Discovery of Novel Natural Inhibitors Against SARS-CoV-2 Main Protease: A Rational Approach to Antiviral Therapeutics
CONCLUSION: These findings highlight the effectiveness of combining computational and experimental approaches to identify potential lead compounds for SARS-CoV-2, with C1-C5 emerging as promising candidates for further drug development against this virus.PMID:38591207 | DOI:10.2174/0109298673292839240329081008 (Source: Molecular Medicine)
Source: Molecular Medicine - April 9, 2024 Category: Molecular Biology Authors: Muhammad Waqas Saeed Ullah Sobia Ahsan Halim Inam Ullah None Najeeb Ur Rehman Afnan Jan Asaad Khalid Amjad Ali Ajmal Khan Ahmed Al-Harrasi Source Type: research
Understanding the Roles of Non-coding RNAs and Exosomal Non-Coding RNAs in Diabetic Nephropathy
Curr Mol Med. 2024 Apr 5. doi: 10.2174/0115665240287631240321072504. Online ahead of print.ABSTRACTOne of the greatest serious side effects of diabetes is diabetic nephropathy (DN), which is also the key factor in the sometimes-deadly diabetic end-stage renal disease. Progressive renal interstitial fibrosis is closely associated with oxidative stress, and the extracellular matrix is typically a feature of DN. Some RNAs formed by genome transcription that are not translated into proteins are recognized as noncoding RNAs. It has been shown that ncRNAs control apoptosis, inflammatory response, cell proliferation, autophagy, a...
Source: Molecular Medicine - April 9, 2024 Category: Molecular Biology Authors: Yuye Zhu Chunying Liu Jamal Hallajzadeh Source Type: research
Capsiate ameliorates secondary hyperparathyroidism by improving insulin sensitivity and inhibiting angiogenesis
This study aims to evaluate the effects and mechanisms of capsiates in the treatment of secondary hyperparathyroidism. To achieve our research objectives, we conducted a study on patients' serum and examined changes in metabolic markers using serum metabolomics. We induced secondary hyperparathyroidism in rat through dietary intervention and divided them into four groups. The first group, referred to as the Parathyroid Hormone (PTH) group, received a low-calcium and high-phosphate diet (0.2% calcium, 1.2% phosphorus). The second group served as the control group, receiving a standard phosphate and calcium diet (0.6% calciu...
Source: Molecular Medicine - April 9, 2024 Category: Molecular Biology Authors: Peiting Li Jianda Zhou Tianyin Wang Jun Li Wei Wu Source Type: research
Vitamin D-A New Therapeutic Target in the Management of Type 2 Diabetes Patients
Conclusions: Vitamin D influences almost every system and organ in the body, so it should be a routine test for all patients with DM to correct the deficiency and prevent other diseases and complications.PMID:38592202 | DOI:10.3390/jcm13051390 (Source: Molecular Medicine)
Source: Molecular Medicine - April 9, 2024 Category: Molecular Biology Authors: Oana Albai Adina Braha Bogdan Timar Ioana Golu Romulus Timar Source Type: research
Obesity and male fertility disorders
Mol Aspects Med. 2024 Apr 8;97:101273. doi: 10.1016/j.mam.2024.101273. Online ahead of print.ABSTRACTOften associated with obesity, male infertility represents a widespread condition that challenges the wellbeing of the couple. In this article, we provide a comprehensive and critical analysis of studies exploring the association between obesity and male reproductive function, to evaluate the frequency of this association, and establish the effects of increased body weight on conventional and biofunctional sperm parameters and infertility. In an attempt to find possible molecular markers of infertility in obese male patient...
Source: Molecular Medicine - April 9, 2024 Category: Molecular Biology Authors: Rossella Cannarella Andrea Crafa Roberto Curto Rosita A Condorelli Sandro La Vignera Aldo E Calogero Source Type: research
Targeting connexins: possible game changer in managing neuropathic pain?
