Neuroplastin splice variants Np55 and Np65: Who is doing the job in macrophages?

Mol Immunol. 2024 Apr 13;170:57-59. doi: 10.1016/j.molimm.2024.03.008. Online ahead of print.ABSTRACTNeuroplastin, a paralog of CD147/Basigin, is known as a neuronal cell adhesion molecule and as an auxiliary subunit of plasma membrane calcium ATPases in both neurons and adaptive immune cells. Recently, an interesting study by Ren et al. (2022) provided evidence for an important role of neuroplastin in macrophages during bacterial infection. Here, we critically discuss one aspect of this study, the assignment of this role to Np65 as one of two prominent splice variants of neuroplastin.PMID:38615628 | DOI:10.1016/j.molimm.2024.03.008
Source: Molecular Medicine - Category: Molecular Biology Authors: Source Type: research