Machine learning –based identification and characterization of mast cells in eosinophilic esophagitis
Eosinophilic esophagitis (EoE) is a food-induced allergic inflammatory disease of the esophagus. Although rare, the prevalence of EoE is increasing with current estimates being 56 cases per 100,000 persons.1,2 Active disease is determined by upper endoscopy, and the pathologic diagnosis is defined by at least 15 eosinophils per high-power field (eos/hpf) identified on esophageal biopsies, yet recent data indicate that eosinophils are not involved in the clinical manifestations of eosinophilic gastrointestinal diseases, which calls attention to the potential pathogenic role of other cell populations. (Source: Journal of All...
Source: Journal of Allergy and Clinical Immunology - February 20, 2024 Category: Allergy & Immunology Authors: Simin Zhang, Julie M. Caldwell, Mark Rochman, Margaret H. Collins, Marc E. Rothenberg Source Type: research

Machine Learning Based Identification and Characterization of Mast Cells in Eosinophilic Esophagitis
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 20, 2024 Category: Allergy & Immunology Authors: Simin Zhang, Julie M. Caldwell, Mark Rochman, Margaret H. Collins, Marc E. Rothenberg Source Type: research

2023: The Year in Review
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 18, 2024 Category: Allergy & Immunology Authors: Zuhair K. Ballas Source Type: research

Navigating the blurred path of mixed neuroimmune signaling
Evolution has created complex mechanisms to sense environmental danger and protect tissues, with the nervous and immune systems playing pivotal roles. These systems work together, coordinating local and systemic reflexes to restore homeostasis in response to tissue injury and infection. By sharing receptors and ligands, they influence the pathogenesis of various diseases. Recently, a less-explored aspect of neuroimmune communication has emerged: the release of neuropeptides from immune cells and cytokines/chemokines from sensory neurons. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 17, 2024 Category: Allergy & Immunology Authors: Surbhi Gupta, Alice Viotti, Tuany Eichwald, Anais Roger, Eva Kaufmann, Rahmeh Othman, Nader Ghasemlou, Moutih Rafei, Simmie L. Foster, Sebastien Talbot Tags: Reviews and feature article Source Type: research

Mast cell –sensory neuron crosstalk in allergic diseases
Mast cells (MCs) are tissue-resident immune cells, well-positioned at the host-environment interface for detecting external antigens and playing a critical role in mobilizing innate and adaptive immune responses. Sensory neurons are afferent neurons innervating most areas of the body but especially in the periphery, where they sense external and internal signals and relay information to the brain. The significance of MC –sensory neuron communication is now increasingly becoming recognized, especially because both cell types are in close physical proximity at the host-environment interface and around major organs of the b...
Source: Journal of Allergy and Clinical Immunology - February 17, 2024 Category: Allergy & Immunology Authors: Chunjing Bao, Soman N. Abraham Source Type: research

Spectrum of Clinical Phenotypes of PLCG2 Gene Variants: just PLAID
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 17, 2024 Category: Allergy & Immunology Authors: Javier Chinen Source Type: research

Mast Cell-Sensory Neuron Crosstalk in Allergic Diseases
Mast cells (MCs) are tissue-resident immune cells, well-positioned at the host-environment interface for detecting external antigens and playing a critical role in mobilizing innate and adaptive immune responses. Sensory neurons are afferent neurons innervating most areas of the body but especially in the periphery, where they sense external and internal signals and relay information to the brain. The significance of MC-sensory neuron communication is now increasingly becoming recognized, especially as both cell types are in close physical proximity at the host-environment interface and around major organs of the body and ...
Source: Journal of Allergy and Clinical Immunology - February 17, 2024 Category: Allergy & Immunology Authors: Chunjing Bao, Soman N. Abraham Source Type: research

Navigating the blurred path of mixed neuro-immune signaling
Evolution has created complex mechanisms to sense environmental danger and protect tissues, with the nervous and immune systems playing pivotal roles. These systems work together, coordinating local and systemic reflexes to restore homeostasis in response to tissue injury and infection. By sharing receptors and ligands, they influence the pathogenesis of various diseases. Recently, a less explored aspect of neuro-immune communication has emerged: the release of neuropeptides from immune cells and cytokines/chemokines from sensory neurons. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 17, 2024 Category: Allergy & Immunology Authors: Surbhi Gupta, Alice Viotti, Tuany Eichwald, Anais Roger, Eva Kaufmann, Rahmeh Othman, Nader Ghasemlou, Moutih Rafei, Simmie L. Foster, Sebastien Talbot Source Type: research

