PET/CT study of dopamine transporter (DAT) binding with the triple reuptake inhibitor toludesvenlafaxine in rats and humans
CONCLUSION: These results represent the first to confirm the binding of toludesvenlafaxine to DAT in both rats and humans using PET/CT, and its elevation of brain DA level, which may help understand the unique pharmacological and functional effects of triple reuptake inhibitors such as toludesvenlafaxine.GOV IDENTIFIERS: NCT05905120. Registered 14 June 2023. (retrospectively registered).PMID:38587645 | DOI:10.1007/s00259-024-06700-2 (Source: Molecular Medicine)
Source: Molecular Medicine - April 8, 2024 Category: Molecular Biology Authors: Zhiwei Huang Junhao Wu Yihui Guan Yumei Wei Fang Xie Yifeng Shen Source Type: research
Artificial intelligence-based application in multiple myeloma
Eur J Nucl Med Mol Imaging. 2024 Apr 8. doi: 10.1007/s00259-024-06711-z. Online ahead of print.NO ABSTRACTPMID:38587646 | DOI:10.1007/s00259-024-06711-z (Source: Molecular Medicine)
Source: Molecular Medicine - April 8, 2024 Category: Molecular Biology Authors: Leandra Piscopo Mariano Scaglione Michele Klain Source Type: research
GHITM regulates malignant phenotype and sensitivity to PD-1 blockade of renal cancer cells via Notch signalling
J Cell Mol Med. 2024 Apr;28(8):e18290. doi: 10.1111/jcmm.18290.ABSTRACTGrowth hormone inducible transmembrane protein (GHITM), one member of Bax inhibitory protein-like family, has been rarely studied, and the clinical importance and biological functions of GHITM in kidney renal clear cell carcinoma (KIRC) still remain unknown. In the present study, we found that GHITM was downregulated in KIRC. Aberrant GHITM downregulation related to clinicopathological feature and unfavourable prognosis of KIRC patients. GHITM overexpression inhibited KIRC cell proliferation, migration and invasion in vitro and in vivo. Mechanistically,...
Source: Molecular Medicine - April 8, 2024 Category: Molecular Biology Authors: Shiyu Huang Jiachen Liu Juncheng Hu Yanguang Hou Min Hu Banghua Zhang Hongbo Luo Shujie Fu Yujie Chen Xiuheng Liu Zhiyuan Chen Lei Wang Source Type: research
A case of polyglucosan body myopathy caused by an RBCK1 gene variant and literature review
CONCLUSIONS: The patient was twice diagnosed with cardiac insufficiency, neglecting the usual manifestations of muscle weakness, resulting in misdiagnosis. Later, novel variants in the RBCK1 gene were discovered through whole-exome sequencing, and symptomatic treatment was given after diagnosis. The importance of whole-exome sequencing technology in disease diagnosis and genetic counseling was emphasized.PMID:38588043 | DOI:10.1002/mgg3.2432 (Source: Molecular Medicine)
Source: Molecular Medicine - April 8, 2024 Category: Molecular Biology Authors: Qiqing Sun Zhenhua Xie Lifang Song Dapeng Fu Source Type: research
The clinical value of optical genome mapping in the rapid characterization of RB1 duplication and 15q23q24.2 triplication, for more appropriate prenatal genetic counselling
CONCLUSION: Along with an increase in diagnostic rates, OGM can rapidly highlight genotype-phenotype correlations, improve genetic counselling and significantly influence prenatal management.PMID:38588252 | DOI:10.1002/mgg3.2437 (Source: Molecular Medicine)
Source: Molecular Medicine - April 8, 2024 Category: Molecular Biology Authors: Malek Bouassida Denise Molina-Gomes Fairouz Koraichi B érénice Hervé Morgane Lhuilier Cl émence Duvillier Jessica Le Gall Marion Gauthier-Villars Val érie Serazin Thibaud Quibel Rodolphe Dard Fran çois Vialard Source Type: research
A series of patients with hospital-acquired diabetic ketoacidosis (HADKA): a descriptive analysis
CONCLUSION: HADKA was identified in a significant number of patients at our hospital and was associated with significant mortality. Earlier recognition of ketonaemia and associated medication use may prevent HADKA and improve outcomes.PMID:38589158 | DOI:10.7861/clinmed.2022-0300 (Source: Molecular Medicine)
