SALL4 in gastrointestinal tract cancers: upstream and downstream regulatory mechanisms
We describe the functions of SALL4 in GIT cancers and discuss its upstream/downstream genes and pathways associated with each cancer. We also consider the possibility of targeting these genes or pathways as potential therapeutic options for GIT cancers.PMID:38584262 | DOI:10.1186/s10020-024-00812-z (Source: Molecular Medicine)
Source: Molecular Medicine - April 7, 2024 Category: Molecular Biology Authors: Tairan Wang Yan Jin Mengyao Wang Boya Chen Jinyu Sun Jiaying Zhang Hui Yang Xinyao Deng Xingyue Cao Lidong Wang Yuanyuan Tang Source Type: research
Clinical and genetic characteristics of three patients with congenital insensitivity to pain with anhidrosis: Case reports and a review of the literature
CONCLUSION: All three patients exhibited variable phenotypes and disease severity. This research enriches our understanding of clinical and genetic aspects of CIPA, highlighting variable phenotypes and disease severity.PMID:38581121 | PMC:PMC10997844 | DOI:10.1002/mgg3.2430 (Source: Molecular Medicine)
Source: Molecular Medicine - April 6, 2024 Category: Molecular Biology Authors: Jun Hee Cho Soojin Hwang Yoon Hae Kwak Mi-Sun Yum Go Hun Seo June-Young Koh Young Seok Ju Ji-Hee Yoon Minji Kang Hyo-Sang Do Soyoung Kim Gu-Hwan Kim Hyunwoo Bae Beom Hee Lee Source Type: research
Autism spectrum disorder profiles in RASopathies: A systematic review
CONCLUSIONS: Our systematic review found no convincing evidence for a specific ASD profile in RASopathies compared to iASD, or in a specific RASopathy compared to other RASopathies. However, we identified important limitations in the research literature which may also account for this result. These limitations are discussed and recommendations for future research are formulated.PMID:38581124 | PMC:PMC10997847 | DOI:10.1002/mgg3.2428 (Source: Molecular Medicine)
Source: Molecular Medicine - April 6, 2024 Category: Molecular Biology Authors: Edward Debbaut Jean Steyaert Mouna El Bakkali Source Type: research
Construction and Biological Evaluation of Biomimetic Coatings on Titanium Surfaces Using Naringin-7-O-Neohesperidoside at Different Concentrations
CONCLUSIONS: NRG biomimetic coatings on titanium surfaces were successfully constructed using the LBL technique. NRG at different concentrations had stronger effects on the proliferation and differentiation of MC3T3-E1 cells compared to the groups without drug and blank groups, with the concentration of 10-6 mol/L demonstrating the best effect. These findings suggest that NRG-loaded biomimetic coatings may enhance the osseointegration of titanium implants, offering promising prospects for dental and orthopedic applications.PMID:38581321 (Source: Molecular Medicine)
Source: Molecular Medicine - April 6, 2024 Category: Molecular Biology Authors: Chengzhong Wu Jingxiao Wang Yajie Huang Xia Shao Source Type: research
An ultra-small organic dye nanocluster for enhancing NIR-II imaging-guided surgery outcomes
CONCLUSION: In summary, our study demonstrates that the dye nanocluster-based NIR-II FGS has substantially improved outcomes for radical lymphadenectomy.PMID:38581443 | DOI:10.1007/s00259-024-06702-0 (Source: Molecular Medicine)
Source: Molecular Medicine - April 6, 2024 Category: Molecular Biology Authors: Yajun Wang Ding Zhou Huilong Ma Dahai Liu Yongye Liang Shoujun Zhu Source Type: research
5 α-reduction of epitestosterone is catalysed by human SRD5A1 and SRD5A2 and increases androgen receptor transactivation
In conclusion, we provide evidence that steroid 5α-reductases regulate the modulatory effect of epitestosterone on androgen receptor signalling.PMID:38582131 | DOI:10.1016/j.jsbmb.2024.106516 (Source: Molecular Medicine)
Source: Molecular Medicine - April 6, 2024 Category: Molecular Biology Authors: Lina Schiffer Wiebke Arlt Karl-Heinz Storbeck Source Type: research
Pelizaeus-Merzbacher disease: on the cusp of myelin medicine
Trends Mol Med. 2024 Apr 5:S1471-4914(24)00060-1. doi: 10.1016/j.molmed.2024.03.005. Online ahead of print.ABSTRACTPelizaeus-Merzbacher disease (PMD) is caused by mutations in the proteolipid protein 1 (PLP1) gene encoding proteolipid protein (PLP). As a major component of myelin, mutated PLP causes progressive neurodegeneration and eventually death due to severe white matter deficits. Medical care has long been limited to symptomatic treatments, but first-in-class PMD therapies with novel mechanisms now stand poised to enter clinical trials. Here, we review PMD disease mechanisms and outline rationale for therapeutic inte...
Source: Molecular Medicine - April 6, 2024 Category: Molecular Biology Authors: Matthew S Elitt Paul J Tesar Source Type: research
Molecular mechanisms in the pathogenesis of dengue infections
Trends Mol Med. 2024 Apr 5:S1471-4914(24)00061-3. doi: 10.1016/j.molmed.2024.03.006. Online ahead of print.ABSTRACTDengue is the most rapidly emerging climate-sensitive infection, and morbidity/mortality and disease incidence are rising markedly, leading to healthcare systems being overwhelmed. There are currently no specific treatments for dengue or prognostic markers to identify those who will progress to severe disease. Owing to an increase in the burden of illness and a change in epidemiology, many patients experience severe disease. Our limited understanding of the complex mechanisms of disease pathogenesis has signif...
