Increased type 1 inflammation in gynecologic cervicovaginal samples in patients with APS-1
Inborn errors of immunity offer important insights into mucosal immunity. In autoimmune polyendocrine syndrome type-1 (APS-1), chronic mucocutaneous candidiasis has been ascribed to neutralizing IL-17 autoantibodies. Recent evidence implicates excessive T-cell IFN- γ secretion and ensuing epithelial barrier disruption in predisposition to candidiasis, but these results remain to be replicated. Whether IL-17 paucity, increased type I inflammation, or their combination underlies susceptibility to chronic mucocutaneus candidiasis in APS-1 is debated.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Iivo Hetem äki, Viivi Saari, Dawit A. Yohannes, Elina Holopainen, Tiina Holster, Suvi Jokiranta, Mikko I. Mäyränpää, Seppo Virtanen, Outi Mäkitie, Eliisa Kekäläinen, Saila Laakso Tags: Brief report Source Type: research
More News: Allergy | Allergy & Immunology