Deferoxamine topical cream superior to patch in rescuing radiation-induced fibrosis of unwounded and wounded skin
J Cell Mol Med. 2024 Apr;28(8):e18306. doi: 10.1111/jcmm.18306.ABSTRACTTopical patch delivery of deferoxamine (DFO) has been studied as a treatment for this fibrotic transformation in irradiated tissue. Efficacy of a novel cream formulation of DFO was studied as a RIF therapeutic in unwounded and excisionally wounded irradiated skin. C57BL/6J mice underwent 30 Gy of radiation to the dorsum followed by 4 weeks of recovery. In a first experiment, mice were separated into six conditions: DFO 50 mg cream (D50), DFO 100 mg cream (D100), soluble DFO injections (DI), DFO 1 mg patch (DP), control cream (Vehicle), and irradiated un...
Source: Molecular Medicine - April 13, 2024 Category: Molecular Biology Authors: Charlotte E Berry Darren B Abbas Michelle Griffin Hendrik Lintel Jason Guo Lionel Kameni Andrew A Churukian Alexander Z Fazilat Kellen Chen Geoffrey C Gurtner Michael T Longaker Arash Momeni Derrick C Wan Source Type: research
The plasma miRNome and venous thromboembolism in high-grade glioma: miRNA Sequencing of a nested case-control cohort
J Cell Mol Med. 2024 Apr;28(8):e18149. doi: 10.1111/jcmm.18149.ABSTRACTPatients with high-grade gliomas are at high risk of venous thromboembolism (VTE). MicroRNAs (miRNAs) are small non-coding RNAs with multiple roles in tumour biology, haemostasis and platelet function. Their association with VTE risk in high-grade glioma has not been comprehensively mapped so far. We thus conducted a nested case-control study within 152 patients with WHO grade IV glioma that had been part of a prospective cohort study on VTE risk factors. At inclusion a single blood draw was taken, and patients were thereafter followed for a maximum of ...
Source: Molecular Medicine - April 13, 2024 Category: Molecular Biology Authors: Friedrich Erhart Georg Widhalm Barbara Kiesel Matthias Hackl Andreas Diendorfer Matthias Preusser Karl R össler Johannes Thaler Ingrid Pabinger Cihan Ay Julia Riedl Source Type: research
Effect of Curcuma longa extract on reproduction function in mice and testosterone production in Leydig cells
This study aimed to investigate the efficacy of Curcuma longa extract (CLE) on Kidney-Yang deficiency mice induced by hydrocortisone and the possible roles in testosterone secretion in Leydig cells. We evaluated male sexual behaviour, reproductive organ weight, testosterone levels, and histological tissue changes in hydrocortisone-induced mice. CLE effectively reversed hydrocortisone-induced Kidney-Yang deficiency syndrome by improving sexual behaviour, testis and epididymis weight, testosterone levels and reducing pathological damage. Our in vitro study further indicated that CLE stimulated testosterone production via upr...
Source: Molecular Medicine - April 13, 2024 Category: Molecular Biology Authors: Yisheng Zhang Liu Yang Shan Xue Yichang Zhang Zihan Li Min Zhang Guoyin Kai Juan Li Source Type: research
Promising predictive molecular biomarkers for cervical cancer (Review)
Int J Mol Med. 2024 Jun;53(6):50. doi: 10.3892/ijmm.2024.5374. Epub 2024 Apr 12.ABSTRACTCervical cancer (CC) constitutes a serious public health problem. Vaccination and screening programs have notably reduced the incidence of CC worldwide by >80%; however, the mortality rate in low‑income countries remains high. The staging of CC is a determining factor in therapeutic strategies: The clinical management of early stages of CC includes surgery and/or radiotherapy, whereas radiotherapy and/or concurrent chemotherapy are the recommended therapeutic strategies for locally advanced CC. The histopathological characteristics...
Source: Molecular Medicine - April 12, 2024 Category: Molecular Biology Authors: Marcela Lizano Adela Carrillo-Garc ía Erick De La Cruz-Hern ández Leonardo Josu é Castro-Muñoz Adriana Contreras-Paredes Source Type: research
Advances in microRNA regulation of deep vein thrombosis through venous vascular endothelial cells (Review)
Mol Med Rep. 2024 Jun;29(6):96. doi: 10.3892/mmr.2024.13220. Epub 2024 Apr 12.ABSTRACTDeep vein thrombosis (DVT) is a prevalent clinical venous thrombotic condition that often manifests independently or in conjunction with other ailments. Thrombi have the propensity to dislodge into the circulatory system, giving rise to complications such as pulmonary embolism, thereby posing a significant risk to the patient. Virchow proposed that blood stagnation, alterations in the vessel wall and hypercoagulation are primary factors contributing to the development of venous thrombosis. Vascular endothelial cells (VECs) constitute the ...
