Journal of Allergy and Clinical Immunology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Efficacy And Safety Of Bradykinin B2 Receptor Antagonism With Oral Deucrictibant In Prophylaxis Of Hereditary Angioedema Attacks: Results Of CHAPTER-1 Phase 2 Trial
In hereditary angioedema (HAE), swelling attacks are caused by excessive bradykinin activating the bradykinin B2 receptors. Deucrictibant (PHA121) is a potent, selective, orally administered antagonist of bradykinin B2 receptor under development for on-demand and prophylactic treatment of HAE attacks. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Marc Riedl, John Anderson, Francesco Arcoleo, Mauro Cancian, Hugo Chapdelaine, Niall Conlon, Efrem Eren, Mark Gompels, Sofia Grigoriadou, Maria Guarino, Padmalal Gurugama, Tamar Kinaciyan, Markus Magerl, Michael Manning, Marcin Stobiecki, Michael Tarzi, A Source Type: research

Updated Results of a Phase 1a Trial of STAR-0215 for Hereditary Angioedema
STAR-0215 is an investigational extended half-life monoclonal antibody for hereditary angioedema (HAE). This trial (NCT05477160) assesses STAR-0215's potential for safe and durable suppression of HAE attacks after single doses in healthy subjects. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: William Lumry, Christopher Morabito, Theodora Cohen, Michele Gunsior, Kristine Bernard, Pamela Gustafson Source Type: research

Pediatric Doses Of neffy (Intranasal Nasal Spray) Demonstrate Pharmacokinetic Profiles That Are Equivalent To Epinephrine Injections Products
Epinephrine is the first-line treatment for severe allergic reactions, including anaphylaxis. Despite epinephrine ’s well documented history of safety and efficacy, patients/caregivers frequently fail to treat or delay treating severe allergic reactions, citing challenges of carrying epinephrine auto-injectors and concerns about injection. These concerns are particularly pronounced in pediatric patients, who, along with their caregivers, tend to be more anxious about injectable devices. An intranasal epinephrine spray (neffy) is being developed as a needle-free option for the treatment of severe allergic reactions. (Sour...
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: David Fleischer, H. Henry Li, Richard Lockey, Michael Kaliner, Wayne Shreffler, Richard Lowenthal, Sarina Tanimoto Source Type: research

Pharmacokinetics and Pharmacodynamics of Epinephrine Following Administration via Sublingual Film, Autoinjector, or Manual Injection
AQST-109, a sublingual film containing a novel prodrug of epinephrine (DESF), is under development for the emergency treatment of Type 1 allergic reactions. The final formulation of AQST-109 was compared with epinephrine delivered by two different approved autoinjectors (EpiPen and Auvi-Q) or by manual injection (IM). (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: David Golden, Jay Lieberman, David Bernstein, John Oppenheimer, Mark Freedman, Carl Kraus, Stephen Wargacki Source Type: research

Pharmacodynamic Profile of Epinephrine Nasal Spray Versus Intramuscular Epinephrine Autoinjector in Healthy Adults
Standard of care for anaphylaxis treatment is intramuscular (IM) epinephrine. An epinephrine nasal spray (ENS) is under development as an alternative form of administration. This analysis compared the pharmacodynamic (PD) profile of 13.2 mg ENS with 0.3 mg IM epinephrine autoinjector. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Jay Lieberman, David Bernstein, Michael Blaiss, Lawrence Dubuske, David Fleischer, Matthew Greenhawt, John Oppenheimer, David Dworaczyk Source Type: research

Pharmacokinetic Profile of Epinephrine Nasal Spray Versus Intramuscular Epinephrine Autoinjector in Healthy Adults
An epinephrine nasal spray (ENS) is under development for treatment of anaphylaxis. This analysis compared the pharmacokinetic (PK) profile of 13.2 mg ENS with that of the standard of care 0.3 mg intramuscular (IM) epinephrine autoinjector. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Matthew Greenhawt, David Bernstein, Michael Blaiss, Lawrence Dubuske, David Fleischer, Jay Lieberman, John Oppenheimer, David Dworaczyk Source Type: research

Real world outcome of children treated with dupilumab for severe atopic dermatitis in a single specialist center
This study looked at real-world outcomes of dupilumab in children of different ethnicities attending a specialist center in the UK. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Timothy Clayton, Michelle Herring, Georgina Devlin, Mozhgan Hosseini-Ashrafi Source Type: research

