Novel insights into the role of Discoidin Domain Receptor 2 (DDR2) in cancer progression: a new avenue of therapeutic intervention
Matrix Biol. 2023 Dec 9:S0945-053X(23)00126-9. doi: 10.1016/j.matbio.2023.12.003. Online ahead of print.ABSTRACTDiscoidin domain receptors (DDRs), including DDR1 and DDR2, are a unique class of receptor tyrosine kinases (RTKs) activated by collagens at the cell-matrix boundary interface. The peculiar mode of activation makes DDRs key cellular sensors of microenvironmental changes, with a critical role in all physiological and pathological processes governed by collagen remodeling. DDRs are widely expressed in fetal and adult tissues, and experimental and clinical evidence has shown that their expression is deregulated in c...
Source: Matrix Biology - December 11, 2023 Category: Molecular Biology Authors: Paola Trono Flavia Ottavi Laura Rosan ò Source Type: research
Collagen prolyl 4-hydroxylase isoenzymes I and II have sequence specificity towards different X-Pro-Gly triplets
In conclusion, this study provides a molecular level explanation for the need of multiple C-P4H isoenzymes to generate collagen molecules capable to assemble into intact extracellular matrix structures.PMID:38081527 | DOI:10.1016/j.matbio.2023.12.001 (Source: Matrix Biology)
Source: Matrix Biology - December 11, 2023 Category: Molecular Biology Authors: Antti M Salo Pekka Rappu M Kristian Koski Emma Karjalainen Valerio Izzi Kati Drushinin Ilkka Miinalainen Jarmo K äpylä Jyrki Heino Johanna Myllyharju Source Type: research
Novel insights into the role of Discoidin Domain Receptor 2 (DDR2) in cancer progression: a new avenue of therapeutic intervention
Matrix Biol. 2023 Dec 9:S0945-053X(23)00126-9. doi: 10.1016/j.matbio.2023.12.003. Online ahead of print.ABSTRACTDiscoidin domain receptors (DDRs), including DDR1 and DDR2, are a unique class of receptor tyrosine kinases (RTKs) activated by collagens at the cell-matrix boundary interface. The peculiar mode of activation makes DDRs key cellular sensors of microenvironmental changes, with a critical role in all physiological and pathological processes governed by collagen remodeling. DDRs are widely expressed in fetal and adult tissues, and experimental and clinical evidence has shown that their expression is deregulated in c...
Source: Matrix Biology - December 11, 2023 Category: Molecular Biology Authors: Paola Trono Flavia Ottavi Laura Rosan ò Source Type: research
Collagen prolyl 4-hydroxylase isoenzymes I and II have sequence specificity towards different X-Pro-Gly triplets
In conclusion, this study provides a molecular level explanation for the need of multiple C-P4H isoenzymes to generate collagen molecules capable to assemble into intact extracellular matrix structures.PMID:38081527 | DOI:10.1016/j.matbio.2023.12.001 (Source: Matrix Biology)
Source: Matrix Biology - December 11, 2023 Category: Molecular Biology Authors: Antti M Salo Pekka Rappu M Kristian Koski Emma Karjalainen Valerio Izzi Kati Drushinin Ilkka Miinalainen Jarmo K äpylä Jyrki Heino Johanna Myllyharju Source Type: research
The Cochlear Matrisome: Importance in Hearing and Deafness
Matrix Biol. 2023 Dec 7:S0945-053X(23)00125-7. doi: 10.1016/j.matbio.2023.12.002. Online ahead of print.ABSTRACTThe extracellular matrix (ECM) consists in a complex meshwork of collagens, glycoproteins, and proteoglycans, which serves a scaffolding function and provides viscoelastic properties to the tissues. ECM acts as a biomechanical support, and actively participates in cell signaling to induce tissular changes in response to environmental forces and soluble cues. Given the remarkable complexity of the inner ear architecture, its exquisite structure-function relationship, and the importance of vibration-induced stimula...
Source: Matrix Biology - December 9, 2023 Category: Molecular Biology Authors: Mary T Press é Brigitte Malgrange Laurence Delacroix Source Type: research
The Cochlear Matrisome: Importance in Hearing and Deafness
Matrix Biol. 2023 Dec 7:S0945-053X(23)00125-7. doi: 10.1016/j.matbio.2023.12.002. Online ahead of print.ABSTRACTThe extracellular matrix (ECM) consists in a complex meshwork of collagens, glycoproteins, and proteoglycans, which serves a scaffolding function and provides viscoelastic properties to the tissues. ECM acts as a biomechanical support, and actively participates in cell signaling to induce tissular changes in response to environmental forces and soluble cues. Given the remarkable complexity of the inner ear architecture, its exquisite structure-function relationship, and the importance of vibration-induced stimula...
