Molecular Medicine This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

MicroRNAs in Cancer Metastasis: Biological and Therapeutic Implications
Expert Rev Mol Med. 2023 Mar 17:1-32. doi: 10.1017/erm.2023.7. Online ahead of print.NO ABSTRACTPMID:36927814 | DOI:10.1017/erm.2023.7 (Source: Molecular Medicine)
Source: Molecular Medicine - March 17, 2023 Category: Molecular Biology Authors: Marie Sell Charmaine A Ramlogan-Steel Jason C Steel Bijay P Dhungel Source Type: research

Smooth muscle cells, interstitial cells and neurons in the gallbladder (GB): Functional syncytium of electrical rhythmicity and GB motility (Review)
Int J Mol Med. 2023 Apr;51(4):33. doi: 10.3892/ijmm.2023.5236. Epub 2023 Mar 17.ABSTRACTThe motility of the gallbladder (GB) involves the storage, concentration and delivery of bile. GB motor functions are controlled by multiple complex factors, such as extrinsic and intrinsic innervation, humoral factors and neuropeptides. GB emptying results from coordinated contractions of the muscular layers of the GB wall. Depolarization of GB smooth muscle (GBSM) depends on the activation of the regular depolarization‑repolarization potential, referred to as slow waves (SWs). These rhythmic SWs of GBSM contraction are mediated by s...
Source: Molecular Medicine - March 17, 2023 Category: Molecular Biology Authors: Fan Ding Qili Hu Yixing Wang Min Jiang Zhengyu Cui Run Guo Liping Liu Fang Chen Hai Hu Gang Zhao Source Type: research

Free fatty acids induce coronary microvascular dysfunction via inhibition of the AMPK/KLF2/eNOS signaling pathway
Int J Mol Med. 2023 Apr;51(4):34. doi: 10.3892/ijmm.2023.5237. Epub 2023 Mar 17.ABSTRACTIncreased levels of serum free fatty acids (FFAs) are closely associated with microvascular dysfunction. In our previous study, a coronary microvascular dysfunction (CMD) model was successfully established via lipid infusion to increase the levels of serum FFAs in mice. However, the underlying mechanisms remained poorly understood. Therefore, the aim of the present study was to explore the mechanism underlying FFA‑induced CMD. A CMD mouse model was established via lipid combined with heparin infusion for 6 h to increase the concentrat...
Source: Molecular Medicine - March 17, 2023 Category: Molecular Biology Authors: Yanda Zhang Jian Zhao Changzhen Ren Bowen Hu Ru Ding Zhiqing He Chun Liang Source Type: research

[Retracted] Bmi ‑1‑targeting suppresses osteosarcoma aggressiveness through the NF‑κB signaling pathway
Mol Med Rep. 2023 Apr;27(4):91. doi: 10.3892/mmr.2023.12978. Epub 2023 Mar 17.ABSTRACTFollowing the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the immunohistochemical data shown in Fig. 1C and F, the cell invasion assay data shown in Fig. 2C and D, and all the data shown in Fig. 4D‑F were strikingly similar to data appearing in different form in other articles by different authors at different research institutes; moreover, some of the scratch‑wound data shown in Fig. 2B appeared to have been duplicated, such that the same data were shown to represent experiments that w...
Source: Molecular Medicine - March 17, 2023 Category: Molecular Biology Authors: Jiaguo Liu Bin Luo Meng Zhao Source Type: research

Development of PSMA-PET-guided CT-based radiomic signature to predict biochemical recurrence after salvage radiotherapy
CONCLUSION: This is the first study to develop a PSMA-PET-guided CT-based radiomic model to predict BCR after sRT. The radiomic models outperformed clinical models and might contribute to guide personalized treatment decisions.PMID:36929180 | DOI:10.1007/s00259-023-06195-3 (Source: Molecular Medicine)
Source: Molecular Medicine - March 17, 2023 Category: Molecular Biology Authors: Simon K B Spohn Nina-Sophie Schmidt-Hegemann Juri Ruf Michael Mix Matthias Benndorf Fabian Bamberg Marcus R Makowski Simon Kirste Alexander R ühle Jerome Nouvel Tanja Sprave Marco M E Vogel Polina Galitsnaya J ürgen E Gschwend Christian Gratzke Christia Source Type: research

Radionuclide-based theranostics - a promising strategy for lung cancer
CONCLUSIONS: Radionuclide-based theranostics show great potential in tailored medical care. We expect that this review can provide an understanding of the latest advances in radionuclide therapy for lung cancer and promote the application of radioligand theranostics in personalized medicine.PMID:36929181 | DOI:10.1007/s00259-023-06174-8 (Source: Molecular Medicine)
Source: Molecular Medicine - March 17, 2023 Category: Molecular Biology Authors: Tianxing Zhu Jessica C Hsu Jingpei Guo Weiyu Chen Weibo Cai Kai Wang Source Type: research

Comparison of two hybrid sentinel node tracers: indocyanine green (ICG)- 99m Tc-nanocolloid vs. ICG- 99m Tc-nanoscan from a nuclear medicine and surgical perspective
CONCLUSIONS: Based on this retrospective analysis, we can conclude that ICG-99mTc-nanoscan has similar capacity for SN identification as ICG-99mTc-nanocolloid and can safely be implemented in SN procedures.PMID:36929210 | DOI:10.1007/s00259-023-06157-9 (Source: Molecular Medicine)
Source: Molecular Medicine - March 17, 2023 Category: Molecular Biology Authors: Manon T A Vreeburg Samaneh Azargoshasb Danny van Willigen Tom Molenaar Matthias N van Oosterom Tessa Buckle Leon J Slof Martin Klop Baris Karakullukcu Maarten Donswijk Henk G van der Poel Fijs W B van Leeuwen Oscar R Brouwer Daphne D D Rietbergen Source Type: research

