Spatial multi-omics analyses of the tumor immune microenvironment
In the past decade, single-cell technologies have revealed the heterogeneity of the tumor-immune microenvironment at the genomic, transcriptomic, and proteomic levels and have furthered our understanding of th... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - November 14, 2022 Category: Biomedical Science Authors: Wan-Chen Hsieh, Bugi Ratno Budiarto, Yi-Fu Wang, Chih-Yu Lin, Mao-Chun Gwo, Dorothy Kazuno So, Yi-Shiuan Tzeng and Shih-Yu Chen Tags: Review Source Type: research
Hepatitis B virus suppresses complement C9 synthesis by limiting the availability of transcription factor USF-1 and inhibits formation of membrane attack complex: implications in disease pathogenesis
The complement system functions primarily as a first-line host defense against invading microbes, including viruses. However, the interaction of Hepatitis B virus (HBV) with the complement-components during ch... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - November 14, 2022 Category: Biomedical Science Authors: Ayana Baidya, Mousumi Khatun, Rajiv Kumar Mondal, Suchandrima Ghosh, Bidhan Chandra Chakraborty, Shreya Mallik, S. K. Mahiuddin Ahammed, Abhijit Chowdhury, Soma Banerjee and Simanti Datta Tags: Research Source Type: research
Thrombin induces IL-8/CXCL8 expression by DCLK1-dependent RhoA and YAP activation in human lung epithelial cells
Doublecortin-like kinase 1 (DCLK1) has been recognized as a marker of cancer stem cell in several malignancies. Thrombin is crucial in asthma severity as it can promote IL-8/CXCL8 production in lung epithelial... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - November 11, 2022 Category: Biomedical Science Authors: Fara Silvia Yuliani, Jing-Yun Chen, Wen-Hao Cheng, Heng-Ching Wen, Bing-Chang Chen and Chien-Huang Lin Tags: Research Source Type: research
Dynamic modulations of urinary sphingolipid and glycerophospholipid levels in COVID-19 and correlations with COVID-19-associated kidney injuries
Among various complications of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), renal complications, namely COVID-19-associated kidney injuries, are ... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - November 10, 2022 Category: Biomedical Science Authors: Makoto Kurano, Daisuke Jubishi, Koh Okamoto, Hideki Hashimoto, Eri Sakai, Yoshifumi Morita, Daisuke Saigusa, Kuniyuki Kano, Junken Aoki, Sohei Harada, Shu Okugawa, Kent Doi, Kyoji Moriya and Yutaka Yatomi Tags: Research Source Type: research
Cancer-derived extracellular succinate: a driver of cancer metastasis
Succinate is a tricarboxylic acid (TCA) cycle intermediate normally confined to the mitochondrial matrix. It is a substrate of succinate dehydrogenase (SDH). Mutation of SDH subunits (SDHD and SDHB) in heredit... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - November 7, 2022 Category: Biomedical Science Authors: Cheng-Chin Kuo, Jing-Yiing Wu and Kenneth K. Wu Tags: Review Source Type: research
PTEN regulates invasiveness in pancreatic neuroendocrine tumors through DUSP19-mediated VEGFR3 dephosphorylation
Phosphatase and tensin homolog (PTEN) is a tumor suppressor. Low PTEN expression has been observed in pancreatic neuroendocrine tumors (pNETs) and is associated with increased liver metastasis and poor surviva... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - November 6, 2022 Category: Biomedical Science Authors: Tsung-Ming Chang, Pei-Yi Chu, Hui-You Lin, Kuo-Wei Huang, Wen-Chun Hung, Yan-Shen Shan, Li-Tzong Chen and Hui-Jen Tsai Tags: Research Source Type: research
Correction: Radioprotective potential of melatonin against 60Co γ-ray-induced testicular injury in male C57BL/6 mice
(Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - November 2, 2022 Category: Biomedical Science Authors: Shahanshah Khan, Jawahar Singh Adhikari, Moshahid Alam Rizvi and Nabo Kumar Chaudhury Tags: Correction Source Type: research
Integrated metabolomic and transcriptomic analyses of the synergistic effect of polymyxin –rifampicin combination against Pseudomonas aeruginosa