Source: Matrix Biology - December 9, 2023 Category: Molecular Biology Authors: Mary T Press é Brigitte Malgrange Laurence Delacroix Source Type: research
Peroxidasin is required for full viability in development and for maintenance of tissue mechanics in adults
Matrix Biol. 2023 Nov 22:S0945-053X(23)00117-8. doi: 10.1016/j.matbio.2023.11.005. Online ahead of print.ABSTRACTBasement membranes are thin strong sheets of extracellular matrix. They provide mechanical and biochemical support to epithelia, muscles, nerves, and blood vessels, among other tissues. The mechanical properties of basement membranes are conferred in part by Collagen IV (Col4), an abundant protein of basement membranes that forms an extensive two-dimensional network through head-to-head and tail-to-tail interactions. After the Col4 network is assembled into a basement membrane, it is crosslinked by the matrix-re...
Source: Matrix Biology - November 24, 2023 Category: Molecular Biology Authors: K Elkie Peebles Kimberly S LaFever Patrick S Page-McCaw Selene Colon Dan Wang Aubrie M Stricker Nicholas Ferrell Gautam Bhave Andrea Page-McCaw Source Type: research
Peroxidasin is required for full viability in development and for maintenance of tissue mechanics in adults
Matrix Biol. 2023 Nov 22:S0945-053X(23)00117-8. doi: 10.1016/j.matbio.2023.11.005. Online ahead of print.ABSTRACTBasement membranes are thin strong sheets of extracellular matrix. They provide mechanical and biochemical support to epithelia, muscles, nerves, and blood vessels, among other tissues. The mechanical properties of basement membranes are conferred in part by Collagen IV (Col4), an abundant protein of basement membranes that forms an extensive two-dimensional network through head-to-head and tail-to-tail interactions. After the Col4 network is assembled into a basement membrane, it is crosslinked by the matrix-re...
Source: Matrix Biology - November 24, 2023 Category: Molecular Biology Authors: K Elkie Peebles Kimberly S LaFever Patrick S Page-McCaw Selene Colon Dan Wang Aubrie M Stricker Nicholas Ferrell Gautam Bhave Andrea Page-McCaw Source Type: research
Peroxidasin is required for full viability in development and for maintenance of tissue mechanics in adults
Matrix Biol. 2023 Nov 22:S0945-053X(23)00117-8. doi: 10.1016/j.matbio.2023.11.005. Online ahead of print.ABSTRACTBasement membranes are thin strong sheets of extracellular matrix. They provide mechanical and biochemical support to epithelia, muscles, nerves, and blood vessels, among other tissues. The mechanical properties of basement membranes are conferred in part by Collagen IV (Col4), an abundant protein of basement membranes that forms an extensive two-dimensional network through head-to-head and tail-to-tail interactions. After the Col4 network is assembled into a basement membrane, it is crosslinked by the matrix-re...
Source: Matrix Biology - November 24, 2023 Category: Molecular Biology Authors: K Elkie Peebles Kimberly S LaFever Patrick S Page-McCaw Selene Colon Dan Wang Aubrie M Stricker Nicholas Ferrell Gautam Bhave Andrea Page-McCaw Source Type: research
Peroxidasin is required for full viability in development and for maintenance of tissue mechanics in adults
Matrix Biol. 2023 Nov 22:S0945-053X(23)00117-8. doi: 10.1016/j.matbio.2023.11.005. Online ahead of print.ABSTRACTBasement membranes are thin strong sheets of extracellular matrix. They provide mechanical and biochemical support to epithelia, muscles, nerves, and blood vessels, among other tissues. The mechanical properties of basement membranes are conferred in part by Collagen IV (Col4), an abundant protein of basement membranes that forms an extensive two-dimensional network through head-to-head and tail-to-tail interactions. After the Col4 network is assembled into a basement membrane, it is crosslinked by the matrix-re...
Source: Matrix Biology - November 24, 2023 Category: Molecular Biology Authors: K Elkie Peebles Kimberly S LaFever Patrick S Page-McCaw Selene Colon Dan Wang Aubrie M Stricker Nicholas Ferrell Gautam Bhave Andrea Page-McCaw Source Type: research
Peroxidasin is required for full viability in development and for maintenance of tissue mechanics in adults
Matrix Biol. 2023 Nov 22:S0945-053X(23)00117-8. doi: 10.1016/j.matbio.2023.11.005. Online ahead of print.ABSTRACTBasement membranes are thin strong sheets of extracellular matrix. They provide mechanical and biochemical support to epithelia, muscles, nerves, and blood vessels, among other tissues. The mechanical properties of basement membranes are conferred in part by Collagen IV (Col4), an abundant protein of basement membranes that forms an extensive two-dimensional network through head-to-head and tail-to-tail interactions. After the Col4 network is assembled into a basement membrane, it is crosslinked by the matrix-re...
