Astatine-211 for PSMA-targeted α-radiation therapy of micrometastatic prostate cancer: a sustainable approach towards precision oncology
Eur J Nucl Med Mol Imaging. 2023 Mar 2. doi: 10.1007/s00259-023-06178-4. Online ahead of print.NO ABSTRACTPMID:36862207 | DOI:10.1007/s00259-023-06178-4 (Source: Molecular Medicine)
Source: Molecular Medicine - March 2, 2023 Category: Molecular Biology Authors: Rubel Chakravarty Xiaoli Lan Sudipta Chakraborty Weibo Cai Source Type: research
TGF- β Activated Kinase 1 (TAK1) Is Activated in Microglia After Experimental Epilepsy and Contributes to Epileptogenesis
Mol Neurobiol. 2023 Mar 2. doi: 10.1007/s12035-023-03290-2. Online ahead of print.ABSTRACTIncreasing evidence suggests that inflammation promotes epileptogenesis. TAK1 is a central enzyme in the upstream pathway of NF-κB and is known to play a central role in promoting neuroinflammation in neurodegenerative diseases. Here, we investigated the cellular role of TAK1 in experimental epilepsy. C57Bl6 and transgenic mice with inducible and microglia-specific deletion of Tak1 (Cx3cr1CreER:Tak1fl/fl) were subjected to the unilateral intracortical kainate mouse model of temporal lobe epilepsy (TLE). Immunohistochemical staining w...
Source: Molecular Medicine - March 2, 2023 Category: Molecular Biology Authors: Dilaware Khan Peter Bedner Julia M üller Fabienne L ülsberg Lukas Henning Marco Prinz Christian Steinh äuser Sajjad Muhammad Source Type: research
Direct co-registration of [ < sup > 18 < /sup > F]FDG uptake and histopathology in surgically excised malignancies of the head and neck: a feasibility study
CONCLUSION: We here describe a novel methodology enabling the direct co-registration of [18F]FDG autoradiography with the gold standard of histopathology in human malignant tissue. The future use of the current methodology could further increase our understanding of the distribution of radionuclides in surgically excised malignancies and hence, improve the integration of pathology and molecular imaging in a multiscale perspective.TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT05068687.PMID:36854863 | DOI:10.1007/s00259-023-06153-z (Source: Molecular Medicine)
Source: Molecular Medicine - March 1, 2023 Category: Molecular Biology Authors: Jens M Debacker Luna Maris Fleur Cordier David Creytens Philippe Deron Benedicte Descamps Yves D'Asseler Kathia De Man Vincent Keereman Sasha Libbrecht Vanessa Schelfhout Koen Van de Vijver Christian Vanhove Wouter Huvenne Source Type: research
Metabolic rewiring in keratinocytes by miR-31-5p identifies therapeutic intervention for psoriasis
EMBO Mol Med. 2023 Mar 1:e15674. doi: 10.15252/emmm.202215674. Online ahead of print.ABSTRACTBesides genetic alterations, the cellular environment also determines disease onset and progression. When different cell types contribute to disease outcome, this imposes environmental challenges as different cell types likely differ in their extracellular dependencies. Hsa-microRNA-31-5p (miR-31) is highly expressed in keratinocytes of psoriatic skin, and we show that expression in keratinocytes is induced by limited glucose availability and enables increased survival under limiting glucose conditions by increasing glutamine metab...
