A secreted form of chorismate mutase (Rv1885c) in Mycobacterium bovis BCG contributes to pathogenesis by inhibiting mitochondria-mediated apoptotic cell death of macrophages
Mycobacterium tuberculosis is the causative agent of tuberculosis (TB), and its pathogenicity is associated with its ability to evade the host defense system. The secretory form of the chorismate mutase of M. tub... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - December 18, 2023 Category: Biomedical Science Authors: Mi-Hyun Lee, Hye Lin Kim, Hyejun Seo, Sangkwon Jung and Bum-Joon Kim Tags: Research Source Type: research
A novel mucosal bivalent vaccine of EV-A71/EV-D68 adjuvanted with polysaccharides from Ganoderma lucidum protects mice against EV-A71 and EV-D68 lethal challenge
Human enteroviruses A71 (EV-A71) and D68 (EV-D68) are the suspected causative agents of hand-foot-and-mouth disease, aseptic meningitis, encephalitis, acute flaccid myelitis, and acute flaccid paralysis in chi... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - December 18, 2023 Category: Biomedical Science Authors: Yu-Li Lin, Pei-Yun Cheng, Chiao-Li Chin, Kuan-Ting Chuang, Jing-Yi Lin, Ning Chang, Chun-Kei Pan, Cheng-Sheng Lin, Siao-Cian Pan and Bor-Luen Chiang Tags: Research Source Type: research
ARID1A loss activates MAPK signaling via DUSP4 downregulation
ARID1A, a tumor suppressor gene encoding BAF250, a protein participating in chromatin remodeling, is frequently mutated in endometrium-related malignancies, including ovarian or uterine clear cell carcinoma (CCC)... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - December 9, 2023 Category: Biomedical Science Authors: Jayaprakash Mandal, Zheng-Cheng Yu, Ie-Ming Shih and Tian-Li Wang Tags: Research Source Type: research
SCEL regulates switches between pro-survival and apoptosis of the TNF- α/TNFR1/NF-κB/c-FLIP axis to control lung colonization of triple negative breast cancer
Patients with metastatic triple-negative breast cancer (mTNBC) have a higher probability of developing visceral metastasis within 5 years after the initial diagnosis. Therefore, a deeper understanding of the p... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - November 30, 2023 Category: Biomedical Science Authors: Shih-Hsuan Chan, Wen-Hung Kuo and Lu-Hai Wang Tags: Research Source Type: research
Butterflies in the gut: the interplay between intestinal microbiota and stress
Psychological stress is a global issue that affects at least one-third of the population worldwide and increases the risk of numerous psychiatric disorders. Accumulating evidence suggests that the gut and its ... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - November 28, 2023 Category: Biomedical Science Authors: Tzu-Ting Lai, Chia-Wei Liou, Yu-Hsuan Tsai, Yuan-Yuan Lin and Wei-Li Wu Tags: Review Source Type: research
Spatiotemporal roles of AMPK in PARP-1- and autophagy-dependent retinal pigment epithelial cell death caused by UVA
Although stimulating autophagy caused by UV has been widely demonstrated in skin cells to exert cell protection, it remains unknown the cellular events in UVA-treated retinal pigment epithelial (RPE) cells. (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - November 7, 2023 Category: Biomedical Science Authors: Anthony Yan-Tang Wu, Ponarulselvam Sekar, Duen-Yi Huang, Shu-Hao Hsu, Chi-Ming Chan and Wan-Wan Lin Tags: Research Source Type: research
The ‘speck’-tacular oversight of the NLRP3-pyroptosis pathway on gastrointestinal inflammatory diseases and tumorigenesis
The NLRP3 inflammasome is an intracellular sensor and an essential component of the innate immune system involved in danger recognition. An important hallmark of inflammasome activation is the formation of a s... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - October 27, 2023 Category: Biomedical Science Authors: Valentina Arr è, Rosanna Scialpi, Matteo Centonze, Gianluigi Giannelli, Maria Principia Scavo and Roberto Negro Tags: Review Source Type: research
Complete spectrum of adverse events associated with chimeric antigen receptor (CAR)-T cell therapies
