Genetic Polymorphisms of Endothelial Nitric Oxide Synthase Associated with Hypertension and Blood Homocysteine Levels
CONCLUSION: eNOS variants rs1799983 and rs2070744 may be risk factors for hypertension linked to hyperhomocysteinemia. These findings provide potentially useful healthcare strategies for the management of hypertension.PMID:38660143 | PMC:PMC11041984 | DOI:10.2147/IJGM.S456519 (Source: Molecular Medicine)
Source: Molecular Medicine - April 25, 2024 Category: Molecular Biology Authors: Charinya Chaichanabut Piyamitr Sritara Jintana Sirivarasai Source Type: research
Copper enhances aggregational toxicity of mutant huntingtin in a Drosophila model of Huntington's Disease
Biochim Biophys Acta Mol Basis Dis. 2024 Jan;1870(1):166928. doi: 10.1016/j.bbadis.2023.166928. Epub 2023 Oct 28.ABSTRACTHuntington's disease (HD) is a progressive neurodegenerative disorder with clinical presentations of moderate to severe cognitive, motor, and psychiatric disturbances. HD is caused by the trinucleotide repeat expansion of CAG of the huntingtin (HTT) gene. The mutant HTT protein containing pathological polyglutamine (polyQ) extension is prone to misfolding and aggregation in the brain. It has previously been observed that copper and iron concentrations are increased in the striata of post-mortem human HD ...
Source: Molecular Medicine - April 25, 2024 Category: Molecular Biology Authors: Amanda G Lobato Natalie Ortiz-Vega Yi Zhu Deepa Neupane Katlyn K Meier R Grace Zhai Source Type: research
Cartilage stem/progenitor cells-derived exosomes facilitate knee cartilage repair in a subacute osteoarthritis rat model
In this study, we prepared exosomes (EXOs) from cartilage stem/progenitor cells (CSPCs) and found that treatment with EXOs increased the viability, migration, and proliferation of cultured primary chondrocytes. In a subacute OA rat model, the application of EXOs facilitated cartilage regeneration as evidenced by histological staining. Exosomal protein analysis together with bioinformatics suggested that cyclin-dependent kinase 9 (CDK9) is a key factor for chondrocyte growth and migration. Functional studies confirmed this prediction, that is, inhibiting CDK9 reduced the beneficial effects induced by EXOs in primary chondro...
Source: Molecular Medicine - April 25, 2024 Category: Molecular Biology Authors: Jing Chen Xiaohui Ni Jian Yang Hongwei Yang Xiaoyu Liu Minhao Chen Cheng Sun Youhua Wang Source Type: research
Detecting early-warning biomarkers associated with heart-exosome genetic-signature for acute myocardial infarction: A source-tracking study of exosome
J Cell Mol Med. 2024 Apr;28(8):e18334. doi: 10.1111/jcmm.18334.ABSTRACTThe genetic information of plasma total-exosomes originating from tissues have already proven useful to assess the severity of coronary artery diseases (CAD). However, plasma total-exosomes include multiple sub-populations secreted by various tissues. Only analysing the genetic information of plasma total-exosomes is perturbed by exosomes derived from other organs except the heart. We aim to detect early-warning biomarkers associated with heart-exosome genetic-signatures for acute myocardial infarction (AMI) by a source-tracking analysis of plasma exoso...
Source: Molecular Medicine - April 25, 2024 Category: Molecular Biology Authors: Xiaojun Jin Weifeng Xu Qiaoping Wu Chen Huang Yongfei Song Jiangfang Lian Source Type: research
Retraction: Silencing of Prrx1b suppresses cellular proliferation, migration, invasion and epithelial-mesenchymal transition in triple-negative breast cancer
J Cell Mol Med. 2024 Apr;28(8):e18312. doi: 10.1111/jcmm.18312.ABSTRACTZhi-Dong Lv, Zhao-Chuan Yang, Xiang-Ping Liu, Li-Ying Jin, Qian Dong, Hui-Li Qu, Fu-Nian Li, Bin Kong, Jiao Sun, Jiao-Jiao Zhao, Hai-Bo Wang, Silencing of Prrx1b suppresses cellular proliferation, migration, invasion and epithelial-mesenchymal transition in triple-negative breast cancer. Journal of Cellular and Molecular Medicine, 20: 1640-1650. https://doi.org/10.1111/jcmm.12856 The above article, published online on 29 March 2016 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the journal Editor-i...
