Overcoming BRAF and CDK4/6 inhibitor resistance by inhibiting MAP3K3-dependent protection against YAP lysosomal degradation

In conclusion, our study reveals a previously unrecognized mechanism for the regulation of YAP stability, suggesting MAP3K3 inhibition as a promising strategy for overcoming resistance to CDK4/6 and BRAF inhibitors in cancer treatment.PMID:38622197 | DOI:10.1038/s12276-024-01210-5

Source: Molecular Medicine - April 15, 2024 Category: Molecular Biology Authors: Sanghyun Park Won-Ji Ryu Tae Yeong Kim Yumi Hwang Hyun Ju Han Jeong Dong Lee Gun Min Kim Joohyuk Sohn Sang Kyum Kim Min Hwan Kim Joon Kim Source Type: research