Macrophage phenotype is determinant for fibrosis development in keloid disease
Matrix Biol. 2024 Mar 12:S0945-053X(24)00037-4. doi: 10.1016/j.matbio.2024.03.001. Online ahead of print.ABSTRACTKeloid refers to a fibroproliferative disorder characterized by an accumulation of extracellular matrix (ECM) components at the dermis level, overgrowth beyond initial wound, and formation of tumor-like nodule areas. Treating keloid is still an unmet clinical need and the lack of an efficient therapy is clearly related to limited knowledge about keloid etiology, despite the growing interest of the scientific community in this pathology. In past decades, keloids were often studied in vitro through the sole prism ...
Source: Matrix Biology - March 14, 2024 Category: Molecular Biology Authors: Z élie Dirand M élissa Maraux Marion Tissot Brice Chatelain Dorothy Supp C éline Viennet Sylvain Perruche Gwena ël Rolin Source Type: research
The role of fibrosis in cardiomyopathies: an opportunity to develop novel biomarkers of disease activity
Matrix Biol. 2024 Feb 27:S0945-053X(24)00035-0. doi: 10.1016/j.matbio.2024.02.008. Online ahead of print.ABSTRACTCardiomyopathies encompass a spectrum of heart disorders with diverse causes and presentations. Fibrosis stands out as a shared hallmark among various cardiomyopathies, reflecting a common thread in their pathogenesis. This prevalent fibrotic response is intricately linked to the consequences of dysregulated extracellular matrix (ECM) remodeling, emphasizing its significance in the development and progression the disease. This review explores the ECM involvement in various cardiomyopathies and its impact on myoc...
Source: Matrix Biology - February 29, 2024 Category: Molecular Biology Authors: Elisavet Angeli Maria Jordan Mandy Otto Stevan D Stojanovi ć Morten Karsdal Johann Bauersachs Thomas Thum Jan Fiedler Federica Genovese Source Type: research
The Role of Positional Information in Determining Dermal Fibroblast Diversity
Matrix Biol. 2024 Feb 27:S0945-053X(24)00036-2. doi: 10.1016/j.matbio.2024.02.009. Online ahead of print.ABSTRACTThe largest mammalian organ, skin, consisting of a dermal connective tissue layer that underlies and supports the epidermis, acts as a protective barrier that excludes external pathogens and disseminates sensory signals emanating from the local microenvironment. Dermal connective tissue is comprised of a collagen-rich extracellular matrix (ECM) that is produced by connective tissue fibroblasts resident within the dermis. When wounded, a tissue repair program is induced whereby fibroblasts, in response to alterat...
Source: Matrix Biology - February 29, 2024 Category: Molecular Biology Authors: Pratyusha Chitturi Andrew Leask Source Type: research
The role of fibrosis in cardiomyopathies: an opportunity to develop novel biomarkers of disease activity
Matrix Biol. 2024 Feb 27:S0945-053X(24)00035-0. doi: 10.1016/j.matbio.2024.02.008. Online ahead of print.ABSTRACTCardiomyopathies encompass a spectrum of heart disorders with diverse causes and presentations. Fibrosis stands out as a shared hallmark among various cardiomyopathies, reflecting a common thread in their pathogenesis. This prevalent fibrotic response is intricately linked to the consequences of dysregulated extracellular matrix (ECM) remodeling, emphasizing its significance in the development and progression the disease. This review explores the ECM involvement in various cardiomyopathies and its impact on myoc...
Source: Matrix Biology - February 29, 2024 Category: Molecular Biology Authors: Elisavet Angeli Maria Jordan Mandy Otto Stevan D Stojanovi ć Morten Karsdal Johann Bauersachs Thomas Thum Jan Fiedler Federica Genovese Source Type: research
The Role of Positional Information in Determining Dermal Fibroblast Diversity
Matrix Biol. 2024 Feb 27:S0945-053X(24)00036-2. doi: 10.1016/j.matbio.2024.02.009. Online ahead of print.ABSTRACTThe largest mammalian organ, skin, consisting of a dermal connective tissue layer that underlies and supports the epidermis, acts as a protective barrier that excludes external pathogens and disseminates sensory signals emanating from the local microenvironment. Dermal connective tissue is comprised of a collagen-rich extracellular matrix (ECM) that is produced by connective tissue fibroblasts resident within the dermis. When wounded, a tissue repair program is induced whereby fibroblasts, in response to alterat...
