A βPP-tau-HAS1 axis trigger HAS1-related nuclear speckles and gene transcription in Alzheimer's disease
Matrix Biol. 2024 Mar 20:S0945-053X(24)00039-8. doi: 10.1016/j.matbio.2024.03.003. Online ahead of print.ABSTRACTAs the backbone of the extracellular matrix (ECM) and the perineuronal nets, Hyaluronic acid (HA) provides binding sites for proteoglycans and other ECM components. Although the pivotal of HA has been recognized in Alzheimer's disease (AD), few studies have addressed the relationship between AD pathology and HA synthases (HASs). Here, HASs in different regions of AD brains were screened in transcriptomic databases and validated in AβPP/PS1 mice. We found that HAS1 was distributed along the axon and nucleus. Its...
Source: Matrix Biology - March 22, 2024 Category: Molecular Biology Authors: Ya-Hong Zhang Xing-Tong Sun Rui-Fang Guo Gang-Yi Feng Hui-Ling Gao Man-Li Zhong Li-Wen Tian Zhong-Yi Qiu Yu-Wei Cui Jia-Yi Li Pu Zhao Source Type: research
A βPP-tau-HAS1 axis trigger HAS1-related nuclear speckles and gene transcription in Alzheimer's disease
Matrix Biol. 2024 Mar 20:S0945-053X(24)00039-8. doi: 10.1016/j.matbio.2024.03.003. Online ahead of print.ABSTRACTAs the backbone of the extracellular matrix (ECM) and the perineuronal nets, Hyaluronic acid (HA) provides binding sites for proteoglycans and other ECM components. Although the pivotal of HA has been recognized in Alzheimer's disease (AD), few studies have addressed the relationship between AD pathology and HA synthases (HASs). Here, HASs in different regions of AD brains were screened in transcriptomic databases and validated in AβPP/PS1 mice. We found that HAS1 was distributed along the axon and nucleus. Its...
Source: Matrix Biology - March 22, 2024 Category: Molecular Biology Authors: Ya-Hong Zhang Xing-Tong Sun Rui-Fang Guo Gang-Yi Feng Hui-Ling Gao Man-Li Zhong Li-Wen Tian Zhong-Yi Qiu Yu-Wei Cui Jia-Yi Li Pu Zhao Source Type: research
A βPP-tau-HAS1 axis trigger HAS1-related nuclear speckles and gene transcription in Alzheimer's disease
Matrix Biol. 2024 Mar 20:S0945-053X(24)00039-8. doi: 10.1016/j.matbio.2024.03.003. Online ahead of print.ABSTRACTAs the backbone of the extracellular matrix (ECM) and the perineuronal nets, Hyaluronic acid (HA) provides binding sites for proteoglycans and other ECM components. Although the pivotal of HA has been recognized in Alzheimer's disease (AD), few studies have addressed the relationship between AD pathology and HA synthases (HASs). Here, HASs in different regions of AD brains were screened in transcriptomic databases and validated in AβPP/PS1 mice. We found that HAS1 was distributed along the axon and nucleus. Its...
Source: Matrix Biology - March 22, 2024 Category: Molecular Biology Authors: Ya-Hong Zhang Xing-Tong Sun Rui-Fang Guo Gang-Yi Feng Hui-Ling Gao Man-Li Zhong Li-Wen Tian Zhong-Yi Qiu Yu-Wei Cui Jia-Yi Li Pu Zhao Source Type: research
A βPP-tau-HAS1 axis trigger HAS1-related nuclear speckles and gene transcription in Alzheimer's disease
Matrix Biol. 2024 Mar 20:S0945-053X(24)00039-8. doi: 10.1016/j.matbio.2024.03.003. Online ahead of print.ABSTRACTAs the backbone of the extracellular matrix (ECM) and the perineuronal nets, Hyaluronic acid (HA) provides binding sites for proteoglycans and other ECM components. Although the pivotal of HA has been recognized in Alzheimer's disease (AD), few studies have addressed the relationship between AD pathology and HA synthases (HASs). Here, HASs in different regions of AD brains were screened in transcriptomic databases and validated in AβPP/PS1 mice. We found that HAS1 was distributed along the axon and nucleus. Its...
Source: Matrix Biology - March 22, 2024 Category: Molecular Biology Authors: Ya-Hong Zhang Xing-Tong Sun Rui-Fang Guo Gang-Yi Feng Hui-Ling Gao Man-Li Zhong Li-Wen Tian Zhong-Yi Qiu Yu-Wei Cui Jia-Yi Li Pu Zhao Source Type: research
A βPP-tau-HAS1 axis trigger HAS1-related nuclear speckles and gene transcription in Alzheimer's disease
Matrix Biol. 2024 Mar 20:S0945-053X(24)00039-8. doi: 10.1016/j.matbio.2024.03.003. Online ahead of print.ABSTRACTAs the backbone of the extracellular matrix (ECM) and the perineuronal nets, Hyaluronic acid (HA) provides binding sites for proteoglycans and other ECM components. Although the pivotal of HA has been recognized in Alzheimer's disease (AD), few studies have addressed the relationship between AD pathology and HA synthases (HASs). Here, HASs in different regions of AD brains were screened in transcriptomic databases and validated in AβPP/PS1 mice. We found that HAS1 was distributed along the axon and nucleus. Its...
