Hesperetin promotes longevity and delays aging via activation of Cisd2 in naturally aged mice
The human CISD2 gene is located within a longevity region mapped on chromosome 4q. In mice, Cisd2 levels decrease during natural aging and genetic studies have shown that a high level of Cisd2 prolongs mouse l... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - July 24, 2022 Category: Biomedical Science Authors: Chi-Hsiao Yeh, Zhao-Qing Shen, Tai-Wen Wang, Cheng-Heng Kao, Yuan-Chi Teng, Teng-Kuang Yeh, Chung-Kuang Lu and Ting-Fen Tsai Tags: Research Source Type: research
Generational synaptic functions of GABAA receptor β3 subunit deteriorations in an animal model of social deficit
Disruption of normal brain development is implicated in numerous psychiatric disorders with neurodevelopmental origins, including autism spectrum disorder (ASD). Widespread abnormalities in brain structure and... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - July 11, 2022 Category: Biomedical Science Authors: Ming-Chia Chu, Han-Fang Wu, Chi-Wei Lee, Yueh-Jung Chung, Hsiang Chi, Po See Chen and Hui-Ching Lin Tags: Research Source Type: research
CLEC5A and TLR2 are critical in SARS-CoV-2-induced NET formation and lung inflammation
Coronavirus-induced disease 19 (COVID-19) infects more than three hundred and sixty million patients worldwide, and people with severe symptoms frequently die of acute respiratory distress syndrome (ARDS). Rec... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - July 11, 2022 Category: Biomedical Science Authors: Pei-Shan Sung, Shao-Ping Yang, Yu-Chun Peng, Cheng-Pu Sun, Mi-Hwa Tao and Shie-Liang Hsieh Tags: Research Source Type: research
A dorsal CA2 to ventral CA1 circuit contributes to oxytocinergic modulation of long-term social recognition memory
Social recognition memory (SRM) is the ability to distinguish familiar from novel conspecifics and is crucial for survival and reproductive success across social species. We previously reported that oxytocin (... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - July 10, 2022 Category: Biomedical Science Authors: Tsung-Chih Tsai, Yi-Syuan Fang, Yu-Chieh Hung, Ling-Chien Hung and Kuei-Sen Hsu Tags: Research Source Type: research
A booster dose of Delta × Omicron hybrid mRNA vaccine produced broadly neutralizing antibody against Omicron and other SARS-CoV-2 variants
With the continuous emergence of new SARS-CoV-2 variants that feature increased transmission and immune escape, there is an urgent demand for a better vaccine design that will provide broader neutralizing effi... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - July 7, 2022 Category: Biomedical Science Authors: I-Jung Lee, Cheng-Pu Sun, Ping-Yi Wu, Yu-Hua Lan, I-Hsuan Wang, Wen-Chun Liu, Joyce Pei-Yi Yuan, Yu-Wei Chang, Sheng-Che Tseng, Szu-I Tsung, Yu-Chi Chou, Monika Kumari, Yin-Shiou Lin, Hui-Feng Chen, Tsung-Yen Chen, Chih-Chao Lin & hellip; Tags: Research Source Type: research
Protective role of VEGF/VEGFR2 signaling against high fatality associated with hepatic encephalopathy via sustaining mitochondrial bioenergetics functions
The lack of better understanding of the pathophysiology and cellular mechanisms associated with high mortality seen in hepatic encephalopathy (HE), a neurological complication arising from acute hepatic failur... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - July 3, 2022 Category: Biomedical Science Authors: Ching-Yi Tsai, Jacqueline C. C. Wu, Chiung-Ju Wu and Samuel H. H. Chan Tags: Research Source Type: research
Dengue and COVID-19: two sides of the same coin
Many countries in Asia and Latin America are currently facing a double burden of outbreaks due to dengue and COVID-19. Here we discuss the similarities and differences between the two infections so that lesson... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - July 3, 2022 Category: Biomedical Science Authors: Gathsaurie Neelika Malavige, Chandima Jeewandara and Graham S. Ogg Tags: Review Source Type: research
HrpA anchors meningococci to the dynein motor and affects the balance between apoptosis and pyroptosis
In Neisseria meningitidis the HrpA/HrpB two-partner secretion system (TPS) was implicated in diverse functions including meningococcal competition, biofilm formation, adherence to epithelial cells, intracellular ... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - June 28, 2022 Category: Biomedical Science Authors: Adelfia Tal à, Flora Guerra, Matteo Calcagnile, Roberta Romano, Silvia Caterina Resta, Aurora Paiano, Mario Chiariello, Graziano Pizzolante, Cecilia Bucci and Pietro Alifano Tags: Research Source Type: research
The down-regulation of XBP1, an unfolded protein response effector, promotes acute kidney injury to chronic kidney disease transition
The activation of the unfolded protein response (UPR) is closely linked to the pathogenesis of renal injuries. However, the role of XBP1, a crucial regulator of adaptive UPR, remains unclear during the transit... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - June 28, 2022 Category: Biomedical Science Authors: Jia-Huang Chen, Chia-Hsien Wu, Jia-Rong Jheng, Chia-Ter Chao, Jenq-Wen Huang, Kuan-Yu Hung, Shing-Hwa Liu and Chih-Kang Chiang Tags: Research Source Type: research
Hepatitis B virus virion secretion is a CRM1-spike-mediated late event
Hepatitis B virus (HBV) is a major human pathogen worldwide. To date, there is no curative treatment for chronic hepatitis B. The mechanism of virion secretion remains to be investigated. Previously, we found ... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - June 21, 2022 Category: Biomedical Science Authors: Pei-Yi Su, Shin-Chwen Bruce Yen, Ching-Chun Yang, Chih-Hsu Chang, Wen-Chang Lin and Chiaho Shih Tags: Research Source Type: research
Human rs75776403 polymorphism links differential phenotypic and clinical outcomes to a CLEC18A p.T151M-driven multiomics
Human traits, diseases susceptibility, and clinical outcomes vary hugely among individuals. Despite a fundamental understanding of genetic (or environmental) contributions, the detailed mechanisms of how genet... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - June 18, 2022 Category: Biomedical Science Authors: Yu-Wen Hsu, Henry Sung-Ching Wong, Wan-Chen Huang, Yi-Hung Yeh, Chwan-Deng Hsiao, Wei-Chiao Chang and Shie-Liang Hsieh Tags: Research Source Type: research
DUSP3 regulates phosphorylation-mediated degradation of occludin and is required for maintaining epithelial tight junction
Tight junctions (TJ) are multi-protein complexes that hold epithelial cells together and form structural and functional barriers for maintaining proper biological activities. Dual specificity phosphatase 3 (DU... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - June 15, 2022 Category: Biomedical Science Authors: Hsiao-Chin Chou, Chun-Mei Cheng, Chi-Hwa Yang, Tzu-Yin Lin, Ya-Wen Liu, Tse-Hua Tan and Yi-Rong Chen Tags: Research Source Type: research
The power of heteronemin in cancers
Heteronemin (Haimian jing) is a sesterterpenoid-type natural marine product that is isolated from sponges and has anticancer properties. It inhibits cancer cell proliferation via different mechanisms, such as ... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - June 15, 2022 Category: Biomedical Science Authors: Kuan Wang, Yi-Fong Chen, Yu-Chen S. H. Yang, Haw-Ming Huang, Sheng-Yang Lee, Ya-Jung Shih, Zi-Lin Li, Jacqueline Whang-Peng, Hung-Yun Lin and Paul J. Davis Tags: Review Source Type: research
MicroRNA-485-5p targets keratin 17 to regulate oral cancer stemness and chemoresistance via the integrin/FAK/Src/ERK/ β-catenin pathway
The development of drug resistance in oral squamous cell carcinoma (OSCC) that frequently leads to recurrence and metastasis after initial treatment remains an unresolved challenge. Presence of cancer stem cel... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - June 15, 2022 Category: Biomedical Science Authors: Te-Hsuan Jang, Wei-Chieh Huang, Shiao-Lin Tung, Sheng-Chieh Lin, Po-Ming Chen, Chun-Yu Cho, Ya-Yu Yang, Tzu-Chen Yen, Guo-Hsuen Lo, Shuang-En Chuang and Lu-Hai Wang Tags: Research Source Type: research
Multidimensional insights into the repeated electromagnetic field stimulation and biosystems interaction in aging and age-related diseases
We describe this process from the quantum to the molecular, cellula... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - June 13, 2022 Category: Biomedical Science Authors: Felipe P. Perez, Joseph P. Bandeira, Cristina N. Perez Chumbiauca, Debomoy K. Lahiri, Jorge Morisaki and Maher Rizkalla Tags: Review Source Type: research