Source: Matrix Biology - February 29, 2024 Category: Molecular Biology Authors: Pratyusha Chitturi Andrew Leask Source Type: research
The role of fibrosis in cardiomyopathies: an opportunity to develop novel biomarkers of disease activity
Matrix Biol. 2024 Feb 27:S0945-053X(24)00035-0. doi: 10.1016/j.matbio.2024.02.008. Online ahead of print.ABSTRACTCardiomyopathies encompass a spectrum of heart disorders with diverse causes and presentations. Fibrosis stands out as a shared hallmark among various cardiomyopathies, reflecting a common thread in their pathogenesis. This prevalent fibrotic response is intricately linked to the consequences of dysregulated extracellular matrix (ECM) remodeling, emphasizing its significance in the development and progression the disease. This review explores the ECM involvement in various cardiomyopathies and its impact on myoc...
Source: Matrix Biology - February 29, 2024 Category: Molecular Biology Authors: Elisavet Angeli Maria Jordan Mandy Otto Stevan D Stojanovi ć Morten Karsdal Johann Bauersachs Thomas Thum Jan Fiedler Federica Genovese Source Type: research
The Role of Positional Information in Determining Dermal Fibroblast Diversity
Matrix Biol. 2024 Feb 27:S0945-053X(24)00036-2. doi: 10.1016/j.matbio.2024.02.009. Online ahead of print.ABSTRACTThe largest mammalian organ, skin, consisting of a dermal connective tissue layer that underlies and supports the epidermis, acts as a protective barrier that excludes external pathogens and disseminates sensory signals emanating from the local microenvironment. Dermal connective tissue is comprised of a collagen-rich extracellular matrix (ECM) that is produced by connective tissue fibroblasts resident within the dermis. When wounded, a tissue repair program is induced whereby fibroblasts, in response to alterat...
Source: Matrix Biology - February 29, 2024 Category: Molecular Biology Authors: Pratyusha Chitturi Andrew Leask Source Type: research
The role of fibrosis in cardiomyopathies: an opportunity to develop novel biomarkers of disease activity
Matrix Biol. 2024 Feb 27:S0945-053X(24)00035-0. doi: 10.1016/j.matbio.2024.02.008. Online ahead of print.ABSTRACTCardiomyopathies encompass a spectrum of heart disorders with diverse causes and presentations. Fibrosis stands out as a shared hallmark among various cardiomyopathies, reflecting a common thread in their pathogenesis. This prevalent fibrotic response is intricately linked to the consequences of dysregulated extracellular matrix (ECM) remodeling, emphasizing its significance in the development and progression the disease. This review explores the ECM involvement in various cardiomyopathies and its impact on myoc...
Source: Matrix Biology - February 29, 2024 Category: Molecular Biology Authors: Elisavet Angeli Maria Jordan Mandy Otto Stevan D Stojanovi ć Morten Karsdal Johann Bauersachs Thomas Thum Jan Fiedler Federica Genovese Source Type: research
The Role of Positional Information in Determining Dermal Fibroblast Diversity
Matrix Biol. 2024 Feb 27:S0945-053X(24)00036-2. doi: 10.1016/j.matbio.2024.02.009. Online ahead of print.ABSTRACTThe largest mammalian organ, skin, consisting of a dermal connective tissue layer that underlies and supports the epidermis, acts as a protective barrier that excludes external pathogens and disseminates sensory signals emanating from the local microenvironment. Dermal connective tissue is comprised of a collagen-rich extracellular matrix (ECM) that is produced by connective tissue fibroblasts resident within the dermis. When wounded, a tissue repair program is induced whereby fibroblasts, in response to alterat...
Source: Matrix Biology - February 29, 2024 Category: Molecular Biology Authors: Pratyusha Chitturi Andrew Leask Source Type: research
The role of fibrosis in cardiomyopathies: an opportunity to develop novel biomarkers of disease activity
Matrix Biol. 2024 Feb 27:S0945-053X(24)00035-0. doi: 10.1016/j.matbio.2024.02.008. Online ahead of print.ABSTRACTCardiomyopathies encompass a spectrum of heart disorders with diverse causes and presentations. Fibrosis stands out as a shared hallmark among various cardiomyopathies, reflecting a common thread in their pathogenesis. This prevalent fibrotic response is intricately linked to the consequences of dysregulated extracellular matrix (ECM) remodeling, emphasizing its significance in the development and progression the disease. This review explores the ECM involvement in various cardiomyopathies and its impact on myoc...