Source: Matrix Biology - November 24, 2023 Category: Molecular Biology Authors: K Elkie Peebles Kimberly S LaFever Patrick S Page-McCaw Selene Colon Dan Wang Aubrie M Stricker Nicholas Ferrell Gautam Bhave Andrea Page-McCaw Source Type: research
Peroxidasin is required for full viability in development and for maintenance of tissue mechanics in adults
Matrix Biol. 2023 Nov 22:S0945-053X(23)00117-8. doi: 10.1016/j.matbio.2023.11.005. Online ahead of print.ABSTRACTBasement membranes are thin strong sheets of extracellular matrix. They provide mechanical and biochemical support to epithelia, muscles, nerves, and blood vessels, among other tissues. The mechanical properties of basement membranes are conferred in part by Collagen IV (Col4), an abundant protein of basement membranes that forms an extensive two-dimensional network through head-to-head and tail-to-tail interactions. After the Col4 network is assembled into a basement membrane, it is crosslinked by the matrix-re...
Source: Matrix Biology - November 24, 2023 Category: Molecular Biology Authors: K Elkie Peebles Kimberly S LaFever Patrick S Page-McCaw Selene Colon Dan Wang Aubrie M Stricker Nicholas Ferrell Gautam Bhave Andrea Page-McCaw Source Type: research
Peroxidasin is required for full viability in development and for maintenance of tissue mechanics in adults
Matrix Biol. 2023 Nov 22:S0945-053X(23)00117-8. doi: 10.1016/j.matbio.2023.11.005. Online ahead of print.ABSTRACTBasement membranes are thin strong sheets of extracellular matrix. They provide mechanical and biochemical support to epithelia, muscles, nerves, and blood vessels, among other tissues. The mechanical properties of basement membranes are conferred in part by Collagen IV (Col4), an abundant protein of basement membranes that forms an extensive two-dimensional network through head-to-head and tail-to-tail interactions. After the Col4 network is assembled into a basement membrane, it is crosslinked by the matrix-re...
Source: Matrix Biology - November 24, 2023 Category: Molecular Biology Authors: K Elkie Peebles Kimberly S LaFever Patrick S Page-McCaw Selene Colon Dan Wang Aubrie M Stricker Nicholas Ferrell Gautam Bhave Andrea Page-McCaw Source Type: research
Peroxidasin is required for full viability in development and for maintenance of tissue mechanics in adults
Matrix Biol. 2023 Nov 22:S0945-053X(23)00117-8. doi: 10.1016/j.matbio.2023.11.005. Online ahead of print.ABSTRACTBasement membranes are thin strong sheets of extracellular matrix. They provide mechanical and biochemical support to epithelia, muscles, nerves, and blood vessels, among other tissues. The mechanical properties of basement membranes are conferred in part by Collagen IV (Col4), an abundant protein of basement membranes that forms an extensive two-dimensional network through head-to-head and tail-to-tail interactions. After the Col4 network is assembled into a basement membrane, it is crosslinked by the matrix-re...
Source: Matrix Biology - November 24, 2023 Category: Molecular Biology Authors: K Elkie Peebles Kimberly S LaFever Patrick S Page-McCaw Selene Colon Dan Wang Aubrie M Stricker Nicholas Ferrell Gautam Bhave Andrea Page-McCaw Source Type: research
Peroxidasin is required for full viability in development and for maintenance of tissue mechanics in adults
Matrix Biol. 2023 Nov 22:S0945-053X(23)00117-8. doi: 10.1016/j.matbio.2023.11.005. Online ahead of print.ABSTRACTBasement membranes are thin strong sheets of extracellular matrix. They provide mechanical and biochemical support to epithelia, muscles, nerves, and blood vessels, among other tissues. The mechanical properties of basement membranes are conferred in part by Collagen IV (Col4), an abundant protein of basement membranes that forms an extensive two-dimensional network through head-to-head and tail-to-tail interactions. After the Col4 network is assembled into a basement membrane, it is crosslinked by the matrix-re...
Source: Matrix Biology - November 24, 2023 Category: Molecular Biology Authors: K Elkie Peebles Kimberly S LaFever Patrick S Page-McCaw Selene Colon Dan Wang Aubrie M Stricker Nicholas Ferrell Gautam Bhave Andrea Page-McCaw Source Type: research