Source: Molecular Medicine - April 12, 2024 Category: Molecular Biology Authors: Chucun Fang Feng Huang Mengting Yao Zilong Wang Jiacheng Ma Dongwen Wu Tianting Guo Fei Zhang Jianwen Mo Source Type: research
[Retracted] MicroRNA ‑202 inhibits endometrial stromal cell migration and invasion by suppressing the K‑Ras/Raf1/MEK/ERK signaling pathway
Int J Mol Med. 2024 Jun;53(6):51. doi: 10.3892/ijmm.2024.5375. Epub 2024 Apr 12.ABSTRACTFollowing the publication of this paper, it was drawn to the Editor's attention by a concerned reader that certain of the Transwell invasion assay data shown in Figs. 2C and 4B were strikingly similar to data appearing in different form in a paper by different authors at a different research institute that had already been submitted for publication. Owing to the fact that the contentious data in the above article had already been submitted for publication prior to its submission to International Journal of Molecular Medicine, the Editor...
Source: Molecular Medicine - April 12, 2024 Category: Molecular Biology Authors: Di Zhang Ling Wang Hua-Lei Guo Zi-Wei Zhang Chong Wang Ri-Cheng Chian Zhi-Fen Zhang Source Type: research
Protective effect of quercetin on lipopolysaccharide ‑induced miscarriage based on animal experiments and network pharmacology
Mol Med Rep. 2024 Jun;29(6):99. doi: 10.3892/mmr.2024.13223. Epub 2024 Apr 12.ABSTRACTSpontaneous abortion (SA) occurs in woman of child‑bearing age, jeopardizing their physical and mental health. Quercetin is a natural flavonoid, which exhibits a variety of pharmacological activities. However, the role and mechanisms of quercetin in SA still need to be further explored. Animal experiments were performed to examine the effect of quercetin in treating SA. Institute of Cancer Research mice were injected with lipopolysaccharide into the tail vein on the 7th day of gestation to establish a SA model. Gavage was performed duri...
Source: Molecular Medicine - April 12, 2024 Category: Molecular Biology Authors: Shuangyu Wu Ye Tian Qiying Zhang Zhujing Fu Huizhen Lan Xuanle Zhou Ling Ma Yiyun Lou Source Type: research
Chromatin looping links gene expression to the assembly of transcription factories (Review)
Mol Med Rep. 2024 Jun;29(6):97. doi: 10.3892/mmr.2024.13221. Epub 2024 Apr 12.ABSTRACTGenes are not randomly dispersed within the nuclear space, instead they occupy precise sites either with respect to the nuclear lamina as well as to each other. This observation stands at the basis of the today well accepted concept of nuclear territories where any chromosome shows reproducible spatial connections with a selection of others in a general picture that meets a functional criterion where genes that answer the same stimuli are grouped in the same sites. In fact, transcription is not visible widely dispersed throughout the nucl...
Source: Molecular Medicine - April 12, 2024 Category: Molecular Biology Authors: Bruno Perillo Antimo Migliaccio Gabriella Castoria Source Type: research
MicroRNA ‑mediated regulation of muscular atrophy: Exploring molecular pathways and therapeutics (Review)
In conclusion, the present review lays a foundation for the development of novel treatment options for individuals affected by muscular atrophy, and explores other regulatory pathways, such as autophagy and inflammatory signaling, to ensure a comprehensive overview of the multifarious nature of muscular atrophy. The objective of the present review was to elucidate the complex molecular pathways involved in muscular atrophy, and to facilitate the development of innovative and specific therapeutic strategies for the prevention or reversal of muscular atrophy in diverse clinical scenarios.PMID:38606516 | DOI:10.3892/mmr.2024....
Source: Molecular Medicine - April 12, 2024 Category: Molecular Biology Authors: Woohyeong Jung Uijin Juang Suhwan Gwon Hounggiang Nguyen Qingzhi Huang Soohyeon Lee Beomwoo Lee So-Hee Kwon Seon-Hwan Kim Jongsun Park Source Type: research
[Retracted] Propofol modulates the proliferation, invasion and migration of bladder cancer cells through the miR ‑145‑5p/TOP2A axis
Mol Med Rep. 2024 Jun;29(6):94. doi: 10.3892/mmr.2024.13218. Epub 2024 Apr 12.ABSTRACTFollowing the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the tumour images shown in Fig. 6B on p. 8 were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes, which had either already been published or were under consideration for publication at around the same time. Owing to the fact that the contentious data in the above article were already under consideration for publication prior to its submission to Mol...
Source: Molecular Medicine - April 12, 2024 Category: Molecular Biology Authors: Yi Du Xudong Zhang Hongwei Zhang Yiding Chen Shuying Zhu Jinjun Shu Hui Pan Source Type: research
Impact of diabetes mellitus on osteoarthritis: a scoping review on biomarkers
Expert Rev Mol Med. 2024 Apr 12;26:e8. doi: 10.1017/erm.2024.7.ABSTRACTOsteoarthritis (OA) commonly affects the knee and hip joints and accounts for 19.3% of disability-adjusted life years and years lived with disability worldwide (Refs , ). Early management is important in order to avoid disability uphold quality of life (Ref. ). However, a lack of awareness of subclinical and early symptomatic stages of OA often hampers early management (Ref. ). Moreover, late diagnosis of OA among those with severe disease, at a stage when OA management becomes more complicated is common (Refs , , , ). Established risk factors for the d...
