TRIM proteins in hepatocellular carcinoma
The tripartite motif (TRIM) protein family is a highly conserved group of E3 ligases with 77 members known in the human, most of which consist of a RING-finger domain, one or two B-box domains, and a coiled-co... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - September 13, 2022 Category: Biomedical Science Authors: Kan Lu, Yonglong Pan, Zhao Huang, Huifang Liang, Ze-yang Ding and Bixiang Zhang Tags: Review Source Type: research
A critical overview of current progress for COVID-19: development of vaccines, antiviral drugs, and therapeutic antibodies
The novel coronavirus disease (COVID-19) pandemic remains a global public health crisis, presenting a broad range of challenges. To help address some of the main problems, the scientific community has designed... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - September 12, 2022 Category: Biomedical Science Authors: Monika Kumari, Ruei-Min Lu, Mu-Chun Li, Jhih-Liang Huang, Fu-Fei Hsu, Shih-Han Ko, Feng-Yi Ke, Shih-Chieh Su, Kang-Hao Liang, Joyce Pei-Yi Yuan, Hsiao-Ling Chiang, Cheng-Pu Sun, I.-Jung Lee, Wen-Shan Li, Hsing-Pang Hsieh, Mi-Hua Tao & hellip; Tags: Review Source Type: research
Correction to: Multidimensional insights into the repeated electromagnetic field stimulation and biosystems interaction in aging and age-related diseases
(Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - September 9, 2022 Category: Biomedical Science Authors: Felipe P. Perez, Joseph P. Bandeira, Cristina N. Perez Chumbiauca, Debomoy K. Lahiri, Jorge Morisaki and Maher Rizkalla Tags: Correction Source Type: research
Distribution of papG alleles among uropathogenic Escherichia coli from reproductive age women
Extraintestinal Escherichia coli (E. coli) causing urinary tract infections (UTIs), and often referred to as uropathogenic E. coli (UPEC), are a major contributor to the morbidity of UTIs and associated healthcar... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - September 7, 2022 Category: Biomedical Science Authors: Timothy Kudinha and Fanrong Kong Tags: Research Source Type: research
Beyond the vaccines: a glance at the small molecule and peptide-based anti-COVID19 arsenal
Unprecedented efforts of the researchers have been witnessed in the recent past towards the development of vaccine platforms for the control of the COVID-19 pandemic. Albeit, vaccination stands as a practical ... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - September 6, 2022 Category: Biomedical Science Authors: Kunal Nepali, Ram Sharma, Sachin Sharma, Amandeep Thakur and Jing-Ping Liou Tags: Review Source Type: research
Protein O-GlcNAcylation and the regulation of energy homeostasis: lessons from knock-out mouse models
O-GlcNAcylation corresponds to the addition of N-Acetylglucosamine (GlcNAc) on serine or threonine residues of cytosolic, nuclear and mitochondrial proteins. This reversible modification is catalysed by a uniq... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - September 4, 2022 Category: Biomedical Science Authors: Tarik Issad, Hasanain Al-Mukh, Abdelouhab Bouaboud and Patrick Pagesy Tags: Review Source Type: research
The novel role of ER protein TXNDC5 in the pathogenesis of organ fibrosis: mechanistic insights and therapeutic implications
Fibrosis-related disorders account for an enormous burden of disease-associated morbidity and mortality worldwide. Fibrosis is defined by excessive extracellular matrix deposition at fibrotic foci in the organ... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - September 2, 2022 Category: Biomedical Science Authors: Chen-Ting Hung, Yi-Wei Tsai, Yu-Shuo Wu, Chih-Fan Yeh and Kai-Chien Yang Tags: Review Source Type: research
Down-regulated miR-146a expression with increased neutrophil extracellular traps and apoptosis formation in autoimmune-mediated diffuse alveolar hemorrhage
