ARID1A loss activates MAPK signaling via DUSP4 downregulation

ARID1A, a tumor suppressor gene encoding BAF250, a protein participating in chromatin remodeling, is frequently mutated in endometrium-related malignancies, including ovarian or uterine clear cell carcinoma (CCC)...

Source: Journal of Biomedical Science - December 9, 2023 Category: Biomedical Science Authors: Jayaprakash Mandal, Zheng-Cheng Yu, Ie-Ming Shih and Tian-Li Wang Tags: Research Source Type: research