Clinical and functional characterization of a novel STUB1 frameshift mutation in autosomal dominant spinocerebellar ataxia type 48 (SCA48)
Heterozygous pathogenic variants in STUB1 are implicated in autosomal dominant spinocerebellar ataxia type 48 (SCA48), which is a rare familial ataxia disorder. We investigated the clinical, genetic and functiona... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - September 26, 2021 Category: Biomedical Science Authors: Huan-Yun Chen, Chia-Lang Hsu, Han-Yi Lin, Yung-Feng Lin, Shih-Feng Tsai, Yu-Jung Ho, Ye-Ru Li, Jin-Wu Tsai, Shu-Chun Teng and Chin-Hsien Lin Tags: Research Source Type: research
Advances in the management of haemophilia: emerging treatments and their mechanisms
Mainstay haemophilia treatment, namely intravenous factor replacement, poses several clinical challenges including frequent injections due to the short half-life of recombinant factors, intravenous administrat... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - September 14, 2021 Category: Biomedical Science Authors: Dide Okaygoun, Danielle D. Oliveira, Sooriya Soman and Riccardo Williams Tags: Review Source Type: research
Control of Spontaneous HPV16 E6/E7 Expressing Oral Cancer in HLA-A2 (AAD) Transgenic Mice with Therapeutic HPV DNA Vaccine
Human Papillomavirus type 16 (HPV16) has been associated with a subset of head and neck cancers. Two HPV encoded oncogenic proteins, E6 and E7, are important for the malignant progression of HPV-associated can... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - September 13, 2021 Category: Biomedical Science Authors: Ssu-Hsueh Tseng, Li Liu, Shiwen Peng, Jinhwi Kim, Louise Ferrall, Chien-Fu Hung and T. -C. Wu Tags: Research Source Type: research
The cell adhesion molecule TMIGD1 binds to moesin and regulates tubulin acetylation and cell migration
The cell adhesion molecule transmembrane and immunoglobulin (Ig) domain containing1 (TMIGD1) is a novel tumor suppressor that plays important roles in regulating cell –cell adhesion, cell proliferation and cell... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - September 9, 2021 Category: Biomedical Science Authors: Nader Rahimi, Rachel X. Y. Ho, Kevin Brown Chandler, Kyle Oliver Corcino De La Cena, Razie Amraei, Ashley J. Mitchel, Nels Engblom and Catherine E. Costello Tags: Research Source Type: research
Design, synthesis, and preliminary evaluation of a potential synthetic opioid rescue agent
One of the most prominent opioid analgesics in the United States is the high potency agonist fentanyl. It is used in the treatment of acute and chronic pain and as an anesthetic adjuvant. When used inappropria... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - September 9, 2021 Category: Biomedical Science Authors: Sidnee L. Hedrick, Dan Luo, Sophia Kaska, Kumar Kulldeep Niloy, Karen Jackson, Rupam Sarma, Jamie Horn, Caroline Baynard, Markos Leggas, Eduardo R. Butelman, Mary Jeanne Kreek and Thomas E. Prisinzano Tags: Research Source Type: research
Bacterial factors required for Streptococcus pneumoniae coinfection with influenza A virus
Streptococcus pneumoniae is a common cause of post-influenza secondary bacterial infection, which results in excessive morbidity and mortality. Although 13-valent pneumococcal conjugate vaccine (PCV13) vaccinatio... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - August 27, 2021 Category: Biomedical Science Authors: Yi-Yin Chen, Ching-Tai Huang, Shiao-Wen Li, Yi-Jiun Pan, Tzu-Lung Lin, Ya-Yu Huang, Ting-Hsuan Li, Yu-Ching Yang, Yu-Nong Gong and Yu-Chia Hsieh Tags: Research Source Type: research
The regulatory roles of microRNAs toward pathogenesis and treatments in Huntington's disease
Huntington ’s disease (HD) is one of neurodegenerative diseases, and is defined as a monogenetic disease due to the mutation of Huntingtin gene. This disease affects several cellular functions in neurons, and furt... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - August 19, 2021 Category: Biomedical Science Authors: Chih-Wei Tung, Pin-Yu Huang, Siew Chin Chan, Pei-Hsun Cheng and Shang-Hsun Yang Tags: Review Source Type: research
More than causing (epi)genomic instability: emerging physiological implications of transposable element modulation
