En route towards a personalized medicine approach: Innovative therapeutic modalities for connective tissue disorders
Matrix Biol. 2023 Aug 30:S0945-053X(23)00092-6. doi: 10.1016/j.matbio.2023.08.005. Online ahead of print.ABSTRACTConnective tissue disorders can be caused by pathogenic variants (mutations) in genes encoding extracellular matrix (ECM) proteins. Such disorders typically manifest during development or postnatal growth and result in significant morbidity and mortality. The development of curative treatments for connective tissue disorders is hampered in part by the inability of many mature connective tissues to efficiently regenerate. To be most effective, therapeutic strategies designed to preserve or restore tissue function...
Source: Matrix Biology - September 1, 2023 Category: Molecular Biology Authors: Charlene Redhead Nandaraj Taye Dirk Hubmacher Source Type: research
En route towards a personalized medicine approach: Innovative therapeutic modalities for connective tissue disorders
Matrix Biol. 2023 Aug 30:S0945-053X(23)00092-6. doi: 10.1016/j.matbio.2023.08.005. Online ahead of print.ABSTRACTConnective tissue disorders can be caused by pathogenic variants (mutations) in genes encoding extracellular matrix (ECM) proteins. Such disorders typically manifest during development or postnatal growth and result in significant morbidity and mortality. The development of curative treatments for connective tissue disorders is hampered in part by the inability of many mature connective tissues to efficiently regenerate. To be most effective, therapeutic strategies designed to preserve or restore tissue function...
Source: Matrix Biology - September 1, 2023 Category: Molecular Biology Authors: Charlene Redhead Nandaraj Taye Dirk Hubmacher Source Type: research
En route towards a personalized medicine approach: Innovative therapeutic modalities for connective tissue disorders
Matrix Biol. 2023 Aug 30:S0945-053X(23)00092-6. doi: 10.1016/j.matbio.2023.08.005. Online ahead of print.ABSTRACTConnective tissue disorders can be caused by pathogenic variants (mutations) in genes encoding extracellular matrix (ECM) proteins. Such disorders typically manifest during development or postnatal growth and result in significant morbidity and mortality. The development of curative treatments for connective tissue disorders is hampered in part by the inability of many mature connective tissues to efficiently regenerate. To be most effective, therapeutic strategies designed to preserve or restore tissue function...
Source: Matrix Biology - September 1, 2023 Category: Molecular Biology Authors: Charlene Redhead Nandaraj Taye Dirk Hubmacher Source Type: research
Global, but not chondrocyte-specific, MT1-MMP deficiency in adult mice causes inflammatory arthritis
Matrix Biol. 2023 Aug 18:S0945-053X(23)00090-2. doi: 10.1016/j.matbio.2023.08.003. Online ahead of print.ABSTRACTMembrane-type I metalloproteinase (MT1-MMP/MMP14) plays a key role in various pathophysiological processes, indicating an unaddressed need for a targeted therapeutic approach. However, mice genetically deficient in Mmp14 show severe defects in development and growth. To investigate the possibility of MT1-MMP inhibition as a safe treatment in adults, we generated global Mmp14 tamoxifen-induced conditional knockout (Mmp14kd) mice and found that MT1-MMP deficiency in adult mice resulted in severe inflammatory arthr...
Source: Matrix Biology - August 20, 2023 Category: Molecular Biology Authors: Xiao-Dan Xia Govind Gill Haiming Lin Daniela M Roth Hong-Mei Gu Xiang-Jiang Wang Feng-Yi Su Adekunle Alabi Maria Alexiou Ziyang Zhang Gui-Qing Wang Daniel Graf Da-Wei Zhang Source Type: research
Global, but not chondrocyte-specific, MT1-MMP deficiency in adult mice causes inflammatory arthritis
Matrix Biol. 2023 Aug 18:S0945-053X(23)00090-2. doi: 10.1016/j.matbio.2023.08.003. Online ahead of print.ABSTRACTMembrane-type I metalloproteinase (MT1-MMP/MMP14) plays a key role in various pathophysiological processes, indicating an unaddressed need for a targeted therapeutic approach. However, mice genetically deficient in Mmp14 show severe defects in development and growth. To investigate the possibility of MT1-MMP inhibition as a safe treatment in adults, we generated global Mmp14 tamoxifen-induced conditional knockout (Mmp14kd) mice and found that MT1-MMP deficiency in adult mice resulted in severe inflammatory arthr...