Chimeric antigen receptor (CAR)-T cell therapies have been approved by FDA to treat relapsed or refractory hematological malignancies. However, the adverse effects of CAR-T cell therapies are complex and can b... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - October 21, 2023 Category: Biomedical Science Authors: Chieh Yang, John Nguyen and Yun Yen Tags: Review Source Type: research
Small interfering RNA (siRNA)-based therapeutic applications against viruses: principles, potential, and challenges
RNA has emerged as a revolutionary and important tool in the battle against emerging infectious diseases, with roles extending beyond its applications in vaccines, in which it is used in the response to the CO... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - October 16, 2023 Category: Biomedical Science Authors: Hara Kang, Yun Ji Ga, Soo Hyun Kim, Young Hoon Cho, Jung Won Kim, Chaeyeon Kim and Jung-Yong Yeh Tags: Review Source Type: research
Human ACE2 protein is a molecular switch controlling the mode of SARS-CoV-2 transmission
Human angiotensin-converting enzyme 2 (hACE2) is the receptor mediating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. hACE2 expression is low in the lungs and is upregulated after SAR... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - October 12, 2023 Category: Biomedical Science Authors: Chao-Fu Yang, Chun-Che Liao, Hung-Wei Hsu, Jian-Jong Liang, Chih-Shin Chang, Hui-Ying Ko, Rue-Hsin Chang, Wei-Chun Tang, Ming-Hao Chang, I-Hsuan Wang and Yi-Ling Lin Tags: Research Source Type: research
Crosstalk between mitochondrial biogenesis and mitophagy to maintain mitochondrial homeostasis
Mitochondrial mass and quality are tightly regulated by two essential and opposing mechanisms, mitochondrial biogenesis (mitobiogenesis) and mitophagy, in response to cellular energy needs and other cellular a... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - October 12, 2023 Category: Biomedical Science Authors: Lei Liu, Yanjun Li, Guo Chen and Quan Chen Tags: Review Source Type: research
Extracellular release in the quality control of the mammalian mitochondria
Mammalian cells release a wealth of materials to their surroundings. Emerging data suggest these materials can even be mitochondria with perturbed morphology and aberrant function. These dysfunctional mitochon... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - October 8, 2023 Category: Biomedical Science Authors: Kuei-Hsiang Pan, Hung Chang and Wei Yuan Yang Tags: Review Source Type: research
mRNA-based vaccines and therapeutics: an in-depth survey of current and upcoming clinical applications
mRNA-based drugs have tremendous potential as clinical treatments, however, a major challenge in realizing this drug class will promise to develop methods for safely delivering the bioactive agents with high e... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - October 7, 2023 Category: Biomedical Science Authors: Yu-Shiuan Wang, Monika Kumari, Guan-Hong Chen, Ming-Hsiang Hong, Joyce Pei-Yi Yuan, Jui-Ling Tsai and Han-Chung Wu Tags: Review Source Type: research
Clinical trials of new drugs for Alzheimer disease: a 2020 –2023 update
Alzheimer's disease (AD) is the leading cause of dementia, presenting a significant unmet medical need worldwide. The pathogenesis of AD involves various pathophysiological events, including the accumulation o... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - October 2, 2023 Category: Biomedical Science Authors: Li-Kai Huang, Yi-Chun Kuan, Ho-Wei Lin and Chaur-Jong Hu Tags: Review Source Type: research
Induced pluripotent stem cells: ex vivo models for human diseases due to mitochondrial DNA mutations
Mitochondria are essential organelles for cellular metabolism and physiology in eukaryotic cells. Human mitochondria have their own genome (mtDNA), which is maternally inherited with 37 genes, encoding 13 poly... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - September 22, 2023 Category: Biomedical Science Authors: Chao Chen and Min-Xin Guan Tags: Review Source Type: research