Trends Mol Med. 2024 Apr 8:S1471-4914(24)00064-9. doi: 10.1016/j.molmed.2024.03.009. Online ahead of print.ABSTRACTNeuropathic pain is a chronic debilitating condition caused by nerve injury or a variety of diseases. At the core of neuropathic pain lies the aberrant neuronal excitability in the peripheral and/or central nervous system (PNS and CNS). Enhanced connexin expression and abnormal activation of connexin-assembled gap junctional channels are prominent in neuropathic pain along with reactive gliosis, contributing to neuronal hypersensitivity and hyperexcitability. In this review, we delve into the current understan...
Source: Molecular Medicine - April 9, 2024 Category: Molecular Biology Authors: Yixun Su Alexei Verkhratsky Chenju Yi Source Type: research
SOX17: escape route from immune destruction in early CRC
Trends Mol Med. 2024 Apr 9:S1471-4914(24)00089-3. doi: 10.1016/j.molmed.2024.04.001. Online ahead of print.ABSTRACTIn a recent report in Nature, Goto et al. reveal a novel immune-evasion mechanism adopted by early colorectal cancer (CRC) cells that is based on the transcription factor sex determining region Y (SRY)-box transcription factor 17 (SOX17). Leveraging colorectal adenoma and cancer models to perform comprehensive transcriptomic/chromatin analyses, this work shows that SOX17 generates immune-silent leucine-rich repeat-containing G protein-coupled receptor 5- (LGR5-) tumor cells, which suppress interferon gamma (IF...
Source: Molecular Medicine - April 9, 2024 Category: Molecular Biology Authors: Kostas A Papavassiliou Christos Adamopoulos Athanasios G Papavassiliou Source Type: research
Caring to care: Nurturing ICU healthcare professionals' wellbeing for enhanced patient safety
This article aims to address the concept of wellbeing by describing how the stressful ICU work-environment threatens the wellbeing of health professionals and discussing how this situation jeopardizes patient safety. To promote wellbeing, it is imperative to explore actionable interventions such as improve communication skills, educational sessions on stress management, or mindfulness. Promoting ICU healthcare professionals' wellbeing through evidence-based strategies will not only increase their personal resilience but might contribute to a safer and more efficient patient care.PMID:38594110 | DOI:10.1016/j.medine.2024.03...
Source: Molecular Medicine - April 9, 2024 Category: Molecular Biology Authors: Emilio Rodriguez-Ruiz Martina Maria Cornelia van Mol Joseph Maria Latour Kristina Fuest Source Type: research
Single-cell characterisation of tissue homing CD4 + and CD8 + T cell clones in immune-mediated refractory arthritis
CONCLUSIONS: Our findings suggest that the local environment in the synovium drives the proliferation of activated cytotoxic T cells, and both CD4 + and CD8 + T cells may contribute to tissue destruction and disease pathogenesis.PMID:38594612 | DOI:10.1186/s10020-024-00802-1 (Source: Molecular Medicine)
Source: Molecular Medicine - April 9, 2024 Category: Molecular Biology Authors: Dipabarna Bhattacharya Jason Theodoropoulos Katariina Nurmi Timo Juutilainen Kari K Eklund Riitta Koivuniemi Tiina Kelkka Satu Mustjoki Tapio L önnberg Source Type: research
Assessment of the FRET-based Teen sensor to monitor ERK activation changes preceding morphological defects in a RASopathy zebrafish model and phenotypic rescue by MEK inhibitor
CONCLUSION: This work proves the usefulness of FRET imaging protocols on both live and fixed Teen ERK reporter fish to readily monitor and quantify pharmacologically- and genetically-induced ERK activity modulations in early embryos, representing a useful tool in pre-clinical applications targeting RAS-MAPK signaling.PMID:38594640 | DOI:10.1186/s10020-024-00807-w (Source: Molecular Medicine)