Source: Molecular Medicine - March 1, 2023 Category: Molecular Biology Authors: Mao-Jie Wang Huan-Jie Huang Yong-Yue Xu Harmjan Vos Can Gulersonmez Edwin Stigter Johan Gerritsen Marc Pages Gallego Robert van Es Li Li Hao Deng Lin Han Run-Yue Huang Chuan-Jian Lu Boudewijn Mt Burgering Source Type: research
Identification of a novel eighteen-gene signature of recurrent metastasis neuroblastoma
In conclusion, our study offers a novel metastasis biomarker and helps understand the mechanisms of tumor recurrent metastasis. KEY MESSAGES: We identified a novel eighteen-gene signature of recurrent metastasis neuroblastoma and build risk and classification models. We dissected the regulatory role of NCAPG in signatures. We found immune exhaustion and immunosuppression in recurrent metastasis neuroblastoma. Vinorelbine and docetaxel were predicted to have high sensitivity against recurrent metastatic neuroblastoma.PMID:36856811 | DOI:10.1007/s00109-023-02299-3 (Source: Molecular Medicine)
Source: Molecular Medicine - March 1, 2023 Category: Molecular Biology Authors: Shufan Zhang Rong Jiang Manqiu Yang Tao Wang Hui Chen Yifan Shi Wei Liu Moli Huang Source Type: research
Criterios PERCIST, Hopkins y par ámetros metabólicos de la PET/TC como factores pronósticos en el cáncer escamoso de cabeza y cuello
CONCLUSION: Application of PERCIST and Hopkins criteria as well as ΔSUVmax, ΔMTV and ΔTLG from PET/CT studies proved to be prognostic factors for survival in patients in our setting for treating head and neck cancer. The results may help to personalize treatment.PMID:36858187 | DOI:10.1016/j.remnie.2023.02.007 (Source: Molecular Medicine)
Source: Molecular Medicine - March 1, 2023 Category: Molecular Biology Authors: Á Baena García J R Infante de la Torre R Barco Carbonero J J Cabrera Rodr íguez A Mart ínez Esteve J Serrano Vicente P Jim énez Granero A Utrera Costero J Ignacio Rayo Source Type: research
BMP7 ameliorates intervertebral disc degeneration in type 1 diabetic rats by inhibiting pyroptosis of nucleus pulposus cells and NLRP3 inflammasome activity
CONCLUSION: Collectively, our findings provided novel mechanistic insights for understanding of the role of BMP7 in IDD of T1DM, and further highlighted BMP7 as a potential therapeutic target for preventing IDD in T1DM.PMID:36858954 | DOI:10.1186/s10020-023-00623-8 (Source: Molecular Medicine)
Source: Molecular Medicine - March 1, 2023 Category: Molecular Biology Authors: Xiao-Jun Yu Ying-Guang Wang Rui Lu Xin-Zhen Guo Yun-Kun Qu Shan-Xi Wang Hao-Ran Xu Hao Kang Hong-Bo You Yong Xu Source Type: research
Evaluation of thresholding methods for the quantification of [ < sup > 68 < /sup > Ga]Ga-PSMA-11 PET molecular tumor volume and their effect on survival prediction in patients with advanced prostate cancer undergoing [ < sup > 177 < /sup > Lu]Lu-PSMA-617 radioligand therapy
CONCLUSION: Thresholding methods commonly used in computer vision are promising tools for the semiautomatic quantification of whole-body PSMA-TV in [68Ga]Ga-PSMA-11-PET. The proposed algorithm-driven thresholding strategy is less arbitrary and less prone to biases than thresholding with predefined values, potentially improving the application of whole-body PSMA-TV as an imaging biomarker.PMID:36859618 | DOI:10.1007/s00259-023-06163-x (Source: Molecular Medicine)
Source: Molecular Medicine - March 1, 2023 Category: Molecular Biology Authors: Moon Kim Robert Seifert Jana Fragemann David Kersting Jacob Murray Frederic Jonske Kelsey L Pomykala Jan Egger Wolfgang P Fendler Ken Herrmann Jens Kleesiek Source Type: research
< sup > 89 < /sup > Zr-immuno-PET using the anti-LAG-3 tracer [ < sup > 89 < /sup > Zr]Zr-BI 754111: demonstrating target specific binding in NSCLC and HNSCC
CONCLUSIONS: [89Zr]Zr-BI-754111 PET imaging shows favorable technical and biological characteristics for developing a potential predictive imaging biomarker for LAG-3-directed therapies.TRIAL REGISTRATION: ClinicalTrials.gov , NCT03780725. Registered 19 December 2018.PMID:36859619 | DOI:10.1007/s00259-023-06164-w (Source: Molecular Medicine)
Source: Molecular Medicine - March 1, 2023 Category: Molecular Biology Authors: Iris H C Miedema Marc C Huisman Gerben J C Zwezerijnen Rolf Grempler Alejandro Perez Pitarch Andrea Thiele Raphael Hesse Mabrouk Elgadi Alexander Peltzer Danielle J Vugts Guus A M S van Dongen Tanja D de Gruijl C Willemien Menke-van der Houven van Oordt I Source Type: research
Direct co-registration of [ < sup > 18 < /sup > F]FDG uptake and histopathology in surgically excised malignancies of the head and neck: a feasibility study
