Engineered EVs with pathogen proteins: promising vaccine alternatives to LNP-mRNA vaccines
Extracellular vesicles (EVs) are tiny, lipid membrane-bound structures that are released by most cells. They play a vital role in facilitating intercellular communication by delivering bioactive cargoes to rec... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - January 17, 2024 Category: Biomedical Science Authors: Bin Zhang, Wei Kian Sim, Tang-Long Shen and Sai Kiang Lim Tags: Review Source Type: research
Scaffold-based 3D cell culture models in cancer research
Three-dimensional (3D) cell cultures have emerged as valuable tools in cancer research, offering significant advantages over traditional two-dimensional (2D) cell culture systems. In 3D cell cultures, cancer c... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - January 14, 2024 Category: Biomedical Science Authors: Waad H. Abuwatfa, William G. Pitt and Ghaleb A. Husseini Tags: Review Source Type: research
Exploring the relationship between metabolism and immune microenvironment in osteosarcoma based on metabolic pathways
Metabolic remodeling and changes in tumor immune microenvironment (TIME) in osteosarcoma are important factors affecting prognosis and treatment. However, the relationship between metabolism and TIME needs to ... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - January 12, 2024 Category: Biomedical Science Authors: Changwu Wu, Jun Tan, Hong Shen, Chao Deng, Christian Kleber, Georg Osterhoff and Nikolas Schopow Tags: Research Source Type: research
Immune evasion in cell-based immunotherapy: unraveling challenges and novel strategies
Cell-based immunotherapies (CBIs), notably exemplified by chimeric antigen receptor (CAR)-engineered T (CAR-T) cell therapy, have emerged as groundbreaking approaches for cancer therapy. Nevertheless, akin to ... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - January 12, 2024 Category: Biomedical Science Authors: Yan-Ruide Li, Tyler Halladay and Lili Yang Tags: Review Source Type: research
Therapeutic antibodies for the prevention and treatment of cancer
The developments of antibodies for cancer therapeutics have made remarkable success in recent years. There are multiple factors contributing to the success of the biological molecule including origin of the an... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - January 12, 2024 Category: Biomedical Science Authors: Mukesh Kumar, Akansha Jalota, Sushil Kumar Sahu and Shabirul Haque Tags: Review Source Type: research
The synergism of cytosolic acidosis and reduced NAD+/NADH ratio is responsible for lactic acidosis-induced vascular smooth muscle cell impairment in sepsis
During sepsis, serve vascular dysfunctions lead to life-threatening multiple organ failure, due to vascular smooth muscle cells (VSMC) impairments, resulting in vasoplegia, hypotension and hypoperfusion. In ad... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - January 9, 2024 Category: Biomedical Science Authors: Philipp Terpe, Stefanie Ruhs, Virginie Dubourg, Michael Bucher and Michael Gekle Tags: Research Source Type: research
Localization, traffic and function of Rab34 in adipocyte lipid and endocrine functions
Excessive lipid accumulation in the adipose tissue in obesity alters the endocrine and energy storage functions of adipocytes. Adipocyte lipid droplets represent key organelles coordinating lipid storage and m... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - January 5, 2024 Category: Biomedical Science Authors: Jaime L ópez-Alcalá, Ana Gordon, Andrés Trávez, Carmen Tercero-Alcázar, Alejandro Correa-Sáez, María Jesús González-Rellán, Oriol A. Rangel-Zúñiga, Amaia Rodríguez, Antonio Membrives, Gema Frühbeck, Rubén Nogueiras, Marco A. Calzado, Rocío Tags: Research Source Type: research
Nano-modified viruses prime the tumor microenvironment and promote the photodynamic virotherapy in liver cancer
As of 2020, hepatocellular carcinoma (HCC), a form of liver cancer, stood as the third most prominent contributor to global cancer-related mortality. Combining immune checkpoint inhibitors (ICI) with other the... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - January 2, 2024 Category: Biomedical Science Authors: Da-Liang Ou, Zi-Xian Liao, Ivan M. Kempson, Lin Li, Pan-Chyr Yang and S.-Ja Tseng Tags: Research Source Type: research