Source: Matrix Biology - August 20, 2023 Category: Molecular Biology Authors: Xiao-Dan Xia Govind Gill Haiming Lin Daniela M Roth Hong-Mei Gu Xiang-Jiang Wang Feng-Yi Su Adekunle Alabi Maria Alexiou Ziyang Zhang Gui-Qing Wang Daniel Graf Da-Wei Zhang Source Type: research
Global, but not chondrocyte-specific, MT1-MMP deficiency in adult mice causes inflammatory arthritis
Matrix Biol. 2023 Aug 18:S0945-053X(23)00090-2. doi: 10.1016/j.matbio.2023.08.003. Online ahead of print.ABSTRACTMembrane-type I metalloproteinase (MT1-MMP/MMP14) plays a key role in various pathophysiological processes, indicating an unaddressed need for a targeted therapeutic approach. However, mice genetically deficient in Mmp14 show severe defects in development and growth. To investigate the possibility of MT1-MMP inhibition as a safe treatment in adults, we generated global Mmp14 tamoxifen-induced conditional knockout (Mmp14kd) mice and found that MT1-MMP deficiency in adult mice resulted in severe inflammatory arthr...
Source: Matrix Biology - August 20, 2023 Category: Molecular Biology Authors: Xiao-Dan Xia Govind Gill Haiming Lin Daniela M Roth Hong-Mei Gu Xiang-Jiang Wang Feng-Yi Su Adekunle Alabi Maria Alexiou Ziyang Zhang Gui-Qing Wang Daniel Graf Da-Wei Zhang Source Type: research
Global, but not chondrocyte-specific, MT1-MMP deficiency in adult mice causes inflammatory arthritis
Matrix Biol. 2023 Aug 18:S0945-053X(23)00090-2. doi: 10.1016/j.matbio.2023.08.003. Online ahead of print.ABSTRACTMembrane-type I metalloproteinase (MT1-MMP/MMP14) plays a key role in various pathophysiological processes, indicating an unaddressed need for a targeted therapeutic approach. However, mice genetically deficient in Mmp14 show severe defects in development and growth. To investigate the possibility of MT1-MMP inhibition as a safe treatment in adults, we generated global Mmp14 tamoxifen-induced conditional knockout (Mmp14kd) mice and found that MT1-MMP deficiency in adult mice resulted in severe inflammatory arthr...
Source: Matrix Biology - August 20, 2023 Category: Molecular Biology Authors: Xiao-Dan Xia Govind Gill Haiming Lin Daniela M Roth Hong-Mei Gu Xiang-Jiang Wang Feng-Yi Su Adekunle Alabi Maria Alexiou Ziyang Zhang Gui-Qing Wang Daniel Graf Da-Wei Zhang Source Type: research
Global, but not chondrocyte-specific, MT1-MMP deficiency in adult mice causes inflammatory arthritis
Matrix Biol. 2023 Aug 18:S0945-053X(23)00090-2. doi: 10.1016/j.matbio.2023.08.003. Online ahead of print.ABSTRACTMembrane-type I metalloproteinase (MT1-MMP/MMP14) plays a key role in various pathophysiological processes, indicating an unaddressed need for a targeted therapeutic approach. However, mice genetically deficient in Mmp14 show severe defects in development and growth. To investigate the possibility of MT1-MMP inhibition as a safe treatment in adults, we generated global Mmp14 tamoxifen-induced conditional knockout (Mmp14kd) mice and found that MT1-MMP deficiency in adult mice resulted in severe inflammatory arthr...
Source: Matrix Biology - August 20, 2023 Category: Molecular Biology Authors: Xiao-Dan Xia Govind Gill Haiming Lin Daniela M Roth Hong-Mei Gu Xiang-Jiang Wang Feng-Yi Su Adekunle Alabi Maria Alexiou Ziyang Zhang Gui-Qing Wang Daniel Graf Da-Wei Zhang Source Type: research
Global, but not chondrocyte-specific, MT1-MMP deficiency in adult mice causes inflammatory arthritis
Matrix Biol. 2023 Aug 18:S0945-053X(23)00090-2. doi: 10.1016/j.matbio.2023.08.003. Online ahead of print.ABSTRACTMembrane-type I metalloproteinase (MT1-MMP/MMP14) plays a key role in various pathophysiological processes, indicating an unaddressed need for a targeted therapeutic approach. However, mice genetically deficient in Mmp14 show severe defects in development and growth. To investigate the possibility of MT1-MMP inhibition as a safe treatment in adults, we generated global Mmp14 tamoxifen-induced conditional knockout (Mmp14kd) mice and found that MT1-MMP deficiency in adult mice resulted in severe inflammatory arthr...
Source: Matrix Biology - August 20, 2023 Category: Molecular Biology Authors: Xiao-Dan Xia Govind Gill Haiming Lin Daniela M Roth Hong-Mei Gu Xiang-Jiang Wang Feng-Yi Su Adekunle Alabi Maria Alexiou Ziyang Zhang Gui-Qing Wang Daniel Graf Da-Wei Zhang Source Type: research
Global, but not chondrocyte-specific, MT1-MMP deficiency in adult mice causes inflammatory arthritis
Matrix Biol. 2023 Aug 18:S0945-053X(23)00090-2. doi: 10.1016/j.matbio.2023.08.003. Online ahead of print.ABSTRACTMembrane-type I metalloproteinase (MT1-MMP/MMP14) plays a key role in various pathophysiological processes, indicating an unaddressed need for a targeted therapeutic approach. However, mice genetically deficient in Mmp14 show severe defects in development and growth. To investigate the possibility of MT1-MMP inhibition as a safe treatment in adults, we generated global Mmp14 tamoxifen-induced conditional knockout (Mmp14kd) mice and found that MT1-MMP deficiency in adult mice resulted in severe inflammatory arthr...
Source: Matrix Biology - August 20, 2023 Category: Molecular Biology Authors: Xiao-Dan Xia Govind Gill Haiming Lin Daniela M Roth Hong-Mei Gu Xiang-Jiang Wang Feng-Yi Su Adekunle Alabi Maria Alexiou Ziyang Zhang Gui-Qing Wang Daniel Graf Da-Wei Zhang Source Type: research
Global, but not chondrocyte-specific, MT1-MMP deficiency in adult mice causes inflammatory arthritis
Matrix Biol. 2023 Aug 18:S0945-053X(23)00090-2. doi: 10.1016/j.matbio.2023.08.003. Online ahead of print.ABSTRACTMembrane-type I metalloproteinase (MT1-MMP/MMP14) plays a key role in various pathophysiological processes, indicating an unaddressed need for a targeted therapeutic approach. However, mice genetically deficient in Mmp14 show severe defects in development and growth. To investigate the possibility of MT1-MMP inhibition as a safe treatment in adults, we generated global Mmp14 tamoxifen-induced conditional knockout (Mmp14kd) mice and found that MT1-MMP deficiency in adult mice resulted in severe inflammatory arthr...
Source: Matrix Biology - August 20, 2023 Category: Molecular Biology Authors: Xiao-Dan Xia Govind Gill Haiming Lin Daniela M Roth Hong-Mei Gu Xiang-Jiang Wang Feng-Yi Su Adekunle Alabi Maria Alexiou Ziyang Zhang Gui-Qing Wang Daniel Graf Da-Wei Zhang Source Type: research
Global, but not chondrocyte-specific, MT1-MMP deficiency in adult mice causes inflammatory arthritis
Matrix Biol. 2023 Aug 18:S0945-053X(23)00090-2. doi: 10.1016/j.matbio.2023.08.003. Online ahead of print.ABSTRACTMembrane-type I metalloproteinase (MT1-MMP/MMP14) plays a key role in various pathophysiological processes, indicating an unaddressed need for a targeted therapeutic approach. However, mice genetically deficient in Mmp14 show severe defects in development and growth. To investigate the possibility of MT1-MMP inhibition as a safe treatment in adults, we generated global Mmp14 tamoxifen-induced conditional knockout (Mmp14kd) mice and found that MT1-MMP deficiency in adult mice resulted in severe inflammatory arthr...