CONCLUSION: We here describe a novel methodology enabling the direct co-registration of [18F]FDG autoradiography with the gold standard of histopathology in human malignant tissue. The future use of the current methodology could further increase our understanding of the distribution of radionuclides in surgically excised malignancies and hence, improve the integration of pathology and molecular imaging in a multiscale perspective.TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT05068687.PMID:36854863 | DOI:10.1007/s00259-023-06153-z (Source: Molecular Medicine)
Source: Molecular Medicine - March 1, 2023 Category: Molecular Biology Authors: Jens M Debacker Luna Maris Fleur Cordier David Creytens Philippe Deron Benedicte Descamps Yves D'Asseler Kathia De Man Vincent Keereman Sasha Libbrecht Vanessa Schelfhout Koen Van de Vijver Christian Vanhove Wouter Huvenne Source Type: research
Preclinical evaluation of a brain penetrant PARP PET imaging probe in rat glioblastoma and nonhuman primates
CONCLUSION: [11C]PyBic is the first brain-penetrant PARP PET tracer validated in a rat glioblastoma model and healthy nonhuman primates. The brain kinetics of [11C]PyBic are suitable for noninvasive quantification of available PARP binding in the brain, which posits [11C]PyBic to have broad applications in oncology and neuroimaging.PMID:36849748 | DOI:10.1007/s00259-023-06162-y (Source: Molecular Medicine)
Source: Molecular Medicine - February 28, 2023 Category: Molecular Biology Authors: Baosheng Chen Devi Prasan Ojha Takuya Toyonaga Jie Tong Richard Pracitto Monique A Thomas Michael Liu Michael Kapinos Li Zhang Ming-Qiang Zheng Daniel Holden Krista Fowles Jim Ropchan Nabeel Nabulsi Henk De Feyter Richard E Carson Yiyun Huang Zhengxin Cai Source Type: research
[ < sup > 18 < /sup > F]mFBG long axial field of view PET-CT without general anaesthesia reveals concise extension of neuroblastoma in a 9-month-old boy
Eur J Nucl Med Mol Imaging. 2023 Feb 28. doi: 10.1007/s00259-023-06160-0. Online ahead of print.NO ABSTRACTPMID:36849749 | DOI:10.1007/s00259-023-06160-0 (Source: Molecular Medicine)
Source: Molecular Medicine - February 28, 2023 Category: Molecular Biology Authors: L Borgwardt J S Brok K F Andersen J Madsen N Gillings M Ø Fosbøl C L Denholt P S Wehner L H Enevoldsen P Oturai D Czyzewska H H Johannesen L H øjgaard I N Petersen L S S ørensen C Schulze E S Saxtoft F L Andersen B M Fischer Source Type: research
Utility of whole-exome sequencing for patients with multiple congenital anomalies with or without intellectual disability/developmental delay in East Asia population
CONCLUSIONS: The careful selection of patients by experienced geneticists and the exclusion of chromosomal aberrations raises the positive rate of the molecular diagnosis for CAs to 40%. However, more than half of the patients with CAs still do not have a genetic diagnosis by current technologies.PMID:36849876 | DOI:10.1002/mgg3.2160 (Source: Molecular Medicine)
Source: Molecular Medicine - February 28, 2023 Category: Molecular Biology Authors: Rai-Hseng Hsu Chen-Hao Lee Yin-Hsiu Chien Shuan-Pei Lin Miao-Zi Hung Nai-Chi Chen Yi-Lin Lin Wuh-Liang Hwu Ni-Chung Lee Source Type: research
Oxidative stress and epigenetics in ocular vascular aging: an updated review
Mol Med. 2023 Feb 27;29(1):28. doi: 10.1186/s10020-023-00624-7.ABSTRACTVascular aging is an inevitable process with advancing age, which plays a crucial role in the pathogenesis of cardiovascular and microvascular diseases. Diabetic retinopathy (DR) and age-related macular degeneration (AMD), characterized by microvascular dysfunction, are the common causes of irreversible blindness worldwide, however there is still a lack of effective therapeutic strategies for rescuing the visual function. In order to develop novel treatments, it is essential to illuminate the pathological mechanisms underlying the vascular aging during ...
Source: Molecular Medicine - February 28, 2023 Category: Molecular Biology Authors: Bowen Zhao Lijia Zhu Meng Ye Xiaotong Lou Qianxue Mou Yuanyuan Hu Hong Zhang Yin Zhao Source Type: research
Can endocan serve as a molecular "hepatostat" in liver regeneration?
CONCLUSIONS: We revealed possible mechanistic insights into liver regeneration by examining the associations of Pcna, Vegf, endocan, endostatin, eEF2K with hepatic regeneration after partial hepatectomy. Indeed, endocan might serve as a useful biomarker to monitor clinical prognosis in a plethora of conditions such as recovery of donor's remaining liver after living-donor liver transplant. Whether endocan might represent a strategy to optimize liver regeneration when given therapeutically needs to be investigated in future studies.PMID:36849916 | DOI:10.1186/s10020-023-00622-9 (Source: Molecular Medicine)
Source: Molecular Medicine - February 28, 2023 Category: Molecular Biology Authors: Sinan Efe Yazici Mustafa Emre Gedik Can Berk Leblebici Kemal Kosemehmetoglu Gurcan Gunaydin Ahmet Bulent Dogrul Source Type: research
