The role of fibrosis in cardiomyopathies: an opportunity to develop novel biomarkers of disease activity
Matrix Biol. 2024 Feb 27:S0945-053X(24)00035-0. doi: 10.1016/j.matbio.2024.02.008. Online ahead of print.ABSTRACTCardiomyopathies encompass a spectrum of heart disorders with diverse causes and presentations. Fibrosis stands out as a shared hallmark among various cardiomyopathies, reflecting a common thread in their pathogenesis. This prevalent fibrotic response is intricately linked to the consequences of dysregulated extracellular matrix (ECM) remodeling, emphasizing its significance in the development and progression the disease. This review explores the ECM involvement in various cardiomyopathies and its impact on myoc...
Source: Matrix Biology - February 29, 2024 Category: Molecular Biology Authors: Elisavet Angeli Maria Jordan Mandy Otto Stevan D Stojanovi ć Morten Karsdal Johann Bauersachs Thomas Thum Jan Fiedler Federica Genovese Source Type: research
The Role of Positional Information in Determining Dermal Fibroblast Diversity
Matrix Biol. 2024 Feb 27:S0945-053X(24)00036-2. doi: 10.1016/j.matbio.2024.02.009. Online ahead of print.ABSTRACTThe largest mammalian organ, skin, consisting of a dermal connective tissue layer that underlies and supports the epidermis, acts as a protective barrier that excludes external pathogens and disseminates sensory signals emanating from the local microenvironment. Dermal connective tissue is comprised of a collagen-rich extracellular matrix (ECM) that is produced by connective tissue fibroblasts resident within the dermis. When wounded, a tissue repair program is induced whereby fibroblasts, in response to alterat...
Source: Matrix Biology - February 29, 2024 Category: Molecular Biology Authors: Pratyusha Chitturi Andrew Leask Source Type: research
Microvascular damage, neuroinflammation and extracellular matrix remodeling in Col18a1 knockout mice as a model for early cerebral small vessel disease
Matrix Biol. 2024 Feb 20:S0945-053X(24)00026-X. doi: 10.1016/j.matbio.2024.02.007. Online ahead of print.ABSTRACTCollagen type XVIII (COL18) is an abundant heparan sulfate proteoglycan in vascular basement membranes. Here, we asked (i) if the loss of COL18 would result in blood-brain barrier (BBB) breakdown, pathological alterations of small arteries and capillaries and neuroinflammation as found in cerebral small vessel disease (CSVD) and (ii) if such changes may be associated with remodeling of synapses and neural extracellular matrix (ECM). We found that 5-month-old Col18a1-/- mice had elevated BBB permeability for mous...
Source: Matrix Biology - February 22, 2024 Category: Molecular Biology Authors: Mahsima Khoshneviszadeh Solveig Henneicke Daniel Pirici Akilashree Senthilnathan Lorena Morton Philipp Arndt Rahul Kaushik Oula Norman Jari Jukkola Ildiko Rita Dunay Constanze Seidenbecher Anne Heikkinen Stefanie Schreiber Alexander Dityatev Source Type: research
Microvascular damage, neuroinflammation and extracellular matrix remodeling in Col18a1 knockout mice as a model for early cerebral small vessel disease
Matrix Biol. 2024 Feb 20:S0945-053X(24)00026-X. doi: 10.1016/j.matbio.2024.02.007. Online ahead of print.ABSTRACTCollagen type XVIII (COL18) is an abundant heparan sulfate proteoglycan in vascular basement membranes. Here, we asked (i) if the loss of COL18 would result in blood-brain barrier (BBB) breakdown, pathological alterations of small arteries and capillaries and neuroinflammation as found in cerebral small vessel disease (CSVD) and (ii) if such changes may be associated with remodeling of synapses and neural extracellular matrix (ECM). We found that 5-month-old Col18a1-/- mice had elevated BBB permeability for mous...
