Matrix Stiffening Facilitates the Collective Invasion of Breast Cancer through the Periostin-Integrin Mechanotransduction Pathway
Matrix Biol. 2023 May 23:S0945-053X(23)00069-0. doi: 10.1016/j.matbio.2023.05.006. Online ahead of print.ABSTRACTMatrix rigidity is a critical contributor to tumor progression; however, whether and how matrix stiffness modulates the collective invasion of tumor cells remain unknown. Here we demonstrate that increased matrix stiffness activates YAP to promote the secretion of periostin (POSTN) in cancer-associated fibroblasts, which in turn augments the matrix rigidity of mammary glands and breast tumor tissues by facilitating collagen crosslinking. Moreover, decreased tissue stiffening resulted from the POSTN deficiency im...
Source: Matrix Biology - May 25, 2023 Category: Molecular Biology Authors: Tiantian Wu Shanshan Xiong Mimi Chen Bjorn T Tam Wei Chen Ke Dong Zhenling Ma Zhe Wang Gaoliang Ouyang Source Type: research
Matrix Stiffening Facilitates the Collective Invasion of Breast Cancer through the Periostin-Integrin Mechanotransduction Pathway
Matrix Biol. 2023 May 23:S0945-053X(23)00069-0. doi: 10.1016/j.matbio.2023.05.006. Online ahead of print.ABSTRACTMatrix rigidity is a critical contributor to tumor progression; however, whether and how matrix stiffness modulates the collective invasion of tumor cells remain unknown. Here we demonstrate that increased matrix stiffness activates YAP to promote the secretion of periostin (POSTN) in cancer-associated fibroblasts, which in turn augments the matrix rigidity of mammary glands and breast tumor tissues by facilitating collagen crosslinking. Moreover, decreased tissue stiffening resulted from the POSTN deficiency im...
Source: Matrix Biology - May 25, 2023 Category: Molecular Biology Authors: Tiantian Wu Shanshan Xiong Mimi Chen Bjorn T Tam Wei Chen Ke Dong Zhenling Ma Zhe Wang Gaoliang Ouyang Source Type: research
Matrix Stiffening Facilitates the Collective Invasion of Breast Cancer through the Periostin-Integrin Mechanotransduction Pathway
Matrix Biol. 2023 May 23:S0945-053X(23)00069-0. doi: 10.1016/j.matbio.2023.05.006. Online ahead of print.ABSTRACTMatrix rigidity is a critical contributor to tumor progression; however, whether and how matrix stiffness modulates the collective invasion of tumor cells remain unknown. Here we demonstrate that increased matrix stiffness activates YAP to promote the secretion of periostin (POSTN) in cancer-associated fibroblasts, which in turn augments the matrix rigidity of mammary glands and breast tumor tissues by facilitating collagen crosslinking. Moreover, decreased tissue stiffening resulted from the POSTN deficiency im...
Source: Matrix Biology - May 25, 2023 Category: Molecular Biology Authors: Tiantian Wu Shanshan Xiong Mimi Chen Bjorn T Tam Wei Chen Ke Dong Zhenling Ma Zhe Wang Gaoliang Ouyang Source Type: research
Matrix Stiffening Facilitates the Collective Invasion of Breast Cancer through the Periostin-Integrin Mechanotransduction Pathway
Matrix Biol. 2023 May 23:S0945-053X(23)00069-0. doi: 10.1016/j.matbio.2023.05.006. Online ahead of print.ABSTRACTMatrix rigidity is a critical contributor to tumor progression; however, whether and how matrix stiffness modulates the collective invasion of tumor cells remain unknown. Here we demonstrate that increased matrix stiffness activates YAP to promote the secretion of periostin (POSTN) in cancer-associated fibroblasts, which in turn augments the matrix rigidity of mammary glands and breast tumor tissues by facilitating collagen crosslinking. Moreover, decreased tissue stiffening resulted from the POSTN deficiency im...
