Interleukin-20 is involved in dry eye disease and is a potential therapeutic target
Dry eye disease (DED) is a common disease in ophthalmology, affecting millions of people worldwide. Recent studies have shown that inflammation is the core mechanism of DED. IL-20 is a proinflammatory cytokine... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - June 9, 2022 Category: Biomedical Science Authors: Hsiao-Hsuan Wang, Wei-Yu Chen, Yi-Hsun Huang, Sheng-Min Hsu, Yeou-Ping Tsao, Yu-Hsiang Hsu and Ming-Shi Chang Tags: Research Source Type: research
Induction of high affinity monoclonal antibodies against SARS-CoV-2 variant infection using a DNA prime-protein boost strategy
Calls for the coronavirus to be treated as an endemic illness, such as the flu, are increasing. After achieving high coverage of COVID-19 vaccination, therapeutic drugs have become important for future SARS-Co... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - June 9, 2022 Category: Biomedical Science Authors: Chen-Yi Chiang, Mei-Yu Chen, Chia-Wei Hsu, Chia-Yeh Liu, Yu-Wen Tsai, Hung-Chun Liao, Jia-Ying Yan, Zih-Shiuan Chuang, Hsin-I. Wang, Chien-Hsiung Pan, Chia-Yi Yu, Guann-Yi Yu, Ching-Len Liao, Shih-Jen Liu and Hsin-Wei Chen Tags: Research Source Type: research
SRF: a seriously responsible factor in cardiac development and disease
The molecular mechanisms that regulate embryogenesis and cardiac development are calibrated by multiple signal transduction pathways within or between different cell lineages via autocrine or paracrine mechani... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - June 9, 2022 Category: Biomedical Science Authors: Anushka Deshpande, Prithviraj Manohar Vijaya Shetty, Norbert Frey and Ashraf Yusuf Rangrez Tags: Review Source Type: research
Bioengineering in salivary gland regeneration
Salivary gland (SG) dysfunction impairs the life quality of many patients, such as patients with radiation therapy for head and neck cancer and patients with Sj ögren’s syndrome. Multiple SG engineering strateg... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - June 6, 2022 Category: Biomedical Science Authors: Maryam Hajiabbas, Claudia D ’Agostino, Julia Simińska-Stanny, Simon D. Tran, Amin Shavandi and Christine Delporte Tags: Review Source Type: research
DYRK1A reinforces epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma via cooperatively activating STAT3 and SMAD
Hepatocellular carcinoma (HCC) accounts for the majority of liver cancer cases, while metastasis is considered the leading cause of HCC-related death. However, the currently available treatment strategies for ... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - June 2, 2022 Category: Biomedical Science Authors: Yang-ling Li, Man-man Zhang, Lin-wen Wu, Ye-han Liu, Zuo-yan Zhang, Ling-hui Zeng, Neng-ming Lin and Chong Zhang Tags: Research Source Type: research
Post-translational modifications on the retinoblastoma protein
The retinoblastoma protein (pRb) functions as a cell cycle regulator controlling G1 to S phase transition and plays critical roles in tumour suppression. It is frequently inactivated in various tumours. The fu... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - June 1, 2022 Category: Biomedical Science Authors: Linbin Zhou, Danny Siu-Chun Ng, Jason C. Yam, Li Jia Chen, Clement C. Tham, Chi Pui Pang and Wai Kit Chu Tags: Review Source Type: research
Preclinical validation and phase I trial of 4-hydroxysalicylanilide, targeting ribonucleotide reductase mediated dNTP synthesis in multiple myeloma
Aberrant DNA repair pathways contribute to malignant transformation or disease progression and the acquisition of drug resistance in multiple myeloma (MM); therefore, these pathways could be therapeutically ex... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - May 12, 2022 Category: Biomedical Science Authors: Yongsheng Xie, Yingcong Wang, Zhijian Xu, Yumeng Lu, Dongliang Song, Lu Gao, Dandan Yu, Bo Li, Gege Chen, Hui Zhang, Qilin Feng, Yong Zhang, Ke Hu, Cheng Huang, Yu Peng, Xiaosong Wu & hellip; Tags: Research Source Type: research
Long noncoding RNA BCRP3 stimulates VPS34 and autophagy activities to promote protein homeostasis and cell survival
