The biology of SCUBE
The SCUBE [Signal peptide-Complement C1r/C1s, Uegf, Bmp1 (CUB)-Epithelial growth factor domain-containing protein] family consists of three proteins in vertebrates, SCUBE1, 2 and 3, which are highly conserved ... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - May 26, 2023 Category: Biomedical Science Authors: Yuh-Charn Lin, Binay K. Sahoo, Shiang-Shin Gau and Ruey-Bing Yang Tags: Review Source Type: research
Extracellular arginine availability modulates eIF2 α O-GlcNAcylation and heme oxygenase 1 translation for cellular homeostasis
Nutrient limitations often lead to metabolic stress during cancer initiation and progression. To combat this stress, the enzyme heme oxygenase 1 (HMOX1, commonly known as HO-1) is thought to play a key role as... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - May 22, 2023 Category: Biomedical Science Authors: Yu-Wen Hung, Ching Ouyang, Xiaoli Ping, Yue Qi, Yi-Chang Wang, Hsing-Jien Kung and David K. Ann Tags: Research Source Type: research
Identification of three capsule depolymerases in a bacteriophage infecting Klebsiella pneumoniae capsular types K7, K20, and K27 and therapeutic application
Klebsiella pneumoniae capsular types K1, K2, K5, K20, K54, and K57 are prevalent hypervirulent types associated with community infections, and worrisomely, hypervirulent strains that acquired drug resistance have... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - May 20, 2023 Category: Biomedical Science Authors: Jia-Wen Wu, Jin-Town Wang, Tzu-Lung Lin, Ya-Zhu Liu, Lii-Tzu Wu and Yi-Jiun Pan Tags: Research Source Type: research
Efficacy analysis and research progress of complementary and alternative medicines in the adjuvant treatment of COVID-19
The coronavirus disease 2019 (COVID-19) pandemic has impacted human lifestyles around the world, causing huge distress in terms of public health systems, emergency response capacity and economic development. T... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - May 3, 2023 Category: Biomedical Science Authors: Jaung-Geng Lin, Guan-Jhong Huang and Yi-Chang Su Tags: Review Source Type: research
Degradation of neurodegenerative disease-associated TDP-43 aggregates and oligomers via a proteolysis-targeting chimera
Amyotrophic lateral sclerosis (ALS) associated with TAR DNA-binding protein 43 (TDP-43) aggregation has been considered as a lethal and progressive motor neuron disease. Recent studies have shown that both C-t... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - April 26, 2023 Category: Biomedical Science Authors: Yu-Ling Tseng, Po-Chao Lu, Chi-Chang Lee, Ruei-Yu He, Yung-An Huang, Yin-Chen Tseng, Ting-Jen Rachel Cheng, Joseph Jen-Tse Huang and Jim-Min Fang Tags: Research Source Type: research
Acetaldehyde via CGRP receptor and TRPA1 in Schwann cells mediates ethanol-evoked periorbital mechanical allodynia in mice: relevance for migraine
Ingestion of alcoholic beverages is a known trigger of migraine attacks. However, whether and how ethanol exerts its pro-migraine action remains poorly known. Ethanol stimulates the transient receptor potentia... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - April 26, 2023 Category: Biomedical Science Authors: Lorenzo Landini, Daniel Souza Monteiro de Araujo, Martina Chieca, Gaetano De Siena, Elisa Bellantoni, Pierangelo Geppetti, Romina Nassini and Francesco De Logu Tags: Research Source Type: research
Therapeutic potential of bacteriophage endolysins for infections caused by Gram-positive bacteria
Gram-positive (G+) bacterial infection is a great burden to both healthcare and community medical resources. As a result of the increasing prevalence of multidrug-resistant G+ bacteria such as methicillin-resista... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - April 26, 2023 Category: Biomedical Science Authors: He Liu, Zhen Hu, Mengyang Li, Yi Yang, Shuguang Lu and Xiancai Rao Tags: Review Source Type: research
Downregulation of the RNA-binding protein PUM2 facilitates MSC-driven bone regeneration and prevents OVX-induced bone loss
Although mRNA dysregulation can induce changes in mesenchymal stem cell (MSC) homeostasis, the mechanisms by which post-transcriptional regulation influences MSC differentiation potential remain understudied. ... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - April 23, 2023 Category: Biomedical Science Authors: Dong Suk Yoon, Yoorim Choi, Kyoung-Mi Lee, Eun Ae Ko, Eun-Ji Kim, Kwang Hwan Park and Jin Woo Lee Tags: Research Source Type: research
