Recent Updates on Applications of Artificial Intelligence for Nuclear Medicine Professionals: Bone Scintigraphy
Nucl Med Mol Imaging. 2024 Apr;58(2):47-51. doi: 10.1007/s13139-023-00833-2. Epub 2024 Jan 9.NO ABSTRACTPMID:38510825 | PMC:PMC10948635 | DOI:10.1007/s13139-023-00833-2 (Source: Molecular Medicine)
Source: Molecular Medicine - March 21, 2024 Category: Molecular Biology Authors: Ki-Seong Park Hee-Seung Henry Bom Source Type: research

Ectopic Intrathoracic Kidney due to Diaphragmatic Eventration Detected on Bone Scan
We present a case of a 67-year-old female in whom the 99mTc-MDP scan, performed 3 hours after injection, revealed abnormal soft tissue uptake in the right thoracic region. No functioning right kidney was seen in the right lumbar region. Hybrid SPECT/CT revealed an ectopic right kidney in the subdiaphragmatic location, accompanied by gut loops and eventration of the right-sided diaphragm. This case underscores the value of SPECT/CT in identifying and characterizing unexpected anatomical abnormalities, such as ectopic kidneys.PMID:38510826 | PMC:PMC10948715 | DOI:10.1007/s13139-023-00829-y (Source: Molecular Medicine)
Source: Molecular Medicine - March 21, 2024 Category: Molecular Biology Authors: Warda Ahmad Nayyar Rubab Farkhanda Gillani Muhammad Shahzad Afzal Muhammad Babar Imran Source Type: research

Preimplantation genetic testing as a means of preventing hereditary congenital myasthenic syndrome caused by RAPSN
CONCLUSION: This report constitutes the first documented case of achieving a CMS-free offspring through PGT-M in a CMS-affected family. By broadening the known variant spectrum of RAPSN in the Chinese population, our findings underscore the feasibility and effectiveness of PGT-M for preventing CMS, offering valuable insights for similarly affected families.PMID:38511267 | DOI:10.1002/mgg3.2409 (Source: Molecular Medicine)
Source: Molecular Medicine - March 21, 2024 Category: Molecular Biology Authors: Zhiping Zhang Xueluo Zhang Huiqin Xue Liming Chu Lina Hu Xingyu Bi Pengfei Zhu Dongdong Zhang Jiayao Chen Xiangrong Cui Lingyin Kong Bo Liang Xueqing Wu Source Type: research

Fine-tuning FAM161A gene augmentation therapy to restore retinal function
EMBO Mol Med. 2024 Mar 19. doi: 10.1038/s44321-024-00053-x. Online ahead of print.ABSTRACTFor 15 years, gene therapy has been viewed as a beacon of hope for inherited retinal diseases. Many preclinical investigations have centered around vectors with maximal gene expression capabilities, yet despite efficient gene transfer, minimal physiological improvements have been observed in various ciliopathies. Retinitis pigmentosa-type 28 (RP28) is the consequence of bi-allelic null mutations in the FAM161A, an essential protein for the structure of the photoreceptor connecting cilium (CC). In its absence, cilia become disorganized...
Source: Molecular Medicine - March 20, 2024 Category: Molecular Biology Authors: Yvan Arsenijevic Ning Chang Olivier Mercey Younes El Fersioui Hanna Koskiniemi-Kuendig Caroline Joubert Alexis-Pierre Bemelmans Carlo Rivolta Eyal Banin Dror Sharon Paul Guichard Virginie Hamel Corinne Kostic Source Type: research

Identification of circRNA-disease associations via multi-model fusion and ensemble learning
J Cell Mol Med. 2024 Apr;28(7):e18180. doi: 10.1111/jcmm.18180.ABSTRACTCircular RNA (circRNA) is a common non-coding RNA and plays an important role in the diagnosis and therapy of human diseases, circRNA-disease associations prediction based on computational methods can provide a new way for better clinical diagnosis. In this article, we proposed a novel method for circRNA-disease associations prediction based on ensemble learning, named ELCDA. First, the association heterogeneous network was constructed via collecting multiple information of circRNAs and diseases, and multiple similarity measures are adopted here, then, ...
Source: Molecular Medicine - March 20, 2024 Category: Molecular Biology Authors: Jing Yang Xiujuan Lei Fa Zhang Source Type: research