Source: Matrix Biology - May 25, 2023 Category: Molecular Biology Authors: Tiantian Wu Shanshan Xiong Mimi Chen Bjorn T Tam Wei Chen Ke Dong Zhenling Ma Zhe Wang Gaoliang Ouyang Source Type: research
Matrix Stiffening Facilitates the Collective Invasion of Breast Cancer through the Periostin-Integrin Mechanotransduction Pathway
Matrix Biol. 2023 May 23:S0945-053X(23)00069-0. doi: 10.1016/j.matbio.2023.05.006. Online ahead of print.ABSTRACTMatrix rigidity is a critical contributor to tumor progression; however, whether and how matrix stiffness modulates the collective invasion of tumor cells remain unknown. Here we demonstrate that increased matrix stiffness activates YAP to promote the secretion of periostin (POSTN) in cancer-associated fibroblasts, which in turn augments the matrix rigidity of mammary glands and breast tumor tissues by facilitating collagen crosslinking. Moreover, decreased tissue stiffening resulted from the POSTN deficiency im...
Source: Matrix Biology - May 25, 2023 Category: Molecular Biology Authors: Tiantian Wu Shanshan Xiong Mimi Chen Bjorn T Tam Wei Chen Ke Dong Zhenling Ma Zhe Wang Gaoliang Ouyang Source Type: research
Matrix Stiffening Facilitates the Collective Invasion of Breast Cancer through the Periostin-Integrin Mechanotransduction Pathway
Matrix Biol. 2023 May 23:S0945-053X(23)00069-0. doi: 10.1016/j.matbio.2023.05.006. Online ahead of print.ABSTRACTMatrix rigidity is a critical contributor to tumor progression; however, whether and how matrix stiffness modulates the collective invasion of tumor cells remain unknown. Here we demonstrate that increased matrix stiffness activates YAP to promote the secretion of periostin (POSTN) in cancer-associated fibroblasts, which in turn augments the matrix rigidity of mammary glands and breast tumor tissues by facilitating collagen crosslinking. Moreover, decreased tissue stiffening resulted from the POSTN deficiency im...
Source: Matrix Biology - May 25, 2023 Category: Molecular Biology Authors: Tiantian Wu Shanshan Xiong Mimi Chen Bjorn T Tam Wei Chen Ke Dong Zhenling Ma Zhe Wang Gaoliang Ouyang Source Type: research
Matrix Stiffening Facilitates the Collective Invasion of Breast Cancer through the Periostin-Integrin Mechanotransduction Pathway
Matrix Biol. 2023 May 23:S0945-053X(23)00069-0. doi: 10.1016/j.matbio.2023.05.006. Online ahead of print.ABSTRACTMatrix rigidity is a critical contributor to tumor progression; however, whether and how matrix stiffness modulates the collective invasion of tumor cells remain unknown. Here we demonstrate that increased matrix stiffness activates YAP to promote the secretion of periostin (POSTN) in cancer-associated fibroblasts, which in turn augments the matrix rigidity of mammary glands and breast tumor tissues by facilitating collagen crosslinking. Moreover, decreased tissue stiffening resulted from the POSTN deficiency im...
Source: Matrix Biology - May 25, 2023 Category: Molecular Biology Authors: Tiantian Wu Shanshan Xiong Mimi Chen Bjorn T Tam Wei Chen Ke Dong Zhenling Ma Zhe Wang Gaoliang Ouyang Source Type: research
Matrix Stiffening Facilitates the Collective Invasion of Breast Cancer through the Periostin-Integrin Mechanotransduction Pathway
Matrix Biol. 2023 May 23:S0945-053X(23)00069-0. doi: 10.1016/j.matbio.2023.05.006. Online ahead of print.ABSTRACTMatrix rigidity is a critical contributor to tumor progression; however, whether and how matrix stiffness modulates the collective invasion of tumor cells remain unknown. Here we demonstrate that increased matrix stiffness activates YAP to promote the secretion of periostin (POSTN) in cancer-associated fibroblasts, which in turn augments the matrix rigidity of mammary glands and breast tumor tissues by facilitating collagen crosslinking. Moreover, decreased tissue stiffening resulted from the POSTN deficiency im...