Autophagy plays important roles in cell homeostasis and protein quality control. Long non-coding RNAs (lncRNAs) have been revealed as an emerging class of autophagy regulators, but the majority of them functio... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - May 10, 2022 Category: Biomedical Science Authors: Ruei-Liang Yan, Chiu-Lin Luan, Chun-Chieh Liao, Li-Heng Liu, Fei-Yun Chen, Hsin-Yi Chen and Ruey-Hwa Chen Tags: Research Source Type: research
Inhibition of ChREBP ubiquitination via the ROS/Akt-dependent downregulation of Smurf2 contributes to lysophosphatidic acid-induced fibrosis in renal mesangial cells
Mesangial cell fibrosis, a typical symptom of diabetic nephropathy (DN), is a major contributor to glomerulosclerosis. We previously reported that the pharmacological blockade of lysophosphatidic acid (LPA) si... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - May 10, 2022 Category: Biomedical Science Authors: Donghee Kim, Ga-Young Nam, Eunhui Seo and Hee-Sook Jun Tags: Research Source Type: research
Natural product myricetin is a pan-KDM4 inhibitor which with poly lactic-co-glycolic acid formulation effectively targets castration-resistant prostate cancer
Castration-resistant prostate cancer (CRPC) with sustained androgen receptor (AR) signaling remains a critical clinical challenge, despite androgen depletion therapy. The Jumonji C-containing histone lysine de... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - May 9, 2022 Category: Biomedical Science Authors: Jai-Shin Liu, Wei-Kai Fang, Shan-Min Yang, Meng-Chen Wu, Tsan-Jan Chen, Chih-Ming Chen, Tung-Yueh Lin, Kai-Lun Liu, Chien-Ming Wu, Yun-Ching Chen, Chih-Pin Chuu, Ling-Yu Wang, Hsing-Pang Hsieh, Hsing-Jien Kung and Wen-Ching Wang Tags: Research Source Type: research
Unravelling the physiological roles of mazEF toxin –antitoxin system on clinical MRSA strain by CRISPR RNA-guided cytidine deaminase
Curiosity on toxin –antitoxin modules has increased intensely over recent years as it is ubiquitously present in many bacterial genomes, including pathogens like Methicillin-resistant Staphylococcus aureus (MRSA).... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - May 7, 2022 Category: Biomedical Science Authors: Sonia Jain, Arghya Bhowmick, Bohyun Jeong, Taeok Bae and Abhrajyoti Ghosh Tags: Research Source Type: research
The effects of SARS-CoV-2 infection on modulating innate immunity and strategies of combating inflammatory response for COVID-19 therapy
The global pandemic of COVID-19 has caused huge causality and unquantifiable loss of social wealth. The innate immune response is the first line of defense against SARS-CoV-2 infection. However, strong inflamm... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - May 3, 2022 Category: Biomedical Science Authors: Yiran Wang, Mandi Wu, Yichen Li, Ho Him Yuen and Ming-Liang He Tags: Review Source Type: research
The fciTABC and feoABI systems contribute to ferric citrate acquisition in Stenotrophomonas maltophilia
Stenotrophomonas maltophilia, a member of γ-proteobacteria, is a ubiquitous environmental bacterium that is recognized as an opportunistic nosocomial pathogen. FecABCD system contributes to ferric citrate acquisi... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - April 27, 2022 Category: Biomedical Science Authors: Chun-Hsing Liao, Hsu-Feng Lu, Hsin-Hui Huang, Yu Chen, Li-Hua Li, Yi-Tsung Lin and Tsuey-Ching Yang Tags: Research Source Type: research
Cysteine-rich protein 2 deficiency attenuates angiotensin II-induced abdominal aortic aneurysm formation in mice
Abdominal aortic aneurysm (AAA) is a relatively common and often fatal condition. A major histopathological hallmark of AAA is the severe degeneration of aortic media with loss of vascular smooth muscle cells ... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - April 12, 2022 Category: Biomedical Science Authors: Chung-Huang Chen, Hua-Hui Ho, Wei-Cheng Jiang, Wai-Sam Ao-Ieong, Jane Wang, Alexander N. Orekhov, Igor A. Sobenin, Matthew D. Layne and Shaw-Fang Yet Tags: Research Source Type: research
A novel HIF1 α-STIL-FOXM1 axis regulates tumor metastasis
Metastasis is the major cause of morbidity and mortality in cancer that involves in multiple steps including epithelial –mesenchymal transition (EMT) process. Centrosome is an organelle that functions as the ma... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - April 1, 2022 Category: Biomedical Science Authors: Yi-Wei Wang, Shu-Chuan Chen, De-Leung Gu, Yi-Chen Yeh, Jhih-Jie Tsai, Kuo-Tai Yang, Yuh-Shan Jou, Teh-Ying Chou and Tang K. Tang Tags: Research Source Type: research
