A rectal gastrointestinal stromal tumor case accompanied by elevated CEA mimicking rectal carcinoma on < sup > 18 < /sup > F-FDG PET/CT
Am J Nucl Med Mol Imaging. 2023 Feb 15;13(1):26-32. eCollection 2023.ABSTRACTGastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasm arising from gastrointestinal tract and can be benign or malignant. Rectal GISTs are rare and have poor prognosis. We here reported an older male who presented with features of distending discomfort in the rectum and pain in the anus due to a large rectal tumor. Physical examinations detected a mass in the rectum without blood staining on the gloved finger. Carcinoembryonic antigen (CEA) was found to be slightly elevated and the prostate-specific antigen level was nor...
Source: Molecular Medicine - March 16, 2023 Category: Molecular Biology Authors: Zihao Tao Sitong Wu Zhao Chen Yongkang Qiu Lele Song Qi Yang Lin Nong Lei Kang Source Type: research
The diagnostic value of the computed tomography scan and ultrasonography in acute appendicitis
Am J Nucl Med Mol Imaging. 2023 Feb 15;13(1):11-17. eCollection 2023.ABSTRACTThe most prevalent cause of emergency abdominal surgery is acute appendicitis. Ultrasonography is safe and widely available, although it's operator-dependent and difficult for people with massive bodies. Computed tomography (CT) scans are more accurate than ultrasonography, with a 93 to 98% accuracy rate. The goal of this investigation is to evaluate the diagnostic value of ultrasonography and CT scanning for acute appendicitis. This is a cross-sectional study that was performed on 231 patients with suspected with acute appendicitis. The Alvarado ...
Source: Molecular Medicine - March 16, 2023 Category: Molecular Biology Authors: Mahshid Bahrami Hannaneh Mirgaloyebayat Zahra Mohajeri Hossein Mohammadi Samira Amin Afshari Pooya Fazeli Dorna Masaeli Sayed Mohammad Amin Nourian Source Type: research
The functional views on response of host rabbit post coronavirus vaccination via ACE2 PET
In conclusion, ACE2 PET gave a more comprehensive view on host response post vaccination, hold substantial promise in continuous monitoring of coronavirus vaccine administration and effectiveness.PMID:36923599 | PMC:PMC10009468 (Source: Molecular Medicine)
Source: Molecular Medicine - March 16, 2023 Category: Molecular Biology Authors: Xiao Li Jie Li Pan Zhou Danni Li Mingxin Wang Qianqian Tong Jian Chen Changjing Zuo Lan Zhang Rou Li Source Type: research
Comparison of PSMA-based < sup > 18 < /sup > F-DCFPyL PET/CT and Tc-99m MDP bone scan in detection of bone metastasis in prostate cancer
Am J Nucl Med Mol Imaging. 2023 Feb 15;13(1):1-10. eCollection 2023.ABSTRACTWhile Tc-99m MDP bone scan (BS) remains the conventional standard for detection of bone metastasis in prostate cancer, newly FDA-approved imaging with PSMA-based 18F-DCFPyL PET/CT has shown promise for early detection of metastatic disease. However, a paucity of data remains in the diagnostic accuracy of PSMA PET/CT in detecting bone metastasis compared to BS. This retrospective study included 91 patients who received both BS and PSMA PET/CT within a 3-month interval from August 2021 to February 2022. Separate concurrent primary cancer, interval PS...
Source: Molecular Medicine - March 16, 2023 Category: Molecular Biology Authors: Zenus J Wilson Guofan Xu Sanjit O Tewari Yang Lu Source Type: research
Assessment of the correlation between arterial lumen density and its metabolic activity in atherosclerotic patients using < sup > 18 < /sup > F-FDG positron emission tomography/computed tomography
Am J Nucl Med Mol Imaging. 2023 Feb 15;13(1):18-25. eCollection 2023.ABSTRACTLarge lipid core (extended into arterial lumen) and high density of macrophages (associated with 18F-fluorodeoxyglucose "18F-FDG" uptake) in atherosclerotic plaque were shown to be an overt feature of plaque rupture. Nineteen participants were imaged with computed tomography (CT) and positron emission tomography (PET) with 18F-FDG in a dynamic mode. The mean lumen density in Hounsfield unit (HU) was measured per region of interest (ROI) on CT images and classified as non-calcified and calcified classifications. Calcified group was divided into par...