Dupilumab Consistently Reduces CCL-17 (TARC) in Patients with Atopic Dermatitis Across All Age Groups
Elevated serum C-C motif chemokine ligand 17 (CCL17)/thymus and activation-regulated chemokine (TARC) has been associated with atopic dermatitis (AD) severity. Reductions in type 2 inflammatory biomarkers such as CCL17/TARC have been reported in adult patients with moderate-to-severe AD treated with dupilumab. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Lisa Beck, Mark Boguniewicz, Yoko Kataoka, Marjolein de Bruin-Weller, Antonella Muraro, Zhen Chen, Ainara Rodriguez-Marco, Parul Shah, Ana Rossi Source Type: research

Probiotic Lactobacillus in the Treatment of Atopic Dermatitis in Premature Children from Kyiv, Ukraine
Atopic dermatitis (AD) in premature infants is a major health issue for which there is limited evidence for the use of probiotics as treatment. The efficacy of the probiotic Lactobacillus (LGG) was assessed in premature infants with AD from the Kyiv, Ukraine region. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Olena Sharikadze, Viktor Litus, Olexander Litus, Iryna Litus, Lawrence Dubuske Source Type: research

Higher Risk of Food Allergy Diagnosis and Increased Objective Testing for Asian Children with Atopic Dermatitis
Atopic dermatitis (AD) is a known risk factor for the development of food allergy. Prior work demonstrated racial/ethnic disparities in the diagnosis of food allergy. However, limited data has been reported regarding the diagnosis of food allergy among Asian Americans, particularly in the high-risk population of children with AD. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Ellen Stephen, Keerthi Bansal, Anandu Dileep, Sven Wang, Manali Shah, Niki Mirhosseini, Shannon Manz, Mahboobeh Mahdavinia Source Type: research

Does detection of S.aureus and resistance to antistaphylococcal drugs in blood cultures of hospitalized patients for infected atopic dermatitis change the hospitalization profile?
S.aureus infection is a constant complication in patients with Atopic Dermatitis (AD) and leads to hospitalizations and use of broad-spectrum antibiotics (AB). We hypothesized that the detection of S.aureus in blood cultures (BC) and the pattern of antimicrobial resistance in patients hospitalized for infected AD impacts their clinical and laboratory parameters. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: David Lobo, Ricardo Madeiro Filho, Ricardo Madeiro Filho, Mayra de Barros Dorna, Beni Morgenstern, Antonio Pastorino, Ana Paula Mosquione Source Type: research

Validation and Assessment of the Psychometric Properties of a Spanish Version of the Atopic Dermatitis Control Scale (ADCT) in a Colombian Population
This study aimed to assess the psychometric properties and validate the Spanish version of ADCT in a Colombian population. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Elizabeth Garcia, Daniela Benavides-del Castillo, Sergio Moreno-L ópez, Lucia Pérez-Herrera, Ricardo Sánchez-Pedraza, Augusto Peñaranda Source Type: research

Allergy, Respiratory Symptoms, And Contact Dermatitis Are Occupational Risks Among Prosthodontists
Mercury in amalgams, acrylate resins in oral prosthetics, and latex, have been associated with allergic contact dermatitis in dentists. Bisphenol-A (BPA) has been linked to atopic dermatitis in children. Prosthodontists may be at higher risk of contact dermatitis due to exposure to amalgams, acrylic resins and BPA as restorative procedure specialists. Dentists may be at higher risk of respiratory symptoms because the most common occupation in an idiopathic pulmonary fibrosis registry was dentistry. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Jennifer Mzobe, Anthony Szema, Mary Lee-Wong, Tanya Somohano, Robert Promisloff, Keely Cheslack-Postava Source Type: research

Dupilumab Reduction of IgE Levels and Probability of Atopic Dermatitis Flares – Analysis of A Randomized Placebo-Controlled 52-Week Study
IgE levels are often elevated in patients with atopic dermatitis (AD) but the clinical relevance of reducing IgE levels in patients with AD remains unclear. This analysis reports the impact of dupilumab treatment on total IgE levels in association with the probability of having flares in patients with moderate-to-severe AD. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Brian Kim, Lisa Beck, Eric Simpson, Lawrence Eichenfield, Jonathan Silverberg, Kilian Eyerich, Shinichi Imafuku, Zhen Chen, Ana Rossi, Sonya Cyr Source Type: research

pH Matters: Identifying Trends in Control of Childhood Atopic Dermatitis Based on pH of Common Over-The-Counter Products
This study examines the pH of common personal care products purchased by infant caregivers and investigates the relationship between pH of products used by parents and AD severity. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Maxwell Librach, Caitlin Schuetz, Jason Ohayon Source Type: research