Hypoxic stress disrupts HGF/Met signaling in human trophoblasts: implications for the pathogenesis of preeclampsia
Preeclampsia (PE), a placenta-associated pregnancy complication, is the leading cause of maternal and perinatal morbidity and mortality. Met/Erk signaling is inhibited in the placentas of patients with early-o... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - February 3, 2022 Category: Biomedical Science Authors: Guanlin Li, Yongqing Wang, Guangming Cao, Yeling Ma, Yu-Xia Li, Yangyu Zhao, Xuan Shao and Yan-Ling Wang Tags: Research Source Type: research
Genomic diversity and antimicrobial resistance of Campylobacter spp. from humans and livestock in Nigeria
Campylobacter spp. are zoonotic pathogens, ubiquitous and are found naturally as commensals in livestock from where they can be transmitted to humans directly or through animal products. The genomic diversity and... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - January 24, 2022 Category: Biomedical Science Authors: Benshak J. Audu, Strachan Norval, Lopes Bruno, Ramjee Meenakshi, Macrae Marion and Ken J. Forbes Tags: Research Source Type: research
LRG1: an emerging player in disease pathogenesis
The secreted glycoprotein leucine-rich α-2 glycoprotein 1 (LRG1) was first described as a key player in pathogenic ocular neovascularization almost a decade ago. Since then, an increasing number of publication... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - January 21, 2022 Category: Biomedical Science Authors: Carlotta Camilli, Alexandra E. Hoeh, Giulia De Rossi, Stephen E. Moss and John Greenwood Tags: Review Source Type: research
Novel FLT3/AURK multikinase inhibitor is efficacious against sorafenib-refractory and sorafenib-resistant hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the sixth most common type of cancer and has a high mortality rate worldwide. Sorafenib is the only systemic treatment demonstrating a statistically significant but modest ove... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - January 21, 2022 Category: Biomedical Science Authors: You-Liang Lai, Kai-Hung Wang, Hsing-Pang Hsieh and Wan-Ching Yen Tags: Research Source Type: research
Estradiol-mediated inhibition of Sp1 decreases miR-3194-5p expression to enhance CD44 expression during lung cancer progression
Sp1, an important transcription factor, is involved in the progression of various cancers. Our previous studies have indicated that Sp1 levels are increased in the early stage of lung cancer progression but de... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - January 17, 2022 Category: Biomedical Science Authors: Ming-Jer Young, Yung-Ching Chen, Shao-An Wang, Hui-Ping Chang, Wen-Bin Yang, Chia-Chi Lee, Chia-Yu Liu, Yau-Lin Tseng, Yi-Ching Wang, H. Sunny Sun, Wen-Chang Chang and Jan-Jong Hung Tags: Research Source Type: research
SLCO4A1-AS1 promotes colorectal tumourigenesis by regulating Cdk2/c-Myc signalling
SLCO4A1-AS1 was found to be upregulated in several cancer types, including colorectal cancer (CRC). However, the detailed roles of SLCO4A1-AS1 in CRC remain to be elucidated. Therefore, we investigated the fun... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - January 17, 2022 Category: Biomedical Science Authors: Jia Zhang, Kaisa Cui, Liuying Huang, Fan Yang, Shengbai Sun, Zehua Bian, Xue Wang, Chaoqun Li, Yuan Yin, Shengling Huang, Leyuan Zhou, Bojian Fei and Zhaohui Huang Tags: Research Source Type: research
Monocarboxylate transporter functions and neuroprotective effects of valproic acid in experimental models of amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a devasting neurodegenerative disorder for which no successful therapeutics are available. Valproic acid (VPA), a monocarboxylate derivative, is a known antiepileptic dru... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - January 10, 2022 Category: Biomedical Science Authors: Asmita Gyawali, Sana Latif, Seung-Hye Choi, Seung Jae Hyeon, Hoon Ryu and Young-Sook Kang Tags: Research Source Type: research
Monoclonal antibodies for COVID-19 therapy and SARS-CoV-2 detection