Source: Matrix Biology - February 29, 2024 Category: Molecular Biology Authors: Elisavet Angeli Maria Jordan Mandy Otto Stevan D Stojanovi ć Morten Karsdal Johann Bauersachs Thomas Thum Jan Fiedler Federica Genovese Source Type: research
The Role of Positional Information in Determining Dermal Fibroblast Diversity
Matrix Biol. 2024 Feb 27:S0945-053X(24)00036-2. doi: 10.1016/j.matbio.2024.02.009. Online ahead of print.ABSTRACTThe largest mammalian organ, skin, consisting of a dermal connective tissue layer that underlies and supports the epidermis, acts as a protective barrier that excludes external pathogens and disseminates sensory signals emanating from the local microenvironment. Dermal connective tissue is comprised of a collagen-rich extracellular matrix (ECM) that is produced by connective tissue fibroblasts resident within the dermis. When wounded, a tissue repair program is induced whereby fibroblasts, in response to alterat...
Source: Matrix Biology - February 29, 2024 Category: Molecular Biology Authors: Pratyusha Chitturi Andrew Leask Source Type: research
The role of fibrosis in cardiomyopathies: an opportunity to develop novel biomarkers of disease activity
Matrix Biol. 2024 Feb 27:S0945-053X(24)00035-0. doi: 10.1016/j.matbio.2024.02.008. Online ahead of print.ABSTRACTCardiomyopathies encompass a spectrum of heart disorders with diverse causes and presentations. Fibrosis stands out as a shared hallmark among various cardiomyopathies, reflecting a common thread in their pathogenesis. This prevalent fibrotic response is intricately linked to the consequences of dysregulated extracellular matrix (ECM) remodeling, emphasizing its significance in the development and progression the disease. This review explores the ECM involvement in various cardiomyopathies and its impact on myoc...
Source: Matrix Biology - February 29, 2024 Category: Molecular Biology Authors: Elisavet Angeli Maria Jordan Mandy Otto Stevan D Stojanovi ć Morten Karsdal Johann Bauersachs Thomas Thum Jan Fiedler Federica Genovese Source Type: research
The Role of Positional Information in Determining Dermal Fibroblast Diversity
Matrix Biol. 2024 Feb 27:S0945-053X(24)00036-2. doi: 10.1016/j.matbio.2024.02.009. Online ahead of print.ABSTRACTThe largest mammalian organ, skin, consisting of a dermal connective tissue layer that underlies and supports the epidermis, acts as a protective barrier that excludes external pathogens and disseminates sensory signals emanating from the local microenvironment. Dermal connective tissue is comprised of a collagen-rich extracellular matrix (ECM) that is produced by connective tissue fibroblasts resident within the dermis. When wounded, a tissue repair program is induced whereby fibroblasts, in response to alterat...
Source: Matrix Biology - February 29, 2024 Category: Molecular Biology Authors: Pratyusha Chitturi Andrew Leask Source Type: research
The role of fibrosis in cardiomyopathies: an opportunity to develop novel biomarkers of disease activity
Matrix Biol. 2024 Feb 27:S0945-053X(24)00035-0. doi: 10.1016/j.matbio.2024.02.008. Online ahead of print.ABSTRACTCardiomyopathies encompass a spectrum of heart disorders with diverse causes and presentations. Fibrosis stands out as a shared hallmark among various cardiomyopathies, reflecting a common thread in their pathogenesis. This prevalent fibrotic response is intricately linked to the consequences of dysregulated extracellular matrix (ECM) remodeling, emphasizing its significance in the development and progression the disease. This review explores the ECM involvement in various cardiomyopathies and its impact on myoc...
Source: Matrix Biology - February 29, 2024 Category: Molecular Biology Authors: Elisavet Angeli Maria Jordan Mandy Otto Stevan D Stojanovi ć Morten Karsdal Johann Bauersachs Thomas Thum Jan Fiedler Federica Genovese Source Type: research
The Role of Positional Information in Determining Dermal Fibroblast Diversity
Matrix Biol. 2024 Feb 27:S0945-053X(24)00036-2. doi: 10.1016/j.matbio.2024.02.009. Online ahead of print.ABSTRACTThe largest mammalian organ, skin, consisting of a dermal connective tissue layer that underlies and supports the epidermis, acts as a protective barrier that excludes external pathogens and disseminates sensory signals emanating from the local microenvironment. Dermal connective tissue is comprised of a collagen-rich extracellular matrix (ECM) that is produced by connective tissue fibroblasts resident within the dermis. When wounded, a tissue repair program is induced whereby fibroblasts, in response to alterat...
Source: Matrix Biology - February 29, 2024 Category: Molecular Biology Authors: Pratyusha Chitturi Andrew Leask Source Type: research