ApoE4 dysregulation incites depressive symptoms and mitochondrial impairments in mice
J Cell Mol Med. 2024 Apr;28(7):e18160. doi: 10.1111/jcmm.18160.ABSTRACTApolipoprotein E4 (ApoE4) is involved in the stress-response processes and is hypothesized to be a risk factor for depression by means of mitochondrial dysfunction. However, their exact roles and underlying mechanisms are largely unknown. ApoE4 transgenic mice (B6. Cg-ApoEtm1Unc Cdh18Tg( GFAP-APOE i4)1Hol /J) were subjected to stress (lipopolysaccharides, LPS) to elucidate the aetiology of ApoE4-induced depression. LPS treatment significantly aggravated depression-like behaviours, concurrent with neuroinflammation and impaired mitochondrial changes, and...
Source: Molecular Medicine - March 20, 2024 Category: Molecular Biology Authors: Weifen Li Tahir Ali Kaiwu He Chengyou Zheng Ningning Li Zhi-Jian Yu Shupeng Li Source Type: research

Long noncoding RNA Glis2 regulates podocyte mitochondrial dysfunction and apoptosis in diabetic nephropathy via sponging miR-328-5p
This study aimed to investigate whether lncRNA Glis2 could regulate podocyte apoptosis in DN and uncover the underlying mechanism. The apoptosis rate was detected by flow cytometry. Mitochondrial membrane potential (ΔΨM) was measured using JC-1 staining. Mitochondrial morphology was detected by MitoTracker Deep Red staining. Then, the histopathological and ultrastructure changes of renal tissues in diabetic mice were observed using periodic acid-Schiff (PAS) staining and transmission electron microscopy. We found that lncRNA Glis2 was significantly downregulated in high-glucose cultured podocytes and renal tissues of db/...
Source: Molecular Medicine - March 20, 2024 Category: Molecular Biology Authors: Ting Wang Yanxia Chen Zhihong Liu Jing Zhou Na Li Yue Shan Yinxi He Source Type: research

Mendelian randomization analysis reveals a causal effect of Streptococcus salivarius on diabetic retinopathy through regulating host fasting glucose
J Cell Mol Med. 2024 Apr;28(7):e18200. doi: 10.1111/jcmm.18200.ABSTRACTDiabetic retinopathy (DR) is one of leading causes of vision loss in adults with increasing prevalence worldwide. Increasing evidence has emphasized the importance of gut microbiome in the aetiology and development of DR. However, the causal relationship between gut microbes and DR remains largely unknown. To investigate the causal associations of DR with gut microbes and DR risk factors, we employed two-sample Mendelian Randomization (MR) analyses to estimate the causal effects of 207 gut microbes on DR outcomes. Inputs for MR included Genome-wide Asso...
Source: Molecular Medicine - March 20, 2024 Category: Molecular Biology Authors: Jingjing Li Gongwei Zheng Dingping Jiang Chunyu Deng Yaru Zhang Yunlong Ma Jianzhong Su Source Type: research

Retraction: Long non-coding RNA LINC00607 silencing exerts antioncogenic effects on thyroid cancer through the CASP9 promoter methylation
J Cell Mol Med. 2024 Apr;28(7):e18251. doi: 10.1111/jcmm.18251.NO ABSTRACTPMID:38506070 | PMC:PMC10951866 | DOI:10.1111/jcmm.18251 (Source: Molecular Medicine)
Source: Molecular Medicine - March 20, 2024 Category: Molecular Biology Source Type: research

Identification and characterization of extrachromosomal circular DNA in large-artery atherosclerotic stroke
J Cell Mol Med. 2024 Apr;28(7):e18210. doi: 10.1111/jcmm.18210.ABSTRACTExtrachromosomal circular DNA (eccDNA) is a new biomarker and regulator of diseases. However, the role of eccDNAs in large-artery atherosclerotic (LAA) stroke remains unclear. Through high-throughput circle-sequencing technique, the length distribution, genomic characteristic and motifs feature of plasma eccDNA from healthy controls (CON) and patients with LAA stroke were analysed. Then, the potential functions of the annotated eccDNAs were investigated using GO and KEGG pathway analyses. EccDNAs mapped to the reference genome showed SHN3 and BCL6 were ...
Source: Molecular Medicine - March 20, 2024 Category: Molecular Biology Authors: Kejie Chen Yanqi Chi Hang Cheng Min Yang Quandan Tan Junli Hao Yapeng Lin Fengkai Mao Song He Jie Yang Source Type: research

