Absence of TRIC-B from type XIV Osteogenesis Imperfecta osteoblasts alters cell adhesion and mitochondrial function - A multi-omics study
Matrix Biol. 2023 Jun 20:S0945-053X(23)00075-6. doi: 10.1016/j.matbio.2023.06.004. Online ahead of print.ABSTRACTOsteogenesis Imperfecta (OI) is a heritable collagen-related bone dysplasia characterized by bone fractures, growth deficiency and skeletal deformity. Type XIV OI is a recessive OI form caused by null mutations in TMEM38B, which encodes the ER membrane intracellular cation channel TRIC-B. Previously, we showed that absence of TMEM38B alters calcium flux in the ER of OI patient osteoblasts and fibroblasts, which further disrupts collagen synthesis and secretion. How the absence of TMEM38B affects osteoblast funct...
Source: Matrix Biology - June 22, 2023 Category: Molecular Biology Authors: Milena Jovanovic Apratim Mitra Roberta Besio Barbara Maria Contento Ka Wai Wong Alberta Derkyi Michael To Antonella Forlino Ryan K Dale Joan C Marini Source Type: research
Absence of TRIC-B from type XIV Osteogenesis Imperfecta osteoblasts alters cell adhesion and mitochondrial function - A multi-omics study
Matrix Biol. 2023 Jun 20:S0945-053X(23)00075-6. doi: 10.1016/j.matbio.2023.06.004. Online ahead of print.ABSTRACTOsteogenesis Imperfecta (OI) is a heritable collagen-related bone dysplasia characterized by bone fractures, growth deficiency and skeletal deformity. Type XIV OI is a recessive OI form caused by null mutations in TMEM38B, which encodes the ER membrane intracellular cation channel TRIC-B. Previously, we showed that absence of TMEM38B alters calcium flux in the ER of OI patient osteoblasts and fibroblasts, which further disrupts collagen synthesis and secretion. How the absence of TMEM38B affects osteoblast funct...
Source: Matrix Biology - June 22, 2023 Category: Molecular Biology Authors: Milena Jovanovic Apratim Mitra Roberta Besio Barbara Maria Contento Ka Wai Wong Alberta Derkyi Michael To Antonella Forlino Ryan K Dale Joan C Marini Source Type: research
Absence of TRIC-B from type XIV Osteogenesis Imperfecta osteoblasts alters cell adhesion and mitochondrial function - A multi-omics study
Matrix Biol. 2023 Jun 20:S0945-053X(23)00075-6. doi: 10.1016/j.matbio.2023.06.004. Online ahead of print.ABSTRACTOsteogenesis Imperfecta (OI) is a heritable collagen-related bone dysplasia characterized by bone fractures, growth deficiency and skeletal deformity. Type XIV OI is a recessive OI form caused by null mutations in TMEM38B, which encodes the ER membrane intracellular cation channel TRIC-B. Previously, we showed that absence of TMEM38B alters calcium flux in the ER of OI patient osteoblasts and fibroblasts, which further disrupts collagen synthesis and secretion. How the absence of TMEM38B affects osteoblast funct...
Source: Matrix Biology - June 22, 2023 Category: Molecular Biology Authors: Milena Jovanovic Apratim Mitra Roberta Besio Barbara Maria Contento Ka Wai Wong Alberta Derkyi Michael To Antonella Forlino Ryan K Dale Joan C Marini Source Type: research
ADAMTS3 restricts cancer invasion in models of early breast cancer progression through enhanced fibronectin degradation
Matrix Biol. 2023 Jun 17:S0945-053X(23)00074-4. doi: 10.1016/j.matbio.2023.06.005. Online ahead of print.ABSTRACTProteases have long been associated with cancer progression, due to their ability to facilitate invasion upon matrix remodelling. However, proteases are not simply degraders of the matrix, but also play fundamental roles in modulating cellular behaviour through the proteolytic processing of specific substrates. Indeed, proteases can elicit both pro- and anti- tumorigenic effects depending on context. Using a heterocellular spheroid model of breast cancer progression, we demonstrate the repressive function of myo...
