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News & Notes
Help us program our next session lineup by completing a proposal for the 2025 AAAAI Annual Meeting. The submission site is open at annualmeeting.aaaai.org. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 1, 2024 Category: Allergy & Immunology Source Type: research

CME Calendar-AAAAI
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 1, 2024 Category: Allergy & Immunology Source Type: research

A Special Thank-You to Our Reviewers
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - March 1, 2024 Category: Allergy & Immunology Source Type: research

Dupilumab in patients with chronic spontaneous urticaria (LIBERTY-CSU CUPID): two randomized, double-blind, placebo-controlled, phase 3 trials
Capsule Summary: Dupilumab significantly reduced urticaria activity in patients with CSU who were symptomatic despite H1-AH; with a trend towards improvement in patients with prior anti-IgE treatment. Safety was consistent with the known dupilumab safety profile. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 28, 2024 Category: Allergy & Immunology Authors: Marcus Maurer, Thomas B. Casale, Sarbjit S. Saini, Moshe Ben-Shoshan, Ana M. Gim énez-Arnau, Jonathan A. Bernstein, Akiko Yagami, Aleksandra Stjepanovic, Allen Radin, Heribert W. Staudinger, Naimish Patel, Nikhil Amin, Bolanle Akinlade, Chunpeng Fan, Deb Source Type: research

Early-life Nasal Microbiota Dynamics Relate to Longitudinal Respiratory Phenotypes in Urban Children
Capsule SummaryWe investigated the risk factors associated with asthma in high-risk children and found evidence that early life respiratory microbiota development is influenced by exposures to environmental microbes and the genetic predisposition of the individual. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 27, 2024 Category: Allergy & Immunology Authors: Kathryn E. McCauley, Juliana Durack, Kole V. Lynch, Douglas W. Fadrosh, Kei E. Fujimura, Faith Vundla, Mustafa Özçam, Petra LeBeau, Agustin Caltroni, Preston Burns, Hoang T. Tran, Leonard B. Bacharier, Meyer Kattan, George T. O’Connor, Robert A. Wood, Source Type: research

Epithelium-derived kallistatin promotes CD4+ T-cell chemotaxis to TH2-type inflammation in chronic rhinosinusitis
The function of kallistatin in airway inflammation, particularly chronic rhinosinusitis with nasal polyps (CRSwNP), has not been elucidated. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 23, 2024 Category: Allergy & Immunology Authors: Lijie Jiang, Haocheng Tang, Tengjiao Lin, Yifeng Jiang, Yanmei Li, Wenxiang Gao, Jie Deng, Zhaoqi Huang, Chuxin Chen, Jianbo Shi, Ti Zhou, Yinyan Lai Source Type: research

Epithelium-derived kallistatin promotes CD4+ T cell chemotaxis to Th2-type inflammation in chronic rhinosinusitis
Capsule summary: Kallistatin has been demonstrated to play a role in the pathogenesis of chronic rhinosinusitis with nasal polyps ( CRSwNP ) by promoting Th2 inflammation. High expression of kallistatin has been associated with the prognosis of CRSwNP and the expression of Th2-type inflammatory cytokines. Interestingly, we discovered that kallistatin deficiency alleviates type 2 inflammation in the sinonasal mucosa, especially blunt the activation of IL-4. Further investigation revealed that kallistatin may be associated with increased IL-4 expression, possibly through the Jagged2-Notch1 signaling pathway in CD4+ T cells. ...
Source: Journal of Allergy and Clinical Immunology - February 23, 2024 Category: Allergy & Immunology Authors: Lijie Jiang, Haocheng Tang, Tengjiao Lin, Yifeng Jiang, Yanmei Li, Wenxiang Gao, Jie Deng, Zhaoqi Huang, Chuxin Chen, Jianbo Shi, Ti Zhou, Yinyan Lai Source Type: research

Bronchiectasis and asthma: Data from The European Bronchiectasis Registry (EMBARC)
Asthma is commonly reported in patients with a diagnosis of bronchiectasis. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 22, 2024 Category: Allergy & Immunology Authors: Eva Polverino, Katerina Dimakou, Letizia Traversi, Apostolos Bossios, Charles S. Haworth, Michael R. Loebinger, Anthony De Soyza, Montserrat Vendrell, Pierre-R égis Burgel, Pontus Mertsch, Melissa McDonnell, Sabina Škrgat, Luis M. Carro, Oriol Sibila, M Source Type: research