Source: Matrix Biology - May 25, 2023 Category: Molecular Biology Authors: Tiantian Wu Shanshan Xiong Mimi Chen Bjorn T Tam Wei Chen Ke Dong Zhenling Ma Zhe Wang Gaoliang Ouyang Source Type: research
Matrix Stiffening Facilitates the Collective Invasion of Breast Cancer through the Periostin-Integrin Mechanotransduction Pathway
Matrix Biol. 2023 May 23:S0945-053X(23)00069-0. doi: 10.1016/j.matbio.2023.05.006. Online ahead of print.ABSTRACTMatrix rigidity is a critical contributor to tumor progression; however, whether and how matrix stiffness modulates the collective invasion of tumor cells remain unknown. Here we demonstrate that increased matrix stiffness activates YAP to promote the secretion of periostin (POSTN) in cancer-associated fibroblasts, which in turn augments the matrix rigidity of mammary glands and breast tumor tissues by facilitating collagen crosslinking. Moreover, decreased tissue stiffening resulted from the POSTN deficiency im...
Source: Matrix Biology - May 25, 2023 Category: Molecular Biology Authors: Tiantian Wu Shanshan Xiong Mimi Chen Bjorn T Tam Wei Chen Ke Dong Zhenling Ma Zhe Wang Gaoliang Ouyang Source Type: research
Matrix Stiffening Facilitates the Collective Invasion of Breast Cancer through the Periostin-Integrin Mechanotransduction Pathway
Matrix Biol. 2023 May 23:S0945-053X(23)00069-0. doi: 10.1016/j.matbio.2023.05.006. Online ahead of print.ABSTRACTMatrix rigidity is a critical contributor to tumor progression; however, whether and how matrix stiffness modulates the collective invasion of tumor cells remain unknown. Here we demonstrate that increased matrix stiffness activates YAP to promote the secretion of periostin (POSTN) in cancer-associated fibroblasts, which in turn augments the matrix rigidity of mammary glands and breast tumor tissues by facilitating collagen crosslinking. Moreover, decreased tissue stiffening resulted from the POSTN deficiency im...
Source: Matrix Biology - May 25, 2023 Category: Molecular Biology Authors: Tiantian Wu Shanshan Xiong Mimi Chen Bjorn T Tam Wei Chen Ke Dong Zhenling Ma Zhe Wang Gaoliang Ouyang Source Type: research
Matrix Stiffening Facilitates the Collective Invasion of Breast Cancer through the Periostin-Integrin Mechanotransduction Pathway
Matrix Biol. 2023 May 23:S0945-053X(23)00069-0. doi: 10.1016/j.matbio.2023.05.006. Online ahead of print.ABSTRACTMatrix rigidity is a critical contributor to tumor progression; however, whether and how matrix stiffness modulates the collective invasion of tumor cells remain unknown. Here we demonstrate that increased matrix stiffness activates YAP to promote the secretion of periostin (POSTN) in cancer-associated fibroblasts, which in turn augments the matrix rigidity of mammary glands and breast tumor tissues by facilitating collagen crosslinking. Moreover, decreased tissue stiffening resulted from the POSTN deficiency im...
Source: Matrix Biology - May 25, 2023 Category: Molecular Biology Authors: Tiantian Wu Shanshan Xiong Mimi Chen Bjorn T Tam Wei Chen Ke Dong Zhenling Ma Zhe Wang Gaoliang Ouyang Source Type: research
Matrix Stiffening Facilitates the Collective Invasion of Breast Cancer through the Periostin-Integrin Mechanotransduction Pathway
Matrix Biol. 2023 May 23:S0945-053X(23)00069-0. doi: 10.1016/j.matbio.2023.05.006. Online ahead of print.ABSTRACTMatrix rigidity is a critical contributor to tumor progression; however, whether and how matrix stiffness modulates the collective invasion of tumor cells remain unknown. Here we demonstrate that increased matrix stiffness activates YAP to promote the secretion of periostin (POSTN) in cancer-associated fibroblasts, which in turn augments the matrix rigidity of mammary glands and breast tumor tissues by facilitating collagen crosslinking. Moreover, decreased tissue stiffening resulted from the POSTN deficiency im...