Source: Matrix Biology - June 19, 2023 Category: Molecular Biology Authors: Shayin V Gibson Elizabeta Madzharova Amandine C Tan Michael D Allen Ulrich Auf dem Keller J Louise Jones Edward P Carter Richard P Grose Source Type: research
Cell differentiation and matrix organization are differentially affected during bone formation in osteogenesis imperfecta zebrafish models with different genetic defects impacting collagen type I structure
Matrix Biol. 2023 Jun 17:S0945-053X(23)00073-2. doi: 10.1016/j.matbio.2023.06.003. Online ahead of print.ABSTRACTOsteogenesis imperfecta (OI) is a family of rare heritable skeletal disorders associated with dominant mutations in the collagen type I encoding genes and recessive defects in proteins involved in collagen type I synthesis and processing and in osteoblast differentiation and activity. Historically, it was believed that the OI bone phenotype was only caused by abnormal collagen type I fibrils in the extracellular matrix, but more recently it became clear that the altered bone cell homeostasis, due to mutant colla...
Source: Matrix Biology - June 19, 2023 Category: Molecular Biology Authors: Valentina Daponte Francesca Tonelli Cecilia Masiero Delfien Syx Chlo é Exbrayat-Héritier Marco Biggiogera Andy Willaert Antonio Rossi Paul J Coucke Florence Ruggiero Antonella Forlino Source Type: research
ADAMTS3 restricts cancer invasion in models of early breast cancer progression through enhanced fibronectin degradation
Matrix Biol. 2023 Jun 17:S0945-053X(23)00074-4. doi: 10.1016/j.matbio.2023.06.005. Online ahead of print.ABSTRACTProteases have long been associated with cancer progression, due to their ability to facilitate invasion upon matrix remodelling. However, proteases are not simply degraders of the matrix, but also play fundamental roles in modulating cellular behaviour through the proteolytic processing of specific substrates. Indeed, proteases can elicit both pro- and anti- tumorigenic effects depending on context. Using a heterocellular spheroid model of breast cancer progression, we demonstrate the repressive function of myo...
Source: Matrix Biology - June 19, 2023 Category: Molecular Biology Authors: Shayin V Gibson Elizabeta Madzharova Amandine C Tan Michael D Allen Ulrich Auf dem Keller J Louise Jones Edward P Carter Richard P Grose Source Type: research
Cell differentiation and matrix organization are differentially affected during bone formation in osteogenesis imperfecta zebrafish models with different genetic defects impacting collagen type I structure
Matrix Biol. 2023 Jun 17:S0945-053X(23)00073-2. doi: 10.1016/j.matbio.2023.06.003. Online ahead of print.ABSTRACTOsteogenesis imperfecta (OI) is a family of rare heritable skeletal disorders associated with dominant mutations in the collagen type I encoding genes and recessive defects in proteins involved in collagen type I synthesis and processing and in osteoblast differentiation and activity. Historically, it was believed that the OI bone phenotype was only caused by abnormal collagen type I fibrils in the extracellular matrix, but more recently it became clear that the altered bone cell homeostasis, due to mutant colla...
Source: Matrix Biology - June 19, 2023 Category: Molecular Biology Authors: Valentina Daponte Francesca Tonelli Cecilia Masiero Delfien Syx Chlo é Exbrayat-Héritier Marco Biggiogera Andy Willaert Antonio Rossi Paul J Coucke Florence Ruggiero Antonella Forlino Source Type: research
ADAMTS3 restricts cancer invasion in models of early breast cancer progression through enhanced fibronectin degradation
Matrix Biol. 2023 Jun 17:S0945-053X(23)00074-4. doi: 10.1016/j.matbio.2023.06.005. Online ahead of print.ABSTRACTProteases have long been associated with cancer progression, due to their ability to facilitate invasion upon matrix remodelling. However, proteases are not simply degraders of the matrix, but also play fundamental roles in modulating cellular behaviour through the proteolytic processing of specific substrates. Indeed, proteases can elicit both pro- and anti- tumorigenic effects depending on context. Using a heterocellular spheroid model of breast cancer progression, we demonstrate the repressive function of myo...