Source: Molecular Medicine - April 12, 2024 Category: Molecular Biology Authors: Shi Rui Seow Sumaiyah Mat Amalina Ahmad Azam Nor Fadilah Rajab Intan Safinar Ismail Devinder Kaur Ajit Singh Suzana Shahar Maw Pin Tan Francis Berenbaum Source Type: research
YAP/TAZ-TEAD signalling axis: A new therapeutic target in malignant pleural mesothelioma
J Cell Mol Med. 2024 Apr;28(8):e18330. doi: 10.1111/jcmm.18330.ABSTRACTThe Hippo signalling pathway, a highly conserved signalling cassette, regulates organ size by controlling cell growth, apoptosis and stem cell self-renewal. The tumourigenic potential of this pathway is largely attributed to the activity of YAP/TAZ, which activate the TEAD1-4 transcription factors, leading to the expression of genes involved in cell proliferation and suppression of cell death. Aberrant regulation of the YAP/TAZ-TEAD signalling axis is commonly observed in malignant pleural mesothelioma (MPM), an insidious neoplasm of the pleural tissue ...
Source: Molecular Medicine - April 12, 2024 Category: Molecular Biology Authors: Kostas A Papavassiliou Amalia A Sofianidi Athanasios G Papavassiliou Source Type: research
Molecular and pathophysiological relationship between obesity and chronic inflammation in the manifestation of metabolic dysfunctions and their inflammation ‑mediating treatment options (Review)
Mol Med Rep. 2024 Jun;29(6):95. doi: 10.3892/mmr.2024.13219. Epub 2024 Apr 12.ABSTRACTObesity reaches up to epidemic proportions globally and increases the risk for a wide spectrum of co‑morbidities, including type‑2 diabetes mellitus (T2DM), hypertension, dyslipidemia, cardiovascular diseases, non‑alcoholic fatty liver disease, kidney diseases, respiratory disorders, sleep apnea, musculoskeletal disorders and osteoarthritis, subfertility, psychosocial problems and certain types of cancers. The underlying inflammatory mechanisms interconnecting obesity with metabolic dysfunction are not completely understood. Increas...
Source: Molecular Medicine - April 12, 2024 Category: Molecular Biology Authors: Fani-Niki Varra Michail Varras Viktoria-Konstantina Varra Panagiotis Theodosis-Nobelos Source Type: research
Intraoperative image-guidance during robotic surgery: is there clinical evidence of enhanced patient outcomes?
CONCLUSIONS: Robot-assisted surgery benefits from image guidance, especially in terms of pathologic outcomes, namely higher detection of metastatic nodes and lower surgical margins. Moreover, IGS enhances renal function preservation and lowers surgical blood loss.PMID:38607386 | DOI:10.1007/s00259-024-06706-w (Source: Molecular Medicine)
Source: Molecular Medicine - April 12, 2024 Category: Molecular Biology Authors: Stefano Tappero Giuseppe Fallara Francesco Chierigo Andrea Micalef Francesca Ambrosini Raquel Diaz Andrea Dorotei Edoardo Pompeo Alessia Limena Carlo Andrea Bravi Mattia Longoni Mattia Luca Piccinelli Francesco Barletta Luigi Albano Elio Mazzone Paolo Del Source Type: research
Central neurocytoma exhibits radial glial cell signatures with FGFR3 hypomethylation and overexpression
Exp Mol Med. 2024 Apr 12. doi: 10.1038/s12276-024-01204-3. Online ahead of print.ABSTRACTWe explored the genomic events underlying central neurocytoma (CN), a rare neoplasm of the central nervous system, via multiomics approaches, including whole-exome sequencing, bulk and single-nuclei RNA sequencing, and methylation sequencing. We identified FGFR3 hypomethylation leading to FGFR3 overexpression as a major event in the ontogeny of CN that affects crucial downstream events, such as aberrant PI3K-AKT activity and neuronal development pathways. Furthermore, we found similarities between CN and radial glial cells based on ana...
Source: Molecular Medicine - April 12, 2024 Category: Molecular Biology Authors: Yeajina Lee Tamrin Chowdhury Sojin Kim Hyeon Jong Yu Kyung-Min Kim Ho Kang Min-Sung Kim Jin Wook Kim Yong-Hwy Kim So Young Ji Kihwan Hwang Jung Ho Han Jinha Hwang Seong-Keun Yoo Kyu Sang Lee Gheeyoung Choe Jae-Kyung Won Sung-Hye Park Yong Kyu Lee Joo Heon Source Type: research
