a CAG repeat-length-dependent manner in human tissues
Mol Med. 2024 Apr 10;30(1):49. doi: 10.1186/s10020-024-00810-1.NO ABSTRACTPMID:38600455 | PMC:PMC11005274 | DOI:10.1186/s10020-024-00810-1 (Source: Molecular Medicine)
Source: Molecular Medicine - April 10, 2024 Category: Molecular Biology Authors: Franziska Hoschek Julia Natan Maximilian Wagner Kirupa Sathasivam Alshaimaa Abdelmoez Bj örn von Einem Gillian P Bates G Bernhard Landwehrmeyer Andreas Neueder Source Type: research
Engeletin alleviates depressive-like behaviours by modulating microglial polarization via the LCN2/CXCL10 signalling pathway
In conclusion, engeletin can alleviate CSDS-induced depressive-like behaviours by regulating the LCN2/CXCL10 pathway and thereby altering the polarization of microglia. These data suggest that the antidepressant effects of engeletin are correlated with the polarization of microglia, highlighting a potential avenue for future design of antidepressant strategies that specifically target the microglia.PMID:38597406 | DOI:10.1111/jcmm.18285 (Source: Molecular Medicine)
Source: Molecular Medicine - April 10, 2024 Category: Molecular Biology Authors: Jie Zhang Zheng Song Yanchao Huo Guangqiang Li Liming Lu Chuanmei Wei Shuping Zhang Xinfu Gao Xingyue Jiang Yangyang Xu Source Type: research
A single-chain antibody construct with specificity of a natural IgM antibody reduces hepatic ischemia reperfusion injury in mice
J Cell Mol Med. 2024 Apr;28(8):e18291. doi: 10.1111/jcmm.18291.ABSTRACTNatural immunoglobulin M (IgM) antibodies have been shown to recognize post-ischemic neoepitopes following reperfusion of tissues and to activate complement. Specifically, IgM antibodies and complement have been shown to drive hepatic ischemia reperfusion injury (IRI). Herein, we investigate the therapeutic effect of C2 scFv (single-chain antibody construct with specificity of a natural IgM antibody) on hepatic IRI in C57BL/6 mice. Compared with PBS-treated mice, C2 scFv-treated mice displayed almost no necrotic areas, significant reduction in serum ALT...
Source: Molecular Medicine - April 10, 2024 Category: Molecular Biology Authors: Zhi Yang Chunmei Li Yongqin Wang Wei Dong Moujie Yang Junfei Jin Source Type: research
Purine metabolism in lung adenocarcinoma: A single-cell analysis revealing prognostic and immunotherapeutic insights
J Cell Mol Med. 2024 Apr;28(8):e18284. doi: 10.1111/jcmm.18284.ABSTRACTLung adenocarcinoma (LUAD) is a prevalent subtype of lung cancer, yet the contribution of purine metabolism (PM) to its pathogenesis remains poorly elucidated. PM, a critical component of intracellular nucleotide synthesis and energy metabolism, is hypothesized to exert a significant influence on LUAD development. Herein, we employed single-cell analysis to investigate the role of PM within the tumour microenvironment (TME) of LUAD. PM scoring (PMS) across distinct cell types was determined using AUCell, UCell, singscore and AddModuleScore algorithms. S...
Source: Molecular Medicine - April 10, 2024 Category: Molecular Biology Authors: Pengpeng Zhang Shengbin Pei Guangyao Zhou Mengzhe Zhang Lianmin Zhang Zhenfa Zhang Source Type: research
Irradiated riboflavin over nonradiated one: Potent antimigratory, antiproliferative and cytotoxic effects on glioblastoma cells
In conclusion, radiated riboflavin clearly demonstrates superior antiproliferative and apoptotic effects on C6 cells at lower doses compared to nonradiated riboflavin.PMID:38597418 | DOI:10.1111/jcmm.18288 (Source: Molecular Medicine)
Source: Molecular Medicine - April 10, 2024 Category: Molecular Biology Authors: Sedat Kacar Ceyhan Hacioglu Fatih Kar Source Type: research
Further delineation of phenotype and genotype of Kenny-Caffey syndrome type 2 (phenotype and genotype of KCS type 2)
CONCLUSION: We provide detailed characteristics of the largest KCS2 group in China and present the first genetically confirmed instance of father-to-daughter transmission of KCS2. Our study confirms that Arg569His is the hot spot variant and summarizes the typical phenotypes of KCS2, which would help early diagnosis and intervention.PMID:38591167 | PMC:PMC11002637 | DOI:10.1002/mgg3.2433 (Source: Molecular Medicine)
Source: Molecular Medicine - April 9, 2024 Category: Molecular Biology Authors: Xuefei Chen Chaochun Zou Source Type: research
