Pulmonary Fibroelastosis - A Review
Matrix Biol. 2023 Nov 1:S0945-053X(23)00106-3. doi: 10.1016/j.matbio.2023.10.003. Online ahead of print.ABSTRACTElastin is a long-lived fibrous protein that is abundant in the extracellular matrix of the lung. Elastic fibers provide the lung the characteristic elasticity during inhalation with recoil during exhalation thereby ensuring efficient gas exchange. Excessive deposition of elastin and other extracellular matrix proteins reduces lung compliance by impairing ventilation and compromising gas exchange. Notably, the degree of elastosis is associated with the progressive decline in lung function and survival in patients...
Source: Matrix Biology - November 3, 2023 Category: Molecular Biology Authors: Dan J K Yombo Satish Madala Chanukya Pavan Vemulapalli Harshavardhana H Ediga William D Hardie Source Type: research
Pulmonary Fibroelastosis - A Review
Matrix Biol. 2023 Nov 1:S0945-053X(23)00106-3. doi: 10.1016/j.matbio.2023.10.003. Online ahead of print.ABSTRACTElastin is a long-lived fibrous protein that is abundant in the extracellular matrix of the lung. Elastic fibers provide the lung the characteristic elasticity during inhalation with recoil during exhalation thereby ensuring efficient gas exchange. Excessive deposition of elastin and other extracellular matrix proteins reduces lung compliance by impairing ventilation and compromising gas exchange. Notably, the degree of elastosis is associated with the progressive decline in lung function and survival in patients...
Source: Matrix Biology - November 3, 2023 Category: Molecular Biology Authors: Dan J K Yombo Satish Madala Chanukya Pavan Vemulapalli Harshavardhana H Ediga William D Hardie Source Type: research
Mmp14 is required for matrisome homeostasis and circadian rhythm in fibroblasts
In conclusion, our study shows that circadian clock-regulated Mmp14 controls the rhythmic synthesis of small diameter collagen fibrils, regulates collagen crosslinking, and its absence disrupts the circadian clock and matrisome in tendon fibroblasts.PMID:37913834 | DOI:10.1016/j.matbio.2023.10.002 (Source: Matrix Biology)
Source: Matrix Biology - November 1, 2023 Category: Molecular Biology Authors: Ching-Yan Chlo é Yeung Richa Garva Adam Pickard Yinhui Lu Venkatesh Mallikarjun Joe Swift Susan H Taylor Jyoti Rai David R Eyre Mayank Chaturvedi Yoshifumi Itoh Qing-Jun Meng Cornelia Mauch Paola Zigrino Karl E Kadler Source Type: research
Mmp14 is required for matrisome homeostasis and circadian rhythm in fibroblasts
In conclusion, our study shows that circadian clock-regulated Mmp14 controls the rhythmic synthesis of small diameter collagen fibrils, regulates collagen crosslinking, and its absence disrupts the circadian clock and matrisome in tendon fibroblasts.PMID:37913834 | DOI:10.1016/j.matbio.2023.10.002 (Source: Matrix Biology)
Source: Matrix Biology - November 1, 2023 Category: Molecular Biology Authors: Ching-Yan Chlo é Yeung Richa Garva Adam Pickard Yinhui Lu Venkatesh Mallikarjun Joe Swift Susan H Taylor Jyoti Rai David R Eyre Mayank Chaturvedi Yoshifumi Itoh Qing-Jun Meng Cornelia Mauch Paola Zigrino Karl E Kadler Source Type: research
Mmp14 is required for matrisome homeostasis and circadian rhythm in fibroblasts
In conclusion, our study shows that circadian clock-regulated Mmp14 controls the rhythmic synthesis of small diameter collagen fibrils, regulates collagen crosslinking, and its absence disrupts the circadian clock and matrisome in tendon fibroblasts.PMID:37913834 | DOI:10.1016/j.matbio.2023.10.002 (Source: Matrix Biology)
Source: Matrix Biology - November 1, 2023 Category: Molecular Biology Authors: Ching-Yan Chlo é Yeung Richa Garva Adam Pickard Yinhui Lu Venkatesh Mallikarjun Joe Swift Susan H Taylor Jyoti Rai David R Eyre Mayank Chaturvedi Yoshifumi Itoh Qing-Jun Meng Cornelia Mauch Paola Zigrino Karl E Kadler Source Type: research
Mmp14 is required for matrisome homeostasis and circadian rhythm in fibroblasts
In conclusion, our study shows that circadian clock-regulated Mmp14 controls the rhythmic synthesis of small diameter collagen fibrils, regulates collagen crosslinking, and its absence disrupts the circadian clock and matrisome in tendon fibroblasts.PMID:37913834 | DOI:10.1016/j.matbio.2023.10.002 (Source: Matrix Biology)
Source: Matrix Biology - November 1, 2023 Category: Molecular Biology Authors: Ching-Yan Chlo é Yeung Richa Garva Adam Pickard Yinhui Lu Venkatesh Mallikarjun Joe Swift Susan H Taylor Jyoti Rai David R Eyre Mayank Chaturvedi Yoshifumi Itoh Qing-Jun Meng Cornelia Mauch Paola Zigrino Karl E Kadler Source Type: research
Tissue Inhibitors of Metalloproteinases are proteolytic targets of Matrix Metalloproteinase 9
Matrix Biol. 2023 Oct 5:S0945-053X(23)00103-8. doi: 10.1016/j.matbio.2023.09.002. Online ahead of print.ABSTRACTExtracellular proteolysis and turnover are core processes of tissue homeostasis. The predominant matrix-degrading enzymes are members of the Matrix Metalloproteinase (MMP) family. MMPs extensively degrade core matrix components in addition to processing a range of other factors in the extracellular, plasma membrane, and intracellular compartments. The proteolytic activity of MMPs is modulated by the Tissue Inhibitors of Metalloproteinases (TIMPs), a family of four multi-functional matrisome proteins with extensiv...