Increased type 1 inflammation in gynecologic cervicovaginal samples in patients with APS-1
Inborn errors of immunity offer important insights into mucosal immunity. In autoimmune polyendocrine syndrome type-1 (APS-1), chronic mucocutaneous candidiasis has been ascribed to neutralizing IL-17 autoantibodies. Recent evidence implicates excessive T-cell IFN- γ secretion and ensuing epithelial barrier disruption in predisposition to candidiasis, but these results remain to be replicated. Whether IL-17 paucity, increased type I inflammation, or their combination underlies susceptibility to chronic mucocutaneus candidiasis in APS-1 is debated. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 21, 2024 Category: Allergy & Immunology Authors: Iivo Hetem äki, Viivi Saari, Dawit A. Yohannes, Elina Holopainen, Tiina Holster, Suvi Jokiranta, Mikko I. Mäyränpää, Seppo Virtanen, Outi Mäkitie, Eliisa Kekäläinen, Saila Laakso Tags: Brief report Source Type: research

Airway hyperresponsiveness in asthma: the role of the epithelium
Airway hyperresponsiveness (AHR) is a key clinical feature of asthma. The presence of AHR in people with asthma provides the substrate for bronchoconstriction in response to numerous diverse stimuli, contributing to airflow limitation and symptoms including breathlessness, wheeze and chest tightness. Dysfunctional airway smooth muscle (ASM) significantly contributes to AHR and is displayed as increased sensitivity to direct pharmacological bronchoconstrictor stimuli, such as inhaled histamine and methacholine (direct AHR), or to endogenous mediators released by activated airway cells such as mast cells (indirect AHR). (Sou...
Source: Journal of Allergy and Clinical Immunology - February 21, 2024 Category: Allergy & Immunology Authors: Peter Bradding, Celeste Porsbjerg, Andr éanne Côté, Sven-Erik Dahlén, Teal S. Hallstrand, Christopher E. Brightling Source Type: research

Increased type 1 inflammation in gynecological cervicovaginal samples in patients with APS-1
Capsule Summary: Analysis of vaginal fluid and cervical brush sample cells from patients with APS-1 reveals excessive Th1 chemokines and upregulation of markers of apoptosis with no signs of Th17 paucity. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 21, 2024 Category: Allergy & Immunology Authors: Iivo Hetem äki, Viivi Saari, Dawit A. Yohannes, Elina Holopainen, Tiina Holster, Suvi Jokiranta, Mikko I. Mäyränpää, Seppo Virtanen, Outi Mäkitie, Eliisa Kekäläinen, Saila Laakso Source Type: research

Machine learning –based identification and characterization of mast cells in eosinophilic esophagitis
Eosinophilic esophagitis (EoE) is a food-induced allergic inflammatory disease of the esophagus. Although rare, the prevalence of EoE is increasing with current estimates being 56 cases per 100,000 persons.1,2 Active disease is determined by upper endoscopy, and the pathologic diagnosis is defined by at least 15 eosinophils per high-power field (eos/hpf) identified on esophageal biopsies, yet recent data indicate that eosinophils are not involved in the clinical manifestations of eosinophilic gastrointestinal diseases, which calls attention to the potential pathogenic role of other cell populations. (Source: Journal of All...
Source: Journal of Allergy and Clinical Immunology - February 20, 2024 Category: Allergy & Immunology Authors: Simin Zhang, Julie M. Caldwell, Mark Rochman, Margaret H. Collins, Marc E. Rothenberg Source Type: research

Machine Learning Based Identification and Characterization of Mast Cells in Eosinophilic Esophagitis
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 20, 2024 Category: Allergy & Immunology Authors: Simin Zhang, Julie M. Caldwell, Mark Rochman, Margaret H. Collins, Marc E. Rothenberg Source Type: research

2023: The Year in Review
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 18, 2024 Category: Allergy & Immunology Authors: Zuhair K. Ballas Source Type: research

Navigating the blurred path of mixed neuroimmune signaling
Evolution has created complex mechanisms to sense environmental danger and protect tissues, with the nervous and immune systems playing pivotal roles. These systems work together, coordinating local and systemic reflexes to restore homeostasis in response to tissue injury and infection. By sharing receptors and ligands, they influence the pathogenesis of various diseases. Recently, a less-explored aspect of neuroimmune communication has emerged: the release of neuropeptides from immune cells and cytokines/chemokines from sensory neurons. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 17, 2024 Category: Allergy & Immunology Authors: Surbhi Gupta, Alice Viotti, Tuany Eichwald, Anais Roger, Eva Kaufmann, Rahmeh Othman, Nader Ghasemlou, Moutih Rafei, Simmie L. Foster, Sebastien Talbot Tags: Reviews and feature article Source Type: research