Source: Matrix Biology - February 22, 2024 Category: Molecular Biology Authors: Mahsima Khoshneviszadeh Solveig Henneicke Daniel Pirici Akilashree Senthilnathan Lorena Morton Philipp Arndt Rahul Kaushik Oula Norman Jari Jukkola Ildiko Rita Dunay Constanze Seidenbecher Anne Heikkinen Stefanie Schreiber Alexander Dityatev Source Type: research
Microvascular damage, neuroinflammation and extracellular matrix remodeling in Col18a1 knockout mice as a model for early cerebral small vessel disease
Matrix Biol. 2024 Feb 20:S0945-053X(24)00026-X. doi: 10.1016/j.matbio.2024.02.007. Online ahead of print.ABSTRACTCollagen type XVIII (COL18) is an abundant heparan sulfate proteoglycan in vascular basement membranes. Here, we asked (i) if the loss of COL18 would result in blood-brain barrier (BBB) breakdown, pathological alterations of small arteries and capillaries and neuroinflammation as found in cerebral small vessel disease (CSVD) and (ii) if such changes may be associated with remodeling of synapses and neural extracellular matrix (ECM). We found that 5-month-old Col18a1-/- mice had elevated BBB permeability for mous...
Source: Matrix Biology - February 22, 2024 Category: Molecular Biology Authors: Mahsima Khoshneviszadeh Solveig Henneicke Daniel Pirici Akilashree Senthilnathan Lorena Morton Philipp Arndt Rahul Kaushik Oula Norman Jari Jukkola Ildiko Rita Dunay Constanze Seidenbecher Anne Heikkinen Stefanie Schreiber Alexander Dityatev Source Type: research
Microvascular damage, neuroinflammation and extracellular matrix remodeling in Col18a1 knockout mice as a model for early cerebral small vessel disease
Matrix Biol. 2024 Feb 20:S0945-053X(24)00026-X. doi: 10.1016/j.matbio.2024.02.007. Online ahead of print.ABSTRACTCollagen type XVIII (COL18) is an abundant heparan sulfate proteoglycan in vascular basement membranes. Here, we asked (i) if the loss of COL18 would result in blood-brain barrier (BBB) breakdown, pathological alterations of small arteries and capillaries and neuroinflammation as found in cerebral small vessel disease (CSVD) and (ii) if such changes may be associated with remodeling of synapses and neural extracellular matrix (ECM). We found that 5-month-old Col18a1-/- mice had elevated BBB permeability for mous...
Source: Matrix Biology - February 22, 2024 Category: Molecular Biology Authors: Mahsima Khoshneviszadeh Solveig Henneicke Daniel Pirici Akilashree Senthilnathan Lorena Morton Philipp Arndt Rahul Kaushik Oula Norman Jari Jukkola Ildiko Rita Dunay Constanze Seidenbecher Anne Heikkinen Stefanie Schreiber Alexander Dityatev Source Type: research
Microvascular damage, neuroinflammation and extracellular matrix remodeling in Col18a1 knockout mice as a model for early cerebral small vessel disease
Matrix Biol. 2024 Feb 20:S0945-053X(24)00026-X. doi: 10.1016/j.matbio.2024.02.007. Online ahead of print.ABSTRACTCollagen type XVIII (COL18) is an abundant heparan sulfate proteoglycan in vascular basement membranes. Here, we asked (i) if the loss of COL18 would result in blood-brain barrier (BBB) breakdown, pathological alterations of small arteries and capillaries and neuroinflammation as found in cerebral small vessel disease (CSVD) and (ii) if such changes may be associated with remodeling of synapses and neural extracellular matrix (ECM). We found that 5-month-old Col18a1-/- mice had elevated BBB permeability for mous...
Source: Matrix Biology - February 22, 2024 Category: Molecular Biology Authors: Mahsima Khoshneviszadeh Solveig Henneicke Daniel Pirici Akilashree Senthilnathan Lorena Morton Philipp Arndt Rahul Kaushik Oula Norman Jari Jukkola Ildiko Rita Dunay Constanze Seidenbecher Anne Heikkinen Stefanie Schreiber Alexander Dityatev Source Type: research
Microvascular damage, neuroinflammation and extracellular matrix remodeling in Col18a1 knockout mice as a model for early cerebral small vessel disease
Matrix Biol. 2024 Feb 20:S0945-053X(24)00026-X. doi: 10.1016/j.matbio.2024.02.007. Online ahead of print.ABSTRACTCollagen type XVIII (COL18) is an abundant heparan sulfate proteoglycan in vascular basement membranes. Here, we asked (i) if the loss of COL18 would result in blood-brain barrier (BBB) breakdown, pathological alterations of small arteries and capillaries and neuroinflammation as found in cerebral small vessel disease (CSVD) and (ii) if such changes may be associated with remodeling of synapses and neural extracellular matrix (ECM). We found that 5-month-old Col18a1-/- mice had elevated BBB permeability for mous...
