Radiolabelling and preclinical characterisation of [ < sup > 89 < /sup > Zr]Zr-Df-ATG-101 bispecific to PD-L1/4-1BB

CONCLUSION: [89Zr]Zr-Df-ATG-101 in vivo distribution is dependent on PD-L1 expression in the MDA-MB-231 xenograft model. Immuno-PET with [89Zr]Zr-Df-ATG-101 provides real-time information about ATG-101 distribution and tumour uptake in vivo. Our data support the use of [89Zr]Zr-Df-ATG-101 to assess tumour and tissue uptake of ATG-101.PMID:38730087 | DOI:10.1007/s00259-024-06742-6

Source: Molecular Medicine - May 10, 2024 Category: Molecular Biology Authors: Zhipeng Cao Christian Werner Wichmann Ingrid Julienne Georgette Burvenich Laura Danielle Osellame Nancy Guo Angela Rigopoulos Graeme Joseph O'Keefe Fiona Elizabeth Scott Nirmal Lorensuhewa Kevin Patrick Lynch Andrew Mark Scott Source Type: research