Source: Matrix Biology - June 19, 2023 Category: Molecular Biology Authors: Shayin V Gibson Elizabeta Madzharova Amandine C Tan Michael D Allen Ulrich Auf dem Keller J Louise Jones Edward P Carter Richard P Grose Source Type: research
Cell differentiation and matrix organization are differentially affected during bone formation in osteogenesis imperfecta zebrafish models with different genetic defects impacting collagen type I structure
Matrix Biol. 2023 Jun 17:S0945-053X(23)00073-2. doi: 10.1016/j.matbio.2023.06.003. Online ahead of print.ABSTRACTOsteogenesis imperfecta (OI) is a family of rare heritable skeletal disorders associated with dominant mutations in the collagen type I encoding genes and recessive defects in proteins involved in collagen type I synthesis and processing and in osteoblast differentiation and activity. Historically, it was believed that the OI bone phenotype was only caused by abnormal collagen type I fibrils in the extracellular matrix, but more recently it became clear that the altered bone cell homeostasis, due to mutant colla...
Source: Matrix Biology - June 19, 2023 Category: Molecular Biology Authors: Valentina Daponte Francesca Tonelli Cecilia Masiero Delfien Syx Chlo é Exbrayat-Héritier Marco Biggiogera Andy Willaert Antonio Rossi Paul J Coucke Florence Ruggiero Antonella Forlino Source Type: research
Collagen VI Deposition Mediates Stromal T cell Trapping through Inhibition of T cell motility in the Prostate Tumor Microenvironment
Matrix Biol. 2023 Jun 16:S0945-053X(23)00072-0. doi: 10.1016/j.matbio.2023.06.002. Online ahead of print.ABSTRACTThe tumor extracellular matrix (ECM) is a barrier to anti-tumor immunity in solid tumors by disrupting T cell-tumor cell interaction underlying the need for elucidating mechanisms by which specific ECM proteins impact T cell motility and activity within the desmoplastic stroma of solid tumors. Here, we show that Collagen VI (Col VI) deposition correlates with stromal T cell density in human prostate cancer specimens. Furthermore, motility of CD4+ T cells is completely ablated on purified Col VI surfaces when com...
Source: Matrix Biology - June 18, 2023 Category: Molecular Biology Authors: Hawley C Pruitt Ya Guan Hudson Liu Alexis E Carey W Nathaniel Brennen Jiayun Lu Corrine Joshu Ashani Weeraratna Tamara L Lotan T S Karin Eisinger-Mathason Sharon Gerecht Source Type: research
Endothelial basement membrane laminins - new players in mouse and human myoendothelial junctions and shear stress communication
Matrix Biol. 2023 Jun 11:S0945-053X(23)00071-9. doi: 10.1016/j.matbio.2023.06.001. Online ahead of print.ABSTRACTBasement membranes (BMs) are critical but frequently ignored components of the vascular system. Using high-resolution confocal imaging of whole-mount-stained mesenteric arteries, we identify integrins, vinculin, focal adhesion kinase (FAK) and several BM proteins including laminins as novel components of myoendothelial junctions (MEJs), anatomical microdomains that are emerging as regulators of cross-talk between endothelium and smooth muscle cells (SMCs). Electron microscopy revealed multiple layers of the endo...
Source: Matrix Biology - June 13, 2023 Category: Molecular Biology Authors: Anna-Liisa Luik Melanie-Jane Hannocks Sophie Loismann Kishan Kapupara Manuela Cerina Miesje van der Stoel Yaroslav Tsytsyura Nataliya Glyvuk Caroline Nordenvall J ürgen Klingauf Stephan Huveneers Sven Meuth Lars Jakobsson Lydia Sorokin Source Type: research
Endothelial basement membrane laminins - new players in mouse and human myoendothelial junctions and shear stress communication
Matrix Biol. 2023 Jun 11:S0945-053X(23)00071-9. doi: 10.1016/j.matbio.2023.06.001. Online ahead of print.ABSTRACTBasement membranes (BMs) are critical but frequently ignored components of the vascular system. Using high-resolution confocal imaging of whole-mount-stained mesenteric arteries, we identify integrins, vinculin, focal adhesion kinase (FAK) and several BM proteins including laminins as novel components of myoendothelial junctions (MEJs), anatomical microdomains that are emerging as regulators of cross-talk between endothelium and smooth muscle cells (SMCs). Electron microscopy revealed multiple layers of the endo...