Understanding the mechanism of antimicrobial action is critical for improving antibiotic therapy. For the first time, we integrated correlative metabolomics and transcriptomics of Pseudomonas aeruginosa to elucid... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - October 30, 2022 Category: Biomedical Science Authors: Mohd Hafidz Mahamad Maifiah, Yan Zhu, Brian T. Tsuji, Darren J. Creek, Tony Velkov and Jian Li Tags: Research Source Type: research
Dysregulation of SOX17/NRF2 axis confers chemoradiotherapy resistance and emerges as a novel therapeutic target in esophageal squamous cell carcinoma
Esophageal squamous cell carcinoma (ESCC) is the sixth leading cause of cancer-associated death worldwide with a dismal overall 5-year survival rate of less than 20%. The standard first-line therapy for advanc... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - October 30, 2022 Category: Biomedical Science Authors: Chih-Hsiung Hsieh, Wen-Hui Kuan, Wei-Lun Chang, I-Ying Kuo, Hsun Liu, Dar-Bin Shieh, Hsuan Liu, Bertrand Tan and Yi-Ching Wang Tags: Research Source Type: research
Enrichment of Prevotella intermedia in human colorectal cancer and its additive effects with Fusobacterium nucleatum on the malignant transformation of colorectal adenomas
Owing to the heterogeneity of microbiota among individuals and populations, only Fusobacterium nucleatum and Bacteroides fragilis have been reported to be enriched in colorectal cancer (CRC) in multiple studies. ... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - October 27, 2022 Category: Biomedical Science Authors: Chia-Hui Lo, Deng-Chyang Wu, Shu-Wen Jao, Chang-Chieh Wu, Chung-Yen Lin, Chia-Hsien Chuang, Ya-Bo Lin, Chien-Hsiun Chen, Ying-Ting Chen, Jiann-Hwa Chen, Koung-Hung Hsiao, Ying-Ju Chen, Yuan-Tsong Chen, Jaw-Yuan Wang and Ling-Hui Li Tags: Research Source Type: research
The pathogenesis of coronavirus-19 disease
Severe acute respiratory syndrome-associated coronavirus-2 (SARS-CoV-2) is the causal agent of coronavirus disease-2019 (COVID-19), a systemic illness characterized by variably severe pulmonary symptoms, cardi... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - October 26, 2022 Category: Biomedical Science Authors: Alain C. Borczuk and Rhonda K. Yantiss Tags: Review Source Type: research
Biomarkers beyond BRCA: promising combinatorial treatment strategies in overcoming resistance to PARP inhibitors
Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) exploit the concept of synthetic lethality and offer great promise in the treatment of tumors with deficiencies in homologous recombination (HR) repair. P... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - October 25, 2022 Category: Biomedical Science Authors: Yu-Yi Chu, Clinton Yam, Hirohito Yamaguchi and Mien-Chie Hung Tags: Review Source Type: research
Tetrandrine ameliorates cognitive deficits and mitigates tau aggregation in cell and animal models of tauopathies
Tauopathies are neurodegenerative diseases that are associated with the pathological accumulation of tau-containing tangles in the brain. Tauopathy can impair cognitive and motor functions and has been observe... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - October 22, 2022 Category: Biomedical Science Authors: Benjamin Chun-Kit Tong, Alexis Shiying Huang, Aston Jiaxi Wu, Ashok Iyaswamy, Olivia Ka-Yi Ho, Anna Hau-Yee Kong, Sravan Gopalkrishnashetty Sreenivasmurthy, Zhou Zhu, Chengfu Su, Jia Liu, Juxian Song, Min Li and King-Ho Cheung Tags: Research Source Type: research
Reprogramming of sentinel lymph node microenvironment during tumor metastasis
Metastasis is a major cause of death in patients with cancer. The two main routes for cancer cell dissemination are the blood and lymphatic systems. The underlying mechanism of hematogenous metastasis has been... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - October 20, 2022 Category: Biomedical Science Authors: Yen-Liang Li and Wen-Chun Hung Tags: Review Source Type: research
Tumor microenvironment: barrier or opportunity towards effective cancer therapy
Tumor microenvironment (TME) is a specialized ecosystem of host components, designed by tumor cells for successful development and metastasis of tumor. With the advent of 3D culture and advanced bioinformatic ... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - October 17, 2022 Category: Biomedical Science Authors: Aadhya Tiwari, Rakesh Trivedi and Shiaw-Yih Lin Tags: Review Source Type: research