Source: Matrix Biology - October 7, 2023 Category: Molecular Biology Authors: Sasha Coates-Park Carolyn Lazaroff Sadeechya Gurung Josh Rich Alexandra Colladay Maura O'Neill Georgina S Butler Christopher M Overall William G Stetler-Stevenson David Peeney Source Type: research
Tissue Inhibitors of Metalloproteinases are proteolytic targets of Matrix Metalloproteinase 9
Matrix Biol. 2023 Oct 5:S0945-053X(23)00103-8. doi: 10.1016/j.matbio.2023.09.002. Online ahead of print.ABSTRACTExtracellular proteolysis and turnover are core processes of tissue homeostasis. The predominant matrix-degrading enzymes are members of the Matrix Metalloproteinase (MMP) family. MMPs extensively degrade core matrix components in addition to processing a range of other factors in the extracellular, plasma membrane, and intracellular compartments. The proteolytic activity of MMPs is modulated by the Tissue Inhibitors of Metalloproteinases (TIMPs), a family of four multi-functional matrisome proteins with extensiv...
Source: Matrix Biology - October 7, 2023 Category: Molecular Biology Authors: Sasha Coates-Park Carolyn Lazaroff Sadeechya Gurung Josh Rich Alexandra Colladay Maura O'Neill Georgina S Butler Christopher M Overall William G Stetler-Stevenson David Peeney Source Type: research
Tissue Inhibitors of Metalloproteinases are proteolytic targets of Matrix Metalloproteinase 9
Matrix Biol. 2023 Oct 5:S0945-053X(23)00103-8. doi: 10.1016/j.matbio.2023.09.002. Online ahead of print.ABSTRACTExtracellular proteolysis and turnover are core processes of tissue homeostasis. The predominant matrix-degrading enzymes are members of the Matrix Metalloproteinase (MMP) family. MMPs extensively degrade core matrix components in addition to processing a range of other factors in the extracellular, plasma membrane, and intracellular compartments. The proteolytic activity of MMPs is modulated by the Tissue Inhibitors of Metalloproteinases (TIMPs), a family of four multi-functional matrisome proteins with extensiv...
Source: Matrix Biology - October 7, 2023 Category: Molecular Biology Authors: Sasha Coates-Park Carolyn Lazaroff Sadeechya Gurung Josh Rich Alexandra Colladay Maura O'Neill Georgina S Butler Christopher M Overall William G Stetler-Stevenson David Peeney Source Type: research
Tissue Inhibitors of Metalloproteinases are proteolytic targets of Matrix Metalloproteinase 9
Matrix Biol. 2023 Oct 5:S0945-053X(23)00103-8. doi: 10.1016/j.matbio.2023.09.002. Online ahead of print.ABSTRACTExtracellular proteolysis and turnover are core processes of tissue homeostasis. The predominant matrix-degrading enzymes are members of the Matrix Metalloproteinase (MMP) family. MMPs extensively degrade core matrix components in addition to processing a range of other factors in the extracellular, plasma membrane, and intracellular compartments. The proteolytic activity of MMPs is modulated by the Tissue Inhibitors of Metalloproteinases (TIMPs), a family of four multi-functional matrisome proteins with extensiv...
Source: Matrix Biology - October 7, 2023 Category: Molecular Biology Authors: Sasha Coates-Park Carolyn Lazaroff Sadeechya Gurung Josh Rich Alexandra Colladay Maura O'Neill Georgina S Butler Christopher M Overall William G Stetler-Stevenson David Peeney Source Type: research
Tissue Inhibitors of Metalloproteinases are proteolytic targets of Matrix Metalloproteinase 9
Matrix Biol. 2023 Oct 5:S0945-053X(23)00103-8. doi: 10.1016/j.matbio.2023.09.002. Online ahead of print.ABSTRACTExtracellular proteolysis and turnover are core processes of tissue homeostasis. The predominant matrix-degrading enzymes are members of the Matrix Metalloproteinase (MMP) family. MMPs extensively degrade core matrix components in addition to processing a range of other factors in the extracellular, plasma membrane, and intracellular compartments. The proteolytic activity of MMPs is modulated by the Tissue Inhibitors of Metalloproteinases (TIMPs), a family of four multi-functional matrisome proteins with extensiv...