Source: Molecular Medicine - March 16, 2023 Category: Molecular Biology Authors: Mamdouh S Al-Enezi Source Type: research
Modeling contrast-to-noise ratio from list mode reconstructions of < sup > 68 < /sup > Ga DOTATATE PET/CT: predicting detectability of hepatic metastases in shorter acquisition PET reconstructions
CONCLUSIONS: CNR for shorter DOTATATE PET imaging times may be accurately predicted using list mode reconstructions of longer acquisitions. A threshold CNR may be applied to longer duration images to ensure lesion detectability of shorter duration reconstructions. This method can aid in the selection of lesions to include in novel data augmentation techniques for deep learning.PMID:36923602 | PMC:PMC10009466 (Source: Molecular Medicine)
Source: Molecular Medicine - March 16, 2023 Category: Molecular Biology Authors: Michael Silosky Fuyong Xing John Wehrend Daniel V Litwiller Scott D Metzler Bennett B Chin Source Type: research
Kaempferol promotes melanogenesis and reduces oxidative stress in PIG1 normal human skin melanocytes
J Cell Mol Med. 2023 Mar 15. doi: 10.1111/jcmm.17711. Online ahead of print.ABSTRACTVitiligo is an autoimmune disease characterized by depigmentation. Kaempferol is a flavonoid compound with broad anti-inflammatory and antioxidant properties. The purpose of this study was to investigate the effect of kaempferol on melanogenesis in PIG1 normal human skin melanocytes and its response to oxidative stress. The effect of kaempferol on melanin synthesis in PIG1 normal human skin melanocytes was explored by measuring tyrosinase activity, melanin content, mRNA and protein expression of key enzymes and expression of related pathway...
Source: Molecular Medicine - March 16, 2023 Category: Molecular Biology Authors: Yihui Xie Xingyu Mei Weimin Shi Source Type: research
LncRNA GAS5 suppresses TGF- β1-induced transformation of pulmonary pericytes into myofibroblasts by recruiting KDM5B and promoting H3K4me2/3 demethylation of the PDGFRα/β promoter
CONCLUSION: GAS5 represses pericyte-myofibroblast transformation by inhibiting PDGFRα/β expression via KDM5B-mediated H3K4me2/3 demethylation in IPF, identifying GAS5 as an intervention target for IPF.PMID:36918759 | PMC:PMC10015786 | DOI:10.1186/s10020-023-00620-x (Source: Molecular Medicine)
Source: Molecular Medicine - March 15, 2023 Category: Molecular Biology Authors: Yichun Wang Diyu Chen Han Xie Shuhua Zhou Mingwang Jia Xiaobo He Feifei Guo Yihuan Lai Xiao Xiao Tang Source Type: research
Caveolin-1 is involved in fatty infiltration and bone-tendon healing of rotator cuff tear
CONCLUSION: Caveolin-1 was identified as a key gene involved in the RCT process. In vitro results demonstrated that Caveolin-1 knockdown inhibited adipogenic differentiation of TSCs by activating the cAMP/PKA pathway. GATA6 inhibited the transcription of Caveolin-1 and inhibited its expression, thus suppressing the adipogenic differentiation of TSCs. In vivo data confirmed that GATA6 overexpression activated the cAMP/PKA pathway by downregulating Caveolin-1 and consequently repressed fatty infiltration, promoted bone-tendon healing, improved biomechanical properties and reduced the rupture risk of injured tendon in rats af...