Rapid identification of carbapenem-resistant Klebsiella pneumoniae based on matrix-assisted laser desorption ionization time-of-flight mass spectrometry and an artificial neural network model
Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a clinically critical pathogen that causes severe infection. Due to improper antibiotic administration, the prevalence of CRKP infection has been increasing co... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - April 17, 2023 Category: Biomedical Science Authors: Yu-Ming Zhang, Mei-Fen Tsao, Ching-Yu Chang, Kuan-Ting Lin, Joseph Jordan Keller and Hsiu-Chen Lin Tags: Research Source Type: research
A tumor microenvironment-based prognostic index for osteosarcoma
The tumor microenvironment (TME) has a central role in the oncogenesis of osteosarcomas. The composition of the TME is essential for the interaction between tumor and immune cells. The aim of this study was to... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - April 13, 2023 Category: Biomedical Science Authors: Changwu Wu, Siming Gong, Yingjuan Duan, Chao Deng, Sonja Kallendrusch, Laura Berninghausen, Georg Osterhoff and Nikolas Schopow Tags: Research Source Type: research
Integrated systems immunology approach identifies impaired effector T cell memory responses as a feature of progression to severe dengue fever
Typical symptoms of uncomplicated dengue fever (DF) include headache, muscle pains, rash, cough, and vomiting. A proportion of cases progress to severe dengue hemorrhagic fever (DHF), associated with increased... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - April 13, 2023 Category: Biomedical Science Authors: Lisa J. Ioannidis, Stephanie I. Studniberg, Emily M. Eriksson, Suhendro Suwarto, Dionisius Denis, Yang Liao, Wei Shi, Alexandra L. Garnham, R. Tedjo Sasmono and Diana S. Hansen Tags: Research Source Type: research
Reduced virulence in tigecycline-resistant Klebsiella pneumoniae caused by overexpression of ompR and down-regulation of ompK35
The development of tigecycline resistance in hypervirulent Klebsiella pneumoniae strains has resulted in decreased virulence that is associated with reduced production of capsular polysaccharides (CPS). In this s... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - March 31, 2023 Category: Biomedical Science Authors: Suyeon Park, Hyunkeun Kim and Kwan Soo Ko Tags: Research Source Type: research
A transcriptomic pan-cancer signature for survival prognostication and prediction of immunotherapy response based on endothelial senescence
The microvascular endothelium inherently controls nutrient delivery, oxygen supply, and immune surveillance of malignant tumors, thus representing both biological prerequisite and therapeutic vulnerability in ... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - March 28, 2023 Category: Biomedical Science Authors: Zhengquan Wu, Bernd Uhl, Olivier Gires and Christoph A. Reichel Tags: Research Source Type: research
PES1 reduces CD8+ T cell infiltration and immunotherapy sensitivity via interrupting ILF3-IL15 complex in esophageal squamous cell carcinoma
Although immune checkpoint blockade (ICB) therapy has brought survival benefits to patients with specific cancer types, most of cancer patients remain refractory to the ICB therapy, which is largely attributed... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - March 23, 2023 Category: Biomedical Science Authors: Ning Ma, Rong Hua, Yang Yang, Zhi-Chao Liu, Jie Pan, Bo-Yao Yu, Yi-Feng Sun, Dong Xie, Yan Wang and Zhi-Gang Li Tags: Research Source Type: research
Antimicrobial and immunoregulatory effects of Lactobacillus delbrueckii 45E against genitourinary pathogens
Lactobacilli are essential microbiota that maintain a healthy, balanced vaginal environment. Vaginitis is a common infection in women during their reproductive years. Many factors are associated with vaginitis... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - March 23, 2023 Category: Biomedical Science Authors: Ameda Abdullah Bnfaga, Kai Wei Lee, Leslie Thian Lung Than and Syafinaz Amin-Nordin Tags: Research Source Type: research
