Dysregulated nasal mucosal antiviral transcriptome in young children with problematic wheeze infected with rhinovirus (RV)
Preschool children with problematic wheeze have significant morbidity and are at increased risk to develop asthma. Our previous studies identified a surprising number with rhinovirus (RV) infection in their airway, despite absence of acute “cold” symptoms, suggesting an impaired anti-viral immune response. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Larry Borish, Ava Noth, Stella Kellams, Kristin Wavell, Elaine Etter, Cameron Griffiths, Monica Lawrence, Ryan Sessuns, Gerald Teague Source Type: research

Impact After Three Years Of Diagnosis Of Covid-19 In Children With Allergic Asthma
The aim of this study was to analyze evolution and differences between children with allergic asthma diagnosed of Covid-19 in 2020 versus those who didn`t, in our allergy unit. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Carlos Blanco-Mota, Paula L ópez-González, Ana María Prieto-Moreno Pfeifer, Elisa Haroun Díaz, María Vázquez-De-La-Torre Gaspar, Diana Pérez-Alzate, María Luisa Quiñones-Obando, Natalia Blanca-López, María Luisa Somoza Álvarez, Francisco Ruano Source Type: research

Asthma episode/attack risk by smoking status, self-reported gender, educational attainment, e-cigarette usage and exposure to marijuana smoke.
Active smokers with asthma have a higher risk of asthma episodes compared to non-smokers. Exposure to marijuana smoke or using e-cigarettes may also increase the frequency of these episodes in individuals with asthma. The association between these factors and asthma attacks may vary based on self-reported gender. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Lillian Cooper, Paulina Ordonez, Katherine Saxton Source Type: research

GATA3 binds to the Cftr locus in CD4+ T cells
Previously we have shown greater type helper 2 (Th2) cell polarization and effector function in cystic fibrosis transmembrane conductance regulator null (Cftr-/-) compared to Cftr+/+ CD4+ T cells with IL-4 or IL-33 pathway activation (Cook et al. AJRCCM. 2023). Given that GATA3 is the master transcriptional regulator of Th2 function, we hypothesized 1) increased GATA3 expression in Cftr-/- compared to Cftr+/+ CD4+ T cells and 2) binding of GATA3 to the Cftr locus to regulate CFTR expression. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Christopher Thomas, Stokes Peebles, Daniel Cook Source Type: research

Untargeted Metabolomic Profiling Of Asthma Severity In Children In Relation To IL4R576 Variant Genotype And Notch4 expression
Asthma is the most common chronic lung disease of childhood, and the mechanisms underlying the severity of its clinical manifestations remain incompletely understood. Asthmatic children carrying the IL4R576 allele have increased risk of severe asthma and have been shown to have increased Notch4 expression on circulating Treg cells as a function of disease severity. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Hani Harb, Mehdi Benamar, Rima Kaddurah-Daouk, Wanda Phipatanakul, Talal Chatila, Elena Crestani Source Type: research

Enhancing Appropriateness of Lung Function Test Orders: Beyond Electronic Medical Record Modifications
This study focuses on non-respiratory providers ordering specialized testing (bronchoprovocation and neuromuscular testing). (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Amogh Nadkarni, Brent Kaufmann Source Type: research

The role of small airways on persistent bronchial hyper-responsiveness (BHR) in asthma children with asthma: the comparison of predicted percentage value vs Z score of spirometry
The bronchial hyperresponsiveness (BHR) is a key component of asthma pathophysiology. BHR at the single point in time reflect the state of airway and is influenced by allergen, irritant and infection and airway size, etc. Persistent BHR is a predictor in subsequent asthma or relapse. To investigate factors related with persistent BHR. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Sun Hee Choi, Yeong-Ho Rha, Kyung Suk Lee Source Type: research

Assessment of Prevalence and Immune Status of Viral-Associated Asthma.
This study assesses prevalence and immune status of patients associating the onset of asthma with acute viral respiratory diseases. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: I. Shchurok, A. Ishchanka, I. Semenova, T. Hardzievich, A. Chernokov, Lawrence Dubuske Source Type: research

Evaluation of the clinical, demographic and inflammatory characteristics of a Spanish cohort of patients with asthma-COPD overlap syndrome.
Asthma-COPD overlap syndrome (ACO) is characterized by a higher burden of both diseases with more symptoms, poorer control, and less quality of life. We aimed to compare ACO's clinical, demographic, and inflammatory characteristics and different severities of asthmatic patients. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Maria Otal Buesa, Diana Betancor, Jaime Bernaola, Joaquin Sastre Source Type: research

Cytokine responses in Chlamydia pneumoniae-stimulated PBMC in asthmatic and non-asthmatic subjects.
Chlamydia pneumoniae (C. pneumoniae) is a gram-negative intracellular bacterium that causes respiratory infections in humans, including asthmatic and non-asthmatic subjects. C. pneumoniae activates cells in vitro and produces cytokines that may contribute to inflammatory responses observed in asthma. Activation of cell-mediated immune (CMI) responses is important for protective immunity; these responses may be impaired in patients with asthma. The aim of this study sought to compare cytokine responses between subjects with or without asthma. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Sarah Shidid, Nutchaya Amornruk, Wefag Ahmed, Haram Abdelmajid, Yitzchok Norowitz, Stephan Kohlhoff, Tamar Smith-Norowitz Source Type: research

Analysis of the features of severe asthma patients with aspirin intolerance.
NSAID-exacerbated respiratory disease(NERD) is a T2-phenotype of severe-asthma(SA), usually associated with chronic rhinosinusitis(CRS) with/without polyps and no allergy. The mean age of patients in studies is>60 years and young adults are poorly known. Moreover, most publications don ´t confirm CRS and NERD. We analyze the features of SA in younger(18-40 years) and aspirin intolerant individuals recruited from eight SA units of BIOBADALER-consortium. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Julia Rodriguez de Guzman Cejudo, Almudena Testera Montes, Laura Zubiaga Fernandez, Joan Bartra, Ibon Eguiluz Gracia, Maria Jose Torres Jaen, Carmen Rondon Segovia, Natalia P érez Sánchez, Rocio Saenz de Santamaría, Marta Ferrer Source Type: research

Using 15-Oxo-ETE for Risk Stratifying Aspirin Hypersensitivity in Asthma Patients
15-oxo-eicosatetraenoic acid (15-oxo-ETE), a downstream product on arachidonic acid (AA) via 15-lipoxygenase-1 (15- LOX-1) pathway was markedly higher in nasal polyp tissue of patients with aspirin-exacerbated respiratory disease (AERD) compared to control groups. We suggested a possible role of 15-oxo-ETE as an in vitro diagnostic biomarker for AERD. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Lucyna Mastalerz, Gabriela Tr ąd, Piotr Szatkowski, Radosław Kacorzyk, Alicja Maciejska, Anna Gielicz, Hanna Plutecka, Bogdan Jakieła, Adam Ćmiel, Marek Sanak Source Type: research

Twelve-Month Health Care Utilization in Individuals Starting on Biologics for Chronic Immune-Mediated Diseases
Individuals with suboptimally controlled chronic immune-mediated diseases (IMDs) have high rates of healthcare utilization. We hypothesized that higher disease activity scores would correlate with a higher rate of non-scheduled healthcare visits among a single center cohort of patients with chronic IMDs mostly starting new biologics (Biologics and Clinical Immunology Cohort at Sinai (BACICS) ). We also sought to determine the proportion of visits related to the primary IMD. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Shira Yellin, Jamie Fried, Sarah Alvi, Rashida Blackwood, Rachel Miller Source Type: research

Caregiver Willingness to use Biologics in Children
Atopic dermatitis (AD) affects around 10% of children globally, with 20% facing treatment-resistant forms. Studies favor biologics over conventional therapies. Our hypothesis is that disease severity and caregiver background and education influence biologic willingness. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Shannon Su, Idil Ezhuthachan, Gerald Lee, Melinda Rathkopf, Brian Vickery, Tricia Lee Source Type: research

MMR and Varicella Immunization Rate During Dupilumab Therapy
Current FDA guidance is to pause administration of live vaccinations during dupilumab therapy. It is currently unknown whether this recommendation results in delayed vaccination. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Hannah Seay, Marissa Perman, Jennifer Heimall, Jonathan Spergel, James Treat, Terri Brown-Whitehorn, Fahad Ahmed Source Type: research