Expanding applications of allogeneic platelets, platelet lysates, and platelet extracellular vesicles in cell therapy, regenerative medicine, and targeted drug delivery
Platelets are small anucleated blood cells primarily known for their vital hemostatic role. Allogeneic platelet concentrates (PCs) collected from healthy donors are an essential cellular product transfused by ... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - September 14, 2023 Category: Biomedical Science Authors: Thierry Burnouf, Ming-Li Chou, David J. Lundy, Er-Yuan Chuang, Ching-Li Tseng and Hadi Goubran Tags: Review Source Type: research
Long noncoding RNA SNHG16 regulates TLR4-mediated autophagy and NETosis formation in alveolar hemorrhage associated with systemic lupus erythematosus
Dysregulated long noncoding RNA (lncRNA) expression with increased apoptosis has been demonstrated in systemic lupus erythematosus (SLE) patients with alveolar hemorrhage (AH). SNHG16, a lncRNA, can enhance pu... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - September 12, 2023 Category: Biomedical Science Authors: Yu-Tung Hsieh, Yi-Cheng Chen, Yu-Chi Chou, Pin ‑Yu Kuo, Yi-Ting Yen, Hung-Wen Tsai and Chrong-Reen Wang Tags: Research Source Type: research
Platelet-derived biomaterial with hyaluronic acid alleviates temporal-mandibular joint osteoarthritis: clinical trial from dish to human
Bioactive materials have now raised considerable attention for the treatment of osteoarthritis (OA), such as knee OA, rheumatoid OA, and temporomandibular joint (TMJ) OA. TMJ-OA is a common disease associated ... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - September 11, 2023 Category: Biomedical Science Authors: Bou-Yue Peng, Abhinay Kumar Singh, Ching-Yu Tsai, Chun-Hao Chan, Yue-Hua Deng, Chi-Ming Wu, Yen-Ru Chou, Wen Tsao, Chia-Yu Wu and Win-Ping Deng Tags: Research Source Type: research
Structural changes in perineuronal nets and their perforating GABAergic synapses precede motor coordination recovery post stroke
Stroke remains one of the leading causes of long-term disability worldwide, and the development of effective restorative therapies is hindered by an incomplete understanding of intrinsic brain recovery mechani... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - September 1, 2023 Category: Biomedical Science Authors: Egor Dzyubenko, Katrin I. Willig, Dongpei Yin, Maryam Sardari, Erdin Tokmak, Patrick Labus, Ben Schmermund and Dirk M. Hermann Tags: Research Source Type: research
A novel phage carrying capsule depolymerase effectively relieves pneumonia caused by multidrug-resistant Klebsiella aerogenes
Klebsiella aerogenes can cause ventilator-associated pneumonia by forming biofilms, and it is frequently associated with multidrug resistance. Phages are good antibiotic alternatives with unique advantages. There... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - August 31, 2023 Category: Biomedical Science Authors: Xiaohu Cui, Bing Du, Junxia Feng, Yanling Feng, Zheng Fan, Jinfeng Chen, Jinghua Cui, Lin Gan, Tongtong Fu, Ziyan Tian, Rui Zhang, Chao Yan, Hanqing Zhao, Wenjian Xu, Ziying Xu, Zihui Yu & hellip; Tags: Research Source Type: research
Harnessing cell reprogramming for cardiac biological pacing
Electrical impulses from cardiac pacemaker cardiomyocytes initiate cardiac contraction and blood pumping and maintain life. Abnormal electrical impulses bring patients with low heart rates to cardiac arrest. T... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - August 26, 2023 Category: Biomedical Science Authors: Chih-Min Liu, Yi-Chun Chen and Yu-Feng Hu Tags: Review Source Type: research
Various arrangements of mobile genetic elements among CC147 subpopulations of Klebsiella pneumoniae harboring blaNDM-1: a comparative genomic analysis of carbapenem resistant strains
Certain clonal complexes (CCs) of Klebsiella pneumoniae such as CC147 (ST147 and ST392) are major drivers of blaNDM dissemination across the world. ST147 has repeatedly reported from our geographical region, but ... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - August 25, 2023 Category: Biomedical Science Authors: Omid Pajand, Hamzeh Rahimi, Farzad Badmasti, Faeze Gholami, Tahereh Alipour, Narges Darabi, Frank M. Aarestrup and Pimlapas Leekitcharoenphon Tags: Research Source Type: research
5 ʹ-Ectonucleotidase CD73/NT5E supports EGFR-mediated invasion of HPV-negative head and neck carcinoma cells