A secreted form of chorismate mutase (Rv1885c) in Mycobacterium bovis BCG contributes to pathogenesis by inhibiting mitochondria-mediated apoptotic cell death of macrophages
Mycobacterium tuberculosis is the causative agent of tuberculosis (TB), and its pathogenicity is associated with its ability to evade the host defense system. The secretory form of the chorismate mutase of M. tub... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - December 18, 2023 Category: Biomedical Science Authors: Mi-Hyun Lee, Hye Lin Kim, Hyejun Seo, Sangkwon Jung and Bum-Joon Kim Tags: Research Source Type: research
A novel mucosal bivalent vaccine of EV-A71/EV-D68 adjuvanted with polysaccharides from Ganoderma lucidum protects mice against EV-A71 and EV-D68 lethal challenge
Human enteroviruses A71 (EV-A71) and D68 (EV-D68) are the suspected causative agents of hand-foot-and-mouth disease, aseptic meningitis, encephalitis, acute flaccid myelitis, and acute flaccid paralysis in chi... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - December 18, 2023 Category: Biomedical Science Authors: Yu-Li Lin, Pei-Yun Cheng, Chiao-Li Chin, Kuan-Ting Chuang, Jing-Yi Lin, Ning Chang, Chun-Kei Pan, Cheng-Sheng Lin, Siao-Cian Pan and Bor-Luen Chiang Tags: Research Source Type: research
ARID1A loss activates MAPK signaling via DUSP4 downregulation
ARID1A, a tumor suppressor gene encoding BAF250, a protein participating in chromatin remodeling, is frequently mutated in endometrium-related malignancies, including ovarian or uterine clear cell carcinoma (CCC)... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - December 9, 2023 Category: Biomedical Science Authors: Jayaprakash Mandal, Zheng-Cheng Yu, Ie-Ming Shih and Tian-Li Wang Tags: Research Source Type: research
SCEL regulates switches between pro-survival and apoptosis of the TNF- α/TNFR1/NF-κB/c-FLIP axis to control lung colonization of triple negative breast cancer
Patients with metastatic triple-negative breast cancer (mTNBC) have a higher probability of developing visceral metastasis within 5 years after the initial diagnosis. Therefore, a deeper understanding of the p... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - November 30, 2023 Category: Biomedical Science Authors: Shih-Hsuan Chan, Wen-Hung Kuo and Lu-Hai Wang Tags: Research Source Type: research
Butterflies in the gut: the interplay between intestinal microbiota and stress
Psychological stress is a global issue that affects at least one-third of the population worldwide and increases the risk of numerous psychiatric disorders. Accumulating evidence suggests that the gut and its ... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - November 28, 2023 Category: Biomedical Science Authors: Tzu-Ting Lai, Chia-Wei Liou, Yu-Hsuan Tsai, Yuan-Yuan Lin and Wei-Li Wu Tags: Review Source Type: research
Spatiotemporal roles of AMPK in PARP-1- and autophagy-dependent retinal pigment epithelial cell death caused by UVA
Although stimulating autophagy caused by UV has been widely demonstrated in skin cells to exert cell protection, it remains unknown the cellular events in UVA-treated retinal pigment epithelial (RPE) cells. (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - November 7, 2023 Category: Biomedical Science Authors: Anthony Yan-Tang Wu, Ponarulselvam Sekar, Duen-Yi Huang, Shu-Hao Hsu, Chi-Ming Chan and Wan-Wan Lin Tags: Research Source Type: research
The ‘speck’-tacular oversight of the NLRP3-pyroptosis pathway on gastrointestinal inflammatory diseases and tumorigenesis
The NLRP3 inflammasome is an intracellular sensor and an essential component of the innate immune system involved in danger recognition. An important hallmark of inflammasome activation is the formation of a s... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - October 27, 2023 Category: Biomedical Science Authors: Valentina Arr è, Rosanna Scialpi, Matteo Centonze, Gianluigi Giannelli, Maria Principia Scavo and Roberto Negro Tags: Review Source Type: research