Retraction: IL-17A-producing T cells exacerbate fine particulate matter-induced lung inflammation and fibrosis by inhibiting PI3K/Akt/mTOR-mediated autophagy
J Cell Mol Med. 2024 Apr;28(7):e18222. doi: 10.1111/jcmm.18222.NO ABSTRACTPMID:38506075 | PMC:PMC10951874 | DOI:10.1111/jcmm.18222 (Source: Molecular Medicine)
Source: Molecular Medicine - March 20, 2024 Category: Molecular Biology Source Type: research

Association between sex hormones and bone age in boys aged 9-18  years from China
This study aimed to analyse the association between sex hormones and bone age (BA) in boys aged 9-18 years, both individually and interactively, and further to explore whether nutritional status may influence this association. A retrospective analysis was performed among 1382 Chinese boys with physical measurements, sexual characteristics, BA radiographs and sex hormone indicators from February 2015 to February 2022. A total of 470 (34.0%) boys had advanced BA. BA was positively associated with estradiol, luteinizing hormone (LH), follicle-stimulating hormone (FSH) and testosterone in both advanced and normal BA groups aft...
Source: Molecular Medicine - March 20, 2024 Category: Molecular Biology Authors: Wen Shu Wenquan Niu Yaqin Zhang Hui Li Source Type: research

Research progress on the regulatory mechanism of integrin-mediated mechanical stress in cells involved in bone metabolism
J Cell Mol Med. 2024 Apr;28(7):e18183. doi: 10.1111/jcmm.18183.ABSTRACTMechanical stress is an internal force between various parts of an object that resists external factors and effects that cause an object to deform, and mechanical stress is essential for various tissues that are constantly subjected to mechanical loads to function normally. Integrins are a class of transmembrane heterodimeric glycoprotein receptors that are important target proteins for the action of mechanical stress stimuli on cells and can convert extracellular physical and mechanical signals into intracellular bioelectrical signals, thereby regulati...
Source: Molecular Medicine - March 20, 2024 Category: Molecular Biology Authors: Li Yang Hong Chen Chanchan Yang Zhengqi Hu Zhiliang Jiang Shengzi Meng Rong Liu Lan Huang Kun Yang Source Type: research

Indoxyl sulphate-initiated activation of cardiac fibroblasts is modulated by aryl hydrocarbon receptor and nuclear factor-erythroid-2-related factor 2
J Cell Mol Med. 2024 Apr;28(7):e18192. doi: 10.1111/jcmm.18192.ABSTRACTIn the last decade, extensive attention has been paid to the uremic toxin indoxyl sulphate (IS) as an inducer of cardiac fibroblast (cFib) activation and cardiac fibrosis in chronic kidney disease. At cellular level, IS engages aryl hydrocarbon receptor (AhR) and regulates many biological functions. We analysed how AhR inhibition by CH-223191 (CH) and overexpression of non-functional (dominant negative, DN) nuclear factor-erythroid-2-related factor 2 (NRF2), a transcription factor recruited by AhR, modulate the response of neonatal mouse (nm) cFib to IS...
Source: Molecular Medicine - March 20, 2024 Category: Molecular Biology Authors: Chiara Barisione Daniela Verzola Silvano Garibaldi Paola Altieri Anna Lisa Furfaro Mariapaola Nitti Giovanni Pratesi Domenico Palombo Pietro Ameri Source Type: research

MRPS16 promotes lung adenocarcinoma growth via the PI3K/AKT/Frataxin signalling axis
J Cell Mol Med. 2024 Apr;28(7):e18166. doi: 10.1111/jcmm.18166.ABSTRACTAlthough MRPS16 is involved in cancer development, its mechanisms in developing LAUD remain unclear. Herein, qRT-PCR, WB and IHC were utilized for evaluating MRPS16 expression levels, while functional assays besides animal experiments were performed to measure MRPS16 effect on LAUD progression. Using WB, the MRPS16 effect on PI3K/AKT/Frataxin signalling pathway was tested. According to our study, MRPS16 was upregulated in LAUD and was correlated to the advanced TNM stage as well as poor clinical outcomes, which represent an independent prognostic factor...
Source: Molecular Medicine - March 20, 2024 Category: Molecular Biology Authors: Zaixing Cheng Kaming Xue Cui Xiong Zhikun Zheng Jinsong Li Xinwei Qiao Source Type: research