Source: Matrix Biology - February 22, 2024 Category: Molecular Biology Authors: Mahsima Khoshneviszadeh Solveig Henneicke Daniel Pirici Akilashree Senthilnathan Lorena Morton Philipp Arndt Rahul Kaushik Oula Norman Jari Jukkola Ildiko Rita Dunay Constanze Seidenbecher Anne Heikkinen Stefanie Schreiber Alexander Dityatev Source Type: research
A Lysyl Oxidase-Responsive Collagen Peptide Illuminates Collagen Remodeling in Wound Healing
Matrix Biol. 2024 Feb 19:S0945-053X(24)00025-8. doi: 10.1016/j.matbio.2024.02.006. Online ahead of print.ABSTRACTTissue repair and fibrosis involve the dynamic remodeling of collagen, and accurate detection of these sites is of utmost importance. Here, we use a collagen peptide sensor (1) to visualize collagen formation and remodeling during wound healing in mice and humans. We show that the probe binds selectively to sites of collagen formation and remodeling at different stages of healing. Compared to conventional methods, the peptide sensor localizes preferentially to areas of collagen synthesis and remodeling at the wo...
Source: Matrix Biology - February 21, 2024 Category: Molecular Biology Authors: Paul Hiebert Giuseppe Antoniazzi Matthew Aronoff Sabine Werner Helma Wennemers Source Type: research
The Adhesion GPCR and PCP component Flamingo (FMI-1) alters body size and regulates the composition of the extracellular matrix
Matrix Biol. 2024 Feb 18:S0945-053X(24)00024-6. doi: 10.1016/j.matbio.2024.02.005. Online ahead of print.ABSTRACTThe extracellular matrix (ECM) is a network of macromolecules that presents a vital scaffold for cells and enables multiple ways of cellular communication. Thus, it is essential for many physiological processes such as development, tissue morphogenesis, homeostasis, the shape and partially the size of the body and its organs. To ensure these, the composition of the ECM is tissue-specific and highly dynamic. ECM homeostasis is therefore tightly controlled by several mechanisms. Here, we show that FMI-1, the homol...
Source: Matrix Biology - February 20, 2024 Category: Molecular Biology Authors: Johanna Lena Sch ön Victoria Elisabeth Gro ß Willem Berend Post Alexandra Daum Daniel Mat úš Johanna Pilz Rene Schnorr Susanne Horn Miriam B äumers Stefanie Weidtkamp-Peters Samantha Hughes Torsten Sch öneberg Simone Pr ömel Source Type: research
The Adhesion GPCR and PCP component Flamingo (FMI-1) alters body size and regulates the composition of the extracellular matrix
Matrix Biol. 2024 Feb 18:S0945-053X(24)00024-6. doi: 10.1016/j.matbio.2024.02.005. Online ahead of print.ABSTRACTThe extracellular matrix (ECM) is a network of macromolecules that presents a vital scaffold for cells and enables multiple ways of cellular communication. Thus, it is essential for many physiological processes such as development, tissue morphogenesis, homeostasis, the shape and partially the size of the body and its organs. To ensure these, the composition of the ECM is tissue-specific and highly dynamic. ECM homeostasis is therefore tightly controlled by several mechanisms. Here, we show that FMI-1, the homol...
Source: Matrix Biology - February 20, 2024 Category: Molecular Biology Authors: Johanna Lena Sch ön Victoria Elisabeth Gro ß Willem Berend Post Alexandra Daum Daniel Mat úš Johanna Pilz Rene Schnorr Susanne Horn Miriam B äumers Stefanie Weidtkamp-Peters Samantha Hughes Torsten Sch öneberg Simone Pr ömel Source Type: research
Dysfunctional Latent Transforming Growth Factor β Activation After Corneal Injury in a Classical Ehlers-Danlos Model
Matrix Biol. 2024 Feb 8:S0945-053X(24)00023-4. doi: 10.1016/j.matbio.2024.02.004. Online ahead of print.ABSTRACTPatients with classical Ehlers Danlos syndrome (cEDS) suffer impaired wound healing and from scars formed after injuries that are atrophic and difficult to close surgically. Haploinsufficiency in COL5A1 creates systemic morphological and functional alterations in the entire body. We investigated mechanisms that impair wound healing from corneal lacerations (full thickness injuries) in a mouse model of cEDS (Col5a1+/-). We found that collagen V reexpression in this model is upregulated during corneal tissue repair...
Source: Matrix Biology - February 10, 2024 Category: Molecular Biology Authors: Mei Sun Ana Carolina Acosta Victoria Emerick Sheila Adams Marcel Y Avila Curtis E Margo Edgar M Espana Source Type: research
Keratinocyte integrin α3β1 induces expression of the macrophage stimulating factor, CSF-1, through a YAP/TEAD-dependent mechanism
Matrix Biol. 2024 Feb 8:S0945-053X(24)00022-2. doi: 10.1016/j.matbio.2024.02.003. Online ahead of print.ABSTRACTThe development of wound therapy targeting integrins is hampered by inadequate understanding of integrin function in cutaneous wound healing and the wound microenvironment. Following cutaneous injury, keratinocytes migrate to restore the skin barrier, and macrophages aid in debris clearance. Thus, both keratinocytes and macrophages are critical to the coordination of tissue repair. Keratinocyte integrins have been shown to participate in this coordinated effort by regulating secreted factors, some of which crosst...
Source: Matrix Biology - February 10, 2024 Category: Molecular Biology Authors: Whitney M Longmate Emily Norton Giesse Albeche Duarte Lei Wu Mathieu R DiPersio John M Lamar C Michael DiPersio Source Type: research
Dysfunctional Latent Transforming Growth Factor β Activation After Corneal Injury in a Classical Ehlers-Danlos Model
Matrix Biol. 2024 Feb 8:S0945-053X(24)00023-4. doi: 10.1016/j.matbio.2024.02.004. Online ahead of print.ABSTRACTPatients with classical Ehlers Danlos syndrome (cEDS) suffer impaired wound healing and from scars formed after injuries that are atrophic and difficult to close surgically. Haploinsufficiency in COL5A1 creates systemic morphological and functional alterations in the entire body. We investigated mechanisms that impair wound healing from corneal lacerations (full thickness injuries) in a mouse model of cEDS (Col5a1+/-). We found that collagen V reexpression in this model is upregulated during corneal tissue repair...
Source: Matrix Biology - February 10, 2024 Category: Molecular Biology Authors: Mei Sun Ana Carolina Acosta Victoria Emerick Sheila Adams Marcel Y Avila Curtis E Margo Edgar M Espana Source Type: research
Keratinocyte integrin α3β1 induces expression of the macrophage stimulating factor, CSF-1, through a YAP/TEAD-dependent mechanism
Matrix Biol. 2024 Feb 8:S0945-053X(24)00022-2. doi: 10.1016/j.matbio.2024.02.003. Online ahead of print.ABSTRACTThe development of wound therapy targeting integrins is hampered by inadequate understanding of integrin function in cutaneous wound healing and the wound microenvironment. Following cutaneous injury, keratinocytes migrate to restore the skin barrier, and macrophages aid in debris clearance. Thus, both keratinocytes and macrophages are critical to the coordination of tissue repair. Keratinocyte integrins have been shown to participate in this coordinated effort by regulating secreted factors, some of which crosst...
Source: Matrix Biology - February 10, 2024 Category: Molecular Biology Authors: Whitney M Longmate Emily Norton Giesse Albeche Duarte Lei Wu Mathieu R DiPersio John M Lamar C Michael DiPersio Source Type: research