Source: Matrix Biology - October 7, 2023 Category: Molecular Biology Authors: Sasha Coates-Park Carolyn Lazaroff Sadeechya Gurung Josh Rich Alexandra Colladay Maura O'Neill Georgina S Butler Christopher M Overall William G Stetler-Stevenson David Peeney Source Type: research
Tissue Inhibitors of Metalloproteinases are proteolytic targets of Matrix Metalloproteinase 9
Matrix Biol. 2023 Oct 5:S0945-053X(23)00103-8. doi: 10.1016/j.matbio.2023.09.002. Online ahead of print.ABSTRACTExtracellular proteolysis and turnover are core processes of tissue homeostasis. The predominant matrix-degrading enzymes are members of the Matrix Metalloproteinase (MMP) family. MMPs extensively degrade core matrix components in addition to processing a range of other factors in the extracellular, plasma membrane, and intracellular compartments. The proteolytic activity of MMPs is modulated by the Tissue Inhibitors of Metalloproteinases (TIMPs), a family of four multi-functional matrisome proteins with extensiv...
Source: Matrix Biology - October 7, 2023 Category: Molecular Biology Authors: Sasha Coates-Park Carolyn Lazaroff Sadeechya Gurung Josh Rich Alexandra Colladay Maura O'Neill Georgina S Butler Christopher M Overall William G Stetler-Stevenson David Peeney Source Type: research
Tissue Inhibitors of Metalloproteinases are proteolytic targets of Matrix Metalloproteinase 9
Matrix Biol. 2023 Oct 5:S0945-053X(23)00103-8. doi: 10.1016/j.matbio.2023.09.002. Online ahead of print.ABSTRACTExtracellular proteolysis and turnover are core processes of tissue homeostasis. The predominant matrix-degrading enzymes are members of the Matrix Metalloproteinase (MMP) family. MMPs extensively degrade core matrix components in addition to processing a range of other factors in the extracellular, plasma membrane, and intracellular compartments. The proteolytic activity of MMPs is modulated by the Tissue Inhibitors of Metalloproteinases (TIMPs), a family of four multi-functional matrisome proteins with extensiv...
Source: Matrix Biology - October 7, 2023 Category: Molecular Biology Authors: Sasha Coates-Park Carolyn Lazaroff Sadeechya Gurung Josh Rich Alexandra Colladay Maura O'Neill Georgina S Butler Christopher M Overall William G Stetler-Stevenson David Peeney Source Type: research
Tissue Inhibitors of Metalloproteinases are proteolytic targets of Matrix Metalloproteinase 9
Matrix Biol. 2023 Oct 5:S0945-053X(23)00103-8. doi: 10.1016/j.matbio.2023.09.002. Online ahead of print.ABSTRACTExtracellular proteolysis and turnover are core processes of tissue homeostasis. The predominant matrix-degrading enzymes are members of the Matrix Metalloproteinase (MMP) family. MMPs extensively degrade core matrix components in addition to processing a range of other factors in the extracellular, plasma membrane, and intracellular compartments. The proteolytic activity of MMPs is modulated by the Tissue Inhibitors of Metalloproteinases (TIMPs), a family of four multi-functional matrisome proteins with extensiv...
Source: Matrix Biology - October 7, 2023 Category: Molecular Biology Authors: Sasha Coates-Park Carolyn Lazaroff Sadeechya Gurung Josh Rich Alexandra Colladay Maura O'Neill Georgina S Butler Christopher M Overall William G Stetler-Stevenson David Peeney Source Type: research
Tissue Inhibitors of Metalloproteinases are proteolytic targets of Matrix Metalloproteinase 9
Matrix Biol. 2023 Oct 5:S0945-053X(23)00103-8. doi: 10.1016/j.matbio.2023.09.002. Online ahead of print.ABSTRACTExtracellular proteolysis and turnover are core processes of tissue homeostasis. The predominant matrix-degrading enzymes are members of the Matrix Metalloproteinase (MMP) family. MMPs extensively degrade core matrix components in addition to processing a range of other factors in the extracellular, plasma membrane, and intracellular compartments. The proteolytic activity of MMPs is modulated by the Tissue Inhibitors of Metalloproteinases (TIMPs), a family of four multi-functional matrisome proteins with extensiv...
Source: Matrix Biology - October 7, 2023 Category: Molecular Biology Authors: Sasha Coates-Park Carolyn Lazaroff Sadeechya Gurung Josh Rich Alexandra Colladay Maura O'Neill Georgina S Butler Christopher M Overall William G Stetler-Stevenson David Peeney Source Type: research