Source: Matrix Biology - June 13, 2023 Category: Molecular Biology Authors: Anna-Liisa Luik Melanie-Jane Hannocks Sophie Loismann Kishan Kapupara Manuela Cerina Miesje van der Stoel Yaroslav Tsytsyura Nataliya Glyvuk Caroline Nordenvall J ürgen Klingauf Stephan Huveneers Sven Meuth Lars Jakobsson Lydia Sorokin Source Type: research
Endothelial basement membrane laminins - new players in mouse and human myoendothelial junctions and shear stress communication
Matrix Biol. 2023 Jun 11:S0945-053X(23)00071-9. doi: 10.1016/j.matbio.2023.06.001. Online ahead of print.ABSTRACTBasement membranes (BMs) are critical but frequently ignored components of the vascular system. Using high-resolution confocal imaging of whole-mount-stained mesenteric arteries, we identify integrins, vinculin, focal adhesion kinase (FAK) and several BM proteins including laminins as novel components of myoendothelial junctions (MEJs), anatomical microdomains that are emerging as regulators of cross-talk between endothelium and smooth muscle cells (SMCs). Electron microscopy revealed multiple layers of the endo...
Source: Matrix Biology - June 13, 2023 Category: Molecular Biology Authors: Anna-Liisa Luik Melanie-Jane Hannocks Sophie Loismann Kishan Kapupara Manuela Cerina Miesje van der Stoel Yaroslav Tsytsyura Nataliya Glyvuk Caroline Nordenvall J ürgen Klingauf Stephan Huveneers Sven Meuth Lars Jakobsson Lydia Sorokin Source Type: research
Endothelial basement membrane laminins - new players in mouse and human myoendothelial junctions and shear stress communication
Matrix Biol. 2023 Jun 11:S0945-053X(23)00071-9. doi: 10.1016/j.matbio.2023.06.001. Online ahead of print.ABSTRACTBasement membranes (BMs) are critical but frequently ignored components of the vascular system. Using high-resolution confocal imaging of whole-mount-stained mesenteric arteries, we identify integrins, vinculin, focal adhesion kinase (FAK) and several BM proteins including laminins as novel components of myoendothelial junctions (MEJs), anatomical microdomains that are emerging as regulators of cross-talk between endothelium and smooth muscle cells (SMCs). Electron microscopy revealed multiple layers of the endo...
Source: Matrix Biology - June 13, 2023 Category: Molecular Biology Authors: Anna-Liisa Luik Melanie-Jane Hannocks Sophie Loismann Kishan Kapupara Manuela Cerina Miesje van der Stoel Yaroslav Tsytsyura Nataliya Glyvuk Caroline Nordenvall J ürgen Klingauf Stephan Huveneers Sven Meuth Lars Jakobsson Lydia Sorokin Source Type: research
Endothelial basement membrane laminins - new players in mouse and human myoendothelial junctions and shear stress communication
Matrix Biol. 2023 Jun 11:S0945-053X(23)00071-9. doi: 10.1016/j.matbio.2023.06.001. Online ahead of print.ABSTRACTBasement membranes (BMs) are critical but frequently ignored components of the vascular system. Using high-resolution confocal imaging of whole-mount-stained mesenteric arteries, we identify integrins, vinculin, focal adhesion kinase (FAK) and several BM proteins including laminins as novel components of myoendothelial junctions (MEJs), anatomical microdomains that are emerging as regulators of cross-talk between endothelium and smooth muscle cells (SMCs). Electron microscopy revealed multiple layers of the endo...
Source: Matrix Biology - June 13, 2023 Category: Molecular Biology Authors: Anna-Liisa Luik Melanie-Jane Hannocks Sophie Loismann Kishan Kapupara Manuela Cerina Miesje van der Stoel Yaroslav Tsytsyura Nataliya Glyvuk Caroline Nordenvall J ürgen Klingauf Stephan Huveneers Sven Meuth Lars Jakobsson Lydia Sorokin Source Type: research