Source: Molecular Medicine - April 8, 2024 Category: Molecular Biology Authors: David M Williams Sofia Taverner Rebecca Watson Siba George Amanda Edwards Ayesha Shaikh Maneesh Udiawar Source Type: research
Visual extended reality tools in image-guided surgery in urology: a systematic review
CONCLUSIONS: AR, VR and MR techniques have emerged as highly effective new tools for image-guided surgery, especially for urologic oncology. Nevertheless, the complete clinical advantages of these innovations are still in the process of evaluation.PMID:38589511 | DOI:10.1007/s00259-024-06699-6 (Source: Molecular Medicine)
Source: Molecular Medicine - April 8, 2024 Category: Molecular Biology Authors: Enrico Checcucci Alberto Piana Gabriele Volpi Alberto Quar à Sabrina De Cillis Federico Piramide Mariano Burgio Juliette Meziere Edoardo Cisero Marco Colombo Gabriele Bignante Michele Sica Stefano Granato Paolo Verri Cecilia Gatti Paolo Alessio Michele D Source Type: research
FOXF1 promotes tumor vessel normalization and prevents lung cancer progression through FZD4
EMBO Mol Med. 2024 Apr 8. doi: 10.1038/s44321-024-00064-8. Online ahead of print.ABSTRACTCancer cells re-program normal lung endothelial cells (EC) into tumor-associated endothelial cells (TEC) that form leaky vessels supporting carcinogenesis. Transcriptional regulators that control the reprogramming of EC into TEC are poorly understood. We identified Forkhead box F1 (FOXF1) as a critical regulator of EC-to-TEC transition. FOXF1 was highly expressed in normal lung vasculature but was decreased in TEC within non-small cell lung cancers (NSCLC). Low FOXF1 correlated with poor overall survival of NSCLC patients. In mice, end...
Source: Molecular Medicine - April 8, 2024 Category: Molecular Biology Authors: Fenghua Bian Chinmayee Goda Guolun Wang Ying-Wei Lan Zicheng Deng Wen Gao Anusha Acharya Abid A Reza Jose Gomez-Arroyo Nawal Merjaneh Xiaomeng Ren Jermaine Goveia Peter Carmeliet Vladimir V Kalinichenko Tanya V Kalin Source Type: research
A missense mutation in human INSC causes peripheral neuropathy
EMBO Mol Med. 2024 Apr 8. doi: 10.1038/s44321-024-00062-w. Online ahead of print.ABSTRACTPAR3/INSC/LGN form an evolutionarily conserved complex required for asymmetric cell division in the developing brain, but its post-developmental function and disease relevance in the peripheral nervous system (PNS) remains unknown. We mapped a new locus for axonal Charcot-Marie-Tooth disease (CMT2) and identified a missense mutation c.209 T > G (p.Met70Arg) in the INSC gene. Modeling the INSCM70R variant in Drosophila, we showed that it caused proprioceptive defects in adult flies, leading to gait defects resembling those in CMT2 pa...
Source: Molecular Medicine - April 8, 2024 Category: Molecular Biology Authors: Jui-Yu Yeh Hua-Chuan Chao Cheng-Li Hong Yu-Chien Hung Fei-Yang Tzou Cheng-Tsung Hsiao Jeng-Lin Li Wen-Jie Chen Cheng-Ta Chou Yu-Shuen Tsai Yi-Chu Liao Yu-Chun Lin Suewei Lin Shu-Yi Huang Marina Kennerson Yi-Chung Lee Chih-Chiang Chan Source Type: research
Frontiers in sarcopenia: Advancements in diagnostics, molecular mechanisms, and therapeutic strategies
Mol Aspects Med. 2024 Apr 6;97:101270. doi: 10.1016/j.mam.2024.101270. Online ahead of print.ABSTRACTThe onset of sarcopenia is intimately linked with aging, posing significant implications not only for individual patient quality of life but also for the broader societal healthcare framework. Early and accurate identification of sarcopenia and a comprehensive understanding of its mechanistic underpinnings and therapeutic targets paramount to addressing this condition effectively. This review endeavors to present a cohesive overview of recent advancements in sarcopenia research and diagnosis. We initially delve into the con...