Characterization of neuroinflammation pattern in anti-LGI1 encephalitis based on TSPO PET and symptom clustering analysis
CONCLUSIONS: Anti-LGI1 encephalitis had a distinctive molecular imaging pattern presented by TSPO PET scan. LGI1-AIE patients with higher retention of [18F]DPA-714 in the frontal cortex were more prone to present with GTC seizures. Further studies are required for verifying its value in clinical application.PMID:36929211 | DOI:10.1007/s00259-023-06190-8 (Source: Molecular Medicine)
Source: Molecular Medicine - March 17, 2023 Category: Molecular Biology Authors: Jingguo Wang Jingjie Ge Lei Jin Bo Deng Weijun Tang Hai Yu Xiang Zhang Xiaoni Liu Le Xue Chuantao Zuo Xiangjun Chen Source Type: research

Correction to: Clinical prospective study of Gallium 68 (68Ga)-labeled fibroblast ‑activation protein inhibitor PET/CT in the diagnosis of biliary tract carcinoma
Eur J Nucl Med Mol Imaging. 2023 Mar 17. doi: 10.1007/s00259-023-06188-2. Online ahead of print.NO ABSTRACTPMID:36929212 | DOI:10.1007/s00259-023-06188-2 (Source: Molecular Medicine)
Source: Molecular Medicine - March 17, 2023 Category: Molecular Biology Authors: Li Jinghua Xu Kui Guo Deliang Liao Bo Zhu Qian Wang Haitao Jiang Yaqun Wu Dongde Xia Xigang Jiang Ping Tang Shengli Yang Zhiyong He Yueming Zhang Zhonglin He Yong Yuan Yufeng Source Type: research

Leveraging homologous recombination repair deficiency in sarcoma
EMBO Mol Med. 2023 Mar 17:e17453. doi: 10.15252/emmm.202317453. Online ahead of print.ABSTRACTPersonalised oncology is at the forefront of cancer research. The goal of personalised oncology is to selectively kill cancer cells while minimising side effects on normal tissue. This can be achieved by identifying and targeting cancer vulnerabilities that distinguish it from normal cells. Many cancers are deficient in high-fidelity DNA repair pathways that maintain genomic stability, such as homologous recombination (HR). Such cancers are highly sensitive to targeted therapies that induce DNA damage or inhibit DNA repair pathway...
Source: Molecular Medicine - March 17, 2023 Category: Molecular Biology Authors: Dea Slade Joanna I Loizou Source Type: research

Neglected immunoregulation: M2 polarization of macrophages triggered by low-dose irradiation plays an important role in bone regeneration
J Cell Mol Med. 2023 Mar 16. doi: 10.1111/jcmm.17721. Online ahead of print.ABSTRACTCurrent studies have found that low-dose irradiation (IR) can promote bone regeneration. However, mechanism studies of IR-triggered bone regeneration mainly focus on the effects of osteoblasts, neglecting the role of the surrounding immune microenvironment. Here in this study, in vitro proliferation experiments showed that low-dose IR ≤2 Gy could promote the proliferation of bone marrow mesenchymal stem cells (BMSCs), and qRT-PCR assay showed that low-dose IR ≤2 Gy could exert the M2 polarization of Raw264.7 cells, while IR >2 Gy inh...
Source: Molecular Medicine - March 17, 2023 Category: Molecular Biology Authors: Shaoqing Chen Su Ni Chun Liu Mu He Yiwen Pan Pengfei Cui Cheng Wang Xinye Ni Source Type: research

Identification of medicinal plant-based phytochemicals as a potential inhibitor for SARS-CoV-2 main protease (M pro ) using molecular docking and deep learning methods
Comput Biol Med. 2023 Mar 11;157:106785. doi: 10.1016/j.compbiomed.2023.106785. Online ahead of print.ABSTRACTHighly transmissive and rapidly evolving Coronavirus disease-2019 (COVID-19), a viral disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), triggered a global pandemic, which is one of the most researched viruses in the academia. Effective drugs to treat people with COVID-19 have yet to be developed to reduce mortality and transmission. Studies on the SARS-CoV-2 virus identified that its main protease (Mpro) might be a potential therapeutic target for drug development, as this enzyme plays...
Source: Molecular Medicine - March 17, 2023 Category: Molecular Biology Authors: Alomgir Hossain Md Ekhtiar Rahman Md Siddiqur Rahman Khondokar Nasirujjaman Mohammad Nurul Matin Md Omar Faruqe Muhammad Fazle Rabbee Source Type: research

Single-cell transcriptome reveals Staphylococcus aureus modulating fibroblast differentiation in the bone-implant interface
CONCLUSIONS: In this study, we discovered the existence of CTHRC1+ fibroblast in the bone-implant interface. Moreover, we revealed a bipolar mode of fibroblast differentiation and put forward the hypothesis that infection could modulate fibroblast toward a pro-inflammatory phenotype through NPAS2 and TFEC.PMID:36927352 | DOI:10.1186/s10020-023-00632-7 (Source: Molecular Medicine)
Source: Molecular Medicine - March 17, 2023 Category: Molecular Biology Authors: Jinlong Yu Boyong Wang Feiyang Zhang Zun Ren Feng Jiang Musha Hamushan Mingzhang Li Geyong Guo Hao Shen Source Type: research