Source: Matrix Biology - August 20, 2023 Category: Molecular Biology Authors: Xiao-Dan Xia Govind Gill Haiming Lin Daniela M Roth Hong-Mei Gu Xiang-Jiang Wang Feng-Yi Su Adekunle Alabi Maria Alexiou Ziyang Zhang Gui-Qing Wang Daniel Graf Da-Wei Zhang Source Type: research
Emilin2 fosters vascular stability by promoting pericyte recruitment
In this study, we discovered that the extracellular matrix glycoprotein Elastin Microfibril Interfacer 2 (Emilin2) plays a prominent role in pericyte physiology. This work was originally prompted by the observations that tumor-associated vessels from Emilin2-/- mice display less pericyte coverage, impaired vascular perfusion, and reduced drug efficacy, suggesting that Emilin2 could promote vessel maturation and stabilization affecting pericyte recruitment. We found that Emilin2 affects different mechanisms engaged in pericyte recruitment and vascular stabilization. First, human primary endothelial cells challenged with rec...
Source: Matrix Biology - August 14, 2023 Category: Molecular Biology Authors: Albina Fejza Lucrezia Camicia Greta Carobolante Evelina Poletto Alice Paulitti Giorgia Schinello Emanuele Di Siena Renato Cannizzaro Renato V Iozzo Gustavo Baldassarre Eva Andreuzzi Paola Spessotto Maurizio Mongiat Source Type: research
Emilin2 fosters vascular stability by promoting pericyte recruitment
In this study, we discovered that the extracellular matrix glycoprotein Elastin Microfibril Interfacer 2 (Emilin2) plays a prominent role in pericyte physiology. This work was originally prompted by the observations that tumor-associated vessels from Emilin2-/- mice display less pericyte coverage, impaired vascular perfusion, and reduced drug efficacy, suggesting that Emilin2 could promote vessel maturation and stabilization affecting pericyte recruitment. We found that Emilin2 affects different mechanisms engaged in pericyte recruitment and vascular stabilization. First, human primary endothelial cells challenged with rec...
Source: Matrix Biology - August 14, 2023 Category: Molecular Biology Authors: Albina Fejza Lucrezia Camicia Greta Carobolante Evelina Poletto Alice Paulitti Giorgia Schinello Emanuele Di Siena Renato Cannizzaro Renato V Iozzo Gustavo Baldassarre Eva Andreuzzi Paola Spessotto Maurizio Mongiat Source Type: research
Emilin2 fosters vascular stability by promoting pericyte recruitment
In this study, we discovered that the extracellular matrix glycoprotein Elastin Microfibril Interfacer 2 (Emilin2) plays a prominent role in pericyte physiology. This work was originally prompted by the observations that tumor-associated vessels from Emilin2-/- mice display less pericyte coverage, impaired vascular perfusion, and reduced drug efficacy, suggesting that Emilin2 could promote vessel maturation and stabilization affecting pericyte recruitment. We found that Emilin2 affects different mechanisms engaged in pericyte recruitment and vascular stabilization. First, human primary endothelial cells challenged with rec...
Source: Matrix Biology - August 14, 2023 Category: Molecular Biology Authors: Albina Fejza Lucrezia Camicia Greta Carobolante Evelina Poletto Alice Paulitti Giorgia Schinello Emanuele Di Siena Renato Cannizzaro Renato V Iozzo Gustavo Baldassarre Eva Andreuzzi Paola Spessotto Maurizio Mongiat Source Type: research
