Glucagon-like peptide-1 receptor agonist exendin 4 ameliorates diabetes-associated vascular calcification by regulating mitophagy through the AMPK signaling pathway

CONCLUSION: EX4 could promote mitophagy by activating the AMPK signaling pathway, attenuate insufficient mitophagy, and thus inhibit the osteogenic phenotype switching of VSMCs.PMID:38720283 | PMC:PMC11080124 | DOI:10.1186/s10020-024-00817-8

Source: Molecular Medicine - May 9, 2024 Category: Molecular Biology Authors: Kui Chen Hao-Jie Jin Zi-Heng Wu Bao-Fu Zhang Jun Wu Zi-Yi Huang Ying-Peng Huang Xin-Wu Lu Xiang-Tao Zheng Source Type: research