A quantitative systems pharmacology workflow toward optimal design and biomarker stratification of atopic dermatitis clinical trials
Atopic dermatitis (AD) is a chronic inflammatory condition of the skin characterized by recurrent eczematous lesions and intense itch that can profoundly impair quality of life.1-6 The pathophysiology of AD is complex and involves local and systemic immune dysregulation, genetic susceptibility, environmental factors, and microbiome effects.7,8 AD is a heterogeneous disease that encompasses a variety of endotypes and phenotypes (see the work cited in Facheris et  al9). The road to novel AD therapeutics10 is tortuous due to a combination of 2 factors: (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 16, 2024 Category: Allergy & Immunology Authors: Natacha Go, Simon Ars ène, Igor Faddeenkov, Théo Galland, Shiny Martis B., Diane Lefaudeux, Yishu Wang, Loic Etheve, Evgueni Jacob, Claudio Monteiro, Jim Bosley, Caterina Sansone, Christian Pasquali, Lorenz Lehr, Alexander Kulesza Source Type: research

The Immune System in Neurological Diseases: What Innate-like T Cells have to Say
The immune system classically consists of two lines of defense: innate and adaptive, both of which interact with one another effectively to protect us against any pathogenic threats. Importantly, there is a diverse subset of cells known as innate-like T cells that act as a bridge between the innate and adaptive immune systems and are pivotal players in eliciting inflammatory immune responses. A growing body of evidence has demonstrated the regulatory impact of these innate-like T cells in central nervous system (CNS) diseases, and that such immune cells can traffic into the brain in multiple pathological conditions, which ...
Source: Journal of Allergy and Clinical Immunology - February 16, 2024 Category: Allergy & Immunology Authors: Season K. Wyatt-Johnson, Reham Afify, Randy R. Brutkiewicz Source Type: research

A quantitative systems pharmacology workflow towards optimal design and biomarker stratification of atopic dermatitis clinical trials
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 16, 2024 Category: Allergy & Immunology Authors: Natacha Go, Simon Ars ène, Igor Faddeenkov, Théo Galland, Shiny Martis B., Diane Lefaudeux, Yishu Wang, Loic Etheve, Evgueni Jacob, Claudio Monteiro, Jim Bosley, Caterina Sansone, Christian Pasquali, Lorenz Lehr, Alexander Kulesza Source Type: research

Epithelial-neuronal-immune cell interactions: implications for immunity, inflammation, and tissue homeostasis at mucosal sites
The epithelial lining of the respiratory tract and intestine provides a critical physical barrier to protect host tissues against environmental insults including dietary antigens, allergens, chemicals, and microorganisms. In addition, specialized epithelial cells directly communicate with hematopoietic and neuronal cells. These epithelial-immune and epithelial-neuronal interactions control host immune responses and have important implications for inflammatory conditions associated with defects in the epithelial barrier, including asthma, allergy, and inflammatory bowel diseases (IBD). (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 16, 2024 Category: Allergy & Immunology Authors: Elizabeth Emanuel, Mohammad Arifuzzaman, David Artis Source Type: research

Accurate determination of house dust mite sensitization in asthma and allergic rhinitis through cytometric detection of Der p 1 and Der p 2 binding on Basophils (CytoBas)
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 13, 2024 Category: Allergy & Immunology Authors: Lin Hsin, Nirupama Varese, Pei Mun Aui, Bruce D. Wines, Anouk von Borstel, Laurent Mascarell, P. Mark Hogarth, Mark Hew, Robyn E. O ’Hehir, Menno C. van Zelm Source Type: research

Genetic, immunologic, and clinical features of 830 patients with Mendelian susceptibility to mycobacterial diseases (MSMD): A  systematic review
Mendelian susceptibility to mycobacterial diseases (MSMD) is a rare clinical syndrome characterized by vulnerability to weakly virulent mycobacterial species, including Bacillus Calmette-Gu érin (BCG) vaccines and environmental mycobacteria. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 8, 2024 Category: Allergy & Immunology Authors: Armin Khavandegar, Seyed Alireza Mahdaviani, Majid Zaki-Dizaji, Fereshteh Khalili-Moghaddam, Sarina Ansari, Saba Alijani, Nooshin Taherzadeh-Ghahfarrokhi, Davood Mansouri, Jean-Laurent Casanova, Jacinta Bustamante, Mahnaz Jamee Source Type: research

Update on Asthma Biology
This is an exciting time to be conducting asthma research. The recent development of targeted asthma biologics has validated the power of basic research to discover new molecules amenable to therapeutic intervention. Advances in high throughput sequencing are providing a wealth of “-omic” data about genetic and epigenetic underpinnings of asthma, as well as new cellular interacting networks and potential endotypes in asthma. Airway epithelial cells have emerged not only as key sensors of the outside environment, but also as central drivers of dysregulated mucosal immune r esponses in asthma. (Source: Journal of Allergy...
Source: Journal of Allergy and Clinical Immunology - February 8, 2024 Category: Allergy & Immunology Authors: Steve N. Georas, Sandhya Khurana Source Type: research