SEMA7a primes integrin α5β1 engagement instructing fibroblast mechanotransduction, phenotype and transcriptional programming
Matrix Biol. 2023 Jul 6:S0945-053X(23)00076-8. doi: 10.1016/j.matbio.2023.06.006. Online ahead of print.ABSTRACTIntegrins are cellular receptors that bind the extracellular matrix (ECM) and facilitate the transduction of biochemical and biophysical microenvironment cues into cellular responses. Upon engaging the ECM, integrin heterodimers must rapidly strengthen their binding with the ECM, resulting in the assembly of force-resistant and force-sensitive integrin associated complexes (IACs). The IACs constitute an essential apparatus for downstream signaling and fibroblast phenotypes. During wound healing, integrin signalin...
Source: Matrix Biology - July 8, 2023 Category: Molecular Biology Authors: Hu P Miller Ae Yeh Cr Bingham Gc Civelek M Barker Th Source Type: research
SEMA7a primes integrin α5β1 engagement instructing fibroblast mechanotransduction, phenotype and transcriptional programming
Matrix Biol. 2023 Jul 6:S0945-053X(23)00076-8. doi: 10.1016/j.matbio.2023.06.006. Online ahead of print.ABSTRACTIntegrins are cellular receptors that bind the extracellular matrix (ECM) and facilitate the transduction of biochemical and biophysical microenvironment cues into cellular responses. Upon engaging the ECM, integrin heterodimers must rapidly strengthen their binding with the ECM, resulting in the assembly of force-resistant and force-sensitive integrin associated complexes (IACs). The IACs constitute an essential apparatus for downstream signaling and fibroblast phenotypes. During wound healing, integrin signalin...
Source: Matrix Biology - July 8, 2023 Category: Molecular Biology Authors: Hu P Miller Ae Yeh Cr Bingham Gc Civelek M Barker Th Source Type: research
SEMA7a primes integrin α5β1 engagement instructing fibroblast mechanotransduction, phenotype and transcriptional programming
Matrix Biol. 2023 Jul 6:S0945-053X(23)00076-8. doi: 10.1016/j.matbio.2023.06.006. Online ahead of print.ABSTRACTIntegrins are cellular receptors that bind the extracellular matrix (ECM) and facilitate the transduction of biochemical and biophysical microenvironment cues into cellular responses. Upon engaging the ECM, integrin heterodimers must rapidly strengthen their binding with the ECM, resulting in the assembly of force-resistant and force-sensitive integrin associated complexes (IACs). The IACs constitute an essential apparatus for downstream signaling and fibroblast phenotypes. During wound healing, integrin signalin...
Source: Matrix Biology - July 8, 2023 Category: Molecular Biology Authors: Hu P Miller Ae Yeh Cr Bingham Gc Civelek M Barker Th Source Type: research
Fibrolamellar Carcinomas-Growth arrested by paracrine signals complexed with synthesized 3-O sulfated heparan sulfate oligosaccharides
Matrix Biol. 2023 Jul 2:S0945-053X(23)00078-1. doi: 10.1016/j.matbio.2023.06.008. Online ahead of print.ABSTRACTFibrolamellar carcinomas (FLCs), lethal tumors occurring in children to young adults, have genetic signatures implicating derivation from biliary tree stem cell (BTSC) subpopulations, co-hepato/pancreatic stem cells, involved in hepatic and pancreatic regeneration. FLCs and BTSCs express pluripotency genes, endodermal transcription factors, and stem cell surface, cytoplasmic and proliferation biomarkers. The FLC-PDX model, FLC-TD-2010, is driven ex vivo to express pancreatic acinar traits, hypothesized responsibl...
Source: Matrix Biology - July 4, 2023 Category: Molecular Biology Authors: Wencheng Zhang Yongmei Xu Xicheng Wang Tsunekazu Oikawa Guowei Su Eliane Wauthier Guoxiu Wu Praveen Sethupathy Zhiying He Jian Liu Lola M Reid Source Type: research
Fibrolamellar Carcinomas-Growth arrested by paracrine signals complexed with synthesized 3-O sulfated heparan sulfate oligosaccharides
Matrix Biol. 2023 Jul 2:S0945-053X(23)00078-1. doi: 10.1016/j.matbio.2023.06.008. Online ahead of print.ABSTRACTFibrolamellar carcinomas (FLCs), lethal tumors occurring in children to young adults, have genetic signatures implicating derivation from biliary tree stem cell (BTSC) subpopulations, co-hepato/pancreatic stem cells, involved in hepatic and pancreatic regeneration. FLCs and BTSCs express pluripotency genes, endodermal transcription factors, and stem cell surface, cytoplasmic and proliferation biomarkers. The FLC-PDX model, FLC-TD-2010, is driven ex vivo to express pancreatic acinar traits, hypothesized responsibl...
Source: Matrix Biology - July 4, 2023 Category: Molecular Biology Authors: Wencheng Zhang Yongmei Xu Xicheng Wang Tsunekazu Oikawa Guowei Su Eliane Wauthier Guoxiu Wu Praveen Sethupathy Zhiying He Jian Liu Lola M Reid Source Type: research
Fibrolamellar Carcinomas-Growth arrested by paracrine signals complexed with synthesized 3-O sulfated heparan sulfate oligosaccharides
Matrix Biol. 2023 Jul 2:S0945-053X(23)00078-1. doi: 10.1016/j.matbio.2023.06.008. Online ahead of print.ABSTRACTFibrolamellar carcinomas (FLCs), lethal tumors occurring in children to young adults, have genetic signatures implicating derivation from biliary tree stem cell (BTSC) subpopulations, co-hepato/pancreatic stem cells, involved in hepatic and pancreatic regeneration. FLCs and BTSCs express pluripotency genes, endodermal transcription factors, and stem cell surface, cytoplasmic and proliferation biomarkers. The FLC-PDX model, FLC-TD-2010, is driven ex vivo to express pancreatic acinar traits, hypothesized responsibl...
Source: Matrix Biology - July 4, 2023 Category: Molecular Biology Authors: Wencheng Zhang Yongmei Xu Xicheng Wang Tsunekazu Oikawa Guowei Su Eliane Wauthier Guoxiu Wu Praveen Sethupathy Zhiying He Jian Liu Lola M Reid Source Type: research
Fibrolamellar Carcinomas-Growth arrested by paracrine signals complexed with synthesized 3-O sulfated heparan sulfate oligosaccharides
Matrix Biol. 2023 Jul 2:S0945-053X(23)00078-1. doi: 10.1016/j.matbio.2023.06.008. Online ahead of print.ABSTRACTFibrolamellar carcinomas (FLCs), lethal tumors occurring in children to young adults, have genetic signatures implicating derivation from biliary tree stem cell (BTSC) subpopulations, co-hepato/pancreatic stem cells, involved in hepatic and pancreatic regeneration. FLCs and BTSCs express pluripotency genes, endodermal transcription factors, and stem cell surface, cytoplasmic and proliferation biomarkers. The FLC-PDX model, FLC-TD-2010, is driven ex vivo to express pancreatic acinar traits, hypothesized responsibl...
Source: Matrix Biology - July 4, 2023 Category: Molecular Biology Authors: Wencheng Zhang Yongmei Xu Xicheng Wang Tsunekazu Oikawa Guowei Su Eliane Wauthier Guoxiu Wu Praveen Sethupathy Zhiying He Jian Liu Lola M Reid Source Type: research
7TSG6 hyaluronan matrix remodeling dampens the inflammatory response during colitis
In conclusion, our data suggests that TSG6 exerts a tissue-protective, anti-inflammatory effect via the generation of HC:HA complexes that become dysregulated in IBD.PMID:37391162 | DOI:10.1016/j.matbio.2023.06.007 (Source: Matrix Biology)
Source: Matrix Biology - June 30, 2023 Category: Molecular Biology Authors: Nansy Albtoush Kimberly A Queisser Ash Zawerton Mark E Lauer Ellen J Beswick Aaron C Petrey Source Type: research
7TSG6 hyaluronan matrix remodeling dampens the inflammatory response during colitis
In conclusion, our data suggests that TSG6 exerts a tissue-protective, anti-inflammatory effect via the generation of HC:HA complexes that become dysregulated in IBD.PMID:37391162 | DOI:10.1016/j.matbio.2023.06.007 (Source: Matrix Biology)
Source: Matrix Biology - June 30, 2023 Category: Molecular Biology Authors: Nansy Albtoush Kimberly A Queisser Ash Zawerton Mark E Lauer Ellen J Beswick Aaron C Petrey Source Type: research
7TSG6 hyaluronan matrix remodeling dampens the inflammatory response during colitis
In conclusion, our data suggests that TSG6 exerts a tissue-protective, anti-inflammatory effect via the generation of HC:HA complexes that become dysregulated in IBD.PMID:37391162 | DOI:10.1016/j.matbio.2023.06.007 (Source: Matrix Biology)
Source: Matrix Biology - June 30, 2023 Category: Molecular Biology Authors: Nansy Albtoush Kimberly A Queisser Ash Zawerton Mark E Lauer Ellen J Beswick Aaron C Petrey Source Type: research
7TSG6 hyaluronan matrix remodeling dampens the inflammatory response during colitis
In conclusion, our data suggests that TSG6 exerts a tissue-protective, anti-inflammatory effect via the generation of HC:HA complexes that become dysregulated in IBD.PMID:37391162 | DOI:10.1016/j.matbio.2023.06.007 (Source: Matrix Biology)
Source: Matrix Biology - June 30, 2023 Category: Molecular Biology Authors: Nansy Albtoush Kimberly A Queisser Ash Zawerton Mark E Lauer Ellen J Beswick Aaron C Petrey Source Type: research
Absence of TRIC-B from type XIV Osteogenesis Imperfecta osteoblasts alters cell adhesion and mitochondrial function - A multi-omics study
Matrix Biol. 2023 Jun 20:S0945-053X(23)00075-6. doi: 10.1016/j.matbio.2023.06.004. Online ahead of print.ABSTRACTOsteogenesis Imperfecta (OI) is a heritable collagen-related bone dysplasia characterized by bone fractures, growth deficiency and skeletal deformity. Type XIV OI is a recessive OI form caused by null mutations in TMEM38B, which encodes the ER membrane intracellular cation channel TRIC-B. Previously, we showed that absence of TMEM38B alters calcium flux in the ER of OI patient osteoblasts and fibroblasts, which further disrupts collagen synthesis and secretion. How the absence of TMEM38B affects osteoblast funct...
