Evidence on the inhibitory effect of Brassica plants against Acinetobacter baumannii lipases: phytochemical analysis, in vitro, and molecular docking studies
CONCLUSION: This study emphasizes the significance of Brassica vegetables as a novel natural source of potential inhibitors of lipase from A. baumannii.PMID:38641582 | PMC:PMC11027383 | DOI:10.1186/s12906-024-04460-y (Source: Molecular Medicine)
Source: Molecular Medicine - April 19, 2024 Category: Molecular Biology Authors: Manal M Sabry Ali M El-Halawany Walaa G Fahmy Basma M Eltanany Laura Pont Fernando Benavente Ahmed S Attia Farag F Sherbiny Rana M Ibrahim Source Type: research
Combined, yet separate: cocktails of carriers (not drugs) for actinium-225 α-particle therapy of solid tumors expressing moderate-to-low levels of targetable markers
CONCLUSION: Tumor-agnostic carrier-cocktails significantly enhance the therapeutic efficacy of existing alpha-particle radionuclide-antibody treatments.PMID:38641714 | DOI:10.1007/s00259-024-06710-0 (Source: Molecular Medicine)
Source: Molecular Medicine - April 19, 2024 Category: Molecular Biology Authors: Rajiv Ranjit Nair Aprameya Prasad Omkar Bhatavdekar Aira Sarkar Kathleen L Gabrielson Stavroula Sofou Source Type: research
Inflammatory breast cancer (IBC) advocacy-Past, present and future!
In conclusion, in defining the evolving roles of Patient Advocacy in IBC over the past 25 years, we examine what has been done, along with its challenges, and what work still remains from the perspectives of different patient advocates.PMID:38637097 | DOI:10.1016/bs.ircmb.2023.11.001 (Source: Molecular Medicine)
Source: Molecular Medicine - April 18, 2024 Category: Molecular Biology Authors: Jeannine Donahue Joshlyn Earls Valerie Fraser Ginny Mason Heather Pirowski Peggy Stephens Source Type: research
Science around the world
Trends Mol Med. 2024 Apr 17:S1471-4914(24)00066-2. doi: 10.1016/j.molmed.2024.03.011. Online ahead of print.NO ABSTRACTPMID:38637175 | DOI:10.1016/j.molmed.2024.03.011 (Source: Molecular Medicine)
Source: Molecular Medicine - April 18, 2024 Category: Molecular Biology Authors: Sarah J Annesley Serkan Kir Yang Liu Alankrita Rani Source Type: research
The role of [18 F]FDOPA PET as an adjunct to conventional MRI in the diagnosis of aggressive glial lesions
CONCLUSION: Dynamic [18 F]FDOPA PET provides a similar diagnostic accuracy as contrast enhancement in MRI to identify the aggressiveness of suspected glial lesions at diagnosis. Both methods, however, are complementary and [18 F]FDOPA PET may be a useful additional tool in equivocal cases.PMID:38637354 | DOI:10.1007/s00259-024-06720-y (Source: Molecular Medicine)
Source: Molecular Medicine - April 18, 2024 Category: Molecular Biology Authors: Adeline Zinsz Celso Pouget Fabien Rech Luc Taillandier Marie Blonski Samir Amlal Laetitia Imbert Timoth ée Zaragori Antoine Verger Source Type: research
Contribution of ChatGPT in Parkinson's Disease Detection
Nucl Med Mol Imaging. 2024 May;58(3):101-103. doi: 10.1007/s13139-024-00857-2. Epub 2024 Mar 15.NO ABSTRACTPMID:38633283 | PMC:PMC11018720 | DOI:10.1007/s13139-024-00857-2 (Source: Molecular Medicine)
Source: Molecular Medicine - April 18, 2024 Category: Molecular Biology Authors: Nikita Aggarwal Barjinder Singh Saini Savita Gupta Source Type: research
Association Between < sup > 18 < /sup > F-FDG PET Activity and HER2 Status in Breast Cancer Brain Metastases
CONCLUSION: The SUVmax ratio may help to identify the HER2 status of breast cancer brain metastases, if validated prospectively.PMID:38633284 | PMC:PMC11018722 | DOI:10.1007/s13139-024-00843-8 (Source: Molecular Medicine)
Source: Molecular Medicine - April 18, 2024 Category: Molecular Biology Authors: Jonathan R Young Julie A Ressler Joanne E Mortimer Daniel Schmolze Mariko Fitzgibbons Bihong T Chen Source Type: research
Annotating the Role of < sup > 18 < /sup > F-FDG PET/CT in Fibromatoses: A Benign Masquerader of Malignancies-Is It Really an Advantageous Tool?
Nucl Med Mol Imaging. 2024 May;58(3):140-146. doi: 10.1007/s13139-024-00846-5. Epub 2024 Feb 14.ABSTRACTFibromatoses are a heterogeneous group of benign proliferating fibroblasts and myofibroblasts which have a high predilection for recurrence and local invasion, especially deep fibromatoses or desmoid fibromatosis. 18F-FDG PET/CT, the workhorse of oncological imaging in nuclear medicine, can be employed to figure out the nature and aggressiveness of the lesions and various sites of involvement and to monitor treatment response to systemic therapies like tyrosine kinase inhibitors in case of deep or desmoid fibromatoses wh...