Epithelial-to-mesenchymal transition (EMT) of malignant cells is a driving force of disease progression in human papillomavirus-negative (HPV-negative) head and neck squamous cell carcinomas (HNSCC). Sustained... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - August 24, 2023 Category: Biomedical Science Authors: Enxian Shi, Zhengquan Wu, Birnur Sinem Karaoglan, Sabina Schwenk-Zieger, Gisela Kranz, Nilofer Abdul Razak, Christoph A. Reichel, Martin Canis, Philipp Baumeister, Reinhard Zeidler and Olivier Gires Tags: Research Source Type: research
ACE2 in chronic disease and COVID-19: gene regulation and post-translational modification
Angiotensin-converting enzyme 2 (ACE2), a counter regulator of the renin-angiotensin system, provides protection against several chronic diseases. Besides chronic diseases, ACE2 is the host receptor for SARS-C... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - August 22, 2023 Category: Biomedical Science Authors: Chia-Wen Wang, Huai-Chia Chuang and Tse-Hua Tan Tags: Review Source Type: research
Exosomal miRNA-mediated intercellular communications and immunomodulatory effects in tumor microenvironments
Extracellular communication, in other words, crosstalk between cells, has a pivotal role in the survival of an organism. This communication occurs by different methods, one of which is extracellular vesicles. ... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - August 21, 2023 Category: Biomedical Science Authors: Howida M. Nail, Chien-Chih Chiu, Chung-Hang Leung, Mahmoud M. M. Ahmed and Hui-Min David Wang Tags: Review Source Type: research
Mitochondrial impairment and synaptic dysfunction are associated with neurological defects in iPSCs-derived cortical neurons of MERRF patients
Myoclonic epilepsy with ragged-red fibers (MERRF) syndrome is a rare inherited mitochondrial disease mainly caused by the m.8344A > G mutation in mitochondrial tRNALys gene, and usually manifested as complex neur... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - August 21, 2023 Category: Biomedical Science Authors: Yu-Ting Wu, Hui-Yi Tay, Jung-Tse Yang, Hsiao-Hui Liao, Yi-Shing Ma and Yau-Huei Wei Tags: Research Source Type: research
Fierce poison to others: the phenomenon of bacterial dependence on antibiotics
Beyond the development of resistance, the effects of antibiotics on bacteria and microbial communities are complex and far from exhaustively studied. In the context of the current global antimicrobial resistan... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - August 14, 2023 Category: Biomedical Science Authors: Claudia C. Paredes-Amaya, Mar ía Teresa Ulloa and Víctor Antonio García-Angulo Tags: Review Source Type: research
The RNA-binding protein KSRP aggravates malignant progression of clear cell renal cell carcinoma through transcriptional inhibition and post-transcriptional destabilization of the NEDD4L ubiquitin ligase
KH-type splicing regulatory protein (KHSRP, also called KSRP), a versatile RNA-binding protein, plays a critical role in various physiological and pathological conditions through modulating gene expressions at... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - August 14, 2023 Category: Biomedical Science Authors: Yi-Chieh Yang, Yung-Wei Lin, Wei-Jiunn Lee, Feng-Ru Lai, Kuo-Hao Ho, Chih-Ying Chu, Kuo-Tai Hua, Ji-Qing Chen, Min-Che Tung, Michael Hsiao, Yu-Ching Wen and Ming-Hsien Chien Tags: Research Source Type: research
Neuroprotective effects of osmotin in Parkinson ’s disease-associated pathology via the AdipoR1/MAPK/AMPK/mTOR signaling pathways
Parkinson ’s disease (PD) is the second most frequent age-related neurodegenerative disorder and is characterized by the loss of dopaminergic neurons. Both environmental and genetic aspects are involved in the ... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - August 11, 2023 Category: Biomedical Science Authors: Jun Sung Park, Kyonghwan Choe, Hyeon Jin Lee, Tae Ju Park and Myeong Ok Kim Tags: Research Source Type: research
Circulating tumour DNA alterations: emerging biomarker in head and neck squamous cell carcinoma
Head and Neck cancers (HNC) are a heterogeneous group of upper aero-digestive tract cancer and account for 931,922 new cases and 467,125 deaths worldwide. About 90% of these cancers are of squamous cell origin... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - August 9, 2023 Category: Biomedical Science Authors: Xiaomin Huang, Pascal H. G. Duijf, Sharath Sriram, Ganganath Perera, Sarju Vasani, Lizbeth Kenny, Paul Leo and Chamindie Punyadeera Tags: Review Source Type: research
