Three decades of Cdk5
Cdk5 is a proline-directed serine/threonine protein kinase that governs a variety of cellular processes in neurons, the dysregulation of which compromises normal brain function. The mechanisms underlying the m... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - November 23, 2021 Category: Biomedical Science Authors: Ping-Chieh Pao and Li-Huei Tsai Tags: Review Source Type: research
Antibody cocktail effective against variants of SARS-CoV-2
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), an RNA virus with a high mutation rate. Importantly, several currently circulating SARS-CoV-2 vari... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - November 23, 2021 Category: Biomedical Science Authors: Kang-Hao Liang, Pao-Yin Chiang, Shih-Han Ko, Yu-Chi Chou, Ruei-Min Lu, Hsiu-Ting Lin, Wan-Yu Chen, Yi-Ling Lin, Mi-Hua Tao, Jia-Tsrong Jan and Han-Chung Wu Tags: Research Source Type: research
The role of noncoding RNAs in Parkinson ’s disease: biomarkers and associations with pathogenic pathways
The discovery of various noncoding RNAs (ncRNAs) and their biological implications is a growing area in cell biology. Increasing evidence has revealed canonical and noncanonical functions of long and small ncR... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - November 18, 2021 Category: Biomedical Science Authors: Ming-Che Kuo, Sam Chi-Hao Liu, Ya-Fang Hsu and Ruey-Meei Wu Tags: Review Source Type: research
CRISPR and KRAS: a match yet to be made
CRISPR (clustered regularly interspaced short palindromic repeats) systems are one of the most fascinating tools of the current era in molecular biotechnology. With the ease that they provide in genome editing... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - November 15, 2021 Category: Biomedical Science Authors: Guzide Bender, Rezan Fahrioglu Yamaci and Bahar Taneri Tags: Review Source Type: research
ROR2 has a protective role in melanoma by inhibiting Akt activity, cell-cycle progression, and proliferation
Receptor tyrosine kinase-like orphan receptor 2 (ROR2) is a Wnt5a receptor aberrantly expressed in cancer that was shown to either suppress or promote carcinogenesis in different tumor types. Our goal was to s... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - November 13, 2021 Category: Biomedical Science Authors: Mar ía Victoria Castro, Gastón Alexis Barbero, María Belén Villanueva, Luca Grumolato, Jérémie Nsengimana, Julia Newton-Bishop, Edith Illescas, María Josefina Quezada and Pablo Lopez-Bergami Tags: Research Source Type: research
Proteasome inhibitors restore the STAT1 pathway and enhance the expression of MHC class I on human colon cancer cells
A new strategy, particularly a novel combination, for immunotherapy in microsatellite stable metastatic colorectal cancer (mCRC) treatment needs to be formulated. Studies on the interferon- γ (IFN-γ)/ Janus kin... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - November 10, 2021 Category: Biomedical Science Authors: Yi-Hsin Liang, Kuo-Hsing Chen, Jia-Huei Tsai, Yung-Ming Cheng, Chang-Cheng Lee, Chiu-Hwa Kao, Kuang-Yu Chan, Yeh-Ting Chen, Wen-Ling Hsu and Kun-Huei Yeh Tags: Research Source Type: research
Restoration of 5-methoxytryptophan protects against atherosclerotic chondrogenesis and calcification in ApoE −/− mice fed high fat diet
Toll-like receptor-2 (TLR2) promotes vascular smooth muscle cell (VSMC) transdifferentiation to chondrocytes and calcification in a p38 MAPK-dependent manner. Vascular 5-methoxytryptophan (5-MTP) is a newly id... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - November 8, 2021 Category: Biomedical Science Authors: Guan-Lin Lee, Tsai-Lien Liao, Jing-Yiing Wu, Kenneth K. Wu and Cheng-Chin Kuo Tags: Research Source Type: research
Transforming growth factor- β1 decreases erythropoietin production through repressing hypoxia-inducible factor 2α in erythropoietin-producing cells
Renal erythropoietin (EPO)-producing (REP) cells produce EPO through hypoxia-inducible factor (HIF) 2 α-activated gene transcription. Insufficient EPO production leads to anemia in patients with chronic kidney ... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - November 2, 2021 Category: Biomedical Science Authors: Hong-Mou Shih, Szu-Yu Pan, Chih-Jen Wu, Yu-Hsiang Chou, Chun-Yuan Chen, Fan-Chi Chang, Yi-Ting Chen, Wen-Chih Chiang, Hsing-Chen Tsai, Yung-Ming Chen and Shuei-Liong Lin Tags: Research Source Type: research
Enhanced enzymatic production of cholesteryl 6 ʹ-acylglucoside impairs lysosomal degradation for the intracellular survival of Helicobacter pylori
During autophagy defense against invading microbes, certain lipid types are indispensable for generating specialized membrane-bound organelles. The lipid composition of autophagosomes remains obscure, as does ... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - October 27, 2021 Category: Biomedical Science Authors: Sasikala Muthusamy, Hau-Ming Jan, Ming-Yen Hsieh, Soumik Mondal, Wen-Chun Liu, Yi-An Ko, Wei-Yuan Yang, Kwok-Kong Tony Mong, Guang-Chao Chen and Chun-Hung Lin Tags: Research Source Type: research
Retraction Note to: Circular RNA circ_0003204 inhibits proliferation, migration and tube formation of endothelial cell in atherosclerosis via miR-370-3p/TGF βR2/phosph-SMAD3 axis
(Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - October 12, 2021 Category: Biomedical Science Authors: Shanchao Zhang, Guixiang Song, Jing Yuan, Shan Qiao, Shan Xu, Zhihua Si, Yang Yang, Xuxu Xu and Aihua Wang Tags: Retraction Note Source Type: research
Modular self-assembly system for development of oligomeric, highly internalizing and potent cytotoxic conjugates targeting fibroblast growth factor receptors
Overexpression of FGFR1 is observed in numerous tumors and therefore this receptor constitutes an attractive molecular target for selective cancer treatment with cytotoxic conjugates. The success of cancer the... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - October 11, 2021 Category: Biomedical Science Authors: Marta Po źniak, Natalia Porębska, Kamil Jastrzębski, Mateusz Adam Krzyścik, Marika Kucińska, Weronika Zarzycka, Agnieszka Barbach, Małgorzata Zakrzewska, Jacek Otlewski, Marta Miączyńska and Łukasz Opaliński Tags: Research Source Type: research
Emerging roles of dysregulated adenosine homeostasis in brain disorders with a specific focus on neurodegenerative diseases
In modern societies, with an increase in the older population, age-related neurodegenerative diseases have progressively become greater socioeconomic burdens. To date, despite the tremendous effort devoted to ... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - October 11, 2021 Category: Biomedical Science Authors: Ching-Pang Chang, Kuo-Chen Wu, Chien-Yu Lin and Yijuang Chern Tags: Review Source Type: research
Reciprocal deregulation of NKX3.1 and AURKA axis in castration-resistant prostate cancer and NEPC models
NKX3.1, a prostate-specific tumor suppressor, is either genomically lost or its protein levels are severely downregulated, which are invariably associated with poor prognosis in prostate cancer (PCa). Neverthe... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - October 8, 2021 Category: Biomedical Science Authors: Moloud Aflaki Sooreshjani, Mohini Kamra, Amina Zoubeidi and Kavita Shah Tags: Research Source Type: research
HBx facilitates ferroptosis in acute liver failure via EZH2 mediated SLC7A11 suppression
Acute liver failure (ALF) is a syndrome of severe hepatocyte injury with high rate of mortality. Hepatitis B virus (HBV) infection is the major cause of ALF worldwide, however, the underlying mechanism by whic... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - October 6, 2021 Category: Biomedical Science Authors: Guo-Zhen Liu, Xu-Wen Xu, Shu-Hui Tao, Ming-Jian Gao and Zhou-Hua Hou Tags: Research Source Type: research
Influenza a virus NS1 resembles a TRAF3-interacting motif to target the RNA sensing-TRAF3-type I IFN axis and impair antiviral innate immunity
Influenza A virus (IAV) evolves strategies to counteract the host antiviral defense for establishing infection. The influenza A virus (IAV) non-structural protein 1 (NS1) is a key viral factor shown to counter... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - October 5, 2021 Category: Biomedical Science Authors: Chun-Yang Lin, Meng-Cen Shih, Hung-Chun Chang, Kuan-Jung Lin, Lin-Fang Chen, Sheng-Wen Huang, Mei-Lin Yang, Sheng-Kai Ma, Ai-Li Shiau, Jen-Ren Wang, Kuan-Ru Chen and Pin Ling Tags: Research Source Type: research