Source: Molecular Medicine - April 7, 2024 Category: Molecular Biology Authors: Dequan Liu Shijin Wang Shuang Liu Qifei Wang Xiangyu Che Guangzhen Wu Source Type: research
SALL4 in gastrointestinal tract cancers: upstream and downstream regulatory mechanisms
We describe the functions of SALL4 in GIT cancers and discuss its upstream/downstream genes and pathways associated with each cancer. We also consider the possibility of targeting these genes or pathways as potential therapeutic options for GIT cancers.PMID:38584262 | DOI:10.1186/s10020-024-00812-z (Source: Molecular Medicine)
Source: Molecular Medicine - April 7, 2024 Category: Molecular Biology Authors: Tairan Wang Yan Jin Mengyao Wang Boya Chen Jinyu Sun Jiaying Zhang Hui Yang Xinyao Deng Xingyue Cao Lidong Wang Yuanyuan Tang Source Type: research
Clinical and genetic characteristics of three patients with congenital insensitivity to pain with anhidrosis: Case reports and a review of the literature
CONCLUSION: All three patients exhibited variable phenotypes and disease severity. This research enriches our understanding of clinical and genetic aspects of CIPA, highlighting variable phenotypes and disease severity.PMID:38581121 | PMC:PMC10997844 | DOI:10.1002/mgg3.2430 (Source: Molecular Medicine)
Source: Molecular Medicine - April 6, 2024 Category: Molecular Biology Authors: Jun Hee Cho Soojin Hwang Yoon Hae Kwak Mi-Sun Yum Go Hun Seo June-Young Koh Young Seok Ju Ji-Hee Yoon Minji Kang Hyo-Sang Do Soyoung Kim Gu-Hwan Kim Hyunwoo Bae Beom Hee Lee Source Type: research
Autism spectrum disorder profiles in RASopathies: A systematic review
CONCLUSIONS: Our systematic review found no convincing evidence for a specific ASD profile in RASopathies compared to iASD, or in a specific RASopathy compared to other RASopathies. However, we identified important limitations in the research literature which may also account for this result. These limitations are discussed and recommendations for future research are formulated.PMID:38581124 | PMC:PMC10997847 | DOI:10.1002/mgg3.2428 (Source: Molecular Medicine)
Source: Molecular Medicine - April 6, 2024 Category: Molecular Biology Authors: Edward Debbaut Jean Steyaert Mouna El Bakkali Source Type: research
Construction and Biological Evaluation of Biomimetic Coatings on Titanium Surfaces Using Naringin-7-O-Neohesperidoside at Different Concentrations
CONCLUSIONS: NRG biomimetic coatings on titanium surfaces were successfully constructed using the LBL technique. NRG at different concentrations had stronger effects on the proliferation and differentiation of MC3T3-E1 cells compared to the groups without drug and blank groups, with the concentration of 10-6 mol/L demonstrating the best effect. These findings suggest that NRG-loaded biomimetic coatings may enhance the osseointegration of titanium implants, offering promising prospects for dental and orthopedic applications.PMID:38581321 (Source: Molecular Medicine)
Source: Molecular Medicine - April 6, 2024 Category: Molecular Biology Authors: Chengzhong Wu Jingxiao Wang Yajie Huang Xia Shao Source Type: research
An ultra-small organic dye nanocluster for enhancing NIR-II imaging-guided surgery outcomes
CONCLUSION: In summary, our study demonstrates that the dye nanocluster-based NIR-II FGS has substantially improved outcomes for radical lymphadenectomy.PMID:38581443 | DOI:10.1007/s00259-024-06702-0 (Source: Molecular Medicine)
Source: Molecular Medicine - April 6, 2024 Category: Molecular Biology Authors: Yajun Wang Ding Zhou Huilong Ma Dahai Liu Yongye Liang Shoujun Zhu Source Type: research