Source: Matrix Biology - June 22, 2023 Category: Molecular Biology Authors: Milena Jovanovic Apratim Mitra Roberta Besio Barbara Maria Contento Ka Wai Wong Alberta Derkyi Michael To Antonella Forlino Ryan K Dale Joan C Marini Source Type: research
Absence of TRIC-B from type XIV Osteogenesis Imperfecta osteoblasts alters cell adhesion and mitochondrial function - A multi-omics study
Matrix Biol. 2023 Jun 20:S0945-053X(23)00075-6. doi: 10.1016/j.matbio.2023.06.004. Online ahead of print.ABSTRACTOsteogenesis Imperfecta (OI) is a heritable collagen-related bone dysplasia characterized by bone fractures, growth deficiency and skeletal deformity. Type XIV OI is a recessive OI form caused by null mutations in TMEM38B, which encodes the ER membrane intracellular cation channel TRIC-B. Previously, we showed that absence of TMEM38B alters calcium flux in the ER of OI patient osteoblasts and fibroblasts, which further disrupts collagen synthesis and secretion. How the absence of TMEM38B affects osteoblast funct...
Source: Matrix Biology - June 22, 2023 Category: Molecular Biology Authors: Milena Jovanovic Apratim Mitra Roberta Besio Barbara Maria Contento Ka Wai Wong Alberta Derkyi Michael To Antonella Forlino Ryan K Dale Joan C Marini Source Type: research
Absence of TRIC-B from type XIV Osteogenesis Imperfecta osteoblasts alters cell adhesion and mitochondrial function - A multi-omics study
Matrix Biol. 2023 Jun 20:S0945-053X(23)00075-6. doi: 10.1016/j.matbio.2023.06.004. Online ahead of print.ABSTRACTOsteogenesis Imperfecta (OI) is a heritable collagen-related bone dysplasia characterized by bone fractures, growth deficiency and skeletal deformity. Type XIV OI is a recessive OI form caused by null mutations in TMEM38B, which encodes the ER membrane intracellular cation channel TRIC-B. Previously, we showed that absence of TMEM38B alters calcium flux in the ER of OI patient osteoblasts and fibroblasts, which further disrupts collagen synthesis and secretion. How the absence of TMEM38B affects osteoblast funct...
Source: Matrix Biology - June 22, 2023 Category: Molecular Biology Authors: Milena Jovanovic Apratim Mitra Roberta Besio Barbara Maria Contento Ka Wai Wong Alberta Derkyi Michael To Antonella Forlino Ryan K Dale Joan C Marini Source Type: research
Absence of TRIC-B from type XIV Osteogenesis Imperfecta osteoblasts alters cell adhesion and mitochondrial function - A multi-omics study
Matrix Biol. 2023 Jun 20:S0945-053X(23)00075-6. doi: 10.1016/j.matbio.2023.06.004. Online ahead of print.ABSTRACTOsteogenesis Imperfecta (OI) is a heritable collagen-related bone dysplasia characterized by bone fractures, growth deficiency and skeletal deformity. Type XIV OI is a recessive OI form caused by null mutations in TMEM38B, which encodes the ER membrane intracellular cation channel TRIC-B. Previously, we showed that absence of TMEM38B alters calcium flux in the ER of OI patient osteoblasts and fibroblasts, which further disrupts collagen synthesis and secretion. How the absence of TMEM38B affects osteoblast funct...
Source: Matrix Biology - June 22, 2023 Category: Molecular Biology Authors: Milena Jovanovic Apratim Mitra Roberta Besio Barbara Maria Contento Ka Wai Wong Alberta Derkyi Michael To Antonella Forlino Ryan K Dale Joan C Marini Source Type: research