Source: Molecular Medicine - April 25, 2024 Category: Molecular Biology Source Type: research
Anti-inflammatory and immunoregulatory effects of colistin sulphate on human PBMCs
J Cell Mol Med. 2024 Apr;28(8):e18322. doi: 10.1111/jcmm.18322.ABSTRACTIn previous studies, CST has been identified as having an immunostimulatory effect on Caenorhabditis elegans and macrophage of rats. Here, we further investigated its immunomodulatory effects on human peripheral blood mononuclear cells (PBMCs). LPS-stimulated PBMCs inflammatory model was established. Flow cytometry was applied to measure phagocytosis of PBMCs. Cytokine mRNA and protein expression levels of LPS-stimulated PBMCs with or without CST were measured by qRT-PCR and ELISA. The transcriptomic profile of CST-treated PBMCs was investigated by RNA-...
Source: Molecular Medicine - April 25, 2024 Category: Molecular Biology Authors: Huiling Chen Tianli Yang Yiran Xu Beibei Liang Xianyong Liu Yun Cai Source Type: research
KIAA0040 enhances glioma growth by controlling the JAK2/STAT3 signalling pathway
In this study, KIAA0040 expression levels were evaluated using qRT-PCR, WB and IHC, and functional assays were conducted to assess its impact on glioma progression, along with animal experiments. Moreover, WB was used to examine the impact of KIAA0040 on the JAK2/STAT3 signalling pathway. Our study found that KIAA0040 was increased in glioma and linked to tumour grade and poor clinical outcomes, serving as an independent prognostic factor. Functional assays showed that KIAA0040 enhances glioma growth, migration and invasion by activating the JAK2/STAT3 pathway. Of course, KIAA0040 enhances glioma growth by preventing tumou...
Source: Molecular Medicine - April 25, 2024 Category: Molecular Biology Authors: Jie He Kaming Xue Fei Fan Lin Li Xinyu Rao Wei Liu Chuansheng Nie Source Type: research
A register-based study describing time trends in risk factor control and serious hypoglycaemia together with the effects of starting continuous glucose monitoring in people with type 1 diabetes in Norway
CONCLUSIONS: Between 2012 and 2020, we found marked improvements in glycaemic control and a considerable decrease in the proportion of individuals reporting serious hypoglycaemia. The proportion of individuals using CGM increased substantially and individuals that had started using CGM by 2020 showed greater improvement in glycaemic control and less serious hypoglycaemia.PMID:38662602 | DOI:10.1111/dme.15335 (Source: Molecular Medicine)
Source: Molecular Medicine - April 25, 2024 Category: Molecular Biology Authors: Una Ørvim Sølvik John Graham Cooper Karianne Fjeld L øvaas Tony Ernes Tone Vonheim Madsen Sverre Sandberg Grethe Åstrøm Ueland Source Type: research
CHMP5 attenuates osteoarthritis via inhibiting chondrocyte apoptosis and extracellular matrix degradation: involvement of NF- κB pathway
CONCLUSIONS: This study demonstrated that CHMP5 repressed IL-1β-induced chondrocyte apoptosis and ECM degradation and blocked NF-κB activation. It was shown that CHMP5 might be a novel potential therapeutic target for OA in the future.PMID:38664616 | PMC:PMC11046779 | DOI:10.1186/s10020-024-00819-6 (Source: Molecular Medicine)
Source: Molecular Medicine - April 25, 2024 Category: Molecular Biology Authors: Weilu Gao Rui Liu Keke Huang Wenhan Fu Anquan Wang Gongwen Du Hao Tang Li Yin Zongsheng S Yin Source Type: research
Anlotinib Inhibiting Mantle Cell Lymphoma Proliferation and Inducing Apoptosis through PI3K/AKT/mTOR Pathway
CONCLUSION: Anlotinib effectively inhibits proliferation and induces apoptosis in MCL both in vitro and in vivo. This inhibition is likely linked to suppressing phosphorylation in the PI3K/Akt/mTOR pathway.PMID:38659267 | DOI:10.2174/0115665240284638240408081133 (Source: Molecular Medicine)
Source: Molecular Medicine - April 25, 2024 Category: Molecular Biology Authors: Jiaping Wang Zhijuan Xu Yanli Lai Yanli Zhang Ping Zhang Qitian Mu Shujun Yang Lixia Sheng Guifang Ouyang Source Type: research
Roles of TRP and PIEZO receptors in autoimmune diseases
Expert Rev Mol Med. 2024 Apr 25;26:e10. doi: 10.1017/erm.2023.23.ABSTRACTAutoimmune diseases are pathological autoimmune reactions in the body caused by various factors, which can lead to tissue damage and organ dysfunction. They can be divided into organ-specific and systemic autoimmune diseases. These diseases usually involve various body systems, including the blood, muscles, bones, joints and soft tissues. The transient receptor potential (TRP) and PIEZO receptors, which resulted in David Julius and Ardem Patapoutian winning the Nobel Prize in Physiology or Medicine in 2021, attracted people's attention. Most current s...