Source: Molecular Medicine - April 6, 2024 Category: Molecular Biology Authors: Gathsaurie Neelika Malavige Graham S Ogg Source Type: research
Cell-free DNA methylation in the clinical management of lung cancer
Trends Mol Med. 2024 Apr 5:S1471-4914(24)00062-5. doi: 10.1016/j.molmed.2024.03.007. Online ahead of print.ABSTRACTThe clinical use of cell-free DNA (cfDNA) methylation in managing lung cancer depends on its ability to differentiate between malignant and healthy cells, assign methylation changes to specific tissue sources, and elucidate opportunities for targeted therapy. From a technical standpoint, cfDNA methylation analysis is primed as a potential clinical tool for lung cancer screening, early diagnosis, prognostication, and treatment, pending the outcome of elaborate validation studies. Here, we discuss the current st...
Source: Molecular Medicine - April 6, 2024 Category: Molecular Biology Authors: Mark Ezegbogu Emma Wilkinson Glen Reid Euan J Rodger Ben Brockway Takiwai Russell-Camp Rajiv Kumar Aniruddha Chatterjee Source Type: research
Clinical and genetic characteristics of three patients with congenital insensitivity to pain with anhidrosis: Case reports and a review of the literature
CONCLUSION: All three patients exhibited variable phenotypes and disease severity. This research enriches our understanding of clinical and genetic aspects of CIPA, highlighting variable phenotypes and disease severity.PMID:38581121 | PMC:PMC10997844 | DOI:10.1002/mgg3.2430 (Source: Molecular Medicine)
Source: Molecular Medicine - April 6, 2024 Category: Molecular Biology Authors: Jun Hee Cho Soojin Hwang Yoon Hae Kwak Mi-Sun Yum Go Hun Seo June-Young Koh Young Seok Ju Ji-Hee Yoon Minji Kang Hyo-Sang Do Soyoung Kim Gu-Hwan Kim Hyunwoo Bae Beom Hee Lee Source Type: research
Autism spectrum disorder profiles in RASopathies: A systematic review
CONCLUSIONS: Our systematic review found no convincing evidence for a specific ASD profile in RASopathies compared to iASD, or in a specific RASopathy compared to other RASopathies. However, we identified important limitations in the research literature which may also account for this result. These limitations are discussed and recommendations for future research are formulated.PMID:38581124 | PMC:PMC10997847 | DOI:10.1002/mgg3.2428 (Source: Molecular Medicine)
Source: Molecular Medicine - April 6, 2024 Category: Molecular Biology Authors: Edward Debbaut Jean Steyaert Mouna El Bakkali Source Type: research
Construction and Biological Evaluation of Biomimetic Coatings on Titanium Surfaces Using Naringin-7-O-Neohesperidoside at Different Concentrations
CONCLUSIONS: NRG biomimetic coatings on titanium surfaces were successfully constructed using the LBL technique. NRG at different concentrations had stronger effects on the proliferation and differentiation of MC3T3-E1 cells compared to the groups without drug and blank groups, with the concentration of 10-6 mol/L demonstrating the best effect. These findings suggest that NRG-loaded biomimetic coatings may enhance the osseointegration of titanium implants, offering promising prospects for dental and orthopedic applications.PMID:38581321 (Source: Molecular Medicine)
Source: Molecular Medicine - April 6, 2024 Category: Molecular Biology Authors: Chengzhong Wu Jingxiao Wang Yajie Huang Xia Shao Source Type: research
An ultra-small organic dye nanocluster for enhancing NIR-II imaging-guided surgery outcomes
CONCLUSION: In summary, our study demonstrates that the dye nanocluster-based NIR-II FGS has substantially improved outcomes for radical lymphadenectomy.PMID:38581443 | DOI:10.1007/s00259-024-06702-0 (Source: Molecular Medicine)
Source: Molecular Medicine - April 6, 2024 Category: Molecular Biology Authors: Yajun Wang Ding Zhou Huilong Ma Dahai Liu Yongye Liang Shoujun Zhu Source Type: research
5 α-reduction of epitestosterone is catalysed by human SRD5A1 and SRD5A2 and increases androgen receptor transactivation
In conclusion, we provide evidence that steroid 5α-reductases regulate the modulatory effect of epitestosterone on androgen receptor signalling.PMID:38582131 | DOI:10.1016/j.jsbmb.2024.106516 (Source: Molecular Medicine)
Source: Molecular Medicine - April 6, 2024 Category: Molecular Biology Authors: Lina Schiffer Wiebke Arlt Karl-Heinz Storbeck Source Type: research
Pelizaeus-Merzbacher disease: on the cusp of myelin medicine
Trends Mol Med. 2024 Apr 5:S1471-4914(24)00060-1. doi: 10.1016/j.molmed.2024.03.005. Online ahead of print.ABSTRACTPelizaeus-Merzbacher disease (PMD) is caused by mutations in the proteolipid protein 1 (PLP1) gene encoding proteolipid protein (PLP). As a major component of myelin, mutated PLP causes progressive neurodegeneration and eventually death due to severe white matter deficits. Medical care has long been limited to symptomatic treatments, but first-in-class PMD therapies with novel mechanisms now stand poised to enter clinical trials. Here, we review PMD disease mechanisms and outline rationale for therapeutic inte...
Source: Molecular Medicine - April 6, 2024 Category: Molecular Biology Authors: Matthew S Elitt Paul J Tesar Source Type: research