Source: Molecular Medicine - April 9, 2024 Category: Molecular Biology Authors: Giulia Fasano Stefania Petrini Valeria Bonavolont à Graziamaria Paradisi Catia Pedalino Marco Tartaglia Antonella Lauri Source Type: research
A Computational Study of Green Tea Extracts and their Derivatives as Potential Inhibitors for Squalene Monooxygenase
CONCLUSION: The results obtained from this study suggest that green tea polyphenols have the potential for inhibition of squalene monooxygenase, except for theasinensin A.PMID:38584555 | DOI:10.2174/0115734064280290240211170037 (Source: Molecular Medicine)
Source: Molecular Medicine - April 8, 2024 Category: Molecular Biology Authors: Kabelo Phuti Mokgopa Kevin A Lobb Tendamudzimu Tshiwawa Source Type: research
Pediatric nuclear medicine: continuing the evolution
Q J Nucl Med Mol Imaging. 2024 Mar;68(1):1-2. doi: 10.23736/S1824-4785.24.03562-3.NO ABSTRACTPMID:38587359 | DOI:10.23736/S1824-4785.24.03562-3 (Source: Molecular Medicine)
Source: Molecular Medicine - April 8, 2024 Category: Molecular Biology Authors: Pinar Ozgen Kiratli Pietro Zucchetta Source Type: research
Gastrointestinal radionuclide imaging in pediatric age group
Q J Nucl Med Mol Imaging. 2024 Mar;68(1):23-31. doi: 10.23736/S1824-4785.24.03548-9.ABSTRACTPediatric gastrointestinal imaging plays a crucial role in evaluating and managing digestive system disorders in children. This comprehensive review dives into the nuances of pediatric gastrointestinal imaging techniques, focusing on three specific modalities: gastric emptying scintigraphy (GES), intestinal transit scintigraphy (ITS), and gastrointestinal bleeding scintigraphy. GES involves real-time monitoring of stomach emptying using radiotracers and gamma camera technology. While challenges exist in standardizing protocols due t...
Source: Molecular Medicine - April 8, 2024 Category: Molecular Biology Authors: Maria C Garganese Milena Pizzoferro Source Type: research
Update on FDG-PET in pediatric lymphoma
Q J Nucl Med Mol Imaging. 2024 Mar;68(1):58-69. doi: 10.23736/S1824-4785.24.03560-X.ABSTRACTLymphoma represent the third most common malignant disease in childhood and adolescence. They are divided into pediatric Hodgkin lymphoma (P-HL) and pediatric non-Hodgkin lymphoma (P-NHL). In P-HL, excellent cure rates are achieved through combined modality treatment using chemotherapy and radiotherapy. For more than 20 years, FDG-PET has been an integral part of the treatment and guides its intensity through improved staging and precise assessment of chemotherapy response. In P-NHL, good cure rates are achieved with chemotherapy al...
Source: Molecular Medicine - April 8, 2024 Category: Molecular Biology Authors: Lars Kurch Regine Kluge Source Type: research
Clinicopathological and molecular predictors of [ < sup > 18 < /sup > F]FDG-PET disease detection in HER2-positive early breast cancer: RESPONSE, a substudy of the randomized PHERGain trial
CONCLUSIONS: These results highlight the clinical, biological, and metabolic heterogeneity of HER2+ breast cancer, which may facilitate the selection of HER2+ EBC patients likely to benefit from [18F]FDG-PET imaging as a tool to guide therapy.TRIAL REGISTRATION: Clinicaltrials.gov; NCT03161353; registration date: May 15, 2017.PMID:38587643 | DOI:10.1007/s00259-024-06683-0 (Source: Molecular Medicine)
Source: Molecular Medicine - April 8, 2024 Category: Molecular Biology Authors: Antonio Llombart-Cussac Aleix Prat Jos é Manuel Pérez-García Jos é Mateos Tom ás Pascual Santiago Escriv à-de-Romani Agostina Stradella Manuel Ruiz-Borrego Bego ña Bermejo de Las Heras Marleen Keyaerts Patricia Galvan Fara Bras ó-Maristany Juan Jo Source Type: research