The coronavirus disease 2019 (COVID-19) pandemic is an exceptional public health crisis that demands the timely creation of new therapeutics and viral detection. Owing to their high specificity and reliability... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - January 4, 2022 Category: Biomedical Science Authors: Yu-Chyi Hwang, Ruei-Min Lu, Shih-Chieh Su, Pao-Yin Chiang, Shih-Han Ko, Feng-Yi Ke, Kang-Hao Liang, Tzung-Yang Hsieh and Han-Chung Wu Tags: Review Source Type: research
The overexpression of GDNF in nucleus accumbens suppresses alcohol-seeking behavior in group-housed C57Bl/6J female mice
Craving for alcohol, in other words powerful desire to drink after withdrawal, is an important contributor to the development and maintenance of alcoholism. Here, we studied the role of GDNF (glial cell line-d... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - December 20, 2021 Category: Biomedical Science Authors: Maryna Koskela, T. Petteri Piepponen, Maria Lindahl, Brandon K. Harvey, Jaan-Olle Andressoo, Vootele V õikar and Mikko Airavaara Tags: Research Source Type: research
Integrative utility of long read sequencing-based whole genome analysis and phenotypic assay on differentiating isoniazid-resistant signature of Mycobacterium tuberculosis
With the advancement of next generation sequencing technologies (NGS), whole-genome sequencing (WGS) has been deployed to a wide range of clinical scenarios. Rapid and accurate classification of drug-resistant My... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - December 18, 2021 Category: Biomedical Science Authors: Ming-Chih Yu, Ching-Sheng Hung, Chun-Kai Huang, Cheng-Hui Wang, Yu-Chih Liang and Jung-Chun Lin Tags: Research Source Type: research
An electrophysiological perspective on Parkinson ’s disease: symptomatic pathogenesis and therapeutic approaches
Parkinson ’s disease (PD), or paralysis agitans, is a common neurodegenerative disease characterized by dopaminergic deprivation in the basal ganglia because of neuronal loss in the substantia nigra pars compac... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - December 9, 2021 Category: Biomedical Science Authors: Lan-Hsin Nancy Lee, Chen-Syuan Huang, Hsiang-Hao Chuang, Hsing-Jung Lai, Cheng-Kai Yang, Ya-Chin Yang and Chung-Chin Kuo Tags: Review Source Type: research
Dopamine, behavior, and addiction
Addictive drugs are habit-forming. Addiction is a learned behavior; repeated exposure to addictive drugs can stamp in learning. Dopamine-depleted or dopamine-deleted animals have only unlearned reflexes; they ... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - December 2, 2021 Category: Biomedical Science Authors: Roy A. Wise and Chloe J. Jordan Tags: Review Source Type: research
Chikungunya virus infection: molecular biology, clinical characteristics, and epidemiology in Asian countries
Chikungunya virus (CHIKV) is a re-emerging mosquito-borne human pathogen that causes chikungunya fever, which is typically accompanied by severe joint pain. In Asia, serological evidence indicated that CHIKV f... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - December 2, 2021 Category: Biomedical Science Authors: Sarawut Khongwichit, Jira Chansaenroj, Chintana Chirathaworn and Yong Poovorawan Tags: Review Source Type: research
A nuanced role of the small loop of hepatitis B virus small envelope protein in virion morphogenesis and secretion
The virion secretion mechanism of human hepatitis B virus (HBV) remains to be investigated. In our current study, we characterized a reverse transcriptase mutant, which changed from the YMDD motif to YMHA. We ... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - December 1, 2021 Category: Biomedical Science Authors: Chih-Hsu Chang, Shu-Fan Chou and Chiaho Shih Tags: Research Source Type: research
Elp1 facilitates RAD51-mediated homologous recombination repair via translational regulation
RAD51-dependent homologous recombination (HR) is one of the most important pathways for repairing DNA double-strand breaks (DSBs), and its regulation is crucial to maintain genome integrity. Elp1 gene encodes IKA... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - November 24, 2021 Category: Biomedical Science Authors: Wei-Ting Chen, Huan-Yi Tseng, Chung-Lin Jiang, Chih-Ying Lee, Peter Chi, Liuh-Yow Chen, Kai-Yin Lo, I-Ching Wang and Fu-Jung Lin Tags: Research Source Type: research