Source: Molecular Medicine - April 25, 2024 Category: Molecular Biology Authors: Baoqi Yang Dan Ma Xueqing Zhu Zewen Wu Qi An Jingwen Zhao Xinnan Gao Liyun Zhang Source Type: research
Genetic Polymorphisms of Endothelial Nitric Oxide Synthase Associated with Hypertension and Blood Homocysteine Levels
CONCLUSION: eNOS variants rs1799983 and rs2070744 may be risk factors for hypertension linked to hyperhomocysteinemia. These findings provide potentially useful healthcare strategies for the management of hypertension.PMID:38660143 | PMC:PMC11041984 | DOI:10.2147/IJGM.S456519 (Source: Molecular Medicine)
Source: Molecular Medicine - April 25, 2024 Category: Molecular Biology Authors: Charinya Chaichanabut Piyamitr Sritara Jintana Sirivarasai Source Type: research
Copper enhances aggregational toxicity of mutant huntingtin in a Drosophila model of Huntington's Disease
Biochim Biophys Acta Mol Basis Dis. 2024 Jan;1870(1):166928. doi: 10.1016/j.bbadis.2023.166928. Epub 2023 Oct 28.ABSTRACTHuntington's disease (HD) is a progressive neurodegenerative disorder with clinical presentations of moderate to severe cognitive, motor, and psychiatric disturbances. HD is caused by the trinucleotide repeat expansion of CAG of the huntingtin (HTT) gene. The mutant HTT protein containing pathological polyglutamine (polyQ) extension is prone to misfolding and aggregation in the brain. It has previously been observed that copper and iron concentrations are increased in the striata of post-mortem human HD ...
Source: Molecular Medicine - April 25, 2024 Category: Molecular Biology Authors: Amanda G Lobato Natalie Ortiz-Vega Yi Zhu Deepa Neupane Katlyn K Meier R Grace Zhai Source Type: research
Cartilage stem/progenitor cells-derived exosomes facilitate knee cartilage repair in a subacute osteoarthritis rat model
In this study, we prepared exosomes (EXOs) from cartilage stem/progenitor cells (CSPCs) and found that treatment with EXOs increased the viability, migration, and proliferation of cultured primary chondrocytes. In a subacute OA rat model, the application of EXOs facilitated cartilage regeneration as evidenced by histological staining. Exosomal protein analysis together with bioinformatics suggested that cyclin-dependent kinase 9 (CDK9) is a key factor for chondrocyte growth and migration. Functional studies confirmed this prediction, that is, inhibiting CDK9 reduced the beneficial effects induced by EXOs in primary chondro...
Source: Molecular Medicine - April 25, 2024 Category: Molecular Biology Authors: Jing Chen Xiaohui Ni Jian Yang Hongwei Yang Xiaoyu Liu Minhao Chen Cheng Sun Youhua Wang Source Type: research
Detecting early-warning biomarkers associated with heart-exosome genetic-signature for acute myocardial infarction: A source-tracking study of exosome
J Cell Mol Med. 2024 Apr;28(8):e18334. doi: 10.1111/jcmm.18334.ABSTRACTThe genetic information of plasma total-exosomes originating from tissues have already proven useful to assess the severity of coronary artery diseases (CAD). However, plasma total-exosomes include multiple sub-populations secreted by various tissues. Only analysing the genetic information of plasma total-exosomes is perturbed by exosomes derived from other organs except the heart. We aim to detect early-warning biomarkers associated with heart-exosome genetic-signatures for acute myocardial infarction (AMI) by a source-tracking analysis of plasma exoso...
Source: Molecular Medicine - April 25, 2024 Category: Molecular Biology Authors: Xiaojun Jin Weifeng Xu Qiaoping Wu Chen Huang Yongfei Song Jiangfang Lian Source Type: research