Source: Molecular Medicine - April 18, 2024 Category: Molecular Biology Authors: Srinivas Ananth Kumar Harmandeep Singh Lileswar Kaman Ritambhra Nada Bhagwant Rai Mittal Source Type: research
Discordant Molecular Imaging Findings with 2-[ < sup > 18 < /sup > F]FDG and [ < sup > 68 < /sup > Ga]Ga-PSMA PET/CT in a Patient with Both Bladder and Prostate Cancer
We present a case of double primary cancer involving the bladder and prostate, where the prostatic primary showed intense [68Ga]Ga-PSMA uptake with non-avid skeletal and pulmonary metastases, which showed intense 2-[18F]FDG uptake, thus showing discordance due to different clonal origins.PMID:38633286 | PMC:PMC11018560 | DOI:10.1007/s13139-024-00839-4 (Source: Molecular Medicine)
Source: Molecular Medicine - April 18, 2024 Category: Molecular Biology Authors: Aparna Mahalik Jasim Jaleel Sambit Sagar Dikhra Khan Shobhana Raju Rakesh Kumar Source Type: research
First Local Experience of Intra-Cavitary Yttrium-90 Citrate Colloid Irradiation via Ommaya Reservoir for Refractory Cystic Craniopharyngioma: a Case Report
Nucl Med Mol Imaging. 2024 May;58(3):129-139. doi: 10.1007/s13139-024-00838-5. Epub 2024 Jan 16.ABSTRACTCraniopharyngioma is uncommon benign intracranial tumour that can be cured by surgical resection followed by conventional radiotherapy. However, its anatomical localisation makes the treatment hazardous or impossible. This case report aims to discuss the first local experience of using beta-emitting Yttrium-90 radioisotope in treating a patient with refractory cystic craniopharyngioma. A 43-year-old male who has underlying refractory cystic craniopharyngioma complicated with visual impairment and panhypopituitarism was r...
Source: Molecular Medicine - April 18, 2024 Category: Molecular Biology Authors: Nadiah Abd Razak Pung Choon Ping Kamalia Kamarulzaman Siti Zarina Amir Hassan Source Type: research
Incidentally Detected Gallbladder Carcinoma: Can F-18 FDG PET/CT Aid in Staging and Prognostication?
CONCLUSION: FDG-PET/CT detects residual and metastatic disease in patients with IGBC, enabling the institution of appropriate management and acting as a tool for prognostication of survival.PMID:38633288 | PMC:PMC11018561 | DOI:10.1007/s13139-024-00841-w (Source: Molecular Medicine)
Source: Molecular Medicine - April 18, 2024 Category: Molecular Biology Authors: Venkata Subramanian Krishnaraju Rajender Kumar Bhagwant Rai Mittal Harjeet Singh Piyush Aggarwal Harmandeep Singh Thakur Deen Yadav Ritambhra Nada Vikas Gupta Rajesh Gupta Source Type: research
Hepatic Superscan in Medullary Thyroid Carcinoma: A Rare Presentation in [ < sup > 18 < /sup > F]FDG PET/CT
Nucl Med Mol Imaging. 2024 May;58(3):147-149. doi: 10.1007/s13139-023-00836-z. Epub 2024 Jan 18.NO ABSTRACTPMID:38633289 | PMC:PMC11018564 | DOI:10.1007/s13139-023-00836-z (Source: Molecular Medicine)
Source: Molecular Medicine - April 18, 2024 Category: Molecular Biology Authors: Ahmed Saad Abdlkadir Dhuha Al-Adhami Baraa Alsyouf Raghad Alhouwari Ula Al-Rasheed Omar Jaber Issa Mohamad Akram Al-Ibraheem Source Type: research
Uncertainty Analysis of Time-Integrated Activity Coefficient in Single-Time-Point Dosimetry Using Bayesian Fitting Method
CONCLUSION: We introduce the BF method to calculate the SD of individual TIACs in STP dosimetry. The presented method might be used as an alternative method for uncertainty analysis in STP dosimetry.SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13139-024-00851-8.PMID:38633290 | PMC:PMC11018592 | DOI:10.1007/s13139-024-00851-8 (Source: Molecular Medicine)
Source: Molecular Medicine - April 18, 2024 Category: Molecular Biology Authors: Achmad Faturrahman Jundi M Dlorifun Naqiyyun Bisma Barron Patrianesha Intan A S Mu'minah Ade Riana Deni Hardiansyah Source Type: research
Recent Updates on Applications of Artificial Intelligence for Nuclear Medicine Professionals: Prostate Cancer and PET/CT
Nucl Med Mol Imaging. 2024 May;58(3):97-100. doi: 10.1007/s13139-024-00856-3. Epub 2024 Feb 24.NO ABSTRACTPMID:38633291 | PMC:PMC11018562 | DOI:10.1007/s13139-024-00856-3 (Source: Molecular Medicine)
Source: Molecular Medicine - April 18, 2024 Category: Molecular Biology Authors: Ki-Seong Park Source Type: research
A robust computational quest: Discovering potential hits to improve the treatment of pyrazinamide-resistant Mycobacterium tuberculosis
This study utilizes a novel integration of computational techniques, including multiscale biomolecular and molecular dynamics simulations, physicochemical and medicinal chemistry predictions, quantum computations and virtual screening from the ZINC and Chembridge databases, to elucidate the resistance mechanism and identify lead compounds that have the potential to improve treatment outcomes for PZA-resistant MTB, namely ZINC15913786, ZINC20735155, Chem10269711, Chem10279789 and Chem10295790. These computational methods offer a cost-effective, rapid alternative to traditional drug trials by bypassing the need for organic s...
Source: Molecular Medicine - April 18, 2024 Category: Molecular Biology Authors: Muhammad Shahab Gabriel Christian de Farias Morais Shopnil Akash Umberto Laino Fulco Jonas Ivan Nobre Oliveira Guojun Zheng Shahina Akter Source Type: research
