Journal of Allergy and Clinical Immunology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Asthma Severity and Access to Guideline-Based Care in a Diverse Urban Population
This study aims to evaluate asthma characteristics in a diverse urban population to identify differences in rates of allergy testing in adults with well-controlled vs. poorly controlled asthma. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Megan Elios, Valerie Press, Christopher Codispoti, Sharmilee Nyenhuis Source Type: research

Single-cell RNA sequencing revealed that lung macrophages were composed differently depending on the asthma phenotypes.
Asthma is a heterogeneous airway inflammatory disease that is divided into eosinophilic and neutrophilic asthma. However, the immunological basis of phenotypic differences has not been elucidated. Therefore, we established a murine asthma model using different doses of lipopolysaccharide (LPS) to demonstrate that lung macrophages are distinctly modified depending on the asthma phenotype. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Ji-Young Bang, Soyun Kim, Hye-Ryun Kang Source Type: research

Asthma and chronic cough: two related conditions
Chronic cough is estimated to affect 5-13% of the world's population, although information is scarce in the general population and asthma patients. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Pedro Martins, iolanda Caires, Ricardo Afonso, Jo ão Gaspar-Marques, André Tomé, Nuno Neuparth Source Type: research

A Prospective Study of Intimate Partner Violence, Uncontrolled Asthma, and Inflammatory Pathways: Insights from Cytokine Profiles
We examined inflammatory pathways through analyses of serum cytokine profiles in a prospective design. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Kelly Shibuya, Sadhana Balasubramanyam, Divya Verma, Kristen Holm, Rafeul Alam, Anne DePrince, Eileen Wang Source Type: research

Genetic Factors Predicting in the Development of Asthma in the Kazakh Population
Asthma has high morbidity and substantial risk of mortality worldwide, including Kazakhstan. The incidence of asthma in the Republic of Kazakhstan per 100,000 population over the past 10 years has increased by almost 3 fold (43.9 in 2011, 126.1 in 2020). Asthma is a disease with a pronounced hereditary predisposition. In various ethnic groups, the genes responsible for the incidence of asthma and associated morbidity differ. Assessment of the genetic characteristics of asthma might allow better prediction of disease course and selection of personalized therapy. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Zhanat Ispayeva, Raikhan Bekmagambetova, Nazgul Dzhanabayeva, Lawrence Dubuske Source Type: research

Dysregulated nasal mucosal antiviral transcriptome in young children with problematic wheeze infected with rhinovirus (RV)
Preschool children with problematic wheeze have significant morbidity and are at increased risk to develop asthma. Our previous studies identified a surprising number with rhinovirus (RV) infection in their airway, despite absence of acute “cold” symptoms, suggesting an impaired anti-viral immune response. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Larry Borish, Ava Noth, Stella Kellams, Kristin Wavell, Elaine Etter, Cameron Griffiths, Monica Lawrence, Ryan Sessuns, Gerald Teague Source Type: research

Impact After Three Years Of Diagnosis Of Covid-19 In Children With Allergic Asthma
The aim of this study was to analyze evolution and differences between children with allergic asthma diagnosed of Covid-19 in 2020 versus those who didn`t, in our allergy unit. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Carlos Blanco-Mota, Paula L ópez-González, Ana María Prieto-Moreno Pfeifer, Elisa Haroun Díaz, María Vázquez-De-La-Torre Gaspar, Diana Pérez-Alzate, María Luisa Quiñones-Obando, Natalia Blanca-López, María Luisa Somoza Álvarez, Francisco Ruano Source Type: research

Asthma episode/attack risk by smoking status, self-reported gender, educational attainment, e-cigarette usage and exposure to marijuana smoke.
Active smokers with asthma have a higher risk of asthma episodes compared to non-smokers. Exposure to marijuana smoke or using e-cigarettes may also increase the frequency of these episodes in individuals with asthma. The association between these factors and asthma attacks may vary based on self-reported gender. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Lillian Cooper, Paulina Ordonez, Katherine Saxton Source Type: research

GATA3 binds to the Cftr locus in CD4+ T cells
Previously we have shown greater type helper 2 (Th2) cell polarization and effector function in cystic fibrosis transmembrane conductance regulator null (Cftr-/-) compared to Cftr+/+ CD4+ T cells with IL-4 or IL-33 pathway activation (Cook et al. AJRCCM. 2023). Given that GATA3 is the master transcriptional regulator of Th2 function, we hypothesized 1) increased GATA3 expression in Cftr-/- compared to Cftr+/+ CD4+ T cells and 2) binding of GATA3 to the Cftr locus to regulate CFTR expression. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Christopher Thomas, Stokes Peebles, Daniel Cook Source Type: research

Untargeted Metabolomic Profiling Of Asthma Severity In Children In Relation To IL4R576 Variant Genotype And Notch4 expression
Asthma is the most common chronic lung disease of childhood, and the mechanisms underlying the severity of its clinical manifestations remain incompletely understood. Asthmatic children carrying the IL4R576 allele have increased risk of severe asthma and have been shown to have increased Notch4 expression on circulating Treg cells as a function of disease severity. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Hani Harb, Mehdi Benamar, Rima Kaddurah-Daouk, Wanda Phipatanakul, Talal Chatila, Elena Crestani Source Type: research

Enhancing Appropriateness of Lung Function Test Orders: Beyond Electronic Medical Record Modifications
This study focuses on non-respiratory providers ordering specialized testing (bronchoprovocation and neuromuscular testing). (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Amogh Nadkarni, Brent Kaufmann Source Type: research

The role of small airways on persistent bronchial hyper-responsiveness (BHR) in asthma children with asthma: the comparison of predicted percentage value vs Z score of spirometry
The bronchial hyperresponsiveness (BHR) is a key component of asthma pathophysiology. BHR at the single point in time reflect the state of airway and is influenced by allergen, irritant and infection and airway size, etc. Persistent BHR is a predictor in subsequent asthma or relapse. To investigate factors related with persistent BHR. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Sun Hee Choi, Yeong-Ho Rha, Kyung Suk Lee Source Type: research

Assessment of Prevalence and Immune Status of Viral-Associated Asthma.
This study assesses prevalence and immune status of patients associating the onset of asthma with acute viral respiratory diseases. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: I. Shchurok, A. Ishchanka, I. Semenova, T. Hardzievich, A. Chernokov, Lawrence Dubuske Source Type: research

Evaluation of the clinical, demographic and inflammatory characteristics of a Spanish cohort of patients with asthma-COPD overlap syndrome.
Asthma-COPD overlap syndrome (ACO) is characterized by a higher burden of both diseases with more symptoms, poorer control, and less quality of life. We aimed to compare ACO's clinical, demographic, and inflammatory characteristics and different severities of asthmatic patients. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Maria Otal Buesa, Diana Betancor, Jaime Bernaola, Joaquin Sastre Source Type: research

Cytokine responses in Chlamydia pneumoniae-stimulated PBMC in asthmatic and non-asthmatic subjects.
Chlamydia pneumoniae (C. pneumoniae) is a gram-negative intracellular bacterium that causes respiratory infections in humans, including asthmatic and non-asthmatic subjects. C. pneumoniae activates cells in vitro and produces cytokines that may contribute to inflammatory responses observed in asthma. Activation of cell-mediated immune (CMI) responses is important for protective immunity; these responses may be impaired in patients with asthma. The aim of this study sought to compare cytokine responses between subjects with or without asthma. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Sarah Shidid, Nutchaya Amornruk, Wefag Ahmed, Haram Abdelmajid, Yitzchok Norowitz, Stephan Kohlhoff, Tamar Smith-Norowitz Source Type: research