Source: Matrix Biology - March 22, 2024 Category: Molecular Biology Authors: Ya-Hong Zhang Xing-Tong Sun Rui-Fang Guo Gang-Yi Feng Hui-Ling Gao Man-Li Zhong Li-Wen Tian Zhong-Yi Qiu Yu-Wei Cui Jia-Yi Li Pu Zhao Source Type: research
Hyaluronan degradation by HYAL2 is essential for odontoblastic differentiation and migration of mouse dental papilla cells
Matrix Biol. 2024 Mar 13:S0945-053X(24)00038-6. doi: 10.1016/j.matbio.2024.03.002. Online ahead of print.ABSTRACTThe coordination between odontoblastic differentiation and directed cell migration of mesenchymal progenitors is necessary for regular dentin formation. The synthesis and degradation of hyaluronan (HA) in the extracellular matrix create a permissive niche that directly regulates cell behaviors. However, the role and mechanisms of HA degradation in dentin formation remain unknown. In this work, we present that HA digestion promotes odontoblastic differentiation and cell migration of mouse dental papilla cells (mD...
Source: Matrix Biology - March 15, 2024 Category: Molecular Biology Authors: Haiyan Huang Xiaoyu Hu Jiayan Wu Chenyu Song Zhixin Tian Beizhan Jiang Source Type: research
Hyaluronan degradation by HYAL2 is essential for odontoblastic differentiation and migration of mouse dental papilla cells
Matrix Biol. 2024 Mar 13:S0945-053X(24)00038-6. doi: 10.1016/j.matbio.2024.03.002. Online ahead of print.ABSTRACTThe coordination between odontoblastic differentiation and directed cell migration of mesenchymal progenitors is necessary for regular dentin formation. The synthesis and degradation of hyaluronan (HA) in the extracellular matrix create a permissive niche that directly regulates cell behaviors. However, the role and mechanisms of HA degradation in dentin formation remain unknown. In this work, we present that HA digestion promotes odontoblastic differentiation and cell migration of mouse dental papilla cells (mD...
Source: Matrix Biology - March 15, 2024 Category: Molecular Biology Authors: Haiyan Huang Xiaoyu Hu Jiayan Wu Chenyu Song Zhixin Tian Beizhan Jiang Source Type: research
Hyaluronan degradation by HYAL2 is essential for odontoblastic differentiation and migration of mouse dental papilla cells
Matrix Biol. 2024 Mar 13:S0945-053X(24)00038-6. doi: 10.1016/j.matbio.2024.03.002. Online ahead of print.ABSTRACTThe coordination between odontoblastic differentiation and directed cell migration of mesenchymal progenitors is necessary for regular dentin formation. The synthesis and degradation of hyaluronan (HA) in the extracellular matrix create a permissive niche that directly regulates cell behaviors. However, the role and mechanisms of HA degradation in dentin formation remain unknown. In this work, we present that HA digestion promotes odontoblastic differentiation and cell migration of mouse dental papilla cells (mD...
Source: Matrix Biology - March 15, 2024 Category: Molecular Biology Authors: Haiyan Huang Xiaoyu Hu Jiayan Wu Chenyu Song Zhixin Tian Beizhan Jiang Source Type: research
Hyaluronan degradation by HYAL2 is essential for odontoblastic differentiation and migration of mouse dental papilla cells
Matrix Biol. 2024 Mar 13:S0945-053X(24)00038-6. doi: 10.1016/j.matbio.2024.03.002. Online ahead of print.ABSTRACTThe coordination between odontoblastic differentiation and directed cell migration of mesenchymal progenitors is necessary for regular dentin formation. The synthesis and degradation of hyaluronan (HA) in the extracellular matrix create a permissive niche that directly regulates cell behaviors. However, the role and mechanisms of HA degradation in dentin formation remain unknown. In this work, we present that HA digestion promotes odontoblastic differentiation and cell migration of mouse dental papilla cells (mD...
Source: Matrix Biology - March 15, 2024 Category: Molecular Biology Authors: Haiyan Huang Xiaoyu Hu Jiayan Wu Chenyu Song Zhixin Tian Beizhan Jiang Source Type: research
Hyaluronan degradation by HYAL2 is essential for odontoblastic differentiation and migration of mouse dental papilla cells
Matrix Biol. 2024 Mar 13:S0945-053X(24)00038-6. doi: 10.1016/j.matbio.2024.03.002. Online ahead of print.ABSTRACTThe coordination between odontoblastic differentiation and directed cell migration of mesenchymal progenitors is necessary for regular dentin formation. The synthesis and degradation of hyaluronan (HA) in the extracellular matrix create a permissive niche that directly regulates cell behaviors. However, the role and mechanisms of HA degradation in dentin formation remain unknown. In this work, we present that HA digestion promotes odontoblastic differentiation and cell migration of mouse dental papilla cells (mD...
Source: Matrix Biology - March 15, 2024 Category: Molecular Biology Authors: Haiyan Huang Xiaoyu Hu Jiayan Wu Chenyu Song Zhixin Tian Beizhan Jiang Source Type: research
Hyaluronan degradation by HYAL2 is essential for odontoblastic differentiation and migration of mouse dental papilla cells
Matrix Biol. 2024 Mar 13:S0945-053X(24)00038-6. doi: 10.1016/j.matbio.2024.03.002. Online ahead of print.ABSTRACTThe coordination between odontoblastic differentiation and directed cell migration of mesenchymal progenitors is necessary for regular dentin formation. The synthesis and degradation of hyaluronan (HA) in the extracellular matrix create a permissive niche that directly regulates cell behaviors. However, the role and mechanisms of HA degradation in dentin formation remain unknown. In this work, we present that HA digestion promotes odontoblastic differentiation and cell migration of mouse dental papilla cells (mD...
Source: Matrix Biology - March 15, 2024 Category: Molecular Biology Authors: Haiyan Huang Xiaoyu Hu Jiayan Wu Chenyu Song Zhixin Tian Beizhan Jiang Source Type: research
Macrophage phenotype is determinant for fibrosis development in keloid disease
Matrix Biol. 2024 Mar 12:S0945-053X(24)00037-4. doi: 10.1016/j.matbio.2024.03.001. Online ahead of print.ABSTRACTKeloid refers to a fibroproliferative disorder characterized by an accumulation of extracellular matrix (ECM) components at the dermis level, overgrowth beyond initial wound, and formation of tumor-like nodule areas. Treating keloid is still an unmet clinical need and the lack of an efficient therapy is clearly related to limited knowledge about keloid etiology, despite the growing interest of the scientific community in this pathology. In past decades, keloids were often studied in vitro through the sole prism ...
Source: Matrix Biology - March 14, 2024 Category: Molecular Biology Authors: Z élie Dirand M élissa Maraux Marion Tissot Brice Chatelain Dorothy Supp C éline Viennet Sylvain Perruche Gwena ël Rolin Source Type: research
Macrophage phenotype is determinant for fibrosis development in keloid disease
Matrix Biol. 2024 Mar 12:S0945-053X(24)00037-4. doi: 10.1016/j.matbio.2024.03.001. Online ahead of print.ABSTRACTKeloid refers to a fibroproliferative disorder characterized by an accumulation of extracellular matrix (ECM) components at the dermis level, overgrowth beyond initial wound, and formation of tumor-like nodule areas. Treating keloid is still an unmet clinical need and the lack of an efficient therapy is clearly related to limited knowledge about keloid etiology, despite the growing interest of the scientific community in this pathology. In past decades, keloids were often studied in vitro through the sole prism ...
Source: Matrix Biology - March 14, 2024 Category: Molecular Biology Authors: Z élie Dirand M élissa Maraux Marion Tissot Brice Chatelain Dorothy Supp C éline Viennet Sylvain Perruche Gwena ël Rolin Source Type: research
The role of fibrosis in cardiomyopathies: an opportunity to develop novel biomarkers of disease activity
Matrix Biol. 2024 Feb 27:S0945-053X(24)00035-0. doi: 10.1016/j.matbio.2024.02.008. Online ahead of print.ABSTRACTCardiomyopathies encompass a spectrum of heart disorders with diverse causes and presentations. Fibrosis stands out as a shared hallmark among various cardiomyopathies, reflecting a common thread in their pathogenesis. This prevalent fibrotic response is intricately linked to the consequences of dysregulated extracellular matrix (ECM) remodeling, emphasizing its significance in the development and progression the disease. This review explores the ECM involvement in various cardiomyopathies and its impact on myoc...
Source: Matrix Biology - February 29, 2024 Category: Molecular Biology Authors: Elisavet Angeli Maria Jordan Mandy Otto Stevan D Stojanovi ć Morten Karsdal Johann Bauersachs Thomas Thum Jan Fiedler Federica Genovese Source Type: research
The Role of Positional Information in Determining Dermal Fibroblast Diversity
Matrix Biol. 2024 Feb 27:S0945-053X(24)00036-2. doi: 10.1016/j.matbio.2024.02.009. Online ahead of print.ABSTRACTThe largest mammalian organ, skin, consisting of a dermal connective tissue layer that underlies and supports the epidermis, acts as a protective barrier that excludes external pathogens and disseminates sensory signals emanating from the local microenvironment. Dermal connective tissue is comprised of a collagen-rich extracellular matrix (ECM) that is produced by connective tissue fibroblasts resident within the dermis. When wounded, a tissue repair program is induced whereby fibroblasts, in response to alterat...
Source: Matrix Biology - February 29, 2024 Category: Molecular Biology Authors: Pratyusha Chitturi Andrew Leask Source Type: research
