The clock transcription factor BMAL1 is a key regulator of extracellular matrix homeostasis and cell fate in the intervertebral disc
Matrix Biol. 2023 Jul 24:S0945-053X(23)00080-X. doi: 10.1016/j.matbio.2023.07.002. Online ahead of print.ABSTRACTThe circadian clock in mammals temporally coordinates physiological and behavioural processes to anticipate daily rhythmic changes in their environment. Chronic disruption to circadian rhythms (e.g., through ageing or shift work) is thought to contribute to a multitude of diseases, including degeneration of the musculoskeletal system. The intervertebral disc (IVD) in the spine contains circadian clocks which control ∼6% of the transcriptome in a rhythmic manner, including key genes involved in extracellular ma...
Source: Matrix Biology - July 26, 2023 Category: Molecular Biology Authors: Michal Dudek Honor Morris Natalie Rogers Dharshika Rj Pathiranage Sujitha Saba Raj Danny Chan Karl E Kadler Judith Hoyland Qing-Jun Meng Source Type: research
The clock transcription factor BMAL1 is a key regulator of extracellular matrix homeostasis and cell fate in the intervertebral disc
Matrix Biol. 2023 Jul 24:S0945-053X(23)00080-X. doi: 10.1016/j.matbio.2023.07.002. Online ahead of print.ABSTRACTThe circadian clock in mammals temporally coordinates physiological and behavioural processes to anticipate daily rhythmic changes in their environment. Chronic disruption to circadian rhythms (e.g., through ageing or shift work) is thought to contribute to a multitude of diseases, including degeneration of the musculoskeletal system. The intervertebral disc (IVD) in the spine contains circadian clocks which control ∼6% of the transcriptome in a rhythmic manner, including key genes involved in extracellular ma...
Source: Matrix Biology - July 26, 2023 Category: Molecular Biology Authors: Michal Dudek Honor Morris Natalie Rogers Dharshika Rj Pathiranage Sujitha Saba Raj Danny Chan Karl E Kadler Judith Hoyland Qing-Jun Meng Source Type: research
The clock transcription factor BMAL1 is a key regulator of extracellular matrix homeostasis and cell fate in the intervertebral disc
Matrix Biol. 2023 Jul 24:S0945-053X(23)00080-X. doi: 10.1016/j.matbio.2023.07.002. Online ahead of print.ABSTRACTThe circadian clock in mammals temporally coordinates physiological and behavioural processes to anticipate daily rhythmic changes in their environment. Chronic disruption to circadian rhythms (e.g., through ageing or shift work) is thought to contribute to a multitude of diseases, including degeneration of the musculoskeletal system. The intervertebral disc (IVD) in the spine contains circadian clocks which control ∼6% of the transcriptome in a rhythmic manner, including key genes involved in extracellular ma...
Source: Matrix Biology - July 26, 2023 Category: Molecular Biology Authors: Michal Dudek Honor Morris Natalie Rogers Dharshika Rj Pathiranage Sujitha Saba Raj Danny Chan Karl E Kadler Judith Hoyland Qing-Jun Meng Source Type: research
Peptide location fingerprinting identifies structural alterations within basement membrane components in ageing kidney
Matrix Biol. 2023 Jul 10:S0945-053X(23)00079-3. doi: 10.1016/j.matbio.2023.07.001. Online ahead of print.ABSTRACTDuring ageing, the glomerular and tubular basement membranes (BM) of the kidney undergo a progressive decline in function that is underpinned by histological changes, including glomerulosclerosis and tubular interstitial fibrosis and atrophy. This BM-specific ageing is thought to result from damage accumulation to long-lived extracellular matrix (ECM) protein structures. Determining which BM proteins are susceptible to these structure-associated changes, and the possible mechanisms and downstream consequences, i...
Source: Matrix Biology - July 12, 2023 Category: Molecular Biology Authors: Alexander Eckersley Mychel Rpt Morais Matiss Ozols Rachel Lennon Source Type: research
Peptide location fingerprinting identifies structural alterations within basement membrane components in ageing kidney
Matrix Biol. 2023 Jul 10:S0945-053X(23)00079-3. doi: 10.1016/j.matbio.2023.07.001. Online ahead of print.ABSTRACTDuring ageing, the glomerular and tubular basement membranes (BM) of the kidney undergo a progressive decline in function that is underpinned by histological changes, including glomerulosclerosis and tubular interstitial fibrosis and atrophy. This BM-specific ageing is thought to result from damage accumulation to long-lived extracellular matrix (ECM) protein structures. Determining which BM proteins are susceptible to these structure-associated changes, and the possible mechanisms and downstream consequences, i...
Source: Matrix Biology - July 12, 2023 Category: Molecular Biology Authors: Alexander Eckersley Mychel Rpt Morais Matiss Ozols Rachel Lennon Source Type: research
Peptide location fingerprinting identifies structural alterations within basement membrane components in ageing kidney
Matrix Biol. 2023 Jul 10:S0945-053X(23)00079-3. doi: 10.1016/j.matbio.2023.07.001. Online ahead of print.ABSTRACTDuring ageing, the glomerular and tubular basement membranes (BM) of the kidney undergo a progressive decline in function that is underpinned by histological changes, including glomerulosclerosis and tubular interstitial fibrosis and atrophy. This BM-specific ageing is thought to result from damage accumulation to long-lived extracellular matrix (ECM) protein structures. Determining which BM proteins are susceptible to these structure-associated changes, and the possible mechanisms and downstream consequences, i...
Source: Matrix Biology - July 12, 2023 Category: Molecular Biology Authors: Alexander Eckersley Mychel Rpt Morais Matiss Ozols Rachel Lennon Source Type: research
Peptide location fingerprinting identifies structural alterations within basement membrane components in ageing kidney
Matrix Biol. 2023 Jul 10:S0945-053X(23)00079-3. doi: 10.1016/j.matbio.2023.07.001. Online ahead of print.ABSTRACTDuring ageing, the glomerular and tubular basement membranes (BM) of the kidney undergo a progressive decline in function that is underpinned by histological changes, including glomerulosclerosis and tubular interstitial fibrosis and atrophy. This BM-specific ageing is thought to result from damage accumulation to long-lived extracellular matrix (ECM) protein structures. Determining which BM proteins are susceptible to these structure-associated changes, and the possible mechanisms and downstream consequences, i...
Source: Matrix Biology - July 12, 2023 Category: Molecular Biology Authors: Alexander Eckersley Mychel Rpt Morais Matiss Ozols Rachel Lennon Source Type: research
Peptide location fingerprinting identifies structural alterations within basement membrane components in ageing kidney
Matrix Biol. 2023 Jul 10:S0945-053X(23)00079-3. doi: 10.1016/j.matbio.2023.07.001. Online ahead of print.ABSTRACTDuring ageing, the glomerular and tubular basement membranes (BM) of the kidney undergo a progressive decline in function that is underpinned by histological changes, including glomerulosclerosis and tubular interstitial fibrosis and atrophy. This BM-specific ageing is thought to result from damage accumulation to long-lived extracellular matrix (ECM) protein structures. Determining which BM proteins are susceptible to these structure-associated changes, and the possible mechanisms and downstream consequences, i...
Source: Matrix Biology - July 12, 2023 Category: Molecular Biology Authors: Alexander Eckersley Mychel Rpt Morais Matiss Ozols Rachel Lennon Source Type: research
Peptide location fingerprinting identifies structural alterations within basement membrane components in ageing kidney
Matrix Biol. 2023 Jul 10:S0945-053X(23)00079-3. doi: 10.1016/j.matbio.2023.07.001. Online ahead of print.ABSTRACTDuring ageing, the glomerular and tubular basement membranes (BM) of the kidney undergo a progressive decline in function that is underpinned by histological changes, including glomerulosclerosis and tubular interstitial fibrosis and atrophy. This BM-specific ageing is thought to result from damage accumulation to long-lived extracellular matrix (ECM) protein structures. Determining which BM proteins are susceptible to these structure-associated changes, and the possible mechanisms and downstream consequences, i...
Source: Matrix Biology - July 12, 2023 Category: Molecular Biology Authors: Alexander Eckersley Mychel Rpt Morais Matiss Ozols Rachel Lennon Source Type: research
Peptide location fingerprinting identifies structural alterations within basement membrane components in ageing kidney
Matrix Biol. 2023 Jul 10:S0945-053X(23)00079-3. doi: 10.1016/j.matbio.2023.07.001. Online ahead of print.ABSTRACTDuring ageing, the glomerular and tubular basement membranes (BM) of the kidney undergo a progressive decline in function that is underpinned by histological changes, including glomerulosclerosis and tubular interstitial fibrosis and atrophy. This BM-specific ageing is thought to result from damage accumulation to long-lived extracellular matrix (ECM) protein structures. Determining which BM proteins are susceptible to these structure-associated changes, and the possible mechanisms and downstream consequences, i...
Source: Matrix Biology - July 12, 2023 Category: Molecular Biology Authors: Alexander Eckersley Mychel Rpt Morais Matiss Ozols Rachel Lennon Source Type: research
Peptide location fingerprinting identifies structural alterations within basement membrane components in ageing kidney
Matrix Biol. 2023 Jul 10:S0945-053X(23)00079-3. doi: 10.1016/j.matbio.2023.07.001. Online ahead of print.ABSTRACTDuring ageing, the glomerular and tubular basement membranes (BM) of the kidney undergo a progressive decline in function that is underpinned by histological changes, including glomerulosclerosis and tubular interstitial fibrosis and atrophy. This BM-specific ageing is thought to result from damage accumulation to long-lived extracellular matrix (ECM) protein structures. Determining which BM proteins are susceptible to these structure-associated changes, and the possible mechanisms and downstream consequences, i...
Source: Matrix Biology - July 12, 2023 Category: Molecular Biology Authors: Alexander Eckersley Mychel Rpt Morais Matiss Ozols Rachel Lennon Source Type: research
Peptide location fingerprinting identifies structural alterations within basement membrane components in ageing kidney
Matrix Biol. 2023 Jul 10:S0945-053X(23)00079-3. doi: 10.1016/j.matbio.2023.07.001. Online ahead of print.ABSTRACTDuring ageing, the glomerular and tubular basement membranes (BM) of the kidney undergo a progressive decline in function that is underpinned by histological changes, including glomerulosclerosis and tubular interstitial fibrosis and atrophy. This BM-specific ageing is thought to result from damage accumulation to long-lived extracellular matrix (ECM) protein structures. Determining which BM proteins are susceptible to these structure-associated changes, and the possible mechanisms and downstream consequences, i...
Source: Matrix Biology - July 12, 2023 Category: Molecular Biology Authors: Alexander Eckersley Mychel Rpt Morais Matiss Ozols Rachel Lennon Source Type: research
Peptide location fingerprinting identifies structural alterations within basement membrane components in ageing kidney
Matrix Biol. 2023 Jul 10:S0945-053X(23)00079-3. doi: 10.1016/j.matbio.2023.07.001. Online ahead of print.ABSTRACTDuring ageing, the glomerular and tubular basement membranes (BM) of the kidney undergo a progressive decline in function that is underpinned by histological changes, including glomerulosclerosis and tubular interstitial fibrosis and atrophy. This BM-specific ageing is thought to result from damage accumulation to long-lived extracellular matrix (ECM) protein structures. Determining which BM proteins are susceptible to these structure-associated changes, and the possible mechanisms and downstream consequences, i...
Source: Matrix Biology - July 12, 2023 Category: Molecular Biology Authors: Alexander Eckersley Mychel Rpt Morais Matiss Ozols Rachel Lennon Source Type: research
Peptide location fingerprinting identifies structural alterations within basement membrane components in ageing kidney
Matrix Biol. 2023 Jul 10:S0945-053X(23)00079-3. doi: 10.1016/j.matbio.2023.07.001. Online ahead of print.ABSTRACTDuring ageing, the glomerular and tubular basement membranes (BM) of the kidney undergo a progressive decline in function that is underpinned by histological changes, including glomerulosclerosis and tubular interstitial fibrosis and atrophy. This BM-specific ageing is thought to result from damage accumulation to long-lived extracellular matrix (ECM) protein structures. Determining which BM proteins are susceptible to these structure-associated changes, and the possible mechanisms and downstream consequences, i...
Source: Matrix Biology - July 12, 2023 Category: Molecular Biology Authors: Alexander Eckersley Mychel Rpt Morais Matiss Ozols Rachel Lennon Source Type: research
SEMA7a primes integrin α5β1 engagement instructing fibroblast mechanotransduction, phenotype and transcriptional programming
Matrix Biol. 2023 Jul 6:S0945-053X(23)00076-8. doi: 10.1016/j.matbio.2023.06.006. Online ahead of print.ABSTRACTIntegrins are cellular receptors that bind the extracellular matrix (ECM) and facilitate the transduction of biochemical and biophysical microenvironment cues into cellular responses. Upon engaging the ECM, integrin heterodimers must rapidly strengthen their binding with the ECM, resulting in the assembly of force-resistant and force-sensitive integrin associated complexes (IACs). The IACs constitute an essential apparatus for downstream signaling and fibroblast phenotypes. During wound healing, integrin signalin...
Source: Matrix Biology - July 8, 2023 Category: Molecular Biology Authors: Hu P Miller Ae Yeh Cr Bingham Gc Civelek M Barker Th Source Type: research