Transposable elements (TEs) initially attracted attention because they comprise a major portion of the genomic sequences in plants and animals. TEs may jump around the genome and disrupt both coding genes as w... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - August 7, 2021 Category: Biomedical Science Authors: Pu-Sheng Hsu, Shu-Han Yu, Yi-Tzang Tsai, Jen-Yun Chang, Li-Kuang Tsai, Chih-Hung Ye, Ning-Yu Song, Lih-Chiao Yau and Shau-Ping Lin Tags: Review Source Type: research
MicroRNA-138-1-3p sensitizes sorafenib to hepatocellular carcinoma by targeting PAK5 mediated β-catenin/ABCB1 signaling pathway
Sorafenib is a kinase inhibitor that is used as a first-line therapy in advanced hepatocellular carcinoma (HCC) patients. However, the existence of sorafenib resistance has limited its therapeutic effect. Thro... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - August 2, 2021 Category: Biomedical Science Authors: Tong-tong Li, Jie Mou, Yao-jie Pan, Fu-chun Huo, Wen-qi Du, Jia Liang, Yang Wang, Lan-sheng Zhang and Dong-sheng Pei Tags: Research Source Type: research
PSPC1 is a new contextual determinant of aberrant subcellular translocation of oncogenes in tumor progression
Dysregulation of nucleocytoplasmic shuttling is commonly observed in cancers and emerging as a cancer hallmark for the development of anticancer therapeutic strategies. Despite its severe adverse effects, seli... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - August 2, 2021 Category: Biomedical Science Authors: Yaw-Dong Lang and Yuh-Shan Jou Tags: Review Source Type: research
AUY922 induces retinal toxicity through attenuating TRPM1
Ocular adverse events are common dose-limiting toxicities in cancer patients treated with HSP90 inhibitors, such as AUY922; however, the pathology and molecular mechanisms that mediate AUY922-induced retinal t... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - July 23, 2021 Category: Biomedical Science Authors: Che-Hung Shen, Chi-Che Hsieh, Kuan-Ying Jiang, Chih-Yu Lin, Nai-Jung Chiang, Ting-Wei Li, Chun-Ting Yen, Wan-Ju Chen, Daw-Yang Hwang and Li-Tzong Chen Tags: Research Source Type: research
Diagnosis of transition zone prostate cancer by multiparametric MRI: added value of MR spectroscopic imaging with sLASER volume selection
Current multiparametric MRI (mp-MRI) in routine clinical practice has poor-to-moderate diagnostic performance for transition zone prostate cancer. The aim of this study was to evaluate the potential diagnostic... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - July 19, 2021 Category: Biomedical Science Authors: Neda Gholizadeh, Peter B. Greer, John Simpson, Jonathan Goodwin, Caixia Fu, Peter Lau, Saabir Siddique, Arend Heerschap and Saadallah Ramadan Tags: Research Source Type: research
Downregulating lncRNA NEAT1 induces proliferation and represses apoptosis of ovarian granulosa cells in polycystic ovary syndrome via microRNA-381/IGF1 axis
This study aimed to understand the role of nuclear-enriched abundant... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - July 15, 2021 Category: Biomedical Science Authors: Jingran Zhen, Jiangli Li, Xia Li, Xue Wang, Yaling Xiao, Zhengyi Sun and Qi Yu Tags: Research Source Type: research
Small heterodimer partner (SHP) aggravates ER stress in Parkinson ’s disease-linked LRRK2 mutant astrocyte by regulating XBP1 SUMOylation
Endoplasmic reticulum (ER) stress is a common feature of Parkinson ’s disease (PD), and several PD-related genes are responsible for ER dysfunction. Recent studies suggested LRRK2-G2019S, a pathogenic mutation ... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - July 7, 2021 Category: Biomedical Science Authors: Jee Hoon Lee, Ji-hye Han, Eun-hye Joe and Ilo Jou Tags: Research Source Type: research
Chandipura virus dysregulates the expression of hsa-miR-21-5p to activate NF- κB in human microglial cells
Chandipura virus (CHPV) is a negative single-stranded RNA virus of the Rhabdoviridae family. CHPV infection has been reported in Central and Western India. CHPV causes acute encephalitis with a case fatality rate... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - July 7, 2021 Category: Biomedical Science Authors: Neha Pandey, Meghana Rastogi and Sunit K. Singh Tags: Research Source Type: research