Increasing evidences have suggested an important role of microRNAs (miRNAs) in regulating cell death processes including NETosis and apoptosis. Dysregulated expression of miRNAs and increased formation of neut... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - August 26, 2022 Category: Biomedical Science Authors: Yu-Tung Hsieh, Yu-Chi Chou, Pin-Yu Kuo, Hung-Wen Tsai, Yi-Ting Yen, Ai-Li Shiau and Chrong-Reen Wang Tags: Research Source Type: research
The A ’-helix of CYP11A1 remodels mitochondrial cristae
CYP11A1 is a protein located in the inner membrane of mitochondria catalyzing the first step of steroid synthesis. As a marker gene for steroid-producing cells, the abundance of CYP11A1 characterizes the exten... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - August 18, 2022 Category: Biomedical Science Authors: Karen G. Rosal, Wei-Yi Chen and Bon-chu Chung Tags: Research Source Type: research
Correction to: Long noncoding RNA BCRP3 stimulates VPS34 and autophagy activities to promote protein homeostasis and cell survival
(Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - August 14, 2022 Category: Biomedical Science Authors: Ruei Liang Yan, Chiu Lin Luan, Chun Chieh Liao, Li Heng Liu, Fei Yun Chen, Hsin Yi Chen and Ruey Hwa Chen Tags: Correction Source Type: research
Homozygous mutation of the LRRK2 ROC domain as a novel genetic model of parkinsonism
Parkinson ’s disease (PD) is one of the most important neurodegenerative disorders in elderly people. Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are found in a large proportion of the patients with... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - August 14, 2022 Category: Biomedical Science Authors: Meng-Ling Chen and Ruey-Meei Wu Tags: Research Source Type: research
Functional and structural characteristics of HLA-B*13:01-mediated specific T cells reaction in dapsone-induced drug hypersensitivity
Severe cutaneous adverse drug reactions (SCARs) are a group of serious clinical conditions caused by immune reaction to certain drugs. The allelic variance of human leukocyte antigens of HLA-B*13:01 has been s... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - August 13, 2022 Category: Biomedical Science Authors: Haiqin Jiang, Chuang-Wei Wang, Zhaoxi Wang, Yufei Dai, Yanping Zhu, Yun-Shien Lee, Yang Cao, Wen-Hung Chung, Songying Ouyang and Hongsheng Wang Tags: Research Source Type: research
Localization of Salmonella and albumin-IL-2 to the tumor microenvironment augments anticancer T cell immunity
For centuries, microbial-based agents have been investigated as a therapeutic modality for the treatment of cancer. In theory, these methods would be cheap to produce, broadly applicable in a wide array of can... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - August 12, 2022 Category: Biomedical Science Authors: Yu-Jui Kung, Brandon Lam, Ssu-Hsueh Tseng, Alana MacDonald, Hsin-Fang Tu, Suyang Wang, John Lin, Ya Chea Tsai, T. C. Wu and Chien-Fu Hung Tags: Research Source Type: research
Recent advances in conventional and unconventional vesicular secretion pathways in the tumor microenvironment
All cells in the changing tumor microenvironment (TME) need a class of checkpoints to regulate the balance among exocytosis, endocytosis, recycling and degradation. The vesicular trafficking and secretion path... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - August 5, 2022 Category: Biomedical Science Authors: I.-Ying Kuo, Chih-Hsiung Hsieh, Wan-Ting Kuo, Chih-Peng Chang and Yi-Ching Wang Tags: Review Source Type: research
TRIM18 is a critical regulator of viral myocarditis and organ inflammation
Infections by viruses including severe acute respiratory syndrome coronavirus 2 could cause organ inflammations such as myocarditis, pneumonia and encephalitis. Innate immunity to viral nucleic acids mediates ... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - July 31, 2022 Category: Biomedical Science Authors: Mingli Fang, Ao Zhang, Yong Du, Wenting Lu, Junying Wang, Laurie J. Minze, Timothy C. Cox, Xian Chang Li, Junji Xing and Zhiqiang Zhang Tags: Research Source Type: research