Source: Matrix Biology - May 25, 2023 Category: Molecular Biology Authors: Tiantian Wu Shanshan Xiong Mimi Chen Bjorn T Tam Wei Chen Ke Dong Zhenling Ma Zhe Wang Gaoliang Ouyang Source Type: research
Matrix Stiffening Facilitates the Collective Invasion of Breast Cancer through the Periostin-Integrin Mechanotransduction Pathway
Matrix Biol. 2023 May 23:S0945-053X(23)00069-0. doi: 10.1016/j.matbio.2023.05.006. Online ahead of print.ABSTRACTMatrix rigidity is a critical contributor to tumor progression; however, whether and how matrix stiffness modulates the collective invasion of tumor cells remain unknown. Here we demonstrate that increased matrix stiffness activates YAP to promote the secretion of periostin (POSTN) in cancer-associated fibroblasts, which in turn augments the matrix rigidity of mammary glands and breast tumor tissues by facilitating collagen crosslinking. Moreover, decreased tissue stiffening resulted from the POSTN deficiency im...
Source: Matrix Biology - May 25, 2023 Category: Molecular Biology Authors: Tiantian Wu Shanshan Xiong Mimi Chen Bjorn T Tam Wei Chen Ke Dong Zhenling Ma Zhe Wang Gaoliang Ouyang Source Type: research
TGF β-2 Haploinsufficiency Causes Early Death in Mice with Marfan Syndrome
Matrix Biol. 2023 May 20:S0945-053X(23)00061-6. doi: 10.1016/j.matbio.2023.05.004. Online ahead of print.ABSTRACTTo assess the contribution of individual TGF-β isoforms to aortopathy in Marfan syndrome (MFS), we quantified the survival and phenotypes of mice with a combined fibrillin1 (the gene defective in MFS) hypomorphic mutation and a TGF-β1, 2, or 3 heterozygous null mutation. The loss of TGF-β2, and only TGF-β2, resulted in 80% of the double mutant animals dying earlier, by post-natal day 20, than MFS only mice. Death was not from thoracic aortic rupture, as observed in MFS mice, but was associated with hyperplas...
Source: Matrix Biology - May 22, 2023 Category: Molecular Biology Authors: Nalani Sachan Colin K L Phoon Lior Zilberberg Matthias C Kugler Taylor Ene Shana B Mintz Sae-Il Murtada Dar Weiss Glenn I Fishman Jay D Humphrey Daniel B Rifkin Source Type: research
TGF β-2 Haploinsufficiency Causes Early Death in Mice with Marfan Syndrome
Matrix Biol. 2023 May 20:S0945-053X(23)00061-6. doi: 10.1016/j.matbio.2023.05.004. Online ahead of print.ABSTRACTTo assess the contribution of individual TGF-β isoforms to aortopathy in Marfan syndrome (MFS), we quantified the survival and phenotypes of mice with a combined fibrillin1 (the gene defective in MFS) hypomorphic mutation and a TGF-β1, 2, or 3 heterozygous null mutation. The loss of TGF-β2, and only TGF-β2, resulted in 80% of the double mutant animals dying earlier, by post-natal day 20, than MFS only mice. Death was not from thoracic aortic rupture, as observed in MFS mice, but was associated with hyperplas...
Source: Matrix Biology - May 22, 2023 Category: Molecular Biology Authors: Nalani Sachan Colin K L Phoon Lior Zilberberg Matthias C Kugler Taylor Ene Shana B Mintz Sae-Il Murtada Dar Weiss Glenn I Fishman Jay D Humphrey Daniel B Rifkin Source Type: research