Source: Molecular Medicine - March 15, 2023 Category: Molecular Biology Authors: Shanhong Fang Mengqiang You Jie Wei Peng Chen Source Type: research
Resveratrol-Exemestane Beneficial Regimen to Overcome the Complications over Existing Therapies for the Management of Breast Cancer
Curr Mol Med. 2023 Mar 14. doi: 10.2174/1566524023666230314104442. Online ahead of print.NO ABSTRACTPMID:36918787 | DOI:10.2174/1566524023666230314104442 (Source: Molecular Medicine)
Source: Molecular Medicine - March 15, 2023 Category: Molecular Biology Authors: Simranjeet Kaur Dilpreet Singh Source Type: research
4-Octyl itaconate attenuates glycemic deterioration by regulating macrophage polarization in mouse models of type 1 diabetes
CONCLUSIONS: These results provided the first evidence to date that OI can prevent the progression of glycemic deterioration, excessive inflammation, and beta cell dysfunction predominantly mediated by restricting macrophage M1 polarization in mouse models of type 1 diabetes.PMID:36918798 | PMC:PMC10015936 | DOI:10.1186/s10020-023-00626-5 (Source: Molecular Medicine)
Source: Molecular Medicine - March 15, 2023 Category: Molecular Biology Authors: Sunyue He Yuchen Zhao Guoxing Wang Qiaofang Ke Nan Wu Lusi Lu Jiahua Wu Shuiya Sun Weihua Jin Wenjing Zhang Jiaqiang Zhou Source Type: research
The role of NEDD4 related HECT-type E3 ubiquitin ligases in defective autophagy in cancer cells: molecular mechanisms and therapeutic perspectives
Mol Med. 2023 Mar 14;29(1):34. doi: 10.1186/s10020-023-00628-3.ABSTRACTThe homologous to the E6-AP carboxyl terminus (HECT)-type E3 ubiquitin ligases are the selective executers in the protein ubiquitination, playing a vital role in modulation of the protein function and stability. Evidence shows the regulatory role of HECT-type E3 ligases in various steps of the autophagic process. Autophagy is an intracellular digestive and recycling process that controls the cellular hemostasis. Defective autophagy is involved in tumorigenesis and has been detected in various types of cancer cells. A growing body of findings indicates t...
Source: Molecular Medicine - March 15, 2023 Category: Molecular Biology Authors: Rui Zhang Shaoqing Shi Source Type: research
Telomerase inhibition in malignant gliomas. A systematic review
Expert Rev Mol Med. 2023 Mar 15:1-25. doi: 10.1017/erm.2023.6. Online ahead of print.NO ABSTRACTPMID:36919343 | DOI:10.1017/erm.2023.6 (Source: Molecular Medicine)
Source: Molecular Medicine - March 15, 2023 Category: Molecular Biology Authors: Quintino Giorgio D'Alessandris Marco Battistelli Giovanni Pennisi Martina Offi Maurizio Martini Tonia Cenci Maria Laura Falchetti Liverana Lauretti Alessandro Olivi Roberto Pallini Nicola Montano Source Type: research
Development and validation of robust metabolism-related gene signature in the prognostic prediction of hepatocellular carcinoma
In conclusion, the metabolic genes related to OS were identified and developed a metabolism-based predictive model for HCC. Through a series of bioinformatics and statistical analyses, the predictive ability of the model was approved.PMID:36919714 | DOI:10.1111/jcmm.17718 (Source: Molecular Medicine)
Source: Molecular Medicine - March 15, 2023 Category: Molecular Biology Authors: Yangxun Pan Deyao Zhang Yuheng Chen Huake Li Jiongliang Wang Ze Yuan Liyang Sun Zhongguo Zhou Minshan Chen Yaojun Zhang Dandan Hu Source Type: research
BDH1 promotes lung cancer cell proliferation and metastases by PARP1-mediated autophagy
This study was undertaken to identify a novel predictive biomarker for predicting lymph node metastases of lung cancer. A total of 364 patients with lung cancer which comprised of 198 patients with transcriptome sequencing data, 110 cases with immunohistochemistry data and 66 patients with serum samples were included to identify and validate the candidate gene. Autophagy was measured by western blots, immunofluorescence and electron microscope. We found that 3-hydroxybutyrate dehydrogenase 1 (BDH1) was associated with proliferation and metastases of lung cancer. BDH1 expression in both tissue and serum samples was associat...
Source: Molecular Medicine - March 15, 2023 Category: Molecular Biology Authors: Zhimin Zhang Xin Bi Xiaojuan Lian Zhongxi Niu